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O25910

- NADA_HELPY

UniProt

O25910 - NADA_HELPY

Protein

Quinolinate synthase A

Gene

nadA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.UniRule annotation

    Catalytic activityi

    Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H2O + phosphate.UniRule annotation

    Cofactori

    Binds 1 4Fe-4S cluster per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei25 – 251IminoaspartateUniRule annotation
    Binding sitei42 – 421Iminoaspartate; via amide nitrogenUniRule annotation
    Binding sitei117 – 1171IminoaspartateUniRule annotation
    Binding sitei138 – 1381IminoaspartateUniRule annotation
    Binding sitei224 – 2241IminoaspartateUniRule annotation
    Binding sitei241 – 2411IminoaspartateUniRule annotation

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. quinolinate synthetase A activity Source: UniProtKB-HAMAP
    4. transferase activity, transferring alkyl or aryl (other than methyl) groups Source: InterPro

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Keywords - Ligandi

    4Fe-4S, Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    BioCyciHPY:HP1356-MONOMER.
    UniPathwayiUPA00253; UER00327.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Quinolinate synthase AUniRule annotation (EC:2.5.1.72UniRule annotation)
    Gene namesi
    Name:nadAUniRule annotation
    Ordered Locus Names:HP_1356
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 336336Quinolinate synthase APRO_0000155818Add
    BLAST

    Proteomic databases

    PRIDEiO25910.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-3397N.
    IntActiO25910. 1 interaction.
    MINTiMINT-168022.
    STRINGi85962.HP1356.

    Structurei

    3D structure databases

    ProteinModelPortaliO25910.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the quinolinate synthase A family. Type 3 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0379.
    KOiK03517.
    OMAiQNKKIFF.
    OrthoDBiEOG6DJZ56.

    Family and domain databases

    HAMAPiMF_00569. NadA_type3.
    InterProiIPR003473. NadA.
    IPR023515. Quinolinate_synth_A_type3.
    [Graphical view]
    PfamiPF02445. NadA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00550. nadA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O25910-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPTDNDLKAA ILELLRDLDV LLVAHFYQKD EIVELAHYTG DSLELAKIAS    50
    QSDKNLIVFC GVHFMGESVK ALAFDKQVIM PKLSCCSMAR MIDSHYYDRS 100
    VHLLKECGVK EFYPITYINS NAEVKAKVAK DDGVVCTSRN ASKIFNHALK 150
    QNKKIFFLPD KCLGENLALE NGLKSAILGA NSQEEIKNAD VVCYNGFCSV 200
    HQLFKLEDIE FYRQKYPDIL IAVHPECEPS VVSNADFSGS TSQIIEFVEK 250
    LSPNQKVAIG TESHLVNRLK AKRHHQNTFI LSSTLALCPT MNETTLKDLF 300
    EVLKAYKNHR AYNTIELKDE VARLAKLALT KMMELS 336
    Length:336
    Mass (Da):37,813
    Last modified:January 1, 1998 - v1
    Checksum:i963569A848239C4F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08398.1.
    PIRiD64689.
    RefSeqiNP_208148.1. NC_000915.1.
    YP_006935278.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD08398; AAD08398; HP_1356.
    GeneIDi13870565.
    900347.
    KEGGiheo:C694_07000.
    hpy:HP1356.
    PATRICi20594099. VBIHelPyl33062_1420.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08398.1 .
    PIRi D64689.
    RefSeqi NP_208148.1. NC_000915.1.
    YP_006935278.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali O25910.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-3397N.
    IntActi O25910. 1 interaction.
    MINTi MINT-168022.
    STRINGi 85962.HP1356.

    Proteomic databases

    PRIDEi O25910.

    Protocols and materials databases

    DNASUi 900347.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD08398 ; AAD08398 ; HP_1356 .
    GeneIDi 13870565.
    900347.
    KEGGi heo:C694_07000.
    hpy:HP1356.
    PATRICi 20594099. VBIHelPyl33062_1420.

    Phylogenomic databases

    eggNOGi COG0379.
    KOi K03517.
    OMAi QNKKIFF.
    OrthoDBi EOG6DJZ56.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00327 .
    BioCyci HPY:HP1356-MONOMER.

    Family and domain databases

    HAMAPi MF_00569. NadA_type3.
    InterProi IPR003473. NadA.
    IPR023515. Quinolinate_synth_A_type3.
    [Graphical view ]
    Pfami PF02445. NadA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00550. nadA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiNADA_HELPY
    AccessioniPrimary (citable) accession number: O25910
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2002
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3