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Protein

Methionine import ATP-binding protein MetN

Gene

metN

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi36 – 43ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Amino-acid transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPY:HP1576-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine import ATP-binding protein MetNUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:metNUniRule annotation
Ordered Locus Names:HP_1576
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002703101 – 327Methionine import ATP-binding protein MetNAdd BLAST327

Proteomic databases

PaxDbiO26096.

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (MetN), two transmembrane proteins (MetI) and a solute-binding protein (MetQ).UniRule annotation

Protein-protein interaction databases

DIPiDIP-3488N.
IntActiO26096. 3 interactors.
MINTiMINT-177552.
STRINGi85962.HP1576.

Structurei

3D structure databases

ProteinModelPortaliO26096.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 239ABC transporterUniRule annotationAdd BLAST237

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family. [View classification]UniRule annotation
Contains 1 ABC transporter domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108JEI. Bacteria.
COG1135. LUCA.
KOiK02071.
OMAiLIRLINC.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR026253. ABC_MetN.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR017908. ABC_transprt_methionine_MetN_C.
IPR018449. NIL_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24220:SF549. PTHR24220:SF549. 1 hit.
PfamiPF00005. ABC_tran. 1 hit.
PF09383. NIL. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00930. NIL. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51264. METN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O26096-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVELKNIEK IYENGFHALK GVNLELKKGD ILGVIGYSGA GKSTLIRLIN
60 70 80 90 100
CLERPSSGEV LVNGVNLLKL KPKELQKARQ KIGMIFQHFN LLSAKNVFEN
110 120 130 140 150
VAFALEIARW EKNKIKSRVH ELLELVGLED KMHFYPKQLS GGQKQRVAIA
160 170 180 190 200
RSLANCPDLL LCDEATSALD SKTTHSILTL LSGIQKKLDL SIVFITHEIE
210 220 230 240 250
VVKELCNQMC VISSGEIVER GSVEEIFANP KHAVTKELLG IRNEHADKKS
260 270 280 290 300
QDVYRIVFLG EHLDEPIISN LIKRFKIDVS IISGNIEELT TKDIGYLVVR
310 320
FLGNTAETQR ALEYLNALGL QVEKLKD
Length:327
Mass (Da):36,622
Last modified:January 1, 1998 - v1
Checksum:i89F50E5A8D7D1E7B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96N → D in AAC45666 (PubMed:9294450).Curated1
Sequence conflicti113N → T in AAC45666 (PubMed:9294450).Curated1
Sequence conflicti132M → V in AAC45666 (PubMed:9294450).Curated1
Sequence conflicti145Q → E in AAC45666 (PubMed:9294450).Curated1
Sequence conflicti192I → V in AAC45666 (PubMed:9294450).Curated1
Sequence conflicti198E → Q in AAC45666 (PubMed:9294450).Curated1
Sequence conflicti247D → N in AAC45666 (PubMed:9294450).Curated1
Sequence conflicti279V → M in AAC45666 (PubMed:9294450).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF010307 Genomic DNA. Translation: AAC45666.1.
AE000511 Genomic DNA. Translation: AAD08616.1.
PIRiH64716.
RefSeqiNP_208367.1. NC_000915.1.
WP_000259757.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08616; AAD08616; HP_1576.
GeneIDi899715.
KEGGiheo:C694_08165.
hpy:HP1576.
PATRICi20594579. VBIHelPyl33062_1657.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF010307 Genomic DNA. Translation: AAC45666.1.
AE000511 Genomic DNA. Translation: AAD08616.1.
PIRiH64716.
RefSeqiNP_208367.1. NC_000915.1.
WP_000259757.1. NC_018939.1.

3D structure databases

ProteinModelPortaliO26096.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3488N.
IntActiO26096. 3 interactors.
MINTiMINT-177552.
STRINGi85962.HP1576.

Proteomic databases

PaxDbiO26096.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08616; AAD08616; HP_1576.
GeneIDi899715.
KEGGiheo:C694_08165.
hpy:HP1576.
PATRICi20594579. VBIHelPyl33062_1657.

Phylogenomic databases

eggNOGiENOG4108JEI. Bacteria.
COG1135. LUCA.
KOiK02071.
OMAiLIRLINC.

Enzyme and pathway databases

BioCyciHPY:HP1576-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR026253. ABC_MetN.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR017908. ABC_transprt_methionine_MetN_C.
IPR018449. NIL_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24220:SF549. PTHR24220:SF549. 1 hit.
PfamiPF00005. ABC_tran. 1 hit.
PF09383. NIL. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00930. NIL. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51264. METN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMETN_HELPY
AccessioniPrimary (citable) accession number: O26096
Secondary accession number(s): O30552
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 1, 1998
Last modified: October 5, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.