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O25911

- PSD_HELPY

UniProt

O25911 - PSD_HELPY

Protein

Phosphatidylserine decarboxylase proenzyme

Gene

psd

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Phosphatidyl-L-serine = phosphatidylethanolamine + CO2.UniRule annotation

    Cofactori

    Pyruvoyl group.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei235 – 2362Cleavage (non-hydrolytic)UniRule annotation

    GO - Molecular functioni

    1. phosphatidylserine decarboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. phosphatidylethanolamine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

    Keywords - Ligandi

    Pyruvate

    Enzyme and pathway databases

    BioCyciHPY:HP1357-MONOMER.
    UniPathwayiUPA00558; UER00616.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylserine decarboxylase proenzymeUniRule annotation (EC:4.1.1.65UniRule annotation)
    Cleaved into the following 2 chains:
    Phosphatidylserine decarboxylase alpha chainUniRule annotation
    Phosphatidylserine decarboxylase beta chainUniRule annotation
    Gene namesi
    Name:psdUniRule annotation
    Ordered Locus Names:HP_1357
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 235235Phosphatidylserine decarboxylase beta chainUniRule annotationPRO_0000029665Add
    BLAST
    Chaini236 – 26732Phosphatidylserine decarboxylase alpha chainUniRule annotationPRO_0000029666Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei236 – 2361Pyruvic acid (Ser)UniRule annotation

    Keywords - PTMi

    Zymogen

    Proteomic databases

    PRIDEiO25911.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-3497N.
    IntActiO25911. 1 interaction.
    MINTiMINT-160147.
    STRINGi85962.HP1357.

    Structurei

    3D structure databases

    ProteinModelPortaliO25911.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the phosphatidylserine decarboxylase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0688.
    KOiK01613.
    OMAiPSLHKNN.
    OrthoDBiEOG6B8XK4.

    Family and domain databases

    HAMAPiMF_00662. PS_decarb_type1.
    InterProiIPR003817. PS_Dcarbxylase.
    IPR005221. PS_decarb.
    [Graphical view]
    PANTHERiPTHR10067. PTHR10067. 1 hit.
    PfamiPF02666. PS_Dcarbxylase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00163. PS_decarb. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O25911-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVALSNALSR VFGSLAGYKF PSFIQKGINA LYVKIFKIDL SEFEPLENYR    50
    SLNALFTRSL KKERPFDKSP NICIAPCDAL ITECAFLDND SALQIKGMPY 100
    KAHELVGEIN PLSPSFFYAN FYLSPKDYHH YHAPCDLEIL EARYFAGKLL 150
    PVNKPSLHKN NNLFVGNERV TLVAKDIQGN RLYFVAVGAL NVGKMRFNFD 200
    KNIQTNAKAR FTQTYSYNPP IKVKKGDNLG NFEMGSTIVL FIQNTAFKDL 250
    KEKNVKFGES IGEFHAN 267
    Length:267
    Mass (Da):30,201
    Last modified:January 1, 1998 - v1
    Checksum:i8CE79AC4126E8A4A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08399.1.
    PIRiE64689.
    RefSeqiNP_208149.1. NC_000915.1.
    YP_006935279.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD08399; AAD08399; HP_1357.
    GeneIDi13870566.
    900346.
    KEGGiheo:C694_07005.
    hpy:HP1357.
    PATRICi20594101. VBIHelPyl33062_1421.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08399.1 .
    PIRi E64689.
    RefSeqi NP_208149.1. NC_000915.1.
    YP_006935279.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali O25911.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-3497N.
    IntActi O25911. 1 interaction.
    MINTi MINT-160147.
    STRINGi 85962.HP1357.

    Proteomic databases

    PRIDEi O25911.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD08399 ; AAD08399 ; HP_1357 .
    GeneIDi 13870566.
    900346.
    KEGGi heo:C694_07005.
    hpy:HP1357.
    PATRICi 20594101. VBIHelPyl33062_1421.

    Phylogenomic databases

    eggNOGi COG0688.
    KOi K01613.
    OMAi PSLHKNN.
    OrthoDBi EOG6B8XK4.

    Enzyme and pathway databases

    UniPathwayi UPA00558 ; UER00616 .
    BioCyci HPY:HP1357-MONOMER.

    Family and domain databases

    HAMAPi MF_00662. PS_decarb_type1.
    InterProi IPR003817. PS_Dcarbxylase.
    IPR005221. PS_decarb.
    [Graphical view ]
    PANTHERi PTHR10067. PTHR10067. 1 hit.
    Pfami PF02666. PS_Dcarbxylase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00163. PS_decarb. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiPSD_HELPY
    AccessioniPrimary (citable) accession number: O25911
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 3, 2003
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3