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O26066 (MFD_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription-repair-coupling factor

Short name=TRCF
EC=3.6.4.-
Gene names
Name:mfd
Ordered Locus Names:HP_1541
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length999 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site By similarity. HAMAP-Rule MF_00969

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00969.

Sequence similarities

In the N-terminal section; belongs to the UvrB family.

In the C-terminal section; belongs to the helicase family. RecG subfamily.

Contains 1 helicase ATP-binding domain.

Contains 1 helicase C-terminal domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 999999Transcription-repair-coupling factor HAMAP-Rule MF_00969
PRO_0000102168

Regions

Domain499 – 656158Helicase ATP-binding
Domain677 – 833157Helicase C-terminal
Nucleotide binding512 – 5198ATP Potential
Motif609 – 6124DEEH box HAMAP-Rule MF_00969

Sequences

Sequence LengthMass (Da)Tools
O26066 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: EE550EFB2A2946E5

FASTA999113,090
        10         20         30         40         50         60 
MIQSSLYRAL NKGFDYQILA CKDFKESELA KEVISYFKPN TKAILFPEFR AKKNDDLRSF 

        70         80         90        100        110        120 
FEEFLQLLGG LREFYQALEN KQETIIIAPI SALLHPLPKK ELLESFKITL LEKYNLKDLK 

       130        140        150        160        170        180 
DKLFYYGYEI LDLVEVEGEA SFRGDIVDIY APNSKAYRLS FFDTECESIK EFDPITQMSL 

       190        200        210        220        230        240 
KEDLLEIEIP PTLFSLDESS YKDLKTKVEQ SPLNSFSKDL TSFGLWFLGE KAQDLLIVYK 

       250        260        270        280        290        300 
SIISPRALEE IQELASLNEL DCERFKFLKV LENAQGYEDL EIHAHALEGF IALHSNHKIT 

       310        320        330        340        350        360 
LLAPNKTILD NAISALDAGN MECVIAPFVL NFKTPDGIFI SLNSFERKKK RQKSKLALNE 

       370        380        390        400        410        420 
LNPGEWVVHD DYGVGVFSQL VQHSVLGSKR DFLEIAYLGE DKLLLPVENL HLIARYVAQS 

       430        440        450        460        470        480 
DSVPAKDRLG KGSFLKLKAK VRTKLLEIAS KIIELAAERN LILGKKMDVH LAELEVFKSH 

       490        500        510        520        530        540 
AGFEYTSDQE KAIAEISKDL SSHRVMDRLL SGDVGFGKTE VAMHAIFCAF LNGFQSALVV 

       550        560        570        580        590        600 
PTTLLAHQHF ETLRARFENF GVKVARLDRY ASEKNKLLKA VELGQVDALI GTHAILGAKF 

       610        620        630        640        650        660 
KNLGLVVVDE EHKFGVKQKE ALKELSKSVH FLSMSATPIP RTLNMALSQI KGISSLKTPP 

       670        680        690        700        710        720 
TDRKPSRTFL KEKNDELLKE IIYRELRRNG QIFYIHNHIA SILKVKTKLE DLIPKLKIAI 

       730        740        750        760        770        780 
LHSQINANES EEIMLEFAKG NYQVLLCTSI VESGIHLPNA NTIIIDNAQN FGLADLHQLR 

       790        800        810        820        830        840 
GRVGRGKKEG FCYFLIEDQK SLNEQALKRL LALEKNSYLG SGESVAYHDL EIRGGGNLLG 

       850        860        870        880        890        900 
QDQSGHIKNI GYALYTRMLE DAIYELSGGK KRLEKSVEIQ LGVSAFLNPE LIASDSLRLD 

       910        920        930        940        950        960 
LYRRLSLCEN TDEVGQIHEE IEDRFGKIDD LSAQFLQIIT LKILANQLGI IKLSNFNQNI 

       970        980        990 
TITYSDEKKE SLKAPSKDDN DILETLLKHL RAQISLKRR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD08581.1.
PIRE64712.
RefSeqNP_208332.1. NC_000915.1.
YP_006935467.1. NC_018939.1.

3D structure databases

ProteinModelPortalO26066.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-3189N.
IntActO26066. 6 interactions.
MINTMINT-166853.
STRING85962.HP1541.

Proteomic databases

PRIDEO26066.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD08581; AAD08581; HP_1541.
GeneID13870760.
899750.
KEGGheo:C694_07985.
hpy:HP1541.
PATRIC20594505. VBIHelPyl33062_1620.

Phylogenomic databases

eggNOGCOG1197.
KOK03723.
OMALLAHQHF.
OrthoDBEOG6FNHKW.
ProtClustDBCLSK872584.

Enzyme and pathway databases

BioCycHPY:HP1541-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_00969. TRCF.
InterProIPR003711. CarD-like/TRCF_domain.
IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR004576. Mfd.
IPR027417. P-loop_NTPase.
IPR005118. TRCF_C.
[Graphical view]
PfamPF02559. CarD_CdnL_TRCF. 1 hit.
PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF03461. TRCF. 1 hit.
[Graphical view]
SMARTSM01058. CarD_TRCF. 1 hit.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00982. TRCF. 1 hit.
[Graphical view]
SUPFAMSSF141259. SSF141259. 1 hit.
SSF52540. SSF52540. 3 hits.
TIGRFAMsTIGR00580. mfd. 1 hit.
PROSITEPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMFD_HELPY
AccessionPrimary (citable) accession number: O26066
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: April 16, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names