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O26073

- SECF_HELPY

UniProt

O26073 - SECF_HELPY

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Protein

Protein translocase subunit SecF

Gene

secF

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.UniRule annotation

GO - Molecular functioni

  1. P-P-bond-hydrolysis-driven protein transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. intracellular protein transmembrane transport Source: UniProtKB-HAMAP
  2. protein targeting Source: UniProtKB-HAMAP
  3. protein transport by the Sec complex Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciHPY:HP1549-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecF
Gene namesi
Name:secFUniRule annotation
Ordered Locus Names:HP_1549
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. intracellular Source: GOC
  3. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Protein translocase subunit SecFPRO_0000095980Add
BLAST

Proteomic databases

PRIDEiO26073.

Interactioni

Subunit structurei

Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.UniRule annotation

Protein-protein interaction databases

STRINGi85962.HP1549.

Structurei

3D structure databases

ProteinModelPortaliO26073.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei19 – 3921HelicalUniRule annotationAdd
BLAST
Transmembranei138 – 15821HelicalUniRule annotationAdd
BLAST
Transmembranei162 – 18221HelicalUniRule annotationAdd
BLAST
Transmembranei189 – 20921HelicalUniRule annotationAdd
BLAST
Transmembranei244 – 26421HelicalUniRule annotationAdd
BLAST
Transmembranei269 – 28921HelicalUniRule annotationAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the SecD/SecF family. SecF subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0341.
KOiK03074.
OMAiLSSKFFE.
OrthoDBiEOG676Z5R.

Family and domain databases

HAMAPiMF_01464_B. SecF_B.
InterProiIPR022813. SecD/SecF_arch_bac.
IPR022645. SecD/SecF_bac.
IPR022646. SecD/SecF_CS.
IPR005665. SecF_bac.
[Graphical view]
PfamiPF07549. Sec_GG. 1 hit.
PF02355. SecD_SecF. 1 hit.
[Graphical view]
PRINTSiPR01755. SECFTRNLCASE.
TIGRFAMsiTIGR00916. 2A0604s01. 1 hit.
TIGR00966. 3a0501s07. 1 hit.

Sequencei

Sequence statusi: Complete.

O26073-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELFKRTRIL SFMRYSNYGV IVSAILALLA LGLLFFKGFS LGIDFAGGSL
60 70 80 90 100
VQVRYTQNAP IKEVRDLFEK EARFKGVQVS EFGSKEEILI KFPFVETAEN
110 120 130 140 150
EDLNAIVANI LKPSGDFEIR KFDTVGPRVG SELKEKGILS LILALIAIMV
160 170 180 190 200
YVSFRYEWRF ALASVIALVH DVILVASSVI VFKIDMNLEV IAALLTLIGY
210 220 230 240 250
SINDTIIIFD RIREEMLSQK TKNATQAIDE AISSTLTRTL LTSLTVFFVV
260 270 280 290 300
LILCVFGSKI IIGFSLPMLI GTIVGTYSSI FIAPKVALLL GFDMDKYYEN
310 320
ETRKIKKAQE KEKMRRLYES GQV
Length:323
Mass (Da):36,277
Last modified:January 1, 1998 - v1
Checksum:iEAD9190473F21F59
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08587.1.
PIRiE64713.
RefSeqiNP_208340.1. NC_000915.1.
YP_006935475.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08587; AAD08587; HP_1549.
GeneIDi13870768.
899742.
KEGGiheo:C694_08025.
hpy:HP1549.
PATRICi20594521. VBIHelPyl33062_1628.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08587.1 .
PIRi E64713.
RefSeqi NP_208340.1. NC_000915.1.
YP_006935475.1. NC_018939.1.

3D structure databases

ProteinModelPortali O26073.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 85962.HP1549.

Proteomic databases

PRIDEi O26073.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD08587 ; AAD08587 ; HP_1549 .
GeneIDi 13870768.
899742.
KEGGi heo:C694_08025.
hpy:HP1549.
PATRICi 20594521. VBIHelPyl33062_1628.

Phylogenomic databases

eggNOGi COG0341.
KOi K03074.
OMAi LSSKFFE.
OrthoDBi EOG676Z5R.

Enzyme and pathway databases

BioCyci HPY:HP1549-MONOMER.

Family and domain databases

HAMAPi MF_01464_B. SecF_B.
InterProi IPR022813. SecD/SecF_arch_bac.
IPR022645. SecD/SecF_bac.
IPR022646. SecD/SecF_CS.
IPR005665. SecF_bac.
[Graphical view ]
Pfami PF07549. Sec_GG. 1 hit.
PF02355. SecD_SecF. 1 hit.
[Graphical view ]
PRINTSi PR01755. SECFTRNLCASE.
TIGRFAMsi TIGR00916. 2A0604s01. 1 hit.
TIGR00966. 3a0501s07. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiSECF_HELPY
AccessioniPrimary (citable) accession number: O26073
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3