Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O25896 (NIKR_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative nickel-responsive regulator
Gene names
Ordered Locus Names:HP_1338
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length148 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional regulator Potential. HAMAP-Rule MF_00476

Cofactor

Binds 1 nickel ion per subunit By similarity. HAMAP-Rule MF_00476

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00476

Sequence similarities

Belongs to the transcriptional regulatory CopG/NikR family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

itself2EBI-528005,EBI-528005

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 148148Putative nickel-responsive regulator HAMAP-Rule MF_00476
PRO_0000139291

Sites

Metal binding881Nickel By similarity
Metal binding991Nickel By similarity
Metal binding1011Nickel By similarity
Metal binding1071Nickel By similarity

Secondary structure

.................... 148
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O25896 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 9C8A2F803E7822B8

FASTA14817,147
        10         20         30         40         50         60 
MDTPNKDDSI IRFSVSLQQN LLDELDNRII KNGYSSRSEL VRDMIREKLV EDNWAEDNPN 

        70         80         90        100        110        120 
DESKIAVLVV IYDHHQRELN QRMIDIQHAS GTHVLCTTHI HMDEHNCLET IILQGNSFEI 

       130        140 
QRLQLEIGGL RGVKFAKLTK ASSFEYNE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD08380.1.
PIRB64687.
RefSeqNP_208130.1. NC_000915.1.
YP_006935259.1. NC_018939.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2CA9X-ray2.05A/B1-148[»]
2CADX-ray2.30A/B1-148[»]
2CAJX-ray2.35A/B1-148[»]
2WVBX-ray1.90A/B1-148[»]
2WVCX-ray2.10A/B1-148[»]
2WVDX-ray2.65A/B/C/D1-148[»]
2WVEX-ray2.30A/B1-148[»]
2WVFX-ray1.60A/B1-148[»]
3LGHX-ray2.37A/B/C/D1-148[»]
3PHTX-ray2.04A/B1-148[»]
3QSIX-ray3.08A/B/C/D/E/F/G/H/I/J61-148[»]
ProteinModelPortalO25896.
SMRO25896. Positions 9-147.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-3711N.
IntActO25896. 3 interactions.
MINTMINT-166516.
STRING85962.HP1338.

Proteomic databases

PRIDEO25896.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD08380; AAD08380; HP_1338.
GeneID900339.
KEGGheo:C694_06905.
hpy:HP1338.
PATRIC20594059. VBIHelPyl33062_1400.

Phylogenomic databases

eggNOGCOG0864.
KOK07722.
OMACLEVTIL.
OrthoDBEOG65QWK8.

Enzyme and pathway databases

BioCycHPY:HP1338-MONOMER.

Family and domain databases

Gene3D1.10.1220.10. 1 hit.
HAMAPMF_00476. NikR.
InterProIPR013321. Arc_rbn_hlx_hlx.
IPR002145. CopG.
IPR022988. Ni_resp_reg_NikR.
IPR010985. Ribbon_hlx_hlx.
IPR014864. TF_NikR_Ni-bd_C.
[Graphical view]
PfamPF08753. NikR_C. 1 hit.
PF01402. RHH_1. 1 hit.
[Graphical view]
SUPFAMSSF47598. SSF47598. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceO25896.

Entry information

Entry nameNIKR_HELPY
AccessionPrimary (citable) accession number: O25896
Entry history
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names