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O25910 (NADA_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Quinolinate synthase A

EC=2.5.1.72
Gene names
Name:nadA
Ordered Locus Names:HP_1356
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length336 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate By similarity. HAMAP-Rule MF_00569

Catalytic activity

Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H2O + phosphate. HAMAP-Rule MF_00569

Cofactor

Binds 1 4Fe-4S cluster per subunit By similarity. HAMAP-Rule MF_00569

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1. HAMAP-Rule MF_00569

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00569.

Sequence similarities

Belongs to the quinolinate synthase A family. Type 3 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 336336Quinolinate synthase A HAMAP-Rule MF_00569
PRO_0000155818

Sites

Binding site251Iminoaspartate By similarity
Binding site421Iminoaspartate; via amide nitrogen By similarity
Binding site1171Iminoaspartate By similarity
Binding site1381Iminoaspartate By similarity
Binding site2241Iminoaspartate By similarity
Binding site2411Iminoaspartate By similarity

Sequences

Sequence LengthMass (Da)Tools
O25910 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 963569A848239C4F

FASTA33637,813
        10         20         30         40         50         60 
MPTDNDLKAA ILELLRDLDV LLVAHFYQKD EIVELAHYTG DSLELAKIAS QSDKNLIVFC 

        70         80         90        100        110        120 
GVHFMGESVK ALAFDKQVIM PKLSCCSMAR MIDSHYYDRS VHLLKECGVK EFYPITYINS 

       130        140        150        160        170        180 
NAEVKAKVAK DDGVVCTSRN ASKIFNHALK QNKKIFFLPD KCLGENLALE NGLKSAILGA 

       190        200        210        220        230        240 
NSQEEIKNAD VVCYNGFCSV HQLFKLEDIE FYRQKYPDIL IAVHPECEPS VVSNADFSGS 

       250        260        270        280        290        300 
TSQIIEFVEK LSPNQKVAIG TESHLVNRLK AKRHHQNTFI LSSTLALCPT MNETTLKDLF 

       310        320        330 
EVLKAYKNHR AYNTIELKDE VARLAKLALT KMMELS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD08398.1.
PIRD64689.
RefSeqNP_208148.1. NC_000915.1.
YP_006935278.1. NC_018939.1.

3D structure databases

ProteinModelPortalO25910.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-3397N.
IntActO25910. 1 interaction.
MINTMINT-168022.
STRING85962.HP1356.

Proteomic databases

PRIDEO25910.

Protocols and materials databases

DNASU900347.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD08398; AAD08398; HP_1356.
GeneID13870565.
900347.
KEGGheo:C694_07000.
hpy:HP1356.
PATRIC20594099. VBIHelPyl33062_1420.

Phylogenomic databases

eggNOGCOG0379.
KOK03517.
OMADKCLGEN.
OrthoDBEOG6DJZ56.
ProtClustDBPRK09375.

Enzyme and pathway databases

BioCycHPY:HP1356-MONOMER.
UniPathwayUPA00253; UER00327.

Family and domain databases

HAMAPMF_00569. NadA_type3.
InterProIPR003473. NadA.
IPR023515. Quinolinate_synth_A_type3.
[Graphical view]
PfamPF02445. NadA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00550. nadA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADA_HELPY
AccessionPrimary (citable) accession number: O25910
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: January 1, 1998
Last modified: April 16, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names