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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei592For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase

Enzyme and pathway databases

BioCyciHPY:HP1532-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:HP_1532
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation
ChainiPRO_00001353402 – 597Glutamine--fructose-6-phosphate aminotransferase [isomerizing]Add BLAST596

Proteomic databases

PaxDbiO26060.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi85962.HP1532.

Structurei

3D structure databases

ProteinModelPortaliO26060.
SMRiO26060.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 218Glutamine amidotransferase type-2UniRule annotationAdd BLAST217
Domaini276 – 416SIS 1UniRule annotationAdd BLAST141
Domaini449 – 587SIS 2UniRule annotationAdd BLAST139

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiENOG4105C46. Bacteria.
COG0449. LUCA.
KOiK00820.
OMAiASEYRYA.

Family and domain databases

CDDicd05008. SIS_GlmS_GlmD_1. 1 hit.
cd05009. SIS_GlmS_GlmD_2. 1 hit.
Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS. 1 hit.
InterProiView protein in InterPro
IPR017932. GATase_2_dom.
IPR035466. GlmS/AgaS_SIS.
IPR035490. GlmS/FrlB_SIS.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiView protein in Pfam
PF01380. SIS. 2 hits.
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiView protein in PROSITE
PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O26060-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIVGYIGD SEKKSVLLEG LKELEYRGYD SAGLAVLSND RLEVFKTQGK
60 70 80 90 100
LENLKLELKN KEFLDFGVSI AHTRWATHGK PSSANAHPHF TENLALVHNG
110 120 130 140 150
IIENYASLKK ELENKGHAFL SQTDTEVIAH LLEETLKSES DLLKAFEKSI
160 170 180 190 200
SLLKGSYAIL MLHKRAKESL FYAKSSSPLV VGKGKEGVFF ASSLSVLAPK
210 220 230 240 250
VDQFVILEEN SVGRISLENF KDLNNIENMK DYAFEDKDYS KGNFRNYLEK
260 270 280 290 300
EIYEQHSSLL ECLEGRLEAL SVYCEIDPEF LKNVSEITLC SCGSSYHASL
310 320 330 340 350
ASVYLFERLA KIRARAILAS EYRYAHFKSN PNELFIAISQ SGETADTLEA
360 370 380 390 400
LKLAKAQGLK TISLCNAPFS MMSRISDHTL LIRAGVERSV ASTKAFSSQV
410 420 430 440 450
MLLWLLSVYL GKQLGTISKE EERIQAKNML NSVNAMKVEP KLHEKIKRLS
460 470 480 490 500
KRYLHGHGFF YIGRDVFYPL ALEGALKLKE ISYLHAEGYA SAEMKHGPIA
510 520 530 540 550
LVDSNLFTIA LLSKHLLFDK TKSNIEELSA RDSTICVLSS EILEIADDFI
560 570 580 590
QLEESESYME EFFRMNLAVQ LLALEIAMRL NHDVDHPRNL AKSVTVE
Length:597
Mass (Da):67,071
Last modified:January 23, 2007 - v3
Checksum:iAA9E6E29D1B903C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08570.1.
PIRiD64711.
RefSeqiNP_208322.1. NC_000915.1.
WP_000334435.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08570; AAD08570; HP_1532.
GeneIDi899758.
KEGGiheo:C694_07935.
hpy:HP1532.
PATRICifig|85962.47.peg.1647.

Similar proteinsi

Entry informationi

Entry nameiGLMS_HELPY
AccessioniPrimary (citable) accession number: O26060
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 110 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names