O26076 (NHAA_HELPY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Na(+)/H(+) antiporter nhaA

Alternative name(s):
Sodium/proton antiporter nhaA

Gene names

Name:	nhaA
Ordered Locus Names:	HP_1552

Organism

Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)

Taxonomic identifier

85962 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	438 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Na+/H+ antiporter that extrudes sodium in exchange for external protons By similarity. HAMAP MF_01844
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_01844.
Sequence similarities	Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family. [View classification]

Ontologies

Keywords
Biological process	Antiport Ion transport Sodium transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Sodium
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of pH Inferred from electronic annotation. Source: InterPro sodium ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	antiporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 438	438	Na(+)/H(+) antiporter nhaA HAMAP MF_01844		PRO_0000334320
Regions
	Transmembrane	23 – 43	21	Helical; Potential
	Transmembrane	62 – 82	21	Helical; Potential
	Transmembrane	104 – 124	21	Helical; Potential
	Transmembrane	133 – 153	21	Helical; Potential
	Transmembrane	162 – 182	21	Helical; Potential
	Transmembrane	185 – 205	21	Helical; Potential
	Transmembrane	221 – 241	21	Helical; Potential
	Transmembrane	302 – 322	21	Helical; Potential
	Transmembrane	337 – 357	21	Helical; Potential
	Transmembrane	372 – 392	21	Helical; Potential
	Transmembrane	410 – 430	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	O26076 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: C3E97BCB74F71414	FASTA	438	47,759
	10 20 30 40 50 60 MNLKKTENAL SLTLKNFIKS ESFGGIFLFL NAVLAMVVAN SFLKESYFAL WHTPFGFQIG 70 80 90 100 110 120 DFFIGFSLHN WIDDVLMALF FLMIGLEIKR ELLFGELSSF KKASFPVIAA IGGMIAPGLI 130 140 150 160 170 180 YFFLNANTPS QHGFGIPMAT DIAFALGVIM LLGKRVPTAL KVFLITLAVA DDLGAIVVIA 190 200 210 220 230 240 LFYTTNLKFA WLLGALGVVL VLAVLNRLNM RSLIPYLLLG VLLWFCVHQS GIHATIAAVI 250 260 270 280 290 300 LAFMIPVKIP KDSKNVELLE LGKRYAETSS GALLSKEQQE ILHSIEEKAS ALQSPLERLE 310 320 330 340 350 360 HFLAPISGYF IMPLFAFANA GVSVDSSINL EVDKVLLGVI LGLCLGKPLG IFLITFISEK 370 380 390 400 410 420 LKITARPKGI SWWHILGAGL LAGIGFTMSM FISNLAFTSE HKDAMEVAKI AILLGSLISG 430 IIGALYLFAL DKRAALKK

References

[1]

"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed: 9252185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000511 Genomic DNA. Translation: AAD08592.1.
PIR	H64713.
RefSeq	NP_208343.1. NC_000915.1.
3D structure databases
HSSP	HSSP built from PDB template 1ZCD based on UniProtKB P13738.
ProteinModelPortal	O26076.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	899739.
GenomeReviews	Gene locus HP_1552 in contig AE000511_GR.
KEGG	hpy:HP1552.
NMPDR	fig|85962.1.peg.1538.
PATRIC	20594527. VBIHelPyl33062_1631.
TIGR	HP_1552.
Phylogenomic databases
HOGENOM	HBG665619.
OMA	HFLAPIS.
ProtClustDB	PRK14856.
Family and domain databases
HAMAP	MF_01844. NhaA. [Tree]
InterPro	IPR023171. Na/H_antiporter_dom. IPR004670. NhaA. [Graphical view]
Gene3D	G3DSA:1.20.1530.10. G3DSA:1.20.1530.10. 2 hits.
KO	K03313.
Pfam	PF06965. Na_H_antiport_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR00773. NhaA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NHAA_HELPY

Accession

Primary (citable) accession number: O26076

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	January 1, 1998
Last modified:	January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program