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Protein

NAD kinase

Gene

nadK

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei70Proton acceptorUniRule annotation1
Binding sitei167NADUniRule annotation1
Binding sitei169NADUniRule annotation1
Binding sitei177NAD; via carbonyl oxygenUniRule annotation1
Binding sitei236NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi70 – 71NADUniRule annotation2
Nucleotide bindingi139 – 140NADUniRule annotation2
Nucleotide bindingi180 – 185NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPY:HP1394-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:HP_1394
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001206231 – 284NAD kinaseAdd BLAST284

Proteomic databases

PaxDbiO25944.

Interactioni

Protein-protein interaction databases

IntActiO25944. 4 interactors.
MINTiMINT-4074458.
STRINGi85962.HP1394.

Structurei

3D structure databases

ProteinModelPortaliO25944.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91. Bacteria.
COG0061. LUCA.
KOiK00858.
OMAiLLWGESP.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase. 1 hit.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

O25944-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDSLQTIGV FVRPTHYQNP LFEKLEQAKE WVLKLLEDEG FESFMIDSLD
60 70 80 90 100
GAKDARLIEK ADAFLCLGGD GTILGALRMT HSYNKPCFGV RIGNLGFLSA
110 120 130 140 150
VELNGLKDFL QDFKQDRIKL EEHLALEGRI GKTSFYAINE IVIAKKKALG
160 170 180 190 200
VLDIKAYAGH TPFNTYKGDG LIIATPLGST AYNLSAHGPI VHALSQSYIL
210 220 230 240 250
TPLCDFSLTQ RPLVLGAEFC LNFCAHEDAL VVIDGQATYD LKANQPLYIQ
260 270 280
KSPTTTKLLQ KNSRDYFKVL KEKLLWGESP SKKR
Length:284
Mass (Da):31,632
Last modified:January 1, 1998 - v1
Checksum:i92050696C7E655F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08434.1.
PIRiB64694.
RefSeqiNP_208185.1. NC_000915.1.
WP_000655300.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08434; AAD08434; HP_1394.
GeneIDi899902.
KEGGiheo:C694_07200.
hpy:HP1394.
PATRICi20594175. VBIHelPyl33062_1458.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08434.1.
PIRiB64694.
RefSeqiNP_208185.1. NC_000915.1.
WP_000655300.1. NC_018939.1.

3D structure databases

ProteinModelPortaliO25944.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO25944. 4 interactors.
MINTiMINT-4074458.
STRINGi85962.HP1394.

Proteomic databases

PaxDbiO25944.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08434; AAD08434; HP_1394.
GeneIDi899902.
KEGGiheo:C694_07200.
hpy:HP1394.
PATRICi20594175. VBIHelPyl33062_1458.

Phylogenomic databases

eggNOGiENOG4105F91. Bacteria.
COG0061. LUCA.
KOiK00858.
OMAiLLWGESP.

Enzyme and pathway databases

BioCyciHPY:HP1394-MONOMER.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase. 1 hit.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNADK_HELPY
AccessioniPrimary (citable) accession number: O25944
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: October 5, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.