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O25916 (DNAB_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Replicative DNA helicase

EC=3.6.4.12
Gene names
Name:dnaB
Ordered Locus Names:HP_1362
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length488 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins By similarity.

Catalytic activity

ATP + H2O = ADP + phosphate.

Sequence similarities

Belongs to the helicase family. DnaB subfamily.

Contains 1 SF4 helicase domain.

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

itself2EBI-7529552,EBI-7529552

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 488488Replicative DNA helicase
PRO_0000102023

Regions

Domain172 – 471300SF4 helicase
Nucleotide binding203 – 2108ATP Potential

Secondary structure

................................................................... 488
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O25916 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 6FF84C2DE4ED606F

FASTA48855,726
        10         20         30         40         50         60 
MDHLKHLQQL QNIERIVLSG IVLANHKIEE VHSVLEPSDF YYPPNGLFFE IALKLHEEDC 

        70         80         90        100        110        120 
PIDENFIRQK MPKDKQIKEE DLVAIFAASP IDNIEAYVEE IKNASIKRKL FGLANTIREQ 

       130        140        150        160        170        180 
ALESAQKSSD ILGAVEREVY ALLNGSTIEG FRNIKEVLES AMDLITENQR KGSLEVTGIP 

       190        200        210        220        230        240 
TGFVQLDNYT SGFNKGSLVI IGARPSMGKT SLMMNMVLSA LNDDRGVAVF SLEMSAEQLA 

       250        260        270        280        290        300 
LRALSDLTSI NMHDLESGRL DDDQWENLAK CFDHLSQKKL FFYDKSYVRI EQIRLQLRKL 

       310        320        330        340        350        360 
KSQHKELGIA FIDYLQLMSG SKATKERHEQ IAEISRELKT LARELEIPII ALVQLNRSLE 

       370        380        390        400        410        420 
NRDDKRPILS DIKDSGGIEQ DADIVLFLYR GYIYQMRAED NKIDKLKKEG KIEEAQELYL 

       430        440        450        460        470        480 
KVNEERRIHK QNGSIEEAEI IVAKNRNGAT GTVYTRFNAP FTRYEDMPID SHLEEGQETK 


VDYDIVTT 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD08402.1.
PIRB64690.
RefSeqNP_208154.1. NC_000915.1.
YP_006935284.1. NC_018939.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3GXVX-ray2.20A/B1-121[»]
C101-122[»]
D98-123[»]
4A1FX-ray2.50A/B152-488[»]
ProteinModelPortalO25916.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-3388N.
IntActO25916. 3 interactions.
MINTMINT-181617.
STRING85962.HP1362.

Proteomic databases

PRIDEO25916.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD08402; AAD08402; HP_1362.
GeneID13870571.
900325.
KEGGheo:C694_07030.
hpy:HP1362.
PATRIC20594113. VBIHelPyl33062_1427.

Phylogenomic databases

eggNOGCOG0305.
KOK02314.
OMAQNMERIV.
OrthoDBEOG6T4RW5.
ProtClustDBPRK08506.

Enzyme and pathway databases

BioCycHPY:HP1362-MONOMER.

Family and domain databases

Gene3D1.10.860.10. 1 hit.
3.40.50.300. 1 hit.
InterProIPR007692. DNA_helicase_DnaB.
IPR007694. DNA_helicase_DnaB-like_C.
IPR007693. DNA_helicase_DnaB-like_N.
IPR016136. DNA_helicase_N/primase_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00772. DnaB. 1 hit.
PF03796. DnaB_C. 1 hit.
[Graphical view]
SUPFAMSSF48024. SSF48024. 1 hit.
SSF52540. SSF52540. 2 hits.
TIGRFAMsTIGR00665. DnaB. 1 hit.
PROSITEPS51199. SF4_HELICASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceO25916.

Entry information

Entry nameDNAB_HELPY
AccessionPrimary (citable) accession number: O25916
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: April 16, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names