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Protein

Putative nickel-responsive regulator

Gene

HP_1338

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional regulator.UniRule annotation

Cofactori

Ni2+UniRule annotationNote: Binds 1 nickel ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi88NickelUniRule annotation1
Metal bindingi99NickelUniRule annotation1
Metal bindingi101NickelUniRule annotation1
Metal bindingi107NickelUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Nickel

Enzyme and pathway databases

BioCyciHPY:HP1338-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative nickel-responsive regulatorUniRule annotation
Gene namesi
Ordered Locus Names:HP_1338
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001392911 – 148Putative nickel-responsive regulatorAdd BLAST148

Proteomic databases

PaxDbiO25896.

Expressioni

Gene expression databases

CollecTFiEXPREG_00000670.

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-528005,EBI-528005

Protein-protein interaction databases

DIPiDIP-3711N.
IntActiO25896. 3 interactors.
MINTiMINT-166516.
STRINGi85962.HP1338.

Structurei

Secondary structure

1148
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi10 – 18Combined sources9
Helixi19 – 32Combined sources14
Helixi37 – 50Combined sources14
Helixi51 – 56Combined sources6
Beta strandi64 – 73Combined sources10
Beta strandi74 – 78Combined sources5
Helixi79 – 89Combined sources11
Beta strandi91 – 101Combined sources11
Beta strandi103 – 115Combined sources13
Helixi117 – 128Combined sources12
Beta strandi133 – 141Combined sources9
Helixi143 – 145Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CA9X-ray2.05A/B1-148[»]
2CADX-ray2.30A/B1-148[»]
2CAJX-ray2.35A/B1-148[»]
2WVBX-ray1.90A/B1-148[»]
2WVCX-ray2.10A/B1-148[»]
2WVDX-ray2.65A/B/C/D1-148[»]
2WVEX-ray2.30A/B1-148[»]
2WVFX-ray1.60A/B1-148[»]
3LGHX-ray2.37A/B/C/D1-148[»]
3PHTX-ray2.04A/B1-148[»]
3QSIX-ray3.08A/B/C/D/E/F/G/H/I/J61-148[»]
ProteinModelPortaliO25896.
SMRiO25896.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO25896.

Family & Domainsi

Sequence similaritiesi

Belongs to the transcriptional regulatory CopG/NikR family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105MRR. Bacteria.
COG0864. LUCA.
KOiK07722.
OMAiAHNCLET.

Family and domain databases

Gene3Di1.10.1220.10. 1 hit.
HAMAPiMF_00476. NikR. 1 hit.
InterProiIPR013321. Arc_rbn_hlx_hlx.
IPR002145. CopG.
IPR022988. Ni_resp_reg_NikR.
IPR010985. Ribbon_hlx_hlx.
IPR014864. TF_NikR_Ni-bd_C.
[Graphical view]
PfamiPF08753. NikR_C. 1 hit.
PF01402. RHH_1. 1 hit.
[Graphical view]
SUPFAMiSSF47598. SSF47598. 1 hit.

Sequencei

Sequence statusi: Complete.

O25896-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTPNKDDSI IRFSVSLQQN LLDELDNRII KNGYSSRSEL VRDMIREKLV
60 70 80 90 100
EDNWAEDNPN DESKIAVLVV IYDHHQRELN QRMIDIQHAS GTHVLCTTHI
110 120 130 140
HMDEHNCLET IILQGNSFEI QRLQLEIGGL RGVKFAKLTK ASSFEYNE
Length:148
Mass (Da):17,147
Last modified:January 1, 1998 - v1
Checksum:i9C8A2F803E7822B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08380.1.
PIRiB64687.
RefSeqiNP_208130.1. NC_000915.1.
WP_000380787.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08380; AAD08380; HP_1338.
GeneIDi900339.
KEGGiheo:C694_06905.
hpy:HP1338.
PATRICi20594059. VBIHelPyl33062_1400.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08380.1.
PIRiB64687.
RefSeqiNP_208130.1. NC_000915.1.
WP_000380787.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CA9X-ray2.05A/B1-148[»]
2CADX-ray2.30A/B1-148[»]
2CAJX-ray2.35A/B1-148[»]
2WVBX-ray1.90A/B1-148[»]
2WVCX-ray2.10A/B1-148[»]
2WVDX-ray2.65A/B/C/D1-148[»]
2WVEX-ray2.30A/B1-148[»]
2WVFX-ray1.60A/B1-148[»]
3LGHX-ray2.37A/B/C/D1-148[»]
3PHTX-ray2.04A/B1-148[»]
3QSIX-ray3.08A/B/C/D/E/F/G/H/I/J61-148[»]
ProteinModelPortaliO25896.
SMRiO25896.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3711N.
IntActiO25896. 3 interactors.
MINTiMINT-166516.
STRINGi85962.HP1338.

Proteomic databases

PaxDbiO25896.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08380; AAD08380; HP_1338.
GeneIDi900339.
KEGGiheo:C694_06905.
hpy:HP1338.
PATRICi20594059. VBIHelPyl33062_1400.

Phylogenomic databases

eggNOGiENOG4105MRR. Bacteria.
COG0864. LUCA.
KOiK07722.
OMAiAHNCLET.

Enzyme and pathway databases

BioCyciHPY:HP1338-MONOMER.

Miscellaneous databases

EvolutionaryTraceiO25896.

Gene expression databases

CollecTFiEXPREG_00000670.

Family and domain databases

Gene3Di1.10.1220.10. 1 hit.
HAMAPiMF_00476. NikR. 1 hit.
InterProiIPR013321. Arc_rbn_hlx_hlx.
IPR002145. CopG.
IPR022988. Ni_resp_reg_NikR.
IPR010985. Ribbon_hlx_hlx.
IPR014864. TF_NikR_Ni-bd_C.
[Graphical view]
PfamiPF08753. NikR_C. 1 hit.
PF01402. RHH_1. 1 hit.
[Graphical view]
SUPFAMiSSF47598. SSF47598. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNIKR_HELPY
AccessioniPrimary (citable) accession number: O25896
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.