Reviewed, UniProtKB/Swiss-Prot O26119 (RNP1_METTH)

Names and origin

Protein names

Recommended name:
    Ribonuclease P protein component 1
      Short name=RNase P component 1
    EC=3.1.26.5

Gene names

Name:	rnp1
Ordered Locus Names:	MTH_11

Organism

Methanobacterium thermoautotrophicum [Complete proteome] [HAMAP]

Taxonomic identifier

187420 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter

Protein attributes

Sequence length	93 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends By similarity.
Catalytic activity	Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor. HAMAP MF_00754
Subunit structure	Consists of a catalytic RNA component and at least 4 protein subunits. HAMAP MF_00754
Sequence similarities	Belongs to the eukaryotic/archaeal RNase P protein component 1 family.

Ontologies

Keywords
Biological process	tRNA processing
Molecular function	Hydrolase
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	mRNA cleavage Inferred from electronic annotation. Source: InterPro rRNA processing Inferred from electronic annotation. Source: InterPro tRNA 5'-leader removal Inferred from electronic annotation. Source: HAMAP
Cellular component	ribonuclease MRP complex Inferred from electronic annotation. Source: InterPro ribonuclease P complex Inferred from electronic annotation. Source: InterPro
Molecular function	RNA binding Inferred from electronic annotation. Source: InterPro ribonuclease P activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 93

93

Ribonuclease P protein component 1 HAMAP MF_00754

PRO_0000128433

Secondary structure

1

.

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.

.

.

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.

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.

.

.

.

.

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.

.

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.

.

93

Helix Strand Turn

Details...

Beta strand

16 – 21

6

Turn

25 – 29

5

Beta strand

31 – 33

3

Beta strand

36 – 38

3

Beta strand

41 – 46

6

Turn

47 – 49

3

Beta strand

50 – 55

6

Beta strand

60 – 65

6

Turn

66 – 68

3

Beta strand

69 – 73

5

Beta strand

75 – 77

3

Sequences

	Sequence		Length	Mass (Da)
	O26119-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 9641D6240AAE7928	FASTA	93	10,740
	10 20 30 40 50 60 MITPRNIFRH ELIGLSVRIA RSVHRDIQGI SGRVVDETRN TLRIEMDDGR EITVPKGIAV 70 80 90 FHFRTPQGEL VEIDGRALVA RPEERIKKKF RKP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics." Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. , Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N. J. Bacteriol. 179:7135-7155(1997) [PubMed: 9371463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Delta H.
[2]	"Archaeal RNase P has multiple protein subunits homologous to eukaryotic nuclear RNase P proteins." Hall T.A., Brown J.W. RNA 8:296-306(2002) [PubMed: 12003490] [Abstract] Cited for: CHARACTERIZATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

AE000666 Genomic DNA. Translation: AAB84512.1.

PIR

B69013.

RefSeq

NP_275156.1.

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1OQK	NMR	-	A	2-93	[»]

ModBase

Search...

Protein-protein interaction databases

STRING

O26119.

Genome annotation databases

GeneID

1469973.

GenomeReviews

Gene locus MTH_11 in contig AE000666_GR.

KEGG

mth:MTH11.

NMPDR

fig|187420.1.peg.11.

Organism-specific databases

CMR

Search...

Phylogenomic databases

HOGENOM

O26119.

OMA

VINETRN.

Enzyme and pathway databases

BioCyc

MTHE187420:MTH11-MON.

BRENDA

3.1.26.5. 270.

Family and domain databases

HAMAP

MF_00754.
[Tree]

InterPro

IPR002730. RNase_P/MRP_p29-sub_euk/arc.
[Graphical view]

Gene3D

G3DSA:2.30.30.210. RNase_P_Rpp29. 1 hit.

Pfam

PF01868. UPF0086. 1 hit.
[Graphical view]

ProDom

PD009163. UPF0086. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SMART

SM00538. POP4. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

RNP1_METTH

Accession

Primary (citable) accession number: O26119

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 1, 1998
Last modified:	November 3, 2009
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)