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Protein

Membrane protein insertase YidC

Gene

yidC

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.UniRule annotation

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciHPY:HP1450-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane protein insertase YidCUniRule annotation
Alternative name(s):
Foldase YidCUniRule annotation
Membrane integrase YidCUniRule annotation
Membrane protein YidCUniRule annotation
Gene namesi
Name:yidCUniRule annotation
Ordered Locus Names:HP_1450
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821HelicalUniRule annotationAdd
BLAST
Transmembranei325 – 34521HelicalUniRule annotationAdd
BLAST
Transmembranei348 – 36821HelicalUniRule annotationAdd
BLAST
Transmembranei414 – 43421HelicalUniRule annotationAdd
BLAST
Transmembranei449 – 46921HelicalUniRule annotationAdd
BLAST
Transmembranei495 – 51521HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 547547Membrane protein insertase YidCPRO_0000124719Add
BLAST

Proteomic databases

PaxDbiO25989.
PRIDEiO25989.

Interactioni

Subunit structurei

Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.UniRule annotation

Protein-protein interaction databases

DIPiDIP-3087N.
IntActiO25989. 3 interactions.
MINTiMINT-183737.
STRINGi85962.HP1450.

Structurei

3D structure databases

ProteinModelPortaliO25989.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DHW. Bacteria.
COG0706. LUCA.
KOiK03217.
OMAiYKGMVSM.

Family and domain databases

HAMAPiMF_01810. YidC_type1. 1 hit.
InterProiIPR019998. Membr_insert_YidC.
IPR028055. Membr_insert_YidC/Oxa1_C.
IPR028053. Membr_insert_YidC_N.
IPR001708. Membrane_insert_OXA1/ALB3/YidC.
[Graphical view]
PANTHERiPTHR12428. PTHR12428. 1 hit.
PfamiPF02096. 60KD_IMP. 1 hit.
PF14849. YidC_periplas. 1 hit.
[Graphical view]
PRINTSiPR01900. YIDCPROTEIN.
TIGRFAMsiTIGR03593. yidC_nterm. 1 hit.
TIGR03592. yidC_oxa1_cterm. 1 hit.

Sequencei

Sequence statusi: Complete.

O25989-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKNNNNLRL ILAIALSFLF IALYSYFFQK PNKTTTQTTK QETTNNHTAT
60 70 80 90 100
SPNAPNAQHF STTQTTPQEN LLSTISFEHA RIEIDSLGRI KQVYLKDKKY
110 120 130 140 150
LTPKQKGFLE HVGHLFSSKE NAQPPLKELP LLAADKLKPL EVRFLDPTLN
160 170 180 190 200
NKAFNTPYSA SKTTLGPNEQ LVLTQDLGTL SIIKTLTFYD DLHYDLKIAF
210 220 230 240 250
KSPNNLIPSY VITNGYRPVA DLDSYTFSGV LLENSDKKIE KIEDKDAKEI
260 270 280 290 300
KRFSNTLFLS SVDRYFTTLL FTKDPQGFEA LIDSEIGTKN PLGFISLKNE
310 320 330 340 350
ANLHGYIGPK DYRSLKAISP MLTDVIEYGL ITFFAKGVFV LLDYLYQFVG
360 370 380 390 400
NWGWAIILLT IIVRIILYPL SYKGMVSMQK LKELAPKMKE LQEKYKGEPQ
410 420 430 440 450
KLQAHMMQLY KKHGANPLGG CLPLILQIPV FFAIYRVLYN AVELKSSEWI
460 470 480 490 500
LWIHDLSIMD PYFILPLLMG ASMYWHQSVT PNTMTDPMQA KIFKLLPLLF
510 520 530 540
TIFLITFPAG LVLYWTTNNI LSVLQQLIIN KVLENKKRMH AQNKKEH
Length:547
Mass (Da):62,584
Last modified:January 1, 1998 - v1
Checksum:i3E5D32C3D3051F93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08491.1.
PIRiB64701.
RefSeqiNP_208241.1. NC_000915.1.
WP_000360153.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08491; AAD08491; HP_1450.
GeneIDi899843.
KEGGiheo:C694_07510.
hpy:HP1450.
PATRICi20594307. VBIHelPyl33062_1522.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08491.1.
PIRiB64701.
RefSeqiNP_208241.1. NC_000915.1.
WP_000360153.1. NC_018939.1.

3D structure databases

ProteinModelPortaliO25989.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3087N.
IntActiO25989. 3 interactions.
MINTiMINT-183737.
STRINGi85962.HP1450.

Proteomic databases

PaxDbiO25989.
PRIDEiO25989.

Protocols and materials databases

DNASUi899843.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08491; AAD08491; HP_1450.
GeneIDi899843.
KEGGiheo:C694_07510.
hpy:HP1450.
PATRICi20594307. VBIHelPyl33062_1522.

Phylogenomic databases

eggNOGiENOG4105DHW. Bacteria.
COG0706. LUCA.
KOiK03217.
OMAiYKGMVSM.

Enzyme and pathway databases

BioCyciHPY:HP1450-MONOMER.

Family and domain databases

HAMAPiMF_01810. YidC_type1. 1 hit.
InterProiIPR019998. Membr_insert_YidC.
IPR028055. Membr_insert_YidC/Oxa1_C.
IPR028053. Membr_insert_YidC_N.
IPR001708. Membrane_insert_OXA1/ALB3/YidC.
[Graphical view]
PANTHERiPTHR12428. PTHR12428. 1 hit.
PfamiPF02096. 60KD_IMP. 1 hit.
PF14849. YidC_periplas. 1 hit.
[Graphical view]
PRINTSiPR01900. YIDCPROTEIN.
TIGRFAMsiTIGR03593. yidC_nterm. 1 hit.
TIGR03592. yidC_oxa1_cterm. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiYIDC_HELPY
AccessioniPrimary (citable) accession number: O25989
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.