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O26060

- GLMS_HELPY

UniProt

O26060 - GLMS_HELPY

Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
    Active sitei592 – 5921For Fru-6P isomerization activityUniRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: InterPro
    2. glutamine metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Enzyme and pathway databases

    BioCyciHPY:HP1532-MONOMER.

    Protein family/group databases

    MEROPSiC44.971.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
    Alternative name(s):
    D-fructose-6-phosphate amidotransferaseUniRule annotation
    GFATUniRule annotation
    Glucosamine-6-phosphate synthaseUniRule annotation
    Hexosephosphate aminotransferaseUniRule annotation
    L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
    Gene namesi
    Name:glmSUniRule annotation
    Ordered Locus Names:HP_1532
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedUniRule annotation
    Chaini2 – 597596Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135340Add
    BLAST

    Proteomic databases

    PRIDEiO26060.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi85962.HP1532.

    Structurei

    3D structure databases

    ProteinModelPortaliO26060.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 218217Glutamine amidotransferase type-2UniRule annotationAdd
    BLAST
    Domaini276 – 416141SIS 1UniRule annotationAdd
    BLAST
    Domaini449 – 587139SIS 2UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
    Contains 2 SIS domains.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase, Repeat

    Phylogenomic databases

    eggNOGiCOG0449.
    KOiK00820.
    OMAiGHKHTLA.
    OrthoDBiEOG6KT2Q1.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    HAMAPiMF_00164. GlmS.
    InterProiIPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view]
    PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
    PfamiPF01380. SIS. 2 hits.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR01135. glmS. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O26060-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCGIVGYIGD SEKKSVLLEG LKELEYRGYD SAGLAVLSND RLEVFKTQGK    50
    LENLKLELKN KEFLDFGVSI AHTRWATHGK PSSANAHPHF TENLALVHNG 100
    IIENYASLKK ELENKGHAFL SQTDTEVIAH LLEETLKSES DLLKAFEKSI 150
    SLLKGSYAIL MLHKRAKESL FYAKSSSPLV VGKGKEGVFF ASSLSVLAPK 200
    VDQFVILEEN SVGRISLENF KDLNNIENMK DYAFEDKDYS KGNFRNYLEK 250
    EIYEQHSSLL ECLEGRLEAL SVYCEIDPEF LKNVSEITLC SCGSSYHASL 300
    ASVYLFERLA KIRARAILAS EYRYAHFKSN PNELFIAISQ SGETADTLEA 350
    LKLAKAQGLK TISLCNAPFS MMSRISDHTL LIRAGVERSV ASTKAFSSQV 400
    MLLWLLSVYL GKQLGTISKE EERIQAKNML NSVNAMKVEP KLHEKIKRLS 450
    KRYLHGHGFF YIGRDVFYPL ALEGALKLKE ISYLHAEGYA SAEMKHGPIA 500
    LVDSNLFTIA LLSKHLLFDK TKSNIEELSA RDSTICVLSS EILEIADDFI 550
    QLEESESYME EFFRMNLAVQ LLALEIAMRL NHDVDHPRNL AKSVTVE 597
    Length:597
    Mass (Da):67,071
    Last modified:January 23, 2007 - v3
    Checksum:iAA9E6E29D1B903C9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08570.1.
    PIRiD64711.
    RefSeqiNP_208322.1. NC_000915.1.
    YP_006935457.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD08570; AAD08570; HP_1532.
    GeneIDi13870750.
    899758.
    KEGGiheo:C694_07935.
    hpy:HP1532.
    PATRICi20594485. VBIHelPyl33062_1610.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08570.1 .
    PIRi D64711.
    RefSeqi NP_208322.1. NC_000915.1.
    YP_006935457.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali O26060.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 85962.HP1532.

    Protein family/group databases

    MEROPSi C44.971.

    Proteomic databases

    PRIDEi O26060.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD08570 ; AAD08570 ; HP_1532 .
    GeneIDi 13870750.
    899758.
    KEGGi heo:C694_07935.
    hpy:HP1532.
    PATRICi 20594485. VBIHelPyl33062_1610.

    Phylogenomic databases

    eggNOGi COG0449.
    KOi K00820.
    OMAi GHKHTLA.
    OrthoDBi EOG6KT2Q1.

    Enzyme and pathway databases

    BioCyci HPY:HP1532-MONOMER.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    HAMAPi MF_00164. GlmS.
    InterProi IPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view ]
    PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
    Pfami PF01380. SIS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR01135. glmS. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiGLMS_HELPY
    AccessioniPrimary (citable) accession number: O26060
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 97 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3