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O26073

- SECF_HELPY

UniProt

O26073 - SECF_HELPY

Protein

Protein translocase subunit SecF

Gene

secF

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.UniRule annotation

    GO - Molecular functioni

    1. P-P-bond-hydrolysis-driven protein transmembrane transporter activity Source: InterPro

    GO - Biological processi

    1. intracellular protein transmembrane transport Source: UniProtKB-HAMAP
    2. protein targeting Source: UniProtKB-HAMAP
    3. protein transport by the Sec complex Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Protein transport, Translocation, Transport

    Enzyme and pathway databases

    BioCyciHPY:HP1549-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein translocase subunit SecF
    Gene namesi
    Name:secFUniRule annotation
    Ordered Locus Names:HP_1549
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. intracellular Source: GOC
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 323323Protein translocase subunit SecFPRO_0000095980Add
    BLAST

    Proteomic databases

    PRIDEiO26073.

    Interactioni

    Subunit structurei

    Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.UniRule annotation

    Protein-protein interaction databases

    STRINGi85962.HP1549.

    Structurei

    3D structure databases

    ProteinModelPortaliO26073.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei19 – 3921HelicalUniRule annotationAdd
    BLAST
    Transmembranei138 – 15821HelicalUniRule annotationAdd
    BLAST
    Transmembranei162 – 18221HelicalUniRule annotationAdd
    BLAST
    Transmembranei189 – 20921HelicalUniRule annotationAdd
    BLAST
    Transmembranei244 – 26421HelicalUniRule annotationAdd
    BLAST
    Transmembranei269 – 28921HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SecD/SecF family. SecF subfamily.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0341.
    KOiK03074.
    OMAiLSSKFFE.
    OrthoDBiEOG676Z5R.

    Family and domain databases

    HAMAPiMF_01464_B. SecF_B.
    InterProiIPR022813. SecD/SecF_arch_bac.
    IPR022645. SecD/SecF_bac.
    IPR022646. SecD/SecF_CS.
    IPR005665. SecF_bac.
    [Graphical view]
    PfamiPF07549. Sec_GG. 1 hit.
    PF02355. SecD_SecF. 1 hit.
    [Graphical view]
    PRINTSiPR01755. SECFTRNLCASE.
    TIGRFAMsiTIGR00916. 2A0604s01. 1 hit.
    TIGR00966. 3a0501s07. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O26073-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELFKRTRIL SFMRYSNYGV IVSAILALLA LGLLFFKGFS LGIDFAGGSL    50
    VQVRYTQNAP IKEVRDLFEK EARFKGVQVS EFGSKEEILI KFPFVETAEN 100
    EDLNAIVANI LKPSGDFEIR KFDTVGPRVG SELKEKGILS LILALIAIMV 150
    YVSFRYEWRF ALASVIALVH DVILVASSVI VFKIDMNLEV IAALLTLIGY 200
    SINDTIIIFD RIREEMLSQK TKNATQAIDE AISSTLTRTL LTSLTVFFVV 250
    LILCVFGSKI IIGFSLPMLI GTIVGTYSSI FIAPKVALLL GFDMDKYYEN 300
    ETRKIKKAQE KEKMRRLYES GQV 323
    Length:323
    Mass (Da):36,277
    Last modified:January 1, 1998 - v1
    Checksum:iEAD9190473F21F59
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08587.1.
    PIRiE64713.
    RefSeqiNP_208340.1. NC_000915.1.
    YP_006935475.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD08587; AAD08587; HP_1549.
    GeneIDi13870768.
    899742.
    KEGGiheo:C694_08025.
    hpy:HP1549.
    PATRICi20594521. VBIHelPyl33062_1628.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08587.1 .
    PIRi E64713.
    RefSeqi NP_208340.1. NC_000915.1.
    YP_006935475.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali O26073.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 85962.HP1549.

    Proteomic databases

    PRIDEi O26073.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD08587 ; AAD08587 ; HP_1549 .
    GeneIDi 13870768.
    899742.
    KEGGi heo:C694_08025.
    hpy:HP1549.
    PATRICi 20594521. VBIHelPyl33062_1628.

    Phylogenomic databases

    eggNOGi COG0341.
    KOi K03074.
    OMAi LSSKFFE.
    OrthoDBi EOG676Z5R.

    Enzyme and pathway databases

    BioCyci HPY:HP1549-MONOMER.

    Family and domain databases

    HAMAPi MF_01464_B. SecF_B.
    InterProi IPR022813. SecD/SecF_arch_bac.
    IPR022645. SecD/SecF_bac.
    IPR022646. SecD/SecF_CS.
    IPR005665. SecF_bac.
    [Graphical view ]
    Pfami PF07549. Sec_GG. 1 hit.
    PF02355. SecD_SecF. 1 hit.
    [Graphical view ]
    PRINTSi PR01755. SECFTRNLCASE.
    TIGRFAMsi TIGR00916. 2A0604s01. 1 hit.
    TIGR00966. 3a0501s07. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiSECF_HELPY
    AccessioniPrimary (citable) accession number: O26073
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3