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Protein

3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ

Gene

fabZ

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.UniRule annotation

Catalytic activityi

A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H2O.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei58UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processLipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciHPY:HP1376-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZUniRule annotation (EC:4.2.1.59UniRule annotation)
Alternative name(s):
(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydrataseUniRule annotation
Short name:
(3R)-hydroxymyristoyl-ACP dehydraseUniRule annotation
Beta-hydroxyacyl-ACP dehydrataseUniRule annotation
Gene namesi
Name:fabZUniRule annotation
Ordered Locus Names:HP_1376
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000916881 – 1593-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZAdd BLAST159

Proteomic databases

PaxDbiO25928.

Interactioni

Protein-protein interaction databases

IntActiO25928. 1 interactor.
STRINGi85962.HP1376.

Chemistry databases

BindingDBiO25928.

Structurei

Secondary structure

1159
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi14 – 20Combined sources7
Beta strandi32 – 37Combined sources6
Turni38 – 40Combined sources3
Beta strandi41 – 47Combined sources7
Helixi54 – 57Combined sources4
Helixi67 – 87Combined sources21
Helixi91 – 94Combined sources4
Beta strandi97 – 109Combined sources13
Beta strandi118 – 141Combined sources24
Beta strandi144 – 157Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GLLX-ray2.20A/B/C/D/E/F1-158[»]
2GLMX-ray2.60A/B/C/D/E/F1-158[»]
2GLPX-ray2.42A/B/C/D/E/F1-158[»]
2GLVX-ray2.50A/B/C/D/E/F/G/H/I/J/K/L1-158[»]
ProteinModelPortaliO25928.
SMRiO25928.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO25928.

Family & Domainsi

Sequence similaritiesi

Belongs to the thioester dehydratase family. FabZ subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108YXN. Bacteria.
COG0764. LUCA.
KOiK02372.
OMAiFPGRPLM.

Family and domain databases

HAMAPiMF_00406. FabZ. 1 hit.
InterProiView protein in InterPro
IPR013114. FabA_FabZ.
IPR010084. FabZ.
IPR029069. HotDog_dom.
PfamiView protein in Pfam
PF07977. FabA. 1 hit.
SUPFAMiSSF54637. SSF54637. 1 hit.
TIGRFAMsiTIGR01750. fabZ. 1 hit.

Sequencei

Sequence statusi: Complete.

O25928-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQSHQNLQS QFFIEHILQI LPHRYPMLLV DRIIELQANK KIVAYKNITF
60 70 80 90 100
NEDVFNGHFP NKPIFPGVLI VEGMAQTGGF LAFTSLWGFD PEIAKTKIVY
110 120 130 140 150
FMTIDKVKFR IPVTPGDRLE YHLEVLKHKG MIWQVGGTAQ VDGKVVAEAE

LKAMIAERD
Length:159
Mass (Da):18,196
Last modified:January 1, 1998 - v1
Checksum:i715B6FBED872AE32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08419.1.
PIRiH64691.
RefSeqiNP_208167.1. NC_000915.1.
WP_000438056.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08419; AAD08419; HP_1376.
GeneIDi900307.
KEGGiheo:C694_07100.
hpy:HP1376.
PATRICifig|85962.47.peg.1473.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFABZ_HELPY
AccessioniPrimary (citable) accession number: O25928
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: January 1, 1998
Last modified: June 7, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families