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Protein

Ribosomal RNA small subunit methyltransferase A

Gene

rsmA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.UniRule annotation

Catalytic activityi

4 S-adenosyl-L-methionine + adenine(1518)/adenine(1519) in 16S rRNA = 4 S-adenosyl-L-homocysteine + N6-dimethyladenine(1518)/N6-dimethyladenine(1519) in 16S rRNA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei11S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei13S-adenosyl-L-methionine; via amide nitrogenUniRule annotation1
Binding sitei38S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei58S-adenosyl-L-methionineUniRule annotation1
Binding sitei86S-adenosyl-L-methionineUniRule annotation1
Binding sitei101S-adenosyl-L-methionineUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, RNA-binding, Transferase
Biological processrRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciHPY:HP1431-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA small subunit methyltransferase AUniRule annotation (EC:2.1.1.182UniRule annotation)
Alternative name(s):
16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferaseUniRule annotation
16S rRNA dimethyladenosine transferaseUniRule annotation
16S rRNA dimethylaseUniRule annotation
S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferaseUniRule annotation
Gene namesi
Name:rsmAUniRule annotation
Synonyms:ksgAUniRule annotation
Ordered Locus Names:HP_1431
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001015401 – 271Ribosomal RNA small subunit methyltransferase AAdd BLAST271

Proteomic databases

PaxDbiO25972.

Interactioni

Protein-protein interaction databases

STRINGi85962.HP1431.

Structurei

3D structure databases

ProteinModelPortaliO25972.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D1X. Bacteria.
COG0030. LUCA.
KOiK02528.
OMAiKRFGQHW.

Family and domain databases

Gene3Di1.10.8.100. 1 hit.
HAMAPiMF_00607. 16SrRNA_methyltr_A. 1 hit.
InterProiView protein in InterPro
IPR001737. KsgA/Erm.
IPR023165. rRNA_Ade_diMease-like.
IPR020596. rRNA_Ade_Mease_Trfase_CS.
IPR020598. rRNA_Ade_methylase_Trfase_N.
IPR011530. rRNA_adenine_dimethylase.
IPR029063. SAM-dependent_MTases.
PANTHERiPTHR11727. PTHR11727. 1 hit.
PfamiView protein in Pfam
PF00398. RrnaAD. 1 hit.
SMARTiView protein in SMART
SM00650. rADc. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00755. ksgA. 1 hit.
PROSITEiView protein in PROSITE
PS01131. RRNA_A_DIMETH. 1 hit.
PS51689. SAM_RNA_A_N6_MT. 1 hit.

Sequencei

Sequence statusi: Complete.

O25972-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVAKKSLGQ HFLTDESFLD RIVNALPPLN PLKLVEIGVG LGDLTLKLLD
60 70 80 90 100
RYPLKTYEID SHLCEKMRSK LKAQKKPFKL ELVEKDALFL KEEEPYFLIS
110 120 130 140 150
NLPYYIATRL VLNAFKDPKC RGLLVMTQKE VALKFCAKDS QNALSVLAHT
160 170 180 190 200
IGNATLLFDV PPSAFSPPPK VFSSVFEVIK EPLKEKALAS LAQAPFFEEA
210 220 230 240 250
LQKGFEMLED FLKACFSSPR KTLSNNLKKS VSYREKLDKV LDFLALENQP
260 270
TSVRASEIKD YLKLLNYLLK G
Length:271
Mass (Da):30,644
Last modified:January 1, 1998 - v1
Checksum:i870D11C671A7DB91
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08470.1.
PIRiG64698.
RefSeqiNP_208222.1. NC_000915.1.
WP_000259453.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08470; AAD08470; HP_1431.
GeneIDi899864.
KEGGiheo:C694_07400.
hpy:HP1431.
PATRICifig|85962.47.peg.1535.

Similar proteinsi

Entry informationi

Entry nameiRSMA_HELPY
AccessioniPrimary (citable) accession number: O25972
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: January 1, 1998
Last modified: August 30, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families