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O25868

- TRPG_HELPY

UniProt

O25868 - TRPG_HELPY

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Protein

Anthranilate synthase component 2

Gene

trpG

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (By similarity).By similarity

Catalytic activityi

Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei84 – 841For GATase activityPROSITE-ProRule annotation
Binding sitei84 – 841GlutamineBy similarity
Binding sitei88 – 881GlutamineBy similarity
Active sitei170 – 1701For GATase activityPROSITE-ProRule annotation
Active sitei172 – 1721For GATase activityPROSITE-ProRule annotation

GO - Molecular functioni

  1. anthranilate synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. glutamine metabolic process Source: UniProtKB-KW
  2. tryptophan biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciHPY:HP1281-MONOMER.
UniPathwayiUPA00035; UER00040.

Names & Taxonomyi

Protein namesi
Recommended name:
Anthranilate synthase component 2 (EC:4.1.3.27)
Short name:
AS
Short name:
ASII
Alternative name(s):
Anthranilate synthase, GATase component
Anthranilate synthase, glutamine amidotransferase component
Gene namesi
Name:trpG
Ordered Locus Names:HP_1281
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 194194Anthranilate synthase component 2PRO_0000056884Add
BLAST

Proteomic databases

PRIDEiO25868.

Interactioni

Subunit structurei

Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).By similarity

Protein-protein interaction databases

IntActiO25868. 1 interaction.
STRINGi85962.HP1281.

Structurei

3D structure databases

ProteinModelPortaliO25868.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 194193Glutamine amidotransferase type-1PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni57 – 593Glutamine bindingBy similarity
Regioni134 – 1352Glutamine bindingBy similarity

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiCOG0512.
KOiK01658.
OMAiHGKLGAM.
OrthoDBiEOG6M9F11.

Family and domain databases

Gene3Di3.40.50.880. 1 hit.
InterProiIPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR006221. TrpG/PapA_dom.
[Graphical view]
PfamiPF00117. GATase. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR00566. trpG_papA. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O25868-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKIFFIDNFD SFSYNLVYEL ECLGYEVAVY QNDIDPSYLM DLMNEESKTP
60 70 80 90 100
LLFISPGPGN PNSSGNLLKI IAMAKKKFPI LGICLGLQAL AQSYGAKIIR
110 120 130 140 150
SKEIVHGKAT AIALKKHAVF KGLGESMVVG RYHSLMASGL PKNLEVIAEH
160 170 180 190
DNIPMAIVNE EDKILAYQFH PESIMTLQGR ALLEQSVGFL EGLL
Length:194
Mass (Da):21,438
Last modified:January 1, 1998 - v1
Checksum:iA03FD6E279345659
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08325.1.
PIRiA64680.
RefSeqiNP_208073.1. NC_000915.1.
YP_006935202.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08325; AAD08325; HP_1281.
GeneIDi13870489.
898814.
KEGGiheo:C694_06620.
hpy:HP1281.
PATRICi20593939. VBIHelPyl33062_1340.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08325.1 .
PIRi A64680.
RefSeqi NP_208073.1. NC_000915.1.
YP_006935202.1. NC_018939.1.

3D structure databases

ProteinModelPortali O25868.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O25868. 1 interaction.
STRINGi 85962.HP1281.

Proteomic databases

PRIDEi O25868.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD08325 ; AAD08325 ; HP_1281 .
GeneIDi 13870489.
898814.
KEGGi heo:C694_06620.
hpy:HP1281.
PATRICi 20593939. VBIHelPyl33062_1340.

Phylogenomic databases

eggNOGi COG0512.
KOi K01658.
OMAi HGKLGAM.
OrthoDBi EOG6M9F11.

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00040 .
BioCyci HPY:HP1281-MONOMER.

Family and domain databases

Gene3Di 3.40.50.880. 1 hit.
InterProi IPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR006221. TrpG/PapA_dom.
[Graphical view ]
Pfami PF00117. GATase. 1 hit.
[Graphical view ]
SUPFAMi SSF52317. SSF52317. 1 hit.
TIGRFAMsi TIGR00566. trpG_papA. 1 hit.
PROSITEi PS51273. GATASE_TYPE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiTRPG_HELPY
AccessioniPrimary (citable) accession number: O25868
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: October 1, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3