Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O26060 (GLMS_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

EC=2.6.1.16
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene names
Name:glmS
Ordered Locus Names:HP_1532
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length597 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity. HAMAP-Rule MF_00164

Catalytic activity

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate. HAMAP-Rule MF_00164

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00164

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00164.

Sequence similarities

Contains 1 glutamine amidotransferase type-2 domain.

Contains 2 SIS domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 597596Glutamine--fructose-6-phosphate aminotransferase [isomerizing] HAMAP-Rule MF_00164
PRO_0000135340

Regions

Domain2 – 218217Glutamine amidotransferase type-2
Domain276 – 416141SIS 1
Domain449 – 587139SIS 2

Sites

Active site21Nucleophile; for GATase activity By similarity
Active site5921For Fru-6P isomerization activity By similarity

Sequences

Sequence LengthMass (Da)Tools
O26060 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: AA9E6E29D1B903C9

FASTA59767,071
        10         20         30         40         50         60 
MCGIVGYIGD SEKKSVLLEG LKELEYRGYD SAGLAVLSND RLEVFKTQGK LENLKLELKN 

        70         80         90        100        110        120 
KEFLDFGVSI AHTRWATHGK PSSANAHPHF TENLALVHNG IIENYASLKK ELENKGHAFL 

       130        140        150        160        170        180 
SQTDTEVIAH LLEETLKSES DLLKAFEKSI SLLKGSYAIL MLHKRAKESL FYAKSSSPLV 

       190        200        210        220        230        240 
VGKGKEGVFF ASSLSVLAPK VDQFVILEEN SVGRISLENF KDLNNIENMK DYAFEDKDYS 

       250        260        270        280        290        300 
KGNFRNYLEK EIYEQHSSLL ECLEGRLEAL SVYCEIDPEF LKNVSEITLC SCGSSYHASL 

       310        320        330        340        350        360 
ASVYLFERLA KIRARAILAS EYRYAHFKSN PNELFIAISQ SGETADTLEA LKLAKAQGLK 

       370        380        390        400        410        420 
TISLCNAPFS MMSRISDHTL LIRAGVERSV ASTKAFSSQV MLLWLLSVYL GKQLGTISKE 

       430        440        450        460        470        480 
EERIQAKNML NSVNAMKVEP KLHEKIKRLS KRYLHGHGFF YIGRDVFYPL ALEGALKLKE 

       490        500        510        520        530        540 
ISYLHAEGYA SAEMKHGPIA LVDSNLFTIA LLSKHLLFDK TKSNIEELSA RDSTICVLSS 

       550        560        570        580        590 
EILEIADDFI QLEESESYME EFFRMNLAVQ LLALEIAMRL NHDVDHPRNL AKSVTVE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD08570.1.
PIRD64711.
RefSeqNP_208322.1. NC_000915.1.
YP_006935457.1. NC_018939.1.

3D structure databases

ProteinModelPortalO26060.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING85962.HP1532.

Protein family/group databases

MEROPSC44.971.

Proteomic databases

PRIDEO26060.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD08570; AAD08570; HP_1532.
GeneID899758.
KEGGheo:C694_07935.
hpy:HP1532.
PATRIC20594485. VBIHelPyl33062_1610.

Phylogenomic databases

eggNOGCOG0449.
KOK00820.
OMAGHKHTLA.
OrthoDBEOG6KT2Q1.

Enzyme and pathway databases

BioCycHPY:HP1532-MONOMER.

Family and domain databases

Gene3D3.60.20.10. 1 hit.
HAMAPMF_00164. GlmS.
InterProIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMSSF56235. SSF56235. 1 hit.
TIGRFAMsTIGR01135. glmS. 1 hit.
PROSITEPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLMS_HELPY
AccessionPrimary (citable) accession number: O26060
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names