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O26066

- MFD_HELPY

UniProt

O26066 - MFD_HELPY

Protein

Transcription-repair-coupling factor

Gene

mfd

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi512 – 5198ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. damaged DNA binding Source: InterPro
    3. helicase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-HAMAP
    2. transcription-coupled nucleotide-excision repair, DNA damage recognition Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Helicase, Hydrolase

    Keywords - Biological processi

    DNA damage, DNA repair

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHPY:HP1541-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription-repair-coupling factorUniRule annotation (EC:3.6.4.-UniRule annotation)
    Short name:
    TRCFUniRule annotation
    Gene namesi
    Name:mfdUniRule annotation
    Ordered Locus Names:HP_1541
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 999999Transcription-repair-coupling factorPRO_0000102168Add
    BLAST

    Proteomic databases

    PRIDEiO26066.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-3189N.
    IntActiO26066. 8 interactions.
    MINTiMINT-166853.
    STRINGi85962.HP1541.

    Structurei

    3D structure databases

    ProteinModelPortaliO26066.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini499 – 656158Helicase ATP-bindingUniRule annotationAdd
    BLAST
    Domaini677 – 833157Helicase C-terminalUniRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi609 – 6124DEEH box

    Sequence similaritiesi

    In the N-terminal section; belongs to the UvrB family.UniRule annotation
    In the C-terminal section; belongs to the helicase family. RecG subfamily.UniRule annotation
    Contains 1 helicase ATP-binding domain.UniRule annotation
    Contains 1 helicase C-terminal domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1197.
    KOiK03723.
    OMAiVAMHAIF.
    OrthoDBiEOG6FNHKW.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_00969. TRCF.
    InterProiIPR003711. CarD-like/TRCF_domain.
    IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR004576. Mfd.
    IPR027417. P-loop_NTPase.
    IPR005118. TRCF_C.
    [Graphical view]
    PfamiPF02559. CarD_CdnL_TRCF. 1 hit.
    PF00270. DEAD. 1 hit.
    PF00271. Helicase_C. 1 hit.
    PF03461. TRCF. 1 hit.
    [Graphical view]
    SMARTiSM01058. CarD_TRCF. 1 hit.
    SM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    SM00982. TRCF. 1 hit.
    [Graphical view]
    SUPFAMiSSF141259. SSF141259. 1 hit.
    SSF52540. SSF52540. 3 hits.
    TIGRFAMsiTIGR00580. mfd. 1 hit.
    PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O26066-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIQSSLYRAL NKGFDYQILA CKDFKESELA KEVISYFKPN TKAILFPEFR    50
    AKKNDDLRSF FEEFLQLLGG LREFYQALEN KQETIIIAPI SALLHPLPKK 100
    ELLESFKITL LEKYNLKDLK DKLFYYGYEI LDLVEVEGEA SFRGDIVDIY 150
    APNSKAYRLS FFDTECESIK EFDPITQMSL KEDLLEIEIP PTLFSLDESS 200
    YKDLKTKVEQ SPLNSFSKDL TSFGLWFLGE KAQDLLIVYK SIISPRALEE 250
    IQELASLNEL DCERFKFLKV LENAQGYEDL EIHAHALEGF IALHSNHKIT 300
    LLAPNKTILD NAISALDAGN MECVIAPFVL NFKTPDGIFI SLNSFERKKK 350
    RQKSKLALNE LNPGEWVVHD DYGVGVFSQL VQHSVLGSKR DFLEIAYLGE 400
    DKLLLPVENL HLIARYVAQS DSVPAKDRLG KGSFLKLKAK VRTKLLEIAS 450
    KIIELAAERN LILGKKMDVH LAELEVFKSH AGFEYTSDQE KAIAEISKDL 500
    SSHRVMDRLL SGDVGFGKTE VAMHAIFCAF LNGFQSALVV PTTLLAHQHF 550
    ETLRARFENF GVKVARLDRY ASEKNKLLKA VELGQVDALI GTHAILGAKF 600
    KNLGLVVVDE EHKFGVKQKE ALKELSKSVH FLSMSATPIP RTLNMALSQI 650
    KGISSLKTPP TDRKPSRTFL KEKNDELLKE IIYRELRRNG QIFYIHNHIA 700
    SILKVKTKLE DLIPKLKIAI LHSQINANES EEIMLEFAKG NYQVLLCTSI 750
    VESGIHLPNA NTIIIDNAQN FGLADLHQLR GRVGRGKKEG FCYFLIEDQK 800
    SLNEQALKRL LALEKNSYLG SGESVAYHDL EIRGGGNLLG QDQSGHIKNI 850
    GYALYTRMLE DAIYELSGGK KRLEKSVEIQ LGVSAFLNPE LIASDSLRLD 900
    LYRRLSLCEN TDEVGQIHEE IEDRFGKIDD LSAQFLQIIT LKILANQLGI 950
    IKLSNFNQNI TITYSDEKKE SLKAPSKDDN DILETLLKHL RAQISLKRR 999
    Length:999
    Mass (Da):113,090
    Last modified:January 1, 1998 - v1
    Checksum:iEE550EFB2A2946E5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08581.1.
    PIRiE64712.
    RefSeqiNP_208332.1. NC_000915.1.
    YP_006935467.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD08581; AAD08581; HP_1541.
    GeneIDi13870760.
    899750.
    KEGGiheo:C694_07985.
    hpy:HP1541.
    PATRICi20594505. VBIHelPyl33062_1620.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08581.1 .
    PIRi E64712.
    RefSeqi NP_208332.1. NC_000915.1.
    YP_006935467.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali O26066.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-3189N.
    IntActi O26066. 8 interactions.
    MINTi MINT-166853.
    STRINGi 85962.HP1541.

    Proteomic databases

    PRIDEi O26066.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD08581 ; AAD08581 ; HP_1541 .
    GeneIDi 13870760.
    899750.
    KEGGi heo:C694_07985.
    hpy:HP1541.
    PATRICi 20594505. VBIHelPyl33062_1620.

    Phylogenomic databases

    eggNOGi COG1197.
    KOi K03723.
    OMAi VAMHAIF.
    OrthoDBi EOG6FNHKW.

    Enzyme and pathway databases

    BioCyci HPY:HP1541-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_00969. TRCF.
    InterProi IPR003711. CarD-like/TRCF_domain.
    IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR004576. Mfd.
    IPR027417. P-loop_NTPase.
    IPR005118. TRCF_C.
    [Graphical view ]
    Pfami PF02559. CarD_CdnL_TRCF. 1 hit.
    PF00270. DEAD. 1 hit.
    PF00271. Helicase_C. 1 hit.
    PF03461. TRCF. 1 hit.
    [Graphical view ]
    SMARTi SM01058. CarD_TRCF. 1 hit.
    SM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    SM00982. TRCF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF141259. SSF141259. 1 hit.
    SSF52540. SSF52540. 3 hits.
    TIGRFAMsi TIGR00580. mfd. 1 hit.
    PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiMFD_HELPY
    AccessioniPrimary (citable) accession number: O26066
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3