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O26119

- RNP1_METTH

UniProt

O26119 - RNP1_METTH

Protein

Ribonuclease P protein component 1

Gene

rnp1

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.2 PublicationsUniRule annotation

    Catalytic activityi

    Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.UniRule annotation

    GO - Molecular functioni

    1. ribonuclease P activity Source: UniProtKB-HAMAP
    2. RNA binding Source: InterPro

    GO - Biological processi

    1. mRNA cleavage Source: InterPro
    2. rRNA processing Source: InterPro
    3. tRNA 5'-leader removal Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Keywords - Biological processi

    tRNA processing

    Enzyme and pathway databases

    BioCyciMTHE187420:GJNM-11-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease P protein component 1UniRule annotation (EC:3.1.26.5UniRule annotation)
    Short name:
    RNase P component 1UniRule annotation
    Alternative name(s):
    Rpp29UniRule annotation
    Gene namesi
    Name:rnp1UniRule annotation
    Ordered Locus Names:MTH_11
    OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
    Taxonomic identifieri187420 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
    ProteomesiUP000005223: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. ribonuclease MRP complex Source: InterPro
    3. ribonuclease P complex Source: UniProtKB-HAMAP

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 9393Ribonuclease P protein component 1PRO_0000128433Add
    BLAST

    Expressioni

    Inductioni

    Constitutively expressed (at protein level).1 Publication

    Interactioni

    Subunit structurei

    Consists of a catalytic RNA component and at least 4-5 protein subunits.1 PublicationUniRule annotation

    Protein-protein interaction databases

    IntActiO26119. 1 interaction.
    STRINGi187420.MTH11.

    Structurei

    Secondary structure

    1
    93
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi16 – 216
    Turni25 – 295
    Beta strandi31 – 333
    Beta strandi36 – 383
    Beta strandi41 – 466
    Turni47 – 493
    Beta strandi50 – 556
    Beta strandi60 – 656
    Turni66 – 683
    Beta strandi69 – 735
    Beta strandi75 – 773

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1OQKNMR-A2-93[»]
    ProteinModelPortaliO26119.
    SMRiO26119. Positions 9-86.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO26119.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the eukaryotic/archaeal RNase P protein component 1 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1588.
    KOiK03538.
    OMAiHEIKMIG.

    Family and domain databases

    Gene3Di2.30.30.210. 1 hit.
    HAMAPiMF_00754. RNase_P_1.
    InterProiIPR002730. RNase_P/MRP_p29.
    IPR023538. RNase_P_comp-1.
    IPR023534. Rof/RNase_P-like.
    [Graphical view]
    PfamiPF01868. UPF0086. 1 hit.
    [Graphical view]
    SMARTiSM00538. POP4. 1 hit.
    [Graphical view]
    SUPFAMiSSF101744. SSF101744. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O26119-1 [UniParc]FASTAAdd to Basket

    « Hide

    MITPRNIFRH ELIGLSVRIA RSVHRDIQGI SGRVVDETRN TLRIEMDDGR   50
    EITVPKGIAV FHFRTPQGEL VEIDGRALVA RPEERIKKKF RKP 93
    Length:93
    Mass (Da):10,740
    Last modified:January 1, 1998 - v1
    Checksum:i9641D6240AAE7928
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000666 Genomic DNA. Translation: AAB84512.1.
    PIRiB69013.
    RefSeqiNP_275156.1. NC_000916.1.
    WP_010875653.1. NC_000916.1.

    Genome annotation databases

    EnsemblBacteriaiAAB84512; AAB84512; MTH_11.
    GeneIDi1469973.
    KEGGimth:MTH11.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000666 Genomic DNA. Translation: AAB84512.1 .
    PIRi B69013.
    RefSeqi NP_275156.1. NC_000916.1.
    WP_010875653.1. NC_000916.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1OQK NMR - A 2-93 [» ]
    ProteinModelPortali O26119.
    SMRi O26119. Positions 9-86.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O26119. 1 interaction.
    STRINGi 187420.MTH11.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB84512 ; AAB84512 ; MTH_11 .
    GeneIDi 1469973.
    KEGGi mth:MTH11.

    Phylogenomic databases

    eggNOGi COG1588.
    KOi K03538.
    OMAi HEIKMIG.

    Enzyme and pathway databases

    BioCyci MTHE187420:GJNM-11-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei O26119.

    Family and domain databases

    Gene3Di 2.30.30.210. 1 hit.
    HAMAPi MF_00754. RNase_P_1.
    InterProi IPR002730. RNase_P/MRP_p29.
    IPR023538. RNase_P_comp-1.
    IPR023534. Rof/RNase_P-like.
    [Graphical view ]
    Pfami PF01868. UPF0086. 1 hit.
    [Graphical view ]
    SMARTi SM00538. POP4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF101744. SSF101744. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.
    2. "Archaeal RNase P has multiple protein subunits homologous to eukaryotic nuclear RNase P proteins."
      Hall T.A., Brown J.W.
      RNA 8:296-306(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT, INDUCTION.
      Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.
    3. "Structure of Mth11/Mth Rpp29, an essential protein subunit of archaeal and eukaryotic RNase P."
      Boomershine W.P., McElroy C.A., Tsai H.Y., Wilson R.C., Gopalan V., Foster M.P.
      Proc. Natl. Acad. Sci. U.S.A. 100:15398-15403(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 2-93, FUNCTION, RNA-BINDING.

    Entry informationi

    Entry nameiRNP1_METTH
    AccessioniPrimary (citable) accession number: O26119
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3