Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ

Gene

fabZ

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.UniRule annotation

Catalytic activityi

A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H2O.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei58 – 581UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciHPY:HP1376-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZUniRule annotation (EC:4.2.1.59UniRule annotation)
Alternative name(s):
(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydrataseUniRule annotation
Short name:
(3R)-hydroxymyristoyl-ACP dehydraseUniRule annotation
Beta-hydroxyacyl-ACP dehydrataseUniRule annotation
Gene namesi
Name:fabZUniRule annotation
Ordered Locus Names:HP_1376
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1591593-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZPRO_0000091688Add
BLAST

Proteomic databases

PaxDbiO25928.
PRIDEiO25928.

Interactioni

Protein-protein interaction databases

IntActiO25928. 1 interaction.
STRINGi85962.HP1376.

Chemistry

BindingDBiO25928.

Structurei

Secondary structure

1
159
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi14 – 207Combined sources
Beta strandi32 – 376Combined sources
Turni38 – 403Combined sources
Beta strandi41 – 477Combined sources
Helixi54 – 574Combined sources
Helixi67 – 8721Combined sources
Helixi91 – 944Combined sources
Beta strandi97 – 10913Combined sources
Beta strandi118 – 14124Combined sources
Beta strandi144 – 15714Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GLLX-ray2.20A/B/C/D/E/F1-158[»]
2GLMX-ray2.60A/B/C/D/E/F1-158[»]
2GLPX-ray2.42A/B/C/D/E/F1-158[»]
2GLVX-ray2.50A/B/C/D/E/F/G/H/I/J/K/L1-158[»]
ProteinModelPortaliO25928.
SMRiO25928. Positions 8-159.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO25928.

Family & Domainsi

Sequence similaritiesi

Belongs to the thioester dehydratase family. FabZ subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108YXN. Bacteria.
COG0764. LUCA.
KOiK02372.
OMAiPTENELY.
OrthoDBiEOG6JTCGM.

Family and domain databases

Gene3Di3.10.129.10. 1 hit.
HAMAPiMF_00406. FabZ.
InterProiIPR013114. FabA_FabZ.
IPR010084. FabZ.
IPR029069. HotDog_dom.
[Graphical view]
PfamiPF07977. FabA. 1 hit.
[Graphical view]
SUPFAMiSSF54637. SSF54637. 1 hit.
TIGRFAMsiTIGR01750. fabZ. 1 hit.

Sequencei

Sequence statusi: Complete.

O25928-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQSHQNLQS QFFIEHILQI LPHRYPMLLV DRIIELQANK KIVAYKNITF
60 70 80 90 100
NEDVFNGHFP NKPIFPGVLI VEGMAQTGGF LAFTSLWGFD PEIAKTKIVY
110 120 130 140 150
FMTIDKVKFR IPVTPGDRLE YHLEVLKHKG MIWQVGGTAQ VDGKVVAEAE

LKAMIAERD
Length:159
Mass (Da):18,196
Last modified:January 1, 1998 - v1
Checksum:i715B6FBED872AE32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08419.1.
PIRiH64691.
RefSeqiNP_208167.1. NC_000915.1.
WP_000438056.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08419; AAD08419; HP_1376.
GeneIDi900307.
KEGGiheo:C694_07100.
hpy:HP1376.
PATRICi20594141. VBIHelPyl33062_1441.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08419.1.
PIRiH64691.
RefSeqiNP_208167.1. NC_000915.1.
WP_000438056.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GLLX-ray2.20A/B/C/D/E/F1-158[»]
2GLMX-ray2.60A/B/C/D/E/F1-158[»]
2GLPX-ray2.42A/B/C/D/E/F1-158[»]
2GLVX-ray2.50A/B/C/D/E/F/G/H/I/J/K/L1-158[»]
ProteinModelPortaliO25928.
SMRiO25928. Positions 8-159.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO25928. 1 interaction.
STRINGi85962.HP1376.

Chemistry

BindingDBiO25928.

Proteomic databases

PaxDbiO25928.
PRIDEiO25928.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08419; AAD08419; HP_1376.
GeneIDi900307.
KEGGiheo:C694_07100.
hpy:HP1376.
PATRICi20594141. VBIHelPyl33062_1441.

Phylogenomic databases

eggNOGiENOG4108YXN. Bacteria.
COG0764. LUCA.
KOiK02372.
OMAiPTENELY.
OrthoDBiEOG6JTCGM.

Enzyme and pathway databases

BioCyciHPY:HP1376-MONOMER.

Miscellaneous databases

EvolutionaryTraceiO25928.

Family and domain databases

Gene3Di3.10.129.10. 1 hit.
HAMAPiMF_00406. FabZ.
InterProiIPR013114. FabA_FabZ.
IPR010084. FabZ.
IPR029069. HotDog_dom.
[Graphical view]
PfamiPF07977. FabA. 1 hit.
[Graphical view]
SUPFAMiSSF54637. SSF54637. 1 hit.
TIGRFAMsiTIGR01750. fabZ. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiFABZ_HELPY
AccessioniPrimary (citable) accession number: O25928
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: January 1, 1998
Last modified: December 9, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.