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O25944

- NADK_HELPY

UniProt

O25944 - NADK_HELPY

Protein

NAD kinase

Gene

nadK

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei70 – 701Proton acceptorUniRule annotation
    Binding sitei167 – 1671NADUniRule annotation
    Binding sitei169 – 1691NADUniRule annotation
    Binding sitei177 – 1771NAD; via carbonyl oxygenUniRule annotation
    Binding sitei236 – 2361NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi70 – 712NADUniRule annotation
    Nucleotide bindingi139 – 1402NADUniRule annotation
    Nucleotide bindingi180 – 1856NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHPY:HP1394-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:HP_1394
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 284284NAD kinasePRO_0000120623Add
    BLAST

    Proteomic databases

    PRIDEiO25944.

    Interactioni

    Protein-protein interaction databases

    IntActiO25944. 4 interactions.
    MINTiMINT-4074458.
    STRINGi85962.HP1394.

    Structurei

    3D structure databases

    ProteinModelPortaliO25944.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    KOiK00858.
    OMAiGAEFCLN.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O25944-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKDSLQTIGV FVRPTHYQNP LFEKLEQAKE WVLKLLEDEG FESFMIDSLD    50
    GAKDARLIEK ADAFLCLGGD GTILGALRMT HSYNKPCFGV RIGNLGFLSA 100
    VELNGLKDFL QDFKQDRIKL EEHLALEGRI GKTSFYAINE IVIAKKKALG 150
    VLDIKAYAGH TPFNTYKGDG LIIATPLGST AYNLSAHGPI VHALSQSYIL 200
    TPLCDFSLTQ RPLVLGAEFC LNFCAHEDAL VVIDGQATYD LKANQPLYIQ 250
    KSPTTTKLLQ KNSRDYFKVL KEKLLWGESP SKKR 284
    Length:284
    Mass (Da):31,632
    Last modified:January 1, 1998 - v1
    Checksum:i92050696C7E655F8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08434.1.
    PIRiB64694.
    RefSeqiNP_208185.1. NC_000915.1.
    YP_006935318.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD08434; AAD08434; HP_1394.
    GeneIDi13870605.
    899902.
    KEGGiheo:C694_07200.
    hpy:HP1394.
    PATRICi20594175. VBIHelPyl33062_1458.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08434.1 .
    PIRi B64694.
    RefSeqi NP_208185.1. NC_000915.1.
    YP_006935318.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali O25944.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O25944. 4 interactions.
    MINTi MINT-4074458.
    STRINGi 85962.HP1394.

    Proteomic databases

    PRIDEi O25944.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD08434 ; AAD08434 ; HP_1394 .
    GeneIDi 13870605.
    899902.
    KEGGi heo:C694_07200.
    hpy:HP1394.
    PATRICi 20594175. VBIHelPyl33062_1458.

    Phylogenomic databases

    eggNOGi COG0061.
    KOi K00858.
    OMAi GAEFCLN.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci HPY:HP1394-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiNADK_HELPY
    AccessioniPrimary (citable) accession number: O25944
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3