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Protein

Probable nicotinate-nucleotide pyrophosphorylase [carboxylating]

Gene

nadC

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the catabolism of quinolinic acid (QA).By similarity

Catalytic activityi

Beta-nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate.

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from quinolinate.
Proteins known to be involved in this subpathway in this organism are:
  1. Probable nicotinate-nucleotide pyrophosphorylase [carboxylating] (nadC)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from quinolinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei91SubstrateBy similarity1
Binding sitei148Substrate1 Publication1
Binding sitei158Substrate1 Publication1
Binding sitei188Substrate1 Publication1
Binding sitei209Substrate1 Publication1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciHPY:HP1355-MONOMER.
BRENDAi2.4.2.19. 2604.
UniPathwayiUPA00253; UER00331.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable nicotinate-nucleotide pyrophosphorylase [carboxylating] (EC:2.4.2.19)
Alternative name(s):
Quinolinate phosphoribosyltransferase [decarboxylating]
Short name:
QAPRTase
Gene namesi
Name:nadC
Ordered Locus Names:HP_1355
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001559431 – 273Probable nicotinate-nucleotide pyrophosphorylase [carboxylating]Add BLAST273

Proteomic databases

PaxDbiO25909.

Interactioni

Subunit structurei

Hexamer formed by 3 homodimers.1 Publication

Protein-protein interaction databases

DIPiDIP-3329N.
IntActiO25909. 3 interactors.
MINTiMINT-182259.
STRINGi85962.HP1355.

Structurei

Secondary structure

1273
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 15Combined sources12
Helixi21 – 24Combined sources4
Beta strandi30 – 39Combined sources10
Helixi46 – 55Combined sources10
Beta strandi59 – 63Combined sources5
Beta strandi75 – 82Combined sources8
Helixi83 – 114Combined sources32
Beta strandi117 – 122Combined sources6
Helixi132 – 140Combined sources9
Turni141 – 143Combined sources3
Turni151 – 153Combined sources3
Beta strandi155 – 157Combined sources3
Helixi159 – 162Combined sources4
Helixi168 – 175Combined sources8
Helixi176 – 178Combined sources3
Beta strandi185 – 191Combined sources7
Helixi192 – 201Combined sources10
Beta strandi204 – 209Combined sources6
Helixi213 – 226Combined sources14
Beta strandi231 – 237Combined sources7
Turni240 – 242Combined sources3
Helixi243 – 247Combined sources5
Turni248 – 250Combined sources3
Beta strandi252 – 255Combined sources4
Helixi258 – 261Combined sources4
Beta strandi268 – 271Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B7NX-ray2.30A/B/C1-273[»]
2B7PX-ray2.51A/B/C1-273[»]
2B7QX-ray3.31A/B/C1-273[»]
ProteinModelPortaliO25909.
SMRiO25909.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO25909.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni124 – 126Substrate binding3
Regioni235 – 237Substrate binding3
Regioni256 – 258Substrate binding3

Sequence similaritiesi

Belongs to the NadC/ModD family.Curated

Phylogenomic databases

eggNOGiENOG4105D18. Bacteria.
COG0157. LUCA.
KOiK00767.
OMAiHQATFID.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
3.90.1170.20. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR004393. NadC.
IPR027277. NadC/ModD.
IPR002638. Quinolinate_PRibosylTrfase_C.
IPR022412. Quinolinate_PRibosylTrfase_N.
[Graphical view]
PfamiPF01729. QRPTase_C. 1 hit.
PF02749. QRPTase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF006250. NadC_ModD. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR00078. nadC. 1 hit.

Sequencei

Sequence statusi: Complete.

O25909-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIRTFLERA LKEDLGHGDL FERVLEKDFK ATAFVRAKQE GVFSGEKYAL
60 70 80 90 100
ELLEMTGIEC VQTIKDKERF KPKDALMEIR GDFSMLLKVE RTLLNLLQHS
110 120 130 140 150
SGIATLTSRF VEALNSHKVR LLDTRKTRPL LRIFEKYSVL NGGASNHRLG
160 170 180 190 200
LDDALMLKDT HLRHVKDLKS FLTHARKNLP FTAKIEIECE SFEEAKNAMN
210 220 230 240 250
AGADIVMCDN LSVLETKEIA AYRDAHYPFV LLEASGNISL ESINAYAKSG
260 270
VDAISVGALI HQATFIDMHM KMA
Length:273
Mass (Da):30,803
Last modified:January 1, 1998 - v1
Checksum:i69CF0F73B2553CD5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08397.1.
PIRiC64689.
RefSeqiNP_208147.1. NC_000915.1.
WP_000405980.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08397; AAD08397; HP_1355.
GeneIDi900348.
KEGGiheo:C694_06995.
hpy:HP1355.
PATRICi20594097. VBIHelPyl33062_1419.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08397.1.
PIRiC64689.
RefSeqiNP_208147.1. NC_000915.1.
WP_000405980.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B7NX-ray2.30A/B/C1-273[»]
2B7PX-ray2.51A/B/C1-273[»]
2B7QX-ray3.31A/B/C1-273[»]
ProteinModelPortaliO25909.
SMRiO25909.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3329N.
IntActiO25909. 3 interactors.
MINTiMINT-182259.
STRINGi85962.HP1355.

Proteomic databases

PaxDbiO25909.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08397; AAD08397; HP_1355.
GeneIDi900348.
KEGGiheo:C694_06995.
hpy:HP1355.
PATRICi20594097. VBIHelPyl33062_1419.

Phylogenomic databases

eggNOGiENOG4105D18. Bacteria.
COG0157. LUCA.
KOiK00767.
OMAiHQATFID.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00331.
BioCyciHPY:HP1355-MONOMER.
BRENDAi2.4.2.19. 2604.

Miscellaneous databases

EvolutionaryTraceiO25909.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
3.90.1170.20. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR004393. NadC.
IPR027277. NadC/ModD.
IPR002638. Quinolinate_PRibosylTrfase_C.
IPR022412. Quinolinate_PRibosylTrfase_N.
[Graphical view]
PfamiPF01729. QRPTase_C. 1 hit.
PF02749. QRPTase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF006250. NadC_ModD. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR00078. nadC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNADC_HELPY
AccessioniPrimary (citable) accession number: O25909
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.