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Protein

Chromosomal replication initiator protein DnaA

Gene

dnaA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi150 – 1578ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPY:HP1529-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosomal replication initiator protein DnaA
Gene namesi
Name:dnaA
Ordered Locus Names:HP_1529
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457Chromosomal replication initiator protein DnaAPRO_0000114188Add
BLAST

Proteomic databases

PaxDbiO26057.
PRIDEiO26057.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HP_1230O258284EBI-527994,EBI-527984

Protein-protein interaction databases

DIPiDIP-3596N.
IntActiO26057. 3 interactions.
MINTiMINT-165841.
STRINGi85962.HP1529.

Structurei

Secondary structure

1
457
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi7 – 104Combined sources
Helixi11 – 166Combined sources
Helixi23 – 286Combined sources
Helixi30 – 323Combined sources
Beta strandi37 – 393Combined sources
Beta strandi42 – 5110Combined sources
Helixi52 – 7120Combined sources
Beta strandi84 – 896Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WP0X-ray2.67C/D1-112[»]
ProteinModelPortaliO26057.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO26057.

Family & Domainsi

Sequence similaritiesi

Belongs to the DnaA family.Curated

Phylogenomic databases

eggNOGiENOG4105CI4. Bacteria.
COG0593. LUCA.
KOiK02313.
OMAiPIEYENC.

Family and domain databases

CDDicd06571. Bac_DnaA_C. 1 hit.
Gene3Di1.10.1750.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00377. DnaA_bact. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR018312. Chromosome_initiator_DnaA_CS.
IPR013317. DnaA.
IPR013159. DnaA_C.
IPR027417. P-loop_NTPase.
IPR010921. Trp_repressor/repl_initiator.
[Graphical view]
PfamiPF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
[Graphical view]
PRINTSiPR00051. DNAA.
SMARTiSM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48295. SSF48295. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00362. DnaA. 1 hit.
PROSITEiPS01008. DNAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O26057-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTNNNIEKE ILALVKQNPK VSLIEYENYF SQLKYNPNAS KSDIAFFYAP
60 70 80 90 100
NQVLCTTITA KYGALLKEIL SQNKVGMHLA HSVDVRIEVA PKIQINAQSN
110 120 130 140 150
INYKAIKTSV KDSYTFENFV VGSCNNTVYE IAKKVAQSDT PPYNPVLFYG
160 170 180 190 200
GTGLGKTHIL NAIGNHALEK HKKVVLVTSE DFLTDFLKHL DNKTMDSFKA
210 220 230 240 250
KYRHCDFFLL DDAQFLQGKP KLEEEFFHTF NELHANSKQI VLISDRSPKN
260 270 280 290 300
IAGLEDRLKS RFEWGITAKV MPPDLETKLS IVKQKCQLNQ ITLPEEVMEY
310 320 330 340 350
IAQHISDNIR QMEGAIIKIS VNANLMNASI DLNLAKTVLE DLQKDHAEGS
360 370 380 390 400
SLENILLAVA QSLNLKSSEI KVSSRQKNVA LARKLVVYFA RLYTPNPTLS
410 420 430 440 450
LAQFLDLKDH SSISKMYSGV KKMLEEEKSP FVLSLREEIK NRLNELNDKK

TAFNSSE
Length:457
Mass (Da):51,683
Last modified:January 1, 1998 - v1
Checksum:i975B30C9AB3A3C97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08568.1.
PIRiA64711.
RefSeqiNP_208319.1. NC_000915.1.
WP_000380647.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08568; AAD08568; HP_1529.
GeneIDi899761.
KEGGiheo:C694_07920.
hpy:HP1529.
PATRICi20594479. VBIHelPyl33062_1607.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08568.1.
PIRiA64711.
RefSeqiNP_208319.1. NC_000915.1.
WP_000380647.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WP0X-ray2.67C/D1-112[»]
ProteinModelPortaliO26057.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3596N.
IntActiO26057. 3 interactions.
MINTiMINT-165841.
STRINGi85962.HP1529.

Proteomic databases

PaxDbiO26057.
PRIDEiO26057.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08568; AAD08568; HP_1529.
GeneIDi899761.
KEGGiheo:C694_07920.
hpy:HP1529.
PATRICi20594479. VBIHelPyl33062_1607.

Phylogenomic databases

eggNOGiENOG4105CI4. Bacteria.
COG0593. LUCA.
KOiK02313.
OMAiPIEYENC.

Enzyme and pathway databases

BioCyciHPY:HP1529-MONOMER.

Miscellaneous databases

EvolutionaryTraceiO26057.

Family and domain databases

CDDicd06571. Bac_DnaA_C. 1 hit.
Gene3Di1.10.1750.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00377. DnaA_bact. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR018312. Chromosome_initiator_DnaA_CS.
IPR013317. DnaA.
IPR013159. DnaA_C.
IPR027417. P-loop_NTPase.
IPR010921. Trp_repressor/repl_initiator.
[Graphical view]
PfamiPF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
[Graphical view]
PRINTSiPR00051. DNAA.
SMARTiSM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48295. SSF48295. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00362. DnaA. 1 hit.
PROSITEiPS01008. DNAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNAA_HELPY
AccessioniPrimary (citable) accession number: O26057
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.