SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O25896

- NIKR_HELPY

UniProt

O25896 - NIKR_HELPY

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Putative nickel-responsive regulator
Gene
HP_1338
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Transcriptional regulator Reviewed prediction.UniRule annotation

Cofactori

Binds 1 nickel ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi88 – 881Nickel By similarity
Metal bindingi99 – 991Nickel By similarity
Metal bindingi101 – 1011Nickel By similarity
Metal bindingi107 – 1071Nickel By similarity

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. identical protein binding Source: IntAct
  3. nickel cation binding Source: UniProtKB-HAMAP
  4. sequence-specific DNA binding transcription factor activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. response to nickel cation Source: InterPro
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Nickel

Enzyme and pathway databases

BioCyciHPY:HP1338-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative nickel-responsive regulator
Gene namesi
Ordered Locus Names:HP_1338
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 148148Putative nickel-responsive regulatorUniRule annotation
PRO_0000139291Add
BLAST

Proteomic databases

PRIDEiO25896.

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-528005,EBI-528005

Protein-protein interaction databases

DIPiDIP-3711N.
IntActiO25896. 3 interactions.
MINTiMINT-166516.
STRINGi85962.HP1338.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi10 – 189
Helixi19 – 3214
Helixi37 – 5014
Beta strandi64 – 7310
Beta strandi74 – 785
Helixi79 – 8911
Beta strandi91 – 10111
Beta strandi103 – 11513
Helixi117 – 12812
Beta strandi133 – 1419
Helixi143 – 1453

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CA9X-ray2.05A/B1-148[»]
2CADX-ray2.30A/B1-148[»]
2CAJX-ray2.35A/B1-148[»]
2WVBX-ray1.90A/B1-148[»]
2WVCX-ray2.10A/B1-148[»]
2WVDX-ray2.65A/B/C/D1-148[»]
2WVEX-ray2.30A/B1-148[»]
2WVFX-ray1.60A/B1-148[»]
3LGHX-ray2.37A/B/C/D1-148[»]
3PHTX-ray2.04A/B1-148[»]
3QSIX-ray3.08A/B/C/D/E/F/G/H/I/J61-148[»]
ProteinModelPortaliO25896.
SMRiO25896. Positions 9-147.

Miscellaneous databases

EvolutionaryTraceiO25896.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0864.
KOiK07722.
OMAiCLEVTIL.
OrthoDBiEOG65QWK8.

Family and domain databases

Gene3Di1.10.1220.10. 1 hit.
HAMAPiMF_00476. NikR.
InterProiIPR013321. Arc_rbn_hlx_hlx.
IPR002145. CopG.
IPR022988. Ni_resp_reg_NikR.
IPR010985. Ribbon_hlx_hlx.
IPR014864. TF_NikR_Ni-bd_C.
[Graphical view]
PfamiPF08753. NikR_C. 1 hit.
PF01402. RHH_1. 1 hit.
[Graphical view]
SUPFAMiSSF47598. SSF47598. 1 hit.

Sequencei

Sequence statusi: Complete.

O25896-1 [UniParc]FASTAAdd to Basket

« Hide

MDTPNKDDSI IRFSVSLQQN LLDELDNRII KNGYSSRSEL VRDMIREKLV    50
EDNWAEDNPN DESKIAVLVV IYDHHQRELN QRMIDIQHAS GTHVLCTTHI 100
HMDEHNCLET IILQGNSFEI QRLQLEIGGL RGVKFAKLTK ASSFEYNE 148
Length:148
Mass (Da):17,147
Last modified:January 1, 1998 - v1
Checksum:i9C8A2F803E7822B8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08380.1.
PIRiB64687.
RefSeqiNP_208130.1. NC_000915.1.
YP_006935259.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08380; AAD08380; HP_1338.
GeneIDi13870546.
900339.
KEGGiheo:C694_06905.
hpy:HP1338.
PATRICi20594059. VBIHelPyl33062_1400.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08380.1 .
PIRi B64687.
RefSeqi NP_208130.1. NC_000915.1.
YP_006935259.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2CA9 X-ray 2.05 A/B 1-148 [» ]
2CAD X-ray 2.30 A/B 1-148 [» ]
2CAJ X-ray 2.35 A/B 1-148 [» ]
2WVB X-ray 1.90 A/B 1-148 [» ]
2WVC X-ray 2.10 A/B 1-148 [» ]
2WVD X-ray 2.65 A/B/C/D 1-148 [» ]
2WVE X-ray 2.30 A/B 1-148 [» ]
2WVF X-ray 1.60 A/B 1-148 [» ]
3LGH X-ray 2.37 A/B/C/D 1-148 [» ]
3PHT X-ray 2.04 A/B 1-148 [» ]
3QSI X-ray 3.08 A/B/C/D/E/F/G/H/I/J 61-148 [» ]
ProteinModelPortali O25896.
SMRi O25896. Positions 9-147.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-3711N.
IntActi O25896. 3 interactions.
MINTi MINT-166516.
STRINGi 85962.HP1338.

Proteomic databases

PRIDEi O25896.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD08380 ; AAD08380 ; HP_1338 .
GeneIDi 13870546.
900339.
KEGGi heo:C694_06905.
hpy:HP1338.
PATRICi 20594059. VBIHelPyl33062_1400.

Phylogenomic databases

eggNOGi COG0864.
KOi K07722.
OMAi CLEVTIL.
OrthoDBi EOG65QWK8.

Enzyme and pathway databases

BioCyci HPY:HP1338-MONOMER.

Miscellaneous databases

EvolutionaryTracei O25896.

Family and domain databases

Gene3Di 1.10.1220.10. 1 hit.
HAMAPi MF_00476. NikR.
InterProi IPR013321. Arc_rbn_hlx_hlx.
IPR002145. CopG.
IPR022988. Ni_resp_reg_NikR.
IPR010985. Ribbon_hlx_hlx.
IPR014864. TF_NikR_Ni-bd_C.
[Graphical view ]
Pfami PF08753. NikR_C. 1 hit.
PF01402. RHH_1. 1 hit.
[Graphical view ]
SUPFAMi SSF47598. SSF47598. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiNIKR_HELPY
AccessioniPrimary (citable) accession number: O25896
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi