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O26119 (RNP1_METTH) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonuclease P protein component 1

Short name=RNase P component 1
EC=3.1.26.5
Alternative name(s):
Rpp29
Gene names
Name:rnp1
Ordered Locus Names:MTH_11
OrganismMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum) [Reference proteome] [HAMAP]
Taxonomic identifier187420 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter

Protein attributes

Sequence length93 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Ref.2 Ref.3

Catalytic activity

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor. HAMAP-Rule MF_00754

Subunit structure

Consists of a catalytic RNA component and at least 4-5 protein subunits. Ref.2

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00754.

Induction

Constitutively expressed (at protein level). Ref.2

Sequence similarities

Belongs to the eukaryotic/archaeal RNase P protein component 1 family.

Ontologies

Keywords
   Biological processtRNA processing
   Cellular componentCytoplasm
   Molecular functionEndonuclease
Hydrolase
Nuclease
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmRNA cleavage

Inferred from electronic annotation. Source: InterPro

rRNA processing

Inferred from electronic annotation. Source: InterPro

tRNA 5'-leader removal

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

ribonuclease MRP complex

Inferred from electronic annotation. Source: InterPro

ribonuclease P complex

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: InterPro

ribonuclease P activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9393Ribonuclease P protein component 1 HAMAP-Rule MF_00754
PRO_0000128433

Secondary structure

................... 93
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O26119 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 9641D6240AAE7928

FASTA9310,740
        10         20         30         40         50         60 
MITPRNIFRH ELIGLSVRIA RSVHRDIQGI SGRVVDETRN TLRIEMDDGR EITVPKGIAV 

        70         80         90 
FHFRTPQGEL VEIDGRALVA RPEERIKKKF RKP 

« Hide

References

« Hide 'large scale' references
[1]"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics."
Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. expand/collapse author list , Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N.
J. Bacteriol. 179:7135-7155(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.
[2]"Archaeal RNase P has multiple protein subunits homologous to eukaryotic nuclear RNase P proteins."
Hall T.A., Brown J.W.
RNA 8:296-306(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBUNIT, INDUCTION.
Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.
[3]"Structure of Mth11/Mth Rpp29, an essential protein subunit of archaeal and eukaryotic RNase P."
Boomershine W.P., McElroy C.A., Tsai H.Y., Wilson R.C., Gopalan V., Foster M.P.
Proc. Natl. Acad. Sci. U.S.A. 100:15398-15403(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 2-93, FUNCTION, RNA-BINDING.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000666 Genomic DNA. Translation: AAB84512.1.
PIRB69013.
RefSeqNP_275156.1. NC_000916.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1OQKNMR-A2-93[»]
ProteinModelPortalO26119.
SMRO26119. Positions 9-86.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO26119. 1 interaction.
STRING187420.MTH11.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB84512; AAB84512; MTH_11.
GeneID1469973.
KEGGmth:MTH11.

Phylogenomic databases

eggNOGCOG1588.
KOK03538.
OMAHEIKMIG.

Enzyme and pathway databases

BioCycMTHE187420:GJNM-11-MONOMER.

Family and domain databases

Gene3D2.30.30.210. 1 hit.
HAMAPMF_00754. RNase_P_1.
InterProIPR002730. RNase_P/MRP_p29.
IPR023538. RNase_P_comp-1.
IPR023534. Rof/RNase_P-like.
[Graphical view]
PfamPF01868. UPF0086. 1 hit.
[Graphical view]
SMARTSM00538. POP4. 1 hit.
[Graphical view]
SUPFAMSSF101744. SSF101744. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceO26119.

Entry information

Entry nameRNP1_METTH
AccessionPrimary (citable) accession number: O26119
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references