Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O25909 (NADC_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable nicotinate-nucleotide pyrophosphorylase [carboxylating]

EC=2.4.2.19
Alternative name(s):
Quinolinate phosphoribosyltransferase [decarboxylating]
Short name=QAPRTase
Gene names
Name:nadC
Ordered Locus Names:HP_1355
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length273 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the catabolism of quinolinic acid (QA) By similarity.

Catalytic activity

Beta-nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate.

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.

Subunit structure

Hexamer formed by 3 homodimers. Ref.2

Sequence similarities

Belongs to the NadC/ModD family.

Ontologies

Keywords
   Biological processPyridine nucleotide biosynthesis
   Molecular functionGlycosyltransferase
Transferase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processNAD biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionnicotinate-nucleotide diphosphorylase (carboxylating) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 273273Probable nicotinate-nucleotide pyrophosphorylase [carboxylating]
PRO_0000155943

Regions

Region124 – 1263Substrate binding
Region235 – 2373Substrate binding
Region256 – 2583Substrate binding

Sites

Binding site911Substrate By similarity
Binding site1481Substrate
Binding site1581Substrate
Binding site1881Substrate
Binding site2091Substrate

Secondary structure

............................................... 273
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O25909 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 69CF0F73B2553CD5

FASTA27330,803
        10         20         30         40         50         60 
MEIRTFLERA LKEDLGHGDL FERVLEKDFK ATAFVRAKQE GVFSGEKYAL ELLEMTGIEC 

        70         80         90        100        110        120 
VQTIKDKERF KPKDALMEIR GDFSMLLKVE RTLLNLLQHS SGIATLTSRF VEALNSHKVR 

       130        140        150        160        170        180 
LLDTRKTRPL LRIFEKYSVL NGGASNHRLG LDDALMLKDT HLRHVKDLKS FLTHARKNLP 

       190        200        210        220        230        240 
FTAKIEIECE SFEEAKNAMN AGADIVMCDN LSVLETKEIA AYRDAHYPFV LLEASGNISL 

       250        260        270 
ESINAYAKSG VDAISVGALI HQATFIDMHM KMA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD08397.1.
PIRC64689.
RefSeqNP_208147.1. NC_000915.1.
YP_006935277.1. NC_018939.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2B7NX-ray2.30A/B/C1-273[»]
2B7PX-ray2.51A/B/C1-273[»]
2B7QX-ray3.31A/B/C1-273[»]
ProteinModelPortalO25909.
SMRO25909. Positions 1-273.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-3329N.
IntActO25909. 3 interactions.
MINTMINT-182259.
STRING85962.HP1355.

Proteomic databases

PRIDEO25909.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD08397; AAD08397; HP_1355.
GeneID13870564.
900348.
KEGGheo:C694_06995.
hpy:HP1355.
PATRIC20594097. VBIHelPyl33062_1419.

Phylogenomic databases

eggNOGCOG0157.
KOK00767.
OMAQSVQHID.
OrthoDBEOG6KT2XH.
ProtClustDBPRK05848.

Enzyme and pathway databases

BioCycHPY:HP1355-MONOMER.
UniPathwayUPA00253; UER00331.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
3.90.1170.20. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR004393. NadC.
IPR027277. NadC/ModD.
IPR002638. Quinolinate_PRibosylTrfase_C.
IPR022412. Quinolinate_PRibosylTrfase_N.
[Graphical view]
PfamPF01729. QRPTase_C. 1 hit.
PF02749. QRPTase_N. 1 hit.
[Graphical view]
PIRSFPIRSF006250. NadC_ModD. 1 hit.
SUPFAMSSF51690. SSF51690. 1 hit.
TIGRFAMsTIGR00078. nadC. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceO25909.

Entry information

Entry nameNADC_HELPY
AccessionPrimary (citable) accession number: O25909
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: December 11, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names