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Protein

Chromosomal replication initiator protein DnaA

Gene

dnaA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi150 – 157ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPY:HP1529-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosomal replication initiator protein DnaA
Gene namesi
Name:dnaA
Ordered Locus Names:HP_1529
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001141881 – 457Chromosomal replication initiator protein DnaAAdd BLAST457

Proteomic databases

PaxDbiO26057
PRIDEiO26057

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HP_1230O2582814EBI-527994,EBI-527984

Protein-protein interaction databases

DIPiDIP-3596N
IntActiO26057, 3 interactors
MINTiO26057
STRINGi85962.HP1529

Structurei

Secondary structure

1457
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 10Combined sources4
Helixi11 – 16Combined sources6
Helixi23 – 28Combined sources6
Helixi30 – 32Combined sources3
Beta strandi37 – 39Combined sources3
Beta strandi42 – 51Combined sources10
Helixi52 – 71Combined sources20
Beta strandi84 – 89Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WP0X-ray2.67C/D1-112[»]
ProteinModelPortaliO26057
SMRiO26057
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO26057

Family & Domainsi

Sequence similaritiesi

Belongs to the DnaA family.Curated

Phylogenomic databases

eggNOGiENOG4105CI4 Bacteria
COG0593 LUCA
KOiK02313
OMAiREFNPLF

Family and domain databases

CDDicd06571 Bac_DnaA_C, 1 hit
Gene3Di1.10.1750.10, 1 hit
3.30.300.180, 1 hit
HAMAPiMF_00377 DnaA_bact, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR001957 Chromosome_initiator_DnaA
IPR020591 Chromosome_initiator_DnaA-like
IPR018312 Chromosome_initiator_DnaA_CS
IPR013317 DnaA
IPR013159 DnaA_C
IPR038454 DnaA_N_sf
IPR027417 P-loop_NTPase
IPR010921 Trp_repressor/repl_initiator
PANTHERiPTHR30050:SF2 PTHR30050:SF2, 1 hit
PfamiView protein in Pfam
PF00308 Bac_DnaA, 1 hit
PF08299 Bac_DnaA_C, 1 hit
PRINTSiPR00051 DNAA
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00760 Bac_DnaA_C, 1 hit
SUPFAMiSSF48295 SSF48295, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00362 DnaA, 1 hit
PROSITEiView protein in PROSITE
PS01008 DNAA, 1 hit

Sequencei

Sequence statusi: Complete.

O26057-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTNNNIEKE ILALVKQNPK VSLIEYENYF SQLKYNPNAS KSDIAFFYAP
60 70 80 90 100
NQVLCTTITA KYGALLKEIL SQNKVGMHLA HSVDVRIEVA PKIQINAQSN
110 120 130 140 150
INYKAIKTSV KDSYTFENFV VGSCNNTVYE IAKKVAQSDT PPYNPVLFYG
160 170 180 190 200
GTGLGKTHIL NAIGNHALEK HKKVVLVTSE DFLTDFLKHL DNKTMDSFKA
210 220 230 240 250
KYRHCDFFLL DDAQFLQGKP KLEEEFFHTF NELHANSKQI VLISDRSPKN
260 270 280 290 300
IAGLEDRLKS RFEWGITAKV MPPDLETKLS IVKQKCQLNQ ITLPEEVMEY
310 320 330 340 350
IAQHISDNIR QMEGAIIKIS VNANLMNASI DLNLAKTVLE DLQKDHAEGS
360 370 380 390 400
SLENILLAVA QSLNLKSSEI KVSSRQKNVA LARKLVVYFA RLYTPNPTLS
410 420 430 440 450
LAQFLDLKDH SSISKMYSGV KKMLEEEKSP FVLSLREEIK NRLNELNDKK

TAFNSSE
Length:457
Mass (Da):51,683
Last modified:January 1, 1998 - v1
Checksum:i975B30C9AB3A3C97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD08568.1
PIRiA64711
RefSeqiNP_208319.1, NC_000915.1
WP_000380647.1, NC_018939.1

Genome annotation databases

EnsemblBacteriaiAAD08568; AAD08568; HP_1529
GeneIDi899761
KEGGiheo:C694_07920
hpy:HP1529
PATRICifig|85962.47.peg.1644

Similar proteinsi

Entry informationi

Entry nameiDNAA_HELPY
AccessioniPrimary (citable) accession number: O26057
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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