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Protein
Submitted name:

Cation efflux system protein (CzcA)

Gene

HP_1329

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

BioCyciHPY:HP1329-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Cation efflux system protein (CzcA)Imported
Gene namesi
Ordered Locus Names:HP_1329Imported
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)Imported
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei333 – 352HelicalSequence analysisAdd BLAST20
Transmembranei359 – 379HelicalSequence analysisAdd BLAST21
Transmembranei385 – 406HelicalSequence analysisAdd BLAST22
Transmembranei434 – 453HelicalSequence analysisAdd BLAST20
Transmembranei473 – 494HelicalSequence analysisAdd BLAST22
Transmembranei526 – 543HelicalSequence analysisAdd BLAST18
Transmembranei860 – 879HelicalSequence analysisAdd BLAST20
Transmembranei886 – 906HelicalSequence analysisAdd BLAST21
Transmembranei912 – 936HelicalSequence analysisAdd BLAST25
Transmembranei970 – 987HelicalSequence analysisAdd BLAST18
Transmembranei999 – 1025HelicalSequence analysisAdd BLAST27

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiO25887.
PRIDEiO25887.

Interactioni

Protein-protein interaction databases

DIPiDIP-3479N.
IntActiO25887. 3 interactors.
MINTiMINT-160952.
STRINGi85962.HP1329.

Structurei

3D structure databases

ProteinModelPortaliO25887.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. [View classification]SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG4108IJF. Bacteria.
COG3696. LUCA.
KOiK07787.
OMAiFLIRIYH.

Family and domain databases

Gene3Di3.30.2090.10. 2 hits.
InterProiIPR027463. AcrB_DN_DC_subdom.
IPR001036. Acrflvin-R.
IPR004763. CzcA/CusA/SilA/NccA/HelA/CnrA.
[Graphical view]
PfamiPF00873. ACR_tran. 1 hit.
[Graphical view]
PRINTSiPR00702. ACRIFLAVINRP.
SUPFAMiSSF82714. SSF82714. 2 hits.
TIGRFAMsiTIGR00914. 2A0601. 1 hit.

Sequencei

Sequence statusi: Complete.

O25887-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEKIIDLSV KNKLLTTLVT LLIFLASLWA IKSVRLDALP DLSPAQVVVQ
60 70 80 90 100
ITYPNQSPKI VQEQVTYPLV STFMSIANID TVRGISSYES GLIYIIFKDG
110 120 130 140 150
VNLYWARDRV LEQLNRVSNL PKDAKVEIGS DSTSIGWAYQ YALSSDSKNL
160 170 180 190 200
SDLKVLQDFY YRYALLGVDG VSEVASVGGF VKDYEVTLQN DSLIRYNLSL
210 220 230 240 250
EQVANAIKNS NNDTGGGVIL ENGFEKIIRS HGYIQSLKDL EEIVVKKEGA
260 270 280 290 300
IPLKIKDIAS VRLTPKPRRG AANLNGDKEV VGGIVMVRYH ADTYKVLKAI
310 320 330 340 350
KEKIATLQAS NPDVKITSVY DRSELIEKGI DNLIHTLIEE SVIVLVIIAI
360 370 380 390 400
FLLHFRSALV VIITLPLSVC ISFLLMRYFN IEASIMSLGG IAIAIGAMVD
410 420 430 440 450
AAIVMVENAH KHLQHIDVKD NAQRVNGIIE GVKHVGGAIF FALMIIVVSF
460 470 480 490 500
LPIFALTGQE EKLFAPLAYT KTFAMLVGAL LSITMVPILM VWLIKGRILE
510 520 530 540 550
ESKNPINAFF MKIYGVSLNV VLKFRYAFLI ASVLGLGGLY VAYKKLNWEF
560 570 580 590 600
IPQINEGVVM YMPVTINGVS IDTALEYLKK SNSAIKRLDF VKQVFGKVGR
610 620 630 640 650
ANTSTDAAGL SMIETYIELK PQNEWKEKLS YKEVRDKLEK TLQLKGLTNS
660 670 680 690 700
WTYPIRGRTD MLLTGIRTPL GIKLYGNDTD KLQELAILME QQLKTLKESL
710 720 730 740 750
SVFAERSNNG YYITLDLNDE NLARYGINKK AVLDAIKFAL GGATLTTMIK
760 770 780 790 800
GVENYPISLR LEDTERNTIE KLKNLYIKTA YNYMPLRELA RIYYDNSPAV
810 820 830 840 850
LKSEKGLNVN FIYIVPQNGI SSDAYRQLAQ KALEKIQLPN GYYYEFSGES
860 870 880 890 900
QYLEEAFKTL QYIVPVSVFI IFILIVFALK NLTNSLLCFF TLPFAFLGGL
910 920 930 940 950
IFMNLMGFNM SVAALVGFLA LLGVASETAI VMIIYLEDAF QKFIKTPLKE
960 970 980 990 1000
QNSTTLKEAI MHGAVLRVRP KLMTFFSILA SLIPIMYSHG TGSEIMKSIA
1010 1020 1030
APMLGGMISS VVLTLFIIPT AYFVIKNAGI KSNQT
Length:1,035
Mass (Da):115,335
Last modified:January 1, 1998 - v1
Checksum:i317880F132983BA5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08370.1.
PIRiA64686.
RefSeqiNP_208121.1. NC_000915.1.
WP_000570460.1. NC_000915.1.

Genome annotation databases

EnsemblBacteriaiAAD08370; AAD08370; HP_1329.
GeneIDi900199.
KEGGihpy:HP1329.
PATRICi20594039. VBIHelPyl33062_1390.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08370.1.
PIRiA64686.
RefSeqiNP_208121.1. NC_000915.1.
WP_000570460.1. NC_000915.1.

3D structure databases

ProteinModelPortaliO25887.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3479N.
IntActiO25887. 3 interactors.
MINTiMINT-160952.
STRINGi85962.HP1329.

Proteomic databases

PaxDbiO25887.
PRIDEiO25887.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08370; AAD08370; HP_1329.
GeneIDi900199.
KEGGihpy:HP1329.
PATRICi20594039. VBIHelPyl33062_1390.

Phylogenomic databases

eggNOGiENOG4108IJF. Bacteria.
COG3696. LUCA.
KOiK07787.
OMAiFLIRIYH.

Enzyme and pathway databases

BioCyciHPY:HP1329-MONOMER.

Family and domain databases

Gene3Di3.30.2090.10. 2 hits.
InterProiIPR027463. AcrB_DN_DC_subdom.
IPR001036. Acrflvin-R.
IPR004763. CzcA/CusA/SilA/NccA/HelA/CnrA.
[Graphical view]
PfamiPF00873. ACR_tran. 1 hit.
[Graphical view]
PRINTSiPR00702. ACRIFLAVINRP.
SUPFAMiSSF82714. SSF82714. 2 hits.
TIGRFAMsiTIGR00914. 2A0601. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiO25887_HELPY
AccessioniPrimary (citable) accession number: O25887
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.