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Protein

Phosphatidylserine decarboxylase proenzyme

Gene

psd

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Phosphatidyl-L-serine = phosphatidylethanolamine + CO2.UniRule annotation

Cofactori

pyruvateUniRule annotationNote: Binds 1 pyruvoyl group covalently per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei235 – 2362Cleavage (non-hydrolytic)UniRule annotation

GO - Molecular functioni

  1. phosphatidylserine decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. phosphatidylethanolamine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

Pyruvate

Enzyme and pathway databases

BioCyciHPY:HP1357-MONOMER.
UniPathwayiUPA00558; UER00616.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylserine decarboxylase proenzymeUniRule annotation (EC:4.1.1.65UniRule annotation)
Cleaved into the following 2 chains:
Phosphatidylserine decarboxylase alpha chainUniRule annotation
Phosphatidylserine decarboxylase beta chainUniRule annotation
Gene namesi
Name:psdUniRule annotation
Ordered Locus Names:HP_1357
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 235235Phosphatidylserine decarboxylase beta chainUniRule annotationPRO_0000029665Add
BLAST
Chaini236 – 26732Phosphatidylserine decarboxylase alpha chainUniRule annotationPRO_0000029666Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei236 – 2361Pyruvic acid (Ser)UniRule annotation

Keywords - PTMi

Zymogen

Proteomic databases

PRIDEiO25911.

Interactioni

Protein-protein interaction databases

DIPiDIP-3497N.
IntActiO25911. 1 interaction.
MINTiMINT-160147.
STRINGi85962.HP1357.

Structurei

3D structure databases

ProteinModelPortaliO25911.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphatidylserine decarboxylase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0688.
KOiK01613.
OMAiYHAPCDL.
OrthoDBiEOG6B8XK4.

Family and domain databases

HAMAPiMF_00662. PS_decarb_type1.
InterProiIPR003817. PS_Dcarbxylase.
[Graphical view]
PANTHERiPTHR10067. PTHR10067. 1 hit.
PfamiPF02666. PS_Dcarbxylase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00163. PS_decarb. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O25911-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVALSNALSR VFGSLAGYKF PSFIQKGINA LYVKIFKIDL SEFEPLENYR
60 70 80 90 100
SLNALFTRSL KKERPFDKSP NICIAPCDAL ITECAFLDND SALQIKGMPY
110 120 130 140 150
KAHELVGEIN PLSPSFFYAN FYLSPKDYHH YHAPCDLEIL EARYFAGKLL
160 170 180 190 200
PVNKPSLHKN NNLFVGNERV TLVAKDIQGN RLYFVAVGAL NVGKMRFNFD
210 220 230 240 250
KNIQTNAKAR FTQTYSYNPP IKVKKGDNLG NFEMGSTIVL FIQNTAFKDL
260
KEKNVKFGES IGEFHAN
Length:267
Mass (Da):30,201
Last modified:January 1, 1998 - v1
Checksum:i8CE79AC4126E8A4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08399.1.
PIRiE64689.
RefSeqiNP_208149.1. NC_000915.1.
YP_006935279.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08399; AAD08399; HP_1357.
GeneIDi900346.
KEGGiheo:C694_07005.
hpy:HP1357.
PATRICi20594101. VBIHelPyl33062_1421.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08399.1.
PIRiE64689.
RefSeqiNP_208149.1. NC_000915.1.
YP_006935279.1. NC_018939.1.

3D structure databases

ProteinModelPortaliO25911.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3497N.
IntActiO25911. 1 interaction.
MINTiMINT-160147.
STRINGi85962.HP1357.

Proteomic databases

PRIDEiO25911.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08399; AAD08399; HP_1357.
GeneIDi900346.
KEGGiheo:C694_07005.
hpy:HP1357.
PATRICi20594101. VBIHelPyl33062_1421.

Phylogenomic databases

eggNOGiCOG0688.
KOiK01613.
OMAiYHAPCDL.
OrthoDBiEOG6B8XK4.

Enzyme and pathway databases

UniPathwayiUPA00558; UER00616.
BioCyciHPY:HP1357-MONOMER.

Family and domain databases

HAMAPiMF_00662. PS_decarb_type1.
InterProiIPR003817. PS_Dcarbxylase.
[Graphical view]
PANTHERiPTHR10067. PTHR10067. 1 hit.
PfamiPF02666. PS_Dcarbxylase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00163. PS_decarb. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiPSD_HELPY
AccessioniPrimary (citable) accession number: O25911
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: January 1, 1998
Last modified: April 1, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.