Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O26103 (PDXA_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
4-hydroxythreonine-4-phosphate dehydrogenase

EC=1.1.1.262
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenase
Gene names
Name:pdxA
Ordered Locus Names:HP_1583
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length307 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) By similarity. HAMAP-Rule MF_00536

Catalytic activity

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH. HAMAP-Rule MF_00536

Cofactor

Binds 1 divalent metal cation per subunit. Can use ions such as zinc, magnesium or cobalt By similarity.

Pathway

Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 4/5. HAMAP-Rule MF_00536

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00536

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00536.

Miscellaneous

The active site is located at the dimer interface By similarity.

Sequence similarities

Belongs to the PdxA family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3073074-hydroxythreonine-4-phosphate dehydrogenase HAMAP-Rule MF_00536
PRO_0000188809

Sites

Metal binding1561Divalent metal cation; shared with dimeric partner By similarity
Metal binding1951Divalent metal cation; shared with dimeric partner By similarity
Metal binding2511Divalent metal cation; shared with dimeric partner By similarity
Binding site1261Substrate By similarity
Binding site1271Substrate By similarity
Binding site2591Substrate By similarity
Binding site2681Substrate By similarity
Binding site2771Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
O26103 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: B122B0A0BB00D70E

FASTA30733,579
        10         20         30         40         50         60 
MAKKKIAISC GDIQGVGLEL ILKSHKEVSA LCEPLYLTDG ELLERANQLL HNAYETKVLN 

        70         80         90        100        110        120 
ALAIDAPLPL LNSSTIGKVS AQSGAYSFES FKKACELADS KEVDGICTLP INKLAWQQAQ 

       130        140        150        160        170        180 
IPFVGHTDFL KQRYKDHQII MMLGCSKLFV GLFSDHVPLG AVSQLIQVGA LVKFLLAFQK 

       190        200        210        220        230        240 
STQAKIVQVC GFNPHAGEEG LFGEEDERIL KAIQKSNQTL GFECFLGPLP ADSAFAPNKR 

       250        260        270        280        290        300 
KITPFYVSMS HDVGLAPLKA LYFDESINVS LNAPILRTST DHGTAFDIAY QNKANNKSYL 


NAIKYLA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD08621.1.
PIRG64717.
RefSeqNP_208374.1. NC_000915.1.
YP_006935510.1. NC_018939.1.

3D structure databases

ProteinModelPortalO26103.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-3611N.
IntActO26103. 1 interaction.
MINTMINT-176457.
STRING85962.HP1583.

PTM databases

PhosSiteP11041011.

Proteomic databases

PRIDEO26103.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD08621; AAD08621; HP_1583.
GeneID13870803.
899708.
KEGGheo:C694_08200.
hpy:HP1583.
PATRIC20594593. VBIHelPyl33062_1664.

Phylogenomic databases

eggNOGCOG1995.
KOK00097.
OMAPINKLAW.
OrthoDBEOG6GN6ZC.
ProtClustDBPRK03946.

Enzyme and pathway databases

BioCycHPY:HP1583-MONOMER.
UniPathwayUPA00244; UER00312.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
HAMAPMF_00536. PdxA.
InterProIPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view]
PfamPF04166. PdxA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00557. pdxA. 1 hit.
ProtoNetSearch...

Entry information

Entry namePDXA_HELPY
AccessionPrimary (citable) accession number: O26103
Entry history
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: January 1, 1998
Last modified: February 19, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names