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Protein

ATP-dependent Clp protease ATP-binding subunit ClpX

Gene

clpX

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri7 – 3933C4-typeUniRule annotationAdd
BLAST
Nucleotide bindingi150 – 1578ATP

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciHPY:HP1374-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease ATP-binding subunit ClpXUniRule annotation
Gene namesi
Name:clpXUniRule annotation
Ordered Locus Names:HP_1374
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446ATP-dependent Clp protease ATP-binding subunit ClpXPRO_0000160365Add
BLAST

Proteomic databases

PaxDbiO25926.
PRIDEiO25926.

Interactioni

Subunit structurei

Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.UniRule annotation1 Publication

Protein-protein interaction databases

DIPiDIP-3286N.
IntActiO25926. 4 interactions.
MINTiMINT-176903.
STRINGi85962.HP1374.

Structurei

Secondary structure

1
446
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi82 – 909Combined sources
Helixi97 – 12327Combined sources
Helixi126 – 13712Combined sources
Beta strandi145 – 1484Combined sources
Helixi155 – 16511Combined sources
Beta strandi170 – 1745Combined sources
Helixi175 – 1773Combined sources
Helixi190 – 1989Combined sources
Turni199 – 2013Combined sources
Helixi203 – 2064Combined sources
Beta strandi209 – 2146Combined sources
Helixi216 – 2183Combined sources
Helixi235 – 24612Combined sources
Beta strandi274 – 2796Combined sources
Helixi284 – 2874Combined sources
Turni288 – 2903Combined sources
Turni306 – 3116Combined sources
Helixi313 – 3153Combined sources
Helixi318 – 3236Combined sources
Helixi328 – 3314Combined sources
Beta strandi336 – 3394Combined sources
Helixi345 – 3539Combined sources
Helixi359 – 36810Combined sources
Turni369 – 3713Combined sources
Beta strandi373 – 3764Combined sources
Helixi378 – 39013Combined sources
Helixi395 – 3973Combined sources
Helixi398 – 41114Combined sources
Helixi413 – 4164Combined sources
Beta strandi419 – 4235Combined sources
Helixi425 – 4284Combined sources
Beta strandi435 – 4373Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UM8X-ray2.60A71-446[»]
ProteinModelPortaliO25926.
SMRiO25926. Positions 75-438.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO25926.

Family & Domainsi

Sequence similaritiesi

Belongs to the ClpX chaperone family.UniRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri7 – 3933C4-typeUniRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG4105CHN. Bacteria.
COG1219. LUCA.
KOiK03544.
OMAiHYKRVQA.
OrthoDBiEOG625JZK.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_00175. ClpX.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR004487. Clp_protease_ATP-bd_su_ClpX.
IPR027417. P-loop_NTPase.
IPR010603. Znf_CppX_C4.
[Graphical view]
PfamiPF07724. AAA_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM01086. ClpB_D2-small. 1 hit.
SM00994. zf-C4_ClpX. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00382. clpX. 1 hit.

Sequencei

Sequence statusi: Complete.

O25926-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNETLYCSFC KKPESRDPKK RRIIFASNLN KDVCVCEYCI DVMHGELHKY
60 70 80 90 100
DNSLLALKRD RLRRMESSAY EEEFLLSYIP APKELKAVLD NYVIGQEQAK
110 120 130 140 150
KVFSVAVYNH YKRLSFKEKL KKQDNQDSNV ELEHLEEVEL SKSNILLIGP
160 170 180 190 200
TGSGKTLMAQ TLAKHLDIPI AISDATSLTE AGYVGEDVEN ILTRLLQASD
210 220 230 240 250
WNVQKAQKGI VFIDEIDKIS RLSENRSITR DVSGEGVQQA LLKIVEGSLV
260 270 280 290 300
NIPPKGGRKH PEGNFIQIDT SDILFICAGA FDGLAEIIKK RTTQNVLGFT
310 320 330 340 350
QEKMSKKEQE AILHLVQTHD LVTYGLIPEL IGRLPVLSTL DSISLEAMVD
360 370 380 390 400
ILQKPKNALI KQYQQLFKMD EVDLIFEEEA IKEIAQLALE RKTGARGLRA
410 420 430 440
IIEDFCLDIM FDLPKLKGSE VRITKDCVLK QAEPLIIAKT HSKILP
Length:446
Mass (Da):50,353
Last modified:January 1, 1998 - v1
Checksum:iF0C6E623F6A17633
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08417.1.
U95641 Genomic DNA. Translation: AAC04557.1.
PIRiF64691.
RefSeqiNP_208165.1. NC_000915.1.
WP_001006287.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08417; AAD08417; HP_1374.
GeneIDi900311.
KEGGiheo:C694_07090.
hpy:HP1374.
PATRICi20594137. VBIHelPyl33062_1439.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08417.1.
U95641 Genomic DNA. Translation: AAC04557.1.
PIRiF64691.
RefSeqiNP_208165.1. NC_000915.1.
WP_001006287.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UM8X-ray2.60A71-446[»]
ProteinModelPortaliO25926.
SMRiO25926. Positions 75-438.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3286N.
IntActiO25926. 4 interactions.
MINTiMINT-176903.
STRINGi85962.HP1374.

Proteomic databases

PaxDbiO25926.
PRIDEiO25926.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08417; AAD08417; HP_1374.
GeneIDi900311.
KEGGiheo:C694_07090.
hpy:HP1374.
PATRICi20594137. VBIHelPyl33062_1439.

Phylogenomic databases

eggNOGiENOG4105CHN. Bacteria.
COG1219. LUCA.
KOiK03544.
OMAiHYKRVQA.
OrthoDBiEOG625JZK.

Enzyme and pathway databases

BioCyciHPY:HP1374-MONOMER.

Miscellaneous databases

EvolutionaryTraceiO25926.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_00175. ClpX.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR004487. Clp_protease_ATP-bd_su_ClpX.
IPR027417. P-loop_NTPase.
IPR010603. Znf_CppX_C4.
[Graphical view]
PfamiPF07724. AAA_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM01086. ClpB_D2-small. 1 hit.
SM00994. zf-C4_ClpX. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00382. clpX. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.
  2. Perez-Casal J.F., O'Toole P.W., Trust T.J.
    Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 431-446.
    Strain: ATCC 43504 / NCTC 11637 / JCM 7653 / RPH 13487.
  3. "Crystal structure of ClpX molecular chaperone from Helicobacter pylori."
    Kim D.Y., Kim K.K.
    J. Biol. Chem. 278:50664-50670(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 71-446 IN COMPLEX WITH ADP, SUBUNIT.

Entry informationi

Entry nameiCLPX_HELPY
AccessioniPrimary (citable) accession number: O25926
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: May 11, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.