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Protein

Membrane protein insertase YidC

Gene

yidC

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionChaperone
Biological processProtein transport, Transport

Enzyme and pathway databases

BioCyciHPY:HP1450-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane protein insertase YidCUniRule annotation
Alternative name(s):
Foldase YidCUniRule annotation
Membrane integrase YidCUniRule annotation
Membrane protein YidCUniRule annotation
Gene namesi
Name:yidCUniRule annotation
Ordered Locus Names:HP_1450
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 28HelicalUniRule annotationAdd BLAST21
Transmembranei325 – 345HelicalUniRule annotationAdd BLAST21
Transmembranei348 – 368HelicalUniRule annotationAdd BLAST21
Transmembranei414 – 434HelicalUniRule annotationAdd BLAST21
Transmembranei449 – 469HelicalUniRule annotationAdd BLAST21
Transmembranei495 – 515HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001247191 – 547Membrane protein insertase YidCAdd BLAST547

Proteomic databases

PaxDbiO25989

Interactioni

Subunit structurei

Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.UniRule annotation

Protein-protein interaction databases

DIPiDIP-3087N
IntActiO25989, 3 interactors
MINTiO25989
STRINGi85962.HP1450

Structurei

3D structure databases

ProteinModelPortaliO25989
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DHW Bacteria
COG0706 LUCA
KOiK03217
OMAiYKGMVSM

Family and domain databases

HAMAPiMF_01810 YidC_type1, 1 hit
InterProiView protein in InterPro
IPR019998 Membr_insert_YidC
IPR028055 Membr_insert_YidC/Oxa1_C
IPR028053 Membr_insert_YidC_N
IPR001708 YidC/ALB3/OXA1/COX18
IPR038210 YidC_periplasmic
PANTHERiPTHR12428 PTHR12428, 1 hit
PfamiView protein in Pfam
PF02096 60KD_IMP, 1 hit
PF14849 YidC_periplas, 1 hit
PRINTSiPR01900 YIDCPROTEIN
TIGRFAMsiTIGR03593 yidC_nterm, 1 hit
TIGR03592 yidC_oxa1_cterm, 1 hit

Sequencei

Sequence statusi: Complete.

O25989-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKNNNNLRL ILAIALSFLF IALYSYFFQK PNKTTTQTTK QETTNNHTAT
60 70 80 90 100
SPNAPNAQHF STTQTTPQEN LLSTISFEHA RIEIDSLGRI KQVYLKDKKY
110 120 130 140 150
LTPKQKGFLE HVGHLFSSKE NAQPPLKELP LLAADKLKPL EVRFLDPTLN
160 170 180 190 200
NKAFNTPYSA SKTTLGPNEQ LVLTQDLGTL SIIKTLTFYD DLHYDLKIAF
210 220 230 240 250
KSPNNLIPSY VITNGYRPVA DLDSYTFSGV LLENSDKKIE KIEDKDAKEI
260 270 280 290 300
KRFSNTLFLS SVDRYFTTLL FTKDPQGFEA LIDSEIGTKN PLGFISLKNE
310 320 330 340 350
ANLHGYIGPK DYRSLKAISP MLTDVIEYGL ITFFAKGVFV LLDYLYQFVG
360 370 380 390 400
NWGWAIILLT IIVRIILYPL SYKGMVSMQK LKELAPKMKE LQEKYKGEPQ
410 420 430 440 450
KLQAHMMQLY KKHGANPLGG CLPLILQIPV FFAIYRVLYN AVELKSSEWI
460 470 480 490 500
LWIHDLSIMD PYFILPLLMG ASMYWHQSVT PNTMTDPMQA KIFKLLPLLF
510 520 530 540
TIFLITFPAG LVLYWTTNNI LSVLQQLIIN KVLENKKRMH AQNKKEH
Length:547
Mass (Da):62,584
Last modified:January 1, 1998 - v1
Checksum:i3E5D32C3D3051F93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD08491.1
PIRiB64701
RefSeqiNP_208241.1, NC_000915.1
WP_000360153.1, NC_018939.1

Genome annotation databases

EnsemblBacteriaiAAD08491; AAD08491; HP_1450
GeneIDi899843
KEGGiheo:C694_07510
hpy:HP1450
PATRICifig|85962.47.peg.1559

Similar proteinsi

Entry informationi

Entry nameiYIDC_HELPY
AccessioniPrimary (citable) accession number: O25989
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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