Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Peptidyl-prolyl cis-trans isomerase

Gene

ppiA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Rotamase

Enzyme and pathway databases

BioCyciHPY:HP1441-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase (EC:5.2.1.8)
Short name:
PPIase
Alternative name(s):
Rotamase
Gene namesi
Name:ppiA
Ordered Locus Names:HP_1441
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000641991 – 163Peptidyl-prolyl cis-trans isomeraseAdd BLAST163

Proteomic databases

PaxDbiO25982

Interactioni

Protein-protein interaction databases

STRINGi85962.HP1441

Structurei

3D structure databases

ProteinModelPortaliO25982
SMRiO25982
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 163PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST147

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.Curated

Phylogenomic databases

eggNOGiENOG4108R5K Bacteria
COG0652 LUCA
KOiK03768
OMAiEIFCDEV

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PIRSFiPIRSF001467 Peptidylpro_ismrse, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

O25982-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDPIKTYEI KEEELAKTAY ATIKTNKGNI ALELFYKDAP QAVSNFVTLA
60 70 80 90 100
KEGFYNGLNF HRVIAGFVAQ GGCPYGTGTG GPGHRIKCEV AHNPNKHKRG
110 120 130 140 150
SISMAHAGRD TGGSQFFLCF VDLPHLDGEH TVFGKITSAE GLSVLDKIKQ
160
GDIIESVVFS SSL
Length:163
Mass (Da):17,621
Last modified:January 1, 1998 - v1
Checksum:i8C1F0648DA84955B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD08479.1
PIRiA64700
RefSeqiNP_208232.1, NC_000915.1
WP_000969162.1, NC_018939.1

Genome annotation databases

EnsemblBacteriaiAAD08479; AAD08479; HP_1441
GeneIDi899853
KEGGihpy:HP1441
PATRICifig|85962.8.peg.1513

Similar proteinsi

Entry informationi

Entry nameiPPIA_HELPY
AccessioniPrimary (citable) accession number: O25982
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health