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O25944

- NADK_HELPY

UniProt

O25944 - NADK_HELPY

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Protein

NAD kinase

Gene

nadK

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei70 – 701Proton acceptorUniRule annotation
Binding sitei167 – 1671NADUniRule annotation
Binding sitei169 – 1691NADUniRule annotation
Binding sitei177 – 1771NAD; via carbonyl oxygenUniRule annotation
Binding sitei236 – 2361NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi70 – 712NADUniRule annotation
Nucleotide bindingi139 – 1402NADUniRule annotation
Nucleotide bindingi180 – 1856NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPY:HP1394-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:HP_1394
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284NAD kinasePRO_0000120623Add
BLAST

Proteomic databases

PRIDEiO25944.

Interactioni

Protein-protein interaction databases

IntActiO25944. 4 interactions.
MINTiMINT-4074458.
STRINGi85962.HP1394.

Structurei

3D structure databases

ProteinModelPortaliO25944.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
KOiK00858.
OMAiGAEFCLN.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

O25944-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKDSLQTIGV FVRPTHYQNP LFEKLEQAKE WVLKLLEDEG FESFMIDSLD
60 70 80 90 100
GAKDARLIEK ADAFLCLGGD GTILGALRMT HSYNKPCFGV RIGNLGFLSA
110 120 130 140 150
VELNGLKDFL QDFKQDRIKL EEHLALEGRI GKTSFYAINE IVIAKKKALG
160 170 180 190 200
VLDIKAYAGH TPFNTYKGDG LIIATPLGST AYNLSAHGPI VHALSQSYIL
210 220 230 240 250
TPLCDFSLTQ RPLVLGAEFC LNFCAHEDAL VVIDGQATYD LKANQPLYIQ
260 270 280
KSPTTTKLLQ KNSRDYFKVL KEKLLWGESP SKKR
Length:284
Mass (Da):31,632
Last modified:January 1, 1998 - v1
Checksum:i92050696C7E655F8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08434.1.
PIRiB64694.
RefSeqiNP_208185.1. NC_000915.1.
YP_006935318.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08434; AAD08434; HP_1394.
GeneIDi13870605.
899902.
KEGGiheo:C694_07200.
hpy:HP1394.
PATRICi20594175. VBIHelPyl33062_1458.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08434.1 .
PIRi B64694.
RefSeqi NP_208185.1. NC_000915.1.
YP_006935318.1. NC_018939.1.

3D structure databases

ProteinModelPortali O25944.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O25944. 4 interactions.
MINTi MINT-4074458.
STRINGi 85962.HP1394.

Proteomic databases

PRIDEi O25944.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD08434 ; AAD08434 ; HP_1394 .
GeneIDi 13870605.
899902.
KEGGi heo:C694_07200.
hpy:HP1394.
PATRICi 20594175. VBIHelPyl33062_1458.

Phylogenomic databases

eggNOGi COG0061.
KOi K00858.
OMAi GAEFCLN.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci HPY:HP1394-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiNADK_HELPY
AccessioniPrimary (citable) accession number: O25944
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3