Reviewed, UniProtKB/Swiss-Prot O25869 (TRPE_HELPY)

Names and origin

Protein names

Recommended name:
    Anthranilate synthase component 1
    EC=4.1.3.27
Alternative name(s):
    Anthranilate synthase component I

Gene names

Name:	trpE
Ordered Locus Names:	HP_1282

Organism

Helicobacter pylori (Campylobacter pylori) [Complete proteome] [HAMAP]

Taxonomic identifier

210 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	500 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity By similarity.
Sequence similarities	Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 500	500	Anthranilate synthase component 1		PRO_0000154094

Sequences

	Sequence		Length	Mass (Da)
	O25869-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: B28485C36E1E635E	FASTA	500	56,556
	10 20 30 40 50 60 MISLIEKAPY IPYPLALYEK LEQPHTLLFE SAEIESKAHT KSLLMAKACL KLICNHNIVT 70 80 90 100 110 120 ITSLTPNGGA FLQKLSAFFK TPIQDNALIL TYTKNKKTQD EFLKLFEPSP FDALRGLFKS 130 140 150 160 170 180 VKTKPKHPFT LLSAGVFSFE MLNFFEDLPH LKAKDNTVHD FIFYLAQNLI IIDHKEKSVE 190 200 210 220 230 240 ILGACFDERF KTEIAQELQD LKELAKSIKS DFVPKKSKQS REVSANCSDS EFEKRVLSLQ 250 260 270 280 290 300 EEIKKGEIFQ AVLSRSFYME CLEGLSAYYH LKLTNPSPYM FYIKDSDFIL FGASPESALK 310 320 330 340 350 360 YNALTNTAEI YPIAGTRLRG KDKQGNIDYD LDSKMEFDLQ HDYKERAEHI MLVDLARNDM 370 380 390 400 410 420 ARVSKKRYCD KLLKVDKYSN VMHLVSRVVG ELKKGCDSLH AYRSFMNAGT LSGAPKISAI 430 440 450 460 470 480 RLIYQLENQR RGSYGGSVGY LNSEGSMDSC ITIRSCFVKN NRAVIQAGAG IVLDSVPQNE 490 500 ANETRAKAQA LIDAIRKTSL

References

[1]

"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed: 9252185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000511 Genomic DNA. Translation: AAD08326.1.
PIR	B64680.
RefSeq	NP_208074.1.
3D structure databases
HSSP	HSSP built from PDB template 1K0E based on UniProtKB P05041.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:3432N.
Genome annotation databases
GeneID	899068.
GenomeReviews	Gene locus HP_1282 in contig AE000511_GR.
KEGG	hpy:HP1282.
NMPDR	fig|85962.1.peg.1270.
TIGR	HP_1282.
Phylogenomic databases
HOGENOM	O25869.
OMA	IITHNFS.
Enzyme and pathway databases
BRENDA	4.1.3.27. 1131.
Family and domain databases
InterPro	IPR005801. ADC_synthase. IPR006805. Anth_synth_I_N. IPR019999. Anthranilate_synth_I_C. IPR015890. Chorismate-bd_C. IPR005257. TrpE_synth. [Graphical view]
Gene3D	G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
PANTHER	PTHR11236. TRPE_1_chor_bd. 1 hit.
Pfam	PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view]
PRINTS	PR00095. ANTSNTHASEI.
ProDom	PD000779. Anth_synth_chor. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00565. trpE_proteo. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPE_HELPY

Accession

Primary (citable) accession number: O25869

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 1, 1998
Last modified:	November 3, 2009
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)