O25897 (EXBB_HELPY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Biopolymer transport protein ExbB

Gene names

Name:	exbB
Ordered Locus Names:	HP_1339

Organism

Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]

Taxonomic identifier

85962 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › Helicobacter pylori

Protein attributes

Sequence length	145 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. Protects ExbD from proteolytic degradation and functionally stabilizes TonB By similarity.
Subunit structure	The accessory proteins ExbB and ExbD seem to form a complex with TonB By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the ExbB/TolQ family.
Sequence caution	The sequence AAD08381.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	protein transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 145	145	Biopolymer transport protein ExbB		PRO_0000145803
Regions
	Transmembrane	13 – 33	21	Helical; Potential
	Transmembrane	67 – 87	21	Helical; Potential
	Transmembrane	101 – 121	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	O25897 [UniParc]. Last modified December 1, 2000. Version 2. Checksum: A44BB5BA436F9540	FASTA	145	15,804
	10 20 30 40 50 60 MGGFSVGMLK DYVDIFVFAV LGVASFLALW FAIERVIFYS KVDLKAYDDI DALNLDLTKN 70 80 90 100 110 120 LTILYVIFSN APYVGLLGTV LGIMVIFYDM GVSGGMDAKT IMVGLSLALK ATALGLAVAI 130 140 PTLIAYNSLL RKSDVLSEKF RIMKK

References

[1]

"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000511 Genomic DNA. Translation: AAD08381.1. Different initiation.
PIR	C64687.
RefSeq	NP_208131.1. NC_000915.1. YP_006935260.1. NC_018939.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	85962.HP1339.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAD08381; AAD08381; HP_1339.
GeneID	13870547. 898784.
KEGG	heo:C694_06910. hpy:HP1339.
PATRIC	20594061. VBIHelPyl33062_1401.
Phylogenomic databases
eggNOG	COG0811.
KO	K03561.
OMA	DAKTIMV.
ProtClustDB	CLSK496456.
Family and domain databases
InterPro	IPR002898. MotA_ExbB_proton_chnl. IPR014172. TonB_ExbB_2. [Graphical view]
Pfam	PF01618. MotA_ExbB. 1 hit. [Graphical view]
TIGRFAMs	TIGR02805. exbB2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

EXBB_HELPY

Accession

Primary (citable) accession number: O25897

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	December 1, 2000
Last modified:	May 1, 2013
This is version 68 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program