O25911 (PSD_HELPY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphatidylserine decarboxylase proenzyme
EC=4.1.1.65

Cleaved into the following 2 chains:

1. Phosphatidylserine decarboxylase alpha chain
2. Phosphatidylserine decarboxylase beta chain

Gene names

Name:	psd
Ordered Locus Names:	HP_1357

Organism

Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]

Taxonomic identifier

85962 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › Helicobacter pylori

Protein attributes

Sequence length	267 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphatidyl-L-serine = phosphatidylethanolamine + CO2. HAMAP-Rule MF_00662
Cofactor	Pyruvoyl group By similarity.
Pathway	Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. HAMAP-Rule MF_00662
Sequence similarities	Belongs to the phosphatidylserine decarboxylase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Lipid biosynthesis Lipid metabolism Phospholipid biosynthesis Phospholipid metabolism
Ligand	Pyruvate
Molecular function	Decarboxylase Lyase
PTM	Zymogen
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	phosphatidylethanolamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	phosphatidylserine decarboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 235	235	Phosphatidylserine decarboxylase beta chain By similarity		PRO_0000029665
	Chain	236 – 267	32	Phosphatidylserine decarboxylase alpha chain By similarity		PRO_0000029666
Sites
	Site	235 – 236	2	Cleavage (non-hydrolytic) By similarity
Amino acid modifications
	Modified residue	236	1	Pyruvic acid (Ser) By similarity

Sequences

	Sequence		Length	Mass (Da)
	O25911 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 8CE79AC4126E8A4A	FASTA	267	30,201
	10 20 30 40 50 60 MVALSNALSR VFGSLAGYKF PSFIQKGINA LYVKIFKIDL SEFEPLENYR SLNALFTRSL 70 80 90 100 110 120 KKERPFDKSP NICIAPCDAL ITECAFLDND SALQIKGMPY KAHELVGEIN PLSPSFFYAN 130 140 150 160 170 180 FYLSPKDYHH YHAPCDLEIL EARYFAGKLL PVNKPSLHKN NNLFVGNERV TLVAKDIQGN 190 200 210 220 230 240 RLYFVAVGAL NVGKMRFNFD KNIQTNAKAR FTQTYSYNPP IKVKKGDNLG NFEMGSTIVL 250 260 FIQNTAFKDL KEKNVKFGES IGEFHAN

References

[1]

"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000511 Genomic DNA. Translation: AAD08399.1.
PIR	E64689.
RefSeq	NP_208149.1. NC_000915.1. YP_006935279.1. NC_018939.1.
3D structure databases
ProteinModelPortal	O25911.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-3497N.
MINT	MINT-160147.
STRING	85962.HP1357.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAD08399; AAD08399; HP_1357.
GeneID	13870566. 900346.
KEGG	heo:C694_07005. hpy:HP1357.
PATRIC	20594101. VBIHelPyl33062_1421.
Phylogenomic databases
eggNOG	COG0688.
KO	K01613.
OMA	YVPGRLF.
ProtClustDB	PRK03934.
Enzyme and pathway databases
UniPathway	UPA00558; UER00616.
Family and domain databases
HAMAP	MF_00662. PS_decarb_type1.
InterPro	IPR003817. PS_Dcarbxylase. IPR005221. PS_decarb. [Graphical view]
PANTHER	PTHR10067. PTHR10067. 1 hit.
Pfam	PF02666. PS_Dcarbxylase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00163. PS_decarb. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PSD_HELPY

Accession

Primary (citable) accession number: O25911

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 3, 2003
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program