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O26060

- GLMS_HELPY

UniProt

O26060 - GLMS_HELPY

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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
Active sitei592 – 5921For Fru-6P isomerization activityUniRule annotation

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciHPY:HP1532-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:HP_1532
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedUniRule annotation
Chaini2 – 597596Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135340Add
BLAST

Proteomic databases

PRIDEiO26060.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi85962.HP1532.

Structurei

3D structure databases

ProteinModelPortaliO26060.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 218217Glutamine amidotransferase type-2UniRule annotationAdd
BLAST
Domaini276 – 416141SIS 1UniRule annotationAdd
BLAST
Domaini449 – 587139SIS 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
Contains 2 SIS domains.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
KOiK00820.
OMAiGHKHTLA.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O26060-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCGIVGYIGD SEKKSVLLEG LKELEYRGYD SAGLAVLSND RLEVFKTQGK
60 70 80 90 100
LENLKLELKN KEFLDFGVSI AHTRWATHGK PSSANAHPHF TENLALVHNG
110 120 130 140 150
IIENYASLKK ELENKGHAFL SQTDTEVIAH LLEETLKSES DLLKAFEKSI
160 170 180 190 200
SLLKGSYAIL MLHKRAKESL FYAKSSSPLV VGKGKEGVFF ASSLSVLAPK
210 220 230 240 250
VDQFVILEEN SVGRISLENF KDLNNIENMK DYAFEDKDYS KGNFRNYLEK
260 270 280 290 300
EIYEQHSSLL ECLEGRLEAL SVYCEIDPEF LKNVSEITLC SCGSSYHASL
310 320 330 340 350
ASVYLFERLA KIRARAILAS EYRYAHFKSN PNELFIAISQ SGETADTLEA
360 370 380 390 400
LKLAKAQGLK TISLCNAPFS MMSRISDHTL LIRAGVERSV ASTKAFSSQV
410 420 430 440 450
MLLWLLSVYL GKQLGTISKE EERIQAKNML NSVNAMKVEP KLHEKIKRLS
460 470 480 490 500
KRYLHGHGFF YIGRDVFYPL ALEGALKLKE ISYLHAEGYA SAEMKHGPIA
510 520 530 540 550
LVDSNLFTIA LLSKHLLFDK TKSNIEELSA RDSTICVLSS EILEIADDFI
560 570 580 590
QLEESESYME EFFRMNLAVQ LLALEIAMRL NHDVDHPRNL AKSVTVE
Length:597
Mass (Da):67,071
Last modified:January 23, 2007 - v3
Checksum:iAA9E6E29D1B903C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08570.1.
PIRiD64711.
RefSeqiNP_208322.1. NC_000915.1.
YP_006935457.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08570; AAD08570; HP_1532.
GeneIDi13870750.
899758.
KEGGiheo:C694_07935.
hpy:HP1532.
PATRICi20594485. VBIHelPyl33062_1610.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08570.1 .
PIRi D64711.
RefSeqi NP_208322.1. NC_000915.1.
YP_006935457.1. NC_018939.1.

3D structure databases

ProteinModelPortali O26060.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 85962.HP1532.

Protein family/group databases

MEROPSi C44.971.

Proteomic databases

PRIDEi O26060.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD08570 ; AAD08570 ; HP_1532 .
GeneIDi 13870750.
899758.
KEGGi heo:C694_07935.
hpy:HP1532.
PATRICi 20594485. VBIHelPyl33062_1610.

Phylogenomic databases

eggNOGi COG0449.
KOi K00820.
OMAi GHKHTLA.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

BioCyci HPY:HP1532-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiGLMS_HELPY
AccessioniPrimary (citable) accession number: O26060
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3