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Protein

Protein translocase subunit SecY

Gene

secY

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.UniRule annotation

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciHPY:HP1300-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecYUniRule annotation
Gene namesi
Name:secYUniRule annotation
Ordered Locus Names:HP_1300
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2921HelicalUniRule annotationAdd
BLAST
Transmembranei61 – 8121HelicalUniRule annotationAdd
BLAST
Transmembranei104 – 12421HelicalUniRule annotationAdd
BLAST
Transmembranei141 – 16121HelicalUniRule annotationAdd
BLAST
Transmembranei173 – 19321HelicalUniRule annotationAdd
BLAST
Transmembranei203 – 22321HelicalUniRule annotationAdd
BLAST
Transmembranei257 – 27721HelicalUniRule annotationAdd
BLAST
Transmembranei300 – 32021HelicalUniRule annotationAdd
BLAST
Transmembranei355 – 37521HelicalUniRule annotationAdd
BLAST
Transmembranei377 – 39721HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 420420Protein translocase subunit SecYPRO_0000131725Add
BLAST

Proteomic databases

PaxDbiO25879.
PRIDEiO25879.

Interactioni

Subunit structurei

Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.UniRule annotation

Protein-protein interaction databases

DIPiDIP-3770N.
IntActiO25879. 1 interaction.
MINTiMINT-169922.
STRINGi85962.HP1300.

Structurei

3D structure databases

ProteinModelPortaliO25879.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CGG. Bacteria.
COG0201. LUCA.
KOiK03076.
OMAiQTYVISQ.
OrthoDBiEOG651SWP.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
HAMAPiMF_01465. SecY.
InterProiIPR026593. SecY.
IPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O25879-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKAIASKIL ITLGFLFLYR VLAYIPIPGV DLAAIKAFFD SNSNNALGLF
60 70 80 90 100
NMFSGNAVSR LSIISLGIMP YITSSIIMEL LSATFPNLAK MKKERDGMQK
110 120 130 140 150
YMQIVRYLTI LITLIQAVSV SVGLRSISGG ANGAIMIDMQ VFMIVSAFSM
160 170 180 190 200
LTGTMLLMWI GEQITQRGVG NGISLIIFAG IVSGIPSAIS GTFNLVNTGV
210 220 230 240 250
INILMLIGIV LIVLATIFAI IYVELAERRI PISYARKVVM QNQNKRIMNY
260 270 280 290 300
IPIKLNLSGV IPPIFASALL VFPSTILQQA TSNKTLQAVA DFLSPQGYAY
310 320 330 340 350
NILMFLLIIF FAYFYSSIVF NSKDIADNLR RNGGYIPGLR PGEGTSSFLN
360 370 380 390 400
SVASKLTLWG SLYLALISTV PWILVKAMGV PFYFGGTAVL IVVQVAIDTM
410 420
KKIEAQIYMS KYKTLSAVGF
Length:420
Mass (Da):45,829
Last modified:January 1, 1998 - v1
Checksum:i9FD337091D905F9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08341.1.
PIRiD64682.
RefSeqiNP_208092.1. NC_000915.1.
WP_001030187.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08341; AAD08341; HP_1300.
GeneIDi899085.
KEGGiheo:C694_06715.
hpy:HP1300.
PATRICi20593981. VBIHelPyl33062_1361.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08341.1.
PIRiD64682.
RefSeqiNP_208092.1. NC_000915.1.
WP_001030187.1. NC_018939.1.

3D structure databases

ProteinModelPortaliO25879.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3770N.
IntActiO25879. 1 interaction.
MINTiMINT-169922.
STRINGi85962.HP1300.

Proteomic databases

PaxDbiO25879.
PRIDEiO25879.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08341; AAD08341; HP_1300.
GeneIDi899085.
KEGGiheo:C694_06715.
hpy:HP1300.
PATRICi20593981. VBIHelPyl33062_1361.

Phylogenomic databases

eggNOGiENOG4105CGG. Bacteria.
COG0201. LUCA.
KOiK03076.
OMAiQTYVISQ.
OrthoDBiEOG651SWP.

Enzyme and pathway databases

BioCyciHPY:HP1300-MONOMER.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
HAMAPiMF_01465. SecY.
InterProiIPR026593. SecY.
IPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiSECY_HELPY
AccessioniPrimary (citable) accession number: O25879
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: November 11, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.