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Protein

Arginase

Gene

HP_1399

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-arginine + H2O = L-ornithine + urea.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi91Manganese 1Combined sources1
Metal bindingi116Manganese 1Combined sources1
Metal bindingi116Manganese 2Combined sources1
Metal bindingi118Manganese 2; via pros nitrogenCombined sources1
Metal bindingi120Manganese 1Combined sources1
Metal bindingi234Manganese 1Combined sources1
Metal bindingi234Manganese 2Combined sources1
Metal bindingi236Manganese 2Combined sources1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

Arginine metabolismUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotationCombined sources, Metal-bindingUniRule annotationCombined sources

Enzyme and pathway databases

BioCyciHPY:HP1399-MONOMER.
BRENDAi3.5.3.1. 2604.
SABIO-RKO25949.

Names & Taxonomyi

Protein namesi
Recommended name:
ArginaseUniRule annotation (EC:3.5.3.1UniRule annotation)
Gene namesi
Ordered Locus Names:HP_1399Imported
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)Imported
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

PTM / Processingi

Proteomic databases

PaxDbiO25949.
PRIDEiO25949.

Interactioni

Protein-protein interaction databases

DIPiDIP-3188N.
IntActiO25949. 3 interactors.
MINTiMINT-178538.
STRINGi85962.HP1399.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4G3HX-ray2.20A/B/C/D1-322[»]
ProteinModelPortaliO25949.
SMRiO25949.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arginase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41066UZ. Bacteria.
COG0010. LUCA.
KOiK01476.
OMAiGMPLGMV.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
InterProiIPR014033. Arginase.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 2 hits.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01229. rocF_arginase. 1 hit.
PROSITEiPS51409. ARGINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O25949-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILVGLEAEL GASKRGTDKG VRRLREALSA THGDVIKGMQ TITQERCVLY
60 70 80 90 100
KEFRYAKNFE DYYLFCKENL IPCMKEVFEK KEFPLILSSE HANMFGIFQA
110 120 130 140 150
FRSVHKDKKI GILYLDAHAD IHTAYDSDSK HIHGMPLGMV LNRVRSGFNR
160 170 180 190 200
MSESEEKAWQ KLCSLGLEKG GLEIDPKCLV YFGVRSTEQS ERDVIRELQI
210 220 230 240 250
PLFSVDAIRE NMQEVVQKTK ESLKAVDIIY LSLDLDIMDG KLFTSTGVRE
260 270 280 290 300
NNGLSFDELK QLLGLLLESF KDRLKAVEVT EYNPTVSIKH NNEEEKQVLE
310 320
ILDLIINSCK IKDKKHSFAR SY
Length:322
Mass (Da):36,925
Last modified:January 1, 1998 - v1
Checksum:i25918577C4202113
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08436.1.
PIRiG64694.
RefSeqiNP_208190.1. NC_000915.1.
WP_000604403.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08436; AAD08436; HP_1399.
GeneIDi899897.
KEGGiheo:C694_07230.
hpy:HP1399.
PATRICi20594187. VBIHelPyl33062_1464.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08436.1.
PIRiG64694.
RefSeqiNP_208190.1. NC_000915.1.
WP_000604403.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4G3HX-ray2.20A/B/C/D1-322[»]
ProteinModelPortaliO25949.
SMRiO25949.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3188N.
IntActiO25949. 3 interactors.
MINTiMINT-178538.
STRINGi85962.HP1399.

Proteomic databases

PaxDbiO25949.
PRIDEiO25949.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08436; AAD08436; HP_1399.
GeneIDi899897.
KEGGiheo:C694_07230.
hpy:HP1399.
PATRICi20594187. VBIHelPyl33062_1464.

Phylogenomic databases

eggNOGiENOG41066UZ. Bacteria.
COG0010. LUCA.
KOiK01476.
OMAiGMPLGMV.

Enzyme and pathway databases

BioCyciHPY:HP1399-MONOMER.
BRENDAi3.5.3.1. 2604.
SABIO-RKO25949.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
InterProiIPR014033. Arginase.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 2 hits.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01229. rocF_arginase. 1 hit.
PROSITEiPS51409. ARGINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO25949_HELPY
AccessioniPrimary (citable) accession number: O25949
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.