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O26119

- RNP1_METTH

UniProt

O26119 - RNP1_METTH

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Protein

Ribonuclease P protein component 1

Gene

rnp1

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.2 PublicationsUniRule annotation

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.UniRule annotation

GO - Molecular functioni

  1. ribonuclease P activity Source: UniProtKB-HAMAP
  2. RNA binding Source: InterPro

GO - Biological processi

  1. mRNA cleavage Source: InterPro
  2. rRNA processing Source: InterPro
  3. tRNA 5'-leader removal Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

tRNA processing

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-11-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein component 1UniRule annotation (EC:3.1.26.5UniRule annotation)
Short name:
RNase P component 1UniRule annotation
Alternative name(s):
Rpp29UniRule annotation
Gene namesi
Name:rnp1UniRule annotation
Ordered Locus Names:MTH_11
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
ProteomesiUP000005223: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
  2. ribonuclease MRP complex Source: InterPro
  3. ribonuclease P complex Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9393Ribonuclease P protein component 1PRO_0000128433Add
BLAST

Expressioni

Inductioni

Constitutively expressed (at protein level).1 Publication

Interactioni

Subunit structurei

Consists of a catalytic RNA component and at least 4-5 protein subunits.1 PublicationUniRule annotation

Protein-protein interaction databases

IntActiO26119. 1 interaction.
STRINGi187420.MTH11.

Structurei

Secondary structure

1
93
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi16 – 216Combined sources
Turni25 – 295Combined sources
Beta strandi31 – 333Combined sources
Beta strandi36 – 383Combined sources
Beta strandi41 – 466Combined sources
Turni47 – 493Combined sources
Beta strandi50 – 556Combined sources
Beta strandi60 – 656Combined sources
Turni66 – 683Combined sources
Beta strandi69 – 735Combined sources
Beta strandi75 – 773Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OQKNMR-A2-93[»]
ProteinModelPortaliO26119.
SMRiO26119. Positions 9-86.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO26119.

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic/archaeal RNase P protein component 1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1588.
KOiK03538.
OMAiHEIKMIG.

Family and domain databases

Gene3Di2.30.30.210. 1 hit.
HAMAPiMF_00754. RNase_P_1.
InterProiIPR002730. RNase_P/MRP_p29.
IPR023538. RNase_P_comp-1.
IPR023534. Rof/RNase_P-like.
[Graphical view]
PfamiPF01868. UPF0086. 1 hit.
[Graphical view]
SMARTiSM00538. POP4. 1 hit.
[Graphical view]
SUPFAMiSSF101744. SSF101744. 1 hit.

Sequencei

Sequence statusi: Complete.

O26119-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MITPRNIFRH ELIGLSVRIA RSVHRDIQGI SGRVVDETRN TLRIEMDDGR
60 70 80 90
EITVPKGIAV FHFRTPQGEL VEIDGRALVA RPEERIKKKF RKP
Length:93
Mass (Da):10,740
Last modified:January 1, 1998 - v1
Checksum:i9641D6240AAE7928
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000666 Genomic DNA. Translation: AAB84512.1.
PIRiB69013.
RefSeqiNP_275156.1. NC_000916.1.
WP_010875653.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB84512; AAB84512; MTH_11.
GeneIDi1469973.
KEGGimth:MTH11.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000666 Genomic DNA. Translation: AAB84512.1 .
PIRi B69013.
RefSeqi NP_275156.1. NC_000916.1.
WP_010875653.1. NC_000916.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1OQK NMR - A 2-93 [» ]
ProteinModelPortali O26119.
SMRi O26119. Positions 9-86.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O26119. 1 interaction.
STRINGi 187420.MTH11.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB84512 ; AAB84512 ; MTH_11 .
GeneIDi 1469973.
KEGGi mth:MTH11.

Phylogenomic databases

eggNOGi COG1588.
KOi K03538.
OMAi HEIKMIG.

Enzyme and pathway databases

BioCyci MTHE187420:GJNM-11-MONOMER.

Miscellaneous databases

EvolutionaryTracei O26119.

Family and domain databases

Gene3Di 2.30.30.210. 1 hit.
HAMAPi MF_00754. RNase_P_1.
InterProi IPR002730. RNase_P/MRP_p29.
IPR023538. RNase_P_comp-1.
IPR023534. Rof/RNase_P-like.
[Graphical view ]
Pfami PF01868. UPF0086. 1 hit.
[Graphical view ]
SMARTi SM00538. POP4. 1 hit.
[Graphical view ]
SUPFAMi SSF101744. SSF101744. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.
  2. "Archaeal RNase P has multiple protein subunits homologous to eukaryotic nuclear RNase P proteins."
    Hall T.A., Brown J.W.
    RNA 8:296-306(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, INDUCTION.
    Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.
  3. "Structure of Mth11/Mth Rpp29, an essential protein subunit of archaeal and eukaryotic RNase P."
    Boomershine W.P., McElroy C.A., Tsai H.Y., Wilson R.C., Gopalan V., Foster M.P.
    Proc. Natl. Acad. Sci. U.S.A. 100:15398-15403(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 2-93, FUNCTION, RNA-BINDING.

Entry informationi

Entry nameiRNP1_METTH
AccessioniPrimary (citable) accession number: O26119
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3