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Protein

Putative nickel-responsive regulator

Gene

HP_1338

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional regulator.UniRule annotation

Cofactori

Ni2+UniRule annotationNote: Binds 1 nickel ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi88 – 881NickelUniRule annotation
Metal bindingi99 – 991NickelUniRule annotation
Metal bindingi101 – 1011NickelUniRule annotation
Metal bindingi107 – 1071NickelUniRule annotation

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. identical protein binding Source: IntAct
  3. nickel cation binding Source: UniProtKB-HAMAP
  4. sequence-specific DNA binding transcription factor activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. response to nickel cation Source: InterPro
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Nickel

Enzyme and pathway databases

BioCyciHPY:HP1338-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative nickel-responsive regulatorUniRule annotation
Gene namesi
Ordered Locus Names:HP_1338
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 148148Putative nickel-responsive regulatorPRO_0000139291Add
BLAST

Proteomic databases

PRIDEiO25896.

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-528005,EBI-528005

Protein-protein interaction databases

DIPiDIP-3711N.
IntActiO25896. 3 interactions.
MINTiMINT-166516.
STRINGi85962.HP1338.

Structurei

Secondary structure

1
148
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi10 – 189Combined sources
Helixi19 – 3214Combined sources
Helixi37 – 5014Combined sources
Beta strandi64 – 7310Combined sources
Beta strandi74 – 785Combined sources
Helixi79 – 8911Combined sources
Beta strandi91 – 10111Combined sources
Beta strandi103 – 11513Combined sources
Helixi117 – 12812Combined sources
Beta strandi133 – 1419Combined sources
Helixi143 – 1453Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CA9X-ray2.05A/B1-148[»]
2CADX-ray2.30A/B1-148[»]
2CAJX-ray2.35A/B1-148[»]
2WVBX-ray1.90A/B1-148[»]
2WVCX-ray2.10A/B1-148[»]
2WVDX-ray2.65A/B/C/D1-148[»]
2WVEX-ray2.30A/B1-148[»]
2WVFX-ray1.60A/B1-148[»]
3LGHX-ray2.37A/B/C/D1-148[»]
3PHTX-ray2.04A/B1-148[»]
3QSIX-ray3.08A/B/C/D/E/F/G/H/I/J61-148[»]
ProteinModelPortaliO25896.
SMRiO25896. Positions 9-147.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO25896.

Family & Domainsi

Sequence similaritiesi

Belongs to the transcriptional regulatory CopG/NikR family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0864.
KOiK07722.
OMAiAHNCLET.
OrthoDBiEOG65QWK8.

Family and domain databases

Gene3Di1.10.1220.10. 1 hit.
HAMAPiMF_00476. NikR.
InterProiIPR013321. Arc_rbn_hlx_hlx.
IPR002145. CopG.
IPR022988. Ni_resp_reg_NikR.
IPR010985. Ribbon_hlx_hlx.
IPR014864. TF_NikR_Ni-bd_C.
[Graphical view]
PfamiPF08753. NikR_C. 1 hit.
PF01402. RHH_1. 1 hit.
[Graphical view]
SUPFAMiSSF47598. SSF47598. 1 hit.

Sequencei

Sequence statusi: Complete.

O25896-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTPNKDDSI IRFSVSLQQN LLDELDNRII KNGYSSRSEL VRDMIREKLV
60 70 80 90 100
EDNWAEDNPN DESKIAVLVV IYDHHQRELN QRMIDIQHAS GTHVLCTTHI
110 120 130 140
HMDEHNCLET IILQGNSFEI QRLQLEIGGL RGVKFAKLTK ASSFEYNE
Length:148
Mass (Da):17,147
Last modified:December 31, 1997 - v1
Checksum:i9C8A2F803E7822B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08380.1.
PIRiB64687.
RefSeqiNP_208130.1. NC_000915.1.
YP_006935259.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08380; AAD08380; HP_1338.
GeneIDi900339.
KEGGiheo:C694_06905.
hpy:HP1338.
PATRICi20594059. VBIHelPyl33062_1400.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08380.1.
PIRiB64687.
RefSeqiNP_208130.1. NC_000915.1.
YP_006935259.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CA9X-ray2.05A/B1-148[»]
2CADX-ray2.30A/B1-148[»]
2CAJX-ray2.35A/B1-148[»]
2WVBX-ray1.90A/B1-148[»]
2WVCX-ray2.10A/B1-148[»]
2WVDX-ray2.65A/B/C/D1-148[»]
2WVEX-ray2.30A/B1-148[»]
2WVFX-ray1.60A/B1-148[»]
3LGHX-ray2.37A/B/C/D1-148[»]
3PHTX-ray2.04A/B1-148[»]
3QSIX-ray3.08A/B/C/D/E/F/G/H/I/J61-148[»]
ProteinModelPortaliO25896.
SMRiO25896. Positions 9-147.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3711N.
IntActiO25896. 3 interactions.
MINTiMINT-166516.
STRINGi85962.HP1338.

Proteomic databases

PRIDEiO25896.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08380; AAD08380; HP_1338.
GeneIDi900339.
KEGGiheo:C694_06905.
hpy:HP1338.
PATRICi20594059. VBIHelPyl33062_1400.

Phylogenomic databases

eggNOGiCOG0864.
KOiK07722.
OMAiAHNCLET.
OrthoDBiEOG65QWK8.

Enzyme and pathway databases

BioCyciHPY:HP1338-MONOMER.

Miscellaneous databases

EvolutionaryTraceiO25896.

Family and domain databases

Gene3Di1.10.1220.10. 1 hit.
HAMAPiMF_00476. NikR.
InterProiIPR013321. Arc_rbn_hlx_hlx.
IPR002145. CopG.
IPR022988. Ni_resp_reg_NikR.
IPR010985. Ribbon_hlx_hlx.
IPR014864. TF_NikR_Ni-bd_C.
[Graphical view]
PfamiPF08753. NikR_C. 1 hit.
PF01402. RHH_1. 1 hit.
[Graphical view]
SUPFAMiSSF47598. SSF47598. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiNIKR_HELPY
AccessioniPrimary (citable) accession number: O25896
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2001
Last sequence update: December 31, 1997
Last modified: March 31, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.