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O26066

- MFD_HELPY

UniProt

O26066 - MFD_HELPY

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Protein

Transcription-repair-coupling factor

Gene

mfd

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi512 – 5198ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. damaged DNA binding Source: InterPro
  3. helicase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-HAMAP
  2. transcription-coupled nucleotide-excision repair, DNA damage recognition Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPY:HP1541-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription-repair-coupling factorUniRule annotation (EC:3.6.4.-UniRule annotation)
Short name:
TRCFUniRule annotation
Gene namesi
Name:mfdUniRule annotation
Ordered Locus Names:HP_1541
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 999999Transcription-repair-coupling factorPRO_0000102168Add
BLAST

Proteomic databases

PRIDEiO26066.

Interactioni

Protein-protein interaction databases

DIPiDIP-3189N.
IntActiO26066. 8 interactions.
MINTiMINT-166853.
STRINGi85962.HP1541.

Structurei

3D structure databases

ProteinModelPortaliO26066.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini499 – 656158Helicase ATP-bindingUniRule annotationAdd
BLAST
Domaini677 – 833157Helicase C-terminalUniRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi609 – 6124DEEH box

Sequence similaritiesi

In the N-terminal section; belongs to the UvrB family.UniRule annotation
In the C-terminal section; belongs to the helicase family. RecG subfamily.UniRule annotation
Contains 1 helicase ATP-binding domain.UniRule annotation
Contains 1 helicase C-terminal domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1197.
KOiK03723.
OMAiVAMHAIF.
OrthoDBiEOG6FNHKW.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_00969. TRCF.
InterProiIPR003711. CarD-like/TRCF_domain.
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR004576. Mfd.
IPR027417. P-loop_NTPase.
IPR005118. TRCF_C.
[Graphical view]
PfamiPF02559. CarD_CdnL_TRCF. 1 hit.
PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF03461. TRCF. 1 hit.
[Graphical view]
SMARTiSM01058. CarD_TRCF. 1 hit.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00982. TRCF. 1 hit.
[Graphical view]
SUPFAMiSSF141259. SSF141259. 1 hit.
SSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00580. mfd. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O26066-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIQSSLYRAL NKGFDYQILA CKDFKESELA KEVISYFKPN TKAILFPEFR
60 70 80 90 100
AKKNDDLRSF FEEFLQLLGG LREFYQALEN KQETIIIAPI SALLHPLPKK
110 120 130 140 150
ELLESFKITL LEKYNLKDLK DKLFYYGYEI LDLVEVEGEA SFRGDIVDIY
160 170 180 190 200
APNSKAYRLS FFDTECESIK EFDPITQMSL KEDLLEIEIP PTLFSLDESS
210 220 230 240 250
YKDLKTKVEQ SPLNSFSKDL TSFGLWFLGE KAQDLLIVYK SIISPRALEE
260 270 280 290 300
IQELASLNEL DCERFKFLKV LENAQGYEDL EIHAHALEGF IALHSNHKIT
310 320 330 340 350
LLAPNKTILD NAISALDAGN MECVIAPFVL NFKTPDGIFI SLNSFERKKK
360 370 380 390 400
RQKSKLALNE LNPGEWVVHD DYGVGVFSQL VQHSVLGSKR DFLEIAYLGE
410 420 430 440 450
DKLLLPVENL HLIARYVAQS DSVPAKDRLG KGSFLKLKAK VRTKLLEIAS
460 470 480 490 500
KIIELAAERN LILGKKMDVH LAELEVFKSH AGFEYTSDQE KAIAEISKDL
510 520 530 540 550
SSHRVMDRLL SGDVGFGKTE VAMHAIFCAF LNGFQSALVV PTTLLAHQHF
560 570 580 590 600
ETLRARFENF GVKVARLDRY ASEKNKLLKA VELGQVDALI GTHAILGAKF
610 620 630 640 650
KNLGLVVVDE EHKFGVKQKE ALKELSKSVH FLSMSATPIP RTLNMALSQI
660 670 680 690 700
KGISSLKTPP TDRKPSRTFL KEKNDELLKE IIYRELRRNG QIFYIHNHIA
710 720 730 740 750
SILKVKTKLE DLIPKLKIAI LHSQINANES EEIMLEFAKG NYQVLLCTSI
760 770 780 790 800
VESGIHLPNA NTIIIDNAQN FGLADLHQLR GRVGRGKKEG FCYFLIEDQK
810 820 830 840 850
SLNEQALKRL LALEKNSYLG SGESVAYHDL EIRGGGNLLG QDQSGHIKNI
860 870 880 890 900
GYALYTRMLE DAIYELSGGK KRLEKSVEIQ LGVSAFLNPE LIASDSLRLD
910 920 930 940 950
LYRRLSLCEN TDEVGQIHEE IEDRFGKIDD LSAQFLQIIT LKILANQLGI
960 970 980 990
IKLSNFNQNI TITYSDEKKE SLKAPSKDDN DILETLLKHL RAQISLKRR
Length:999
Mass (Da):113,090
Last modified:January 1, 1998 - v1
Checksum:iEE550EFB2A2946E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08581.1.
PIRiE64712.
RefSeqiNP_208332.1. NC_000915.1.
YP_006935467.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08581; AAD08581; HP_1541.
GeneIDi13870760.
899750.
KEGGiheo:C694_07985.
hpy:HP1541.
PATRICi20594505. VBIHelPyl33062_1620.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08581.1 .
PIRi E64712.
RefSeqi NP_208332.1. NC_000915.1.
YP_006935467.1. NC_018939.1.

3D structure databases

ProteinModelPortali O26066.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-3189N.
IntActi O26066. 8 interactions.
MINTi MINT-166853.
STRINGi 85962.HP1541.

Proteomic databases

PRIDEi O26066.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD08581 ; AAD08581 ; HP_1541 .
GeneIDi 13870760.
899750.
KEGGi heo:C694_07985.
hpy:HP1541.
PATRICi 20594505. VBIHelPyl33062_1620.

Phylogenomic databases

eggNOGi COG1197.
KOi K03723.
OMAi VAMHAIF.
OrthoDBi EOG6FNHKW.

Enzyme and pathway databases

BioCyci HPY:HP1541-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_00969. TRCF.
InterProi IPR003711. CarD-like/TRCF_domain.
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR004576. Mfd.
IPR027417. P-loop_NTPase.
IPR005118. TRCF_C.
[Graphical view ]
Pfami PF02559. CarD_CdnL_TRCF. 1 hit.
PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF03461. TRCF. 1 hit.
[Graphical view ]
SMARTi SM01058. CarD_TRCF. 1 hit.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00982. TRCF. 1 hit.
[Graphical view ]
SUPFAMi SSF141259. SSF141259. 1 hit.
SSF52540. SSF52540. 3 hits.
TIGRFAMsi TIGR00580. mfd. 1 hit.
PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiMFD_HELPY
AccessioniPrimary (citable) accession number: O26066
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3