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O26103

- PDXA_HELPY

UniProt

O26103 - PDXA_HELPY

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Protein

4-hydroxythreonine-4-phosphate dehydrogenase

Gene

pdxA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).UniRule annotation

Catalytic activityi

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.

Cofactori

Zn2+UniRule annotation, Mg2+UniRule annotation, Co2+UniRule annotationNote: Binds 1 divalent metal cation per subunit. Can use ions such as Zn(2+), Mg(2+) or Co(2+).UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei126 – 1261SubstrateUniRule annotation
Binding sitei127 – 1271SubstrateUniRule annotation
Metal bindingi156 – 1561Divalent metal cation; shared with dimeric partnerUniRule annotation
Metal bindingi195 – 1951Divalent metal cation; shared with dimeric partnerUniRule annotation
Metal bindingi251 – 2511Divalent metal cation; shared with dimeric partnerUniRule annotation
Binding sitei259 – 2591SubstrateUniRule annotation
Binding sitei268 – 2681SubstrateUniRule annotation
Binding sitei277 – 2771SubstrateUniRule annotation

GO - Molecular functioni

  1. 4-hydroxythreonine-4-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. cobalt ion binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. NAD binding Source: InterPro
  5. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. pyridoxal phosphate biosynthetic process Source: UniProtKB-HAMAP
  2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridoxine biosynthesis

Keywords - Ligandi

Cobalt, Magnesium, Metal-binding, NAD, NADP, Zinc

Enzyme and pathway databases

BioCyciHPY:HP1583-MONOMER.
UniPathwayiUPA00244; UER00312.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxythreonine-4-phosphate dehydrogenaseUniRule annotation (EC:1.1.1.262UniRule annotation)
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenaseUniRule annotation
Gene namesi
Name:pdxAUniRule annotation
Ordered Locus Names:HP_1583
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3073074-hydroxythreonine-4-phosphate dehydrogenasePRO_0000188809Add
BLAST

Proteomic databases

PRIDEiO26103.

PTM databases

PhosSiteiP11041011.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

DIPiDIP-3611N.
IntActiO26103. 1 interaction.
MINTiMINT-176457.
STRINGi85962.HP1583.

Structurei

3D structure databases

ProteinModelPortaliO26103.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxA family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1995.
KOiK00097.
OMAiERLNTIH.
OrthoDBiEOG6GN6ZC.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
HAMAPiMF_00536. PdxA.
InterProiIPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view]
PfamiPF04166. PdxA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00557. pdxA. 1 hit.

Sequencei

Sequence statusi: Complete.

O26103-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKKKIAISC GDIQGVGLEL ILKSHKEVSA LCEPLYLTDG ELLERANQLL
60 70 80 90 100
HNAYETKVLN ALAIDAPLPL LNSSTIGKVS AQSGAYSFES FKKACELADS
110 120 130 140 150
KEVDGICTLP INKLAWQQAQ IPFVGHTDFL KQRYKDHQII MMLGCSKLFV
160 170 180 190 200
GLFSDHVPLG AVSQLIQVGA LVKFLLAFQK STQAKIVQVC GFNPHAGEEG
210 220 230 240 250
LFGEEDERIL KAIQKSNQTL GFECFLGPLP ADSAFAPNKR KITPFYVSMS
260 270 280 290 300
HDVGLAPLKA LYFDESINVS LNAPILRTST DHGTAFDIAY QNKANNKSYL

NAIKYLA
Length:307
Mass (Da):33,579
Last modified:January 1, 1998 - v1
Checksum:iB122B0A0BB00D70E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08621.1.
PIRiG64717.
RefSeqiNP_208374.1. NC_000915.1.
YP_006935510.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08621; AAD08621; HP_1583.
GeneIDi13870803.
899708.
KEGGiheo:C694_08200.
hpy:HP1583.
PATRICi20594593. VBIHelPyl33062_1664.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08621.1 .
PIRi G64717.
RefSeqi NP_208374.1. NC_000915.1.
YP_006935510.1. NC_018939.1.

3D structure databases

ProteinModelPortali O26103.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-3611N.
IntActi O26103. 1 interaction.
MINTi MINT-176457.
STRINGi 85962.HP1583.

PTM databases

PhosSitei P11041011.

Proteomic databases

PRIDEi O26103.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD08621 ; AAD08621 ; HP_1583 .
GeneIDi 13870803.
899708.
KEGGi heo:C694_08200.
hpy:HP1583.
PATRICi 20594593. VBIHelPyl33062_1664.

Phylogenomic databases

eggNOGi COG1995.
KOi K00097.
OMAi ERLNTIH.
OrthoDBi EOG6GN6ZC.

Enzyme and pathway databases

UniPathwayi UPA00244 ; UER00312 .
BioCyci HPY:HP1583-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
HAMAPi MF_00536. PdxA.
InterProi IPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view ]
Pfami PF04166. PdxA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00557. pdxA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiPDXA_HELPY
AccessioniPrimary (citable) accession number: O26103
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: January 1, 1998
Last modified: November 26, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The active site is located at the dimer interface.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3