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O25910

- NADA_HELPY

UniProt

O25910 - NADA_HELPY

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Protein

Quinolinate synthase A

Gene

nadA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.UniRule annotation

Catalytic activityi

Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H2O + phosphate.UniRule annotation

Cofactori

Binds 1 4Fe-4S cluster per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei25 – 251IminoaspartateUniRule annotation
Binding sitei42 – 421Iminoaspartate; via amide nitrogenUniRule annotation
Binding sitei117 – 1171IminoaspartateUniRule annotation
Binding sitei138 – 1381IminoaspartateUniRule annotation
Binding sitei224 – 2241IminoaspartateUniRule annotation
Binding sitei241 – 2411IminoaspartateUniRule annotation

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. quinolinate synthetase A activity Source: UniProtKB-HAMAP
  4. transferase activity, transferring alkyl or aryl (other than methyl) groups Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciHPY:HP1356-MONOMER.
UniPathwayiUPA00253; UER00327.

Names & Taxonomyi

Protein namesi
Recommended name:
Quinolinate synthase AUniRule annotation (EC:2.5.1.72UniRule annotation)
Gene namesi
Name:nadAUniRule annotation
Ordered Locus Names:HP_1356
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 336336Quinolinate synthase APRO_0000155818Add
BLAST

Proteomic databases

PRIDEiO25910.

Interactioni

Protein-protein interaction databases

DIPiDIP-3397N.
IntActiO25910. 1 interaction.
MINTiMINT-168022.
STRINGi85962.HP1356.

Structurei

3D structure databases

ProteinModelPortaliO25910.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the quinolinate synthase A family. Type 3 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0379.
KOiK03517.
OMAiQNKKIFF.
OrthoDBiEOG6DJZ56.

Family and domain databases

HAMAPiMF_00569. NadA_type3.
InterProiIPR003473. NadA.
IPR023515. Quinolinate_synth_A_type3.
[Graphical view]
PfamiPF02445. NadA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00550. nadA. 1 hit.

Sequencei

Sequence statusi: Complete.

O25910-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPTDNDLKAA ILELLRDLDV LLVAHFYQKD EIVELAHYTG DSLELAKIAS
60 70 80 90 100
QSDKNLIVFC GVHFMGESVK ALAFDKQVIM PKLSCCSMAR MIDSHYYDRS
110 120 130 140 150
VHLLKECGVK EFYPITYINS NAEVKAKVAK DDGVVCTSRN ASKIFNHALK
160 170 180 190 200
QNKKIFFLPD KCLGENLALE NGLKSAILGA NSQEEIKNAD VVCYNGFCSV
210 220 230 240 250
HQLFKLEDIE FYRQKYPDIL IAVHPECEPS VVSNADFSGS TSQIIEFVEK
260 270 280 290 300
LSPNQKVAIG TESHLVNRLK AKRHHQNTFI LSSTLALCPT MNETTLKDLF
310 320 330
EVLKAYKNHR AYNTIELKDE VARLAKLALT KMMELS
Length:336
Mass (Da):37,813
Last modified:January 1, 1998 - v1
Checksum:i963569A848239C4F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08398.1.
PIRiD64689.
RefSeqiNP_208148.1. NC_000915.1.
YP_006935278.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08398; AAD08398; HP_1356.
GeneIDi13870565.
900347.
KEGGiheo:C694_07000.
hpy:HP1356.
PATRICi20594099. VBIHelPyl33062_1420.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08398.1 .
PIRi D64689.
RefSeqi NP_208148.1. NC_000915.1.
YP_006935278.1. NC_018939.1.

3D structure databases

ProteinModelPortali O25910.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-3397N.
IntActi O25910. 1 interaction.
MINTi MINT-168022.
STRINGi 85962.HP1356.

Proteomic databases

PRIDEi O25910.

Protocols and materials databases

DNASUi 900347.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD08398 ; AAD08398 ; HP_1356 .
GeneIDi 13870565.
900347.
KEGGi heo:C694_07000.
hpy:HP1356.
PATRICi 20594099. VBIHelPyl33062_1420.

Phylogenomic databases

eggNOGi COG0379.
KOi K03517.
OMAi QNKKIFF.
OrthoDBi EOG6DJZ56.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00327 .
BioCyci HPY:HP1356-MONOMER.

Family and domain databases

HAMAPi MF_00569. NadA_type3.
InterProi IPR003473. NadA.
IPR023515. Quinolinate_synth_A_type3.
[Graphical view ]
Pfami PF02445. NadA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00550. nadA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiNADA_HELPY
AccessioniPrimary (citable) accession number: O25910
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3