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O25868

- TRPG_HELPY

UniProt

O25868 - TRPG_HELPY

Protein

Anthranilate synthase component 2

Gene

trpG

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia By similarity.By similarity

    Catalytic activityi

    Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei84 – 841For GATase activityPROSITE-ProRule annotation
    Binding sitei84 – 841GlutamineBy similarity
    Binding sitei88 – 881GlutamineBy similarity
    Active sitei170 – 1701For GATase activityPROSITE-ProRule annotation
    Active sitei172 – 1721For GATase activityPROSITE-ProRule annotation

    GO - Molecular functioni

    1. anthranilate synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glutamine metabolic process Source: UniProtKB-KW
    2. tryptophan biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

    Enzyme and pathway databases

    BioCyciHPY:HP1281-MONOMER.
    UniPathwayiUPA00035; UER00040.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Anthranilate synthase component 2 (EC:4.1.3.27)
    Short name:
    AS
    Short name:
    ASII
    Alternative name(s):
    Anthranilate synthase, GATase component
    Anthranilate synthase, glutamine amidotransferase component
    Gene namesi
    Name:trpG
    Ordered Locus Names:HP_1281
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 194194Anthranilate synthase component 2PRO_0000056884Add
    BLAST

    Proteomic databases

    PRIDEiO25868.

    Interactioni

    Subunit structurei

    Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).By similarity

    Protein-protein interaction databases

    IntActiO25868. 1 interaction.
    STRINGi85962.HP1281.

    Structurei

    3D structure databases

    ProteinModelPortaliO25868.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 194193Glutamine amidotransferase type-1PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni57 – 593Glutamine bindingBy similarity
    Regioni134 – 1352Glutamine bindingBy similarity

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Glutamine amidotransferase

    Phylogenomic databases

    eggNOGiCOG0512.
    KOiK01658.
    OMAiHGKLGAM.
    OrthoDBiEOG6M9F11.

    Family and domain databases

    Gene3Di3.40.50.880. 1 hit.
    InterProiIPR029062. Class_I_gatase-like.
    IPR017926. GATASE.
    IPR006221. TrpG/PapA_dom.
    [Graphical view]
    PfamiPF00117. GATase. 1 hit.
    [Graphical view]
    SUPFAMiSSF52317. SSF52317. 1 hit.
    TIGRFAMsiTIGR00566. trpG_papA. 1 hit.
    PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O25868-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIFFIDNFD SFSYNLVYEL ECLGYEVAVY QNDIDPSYLM DLMNEESKTP    50
    LLFISPGPGN PNSSGNLLKI IAMAKKKFPI LGICLGLQAL AQSYGAKIIR 100
    SKEIVHGKAT AIALKKHAVF KGLGESMVVG RYHSLMASGL PKNLEVIAEH 150
    DNIPMAIVNE EDKILAYQFH PESIMTLQGR ALLEQSVGFL EGLL 194
    Length:194
    Mass (Da):21,438
    Last modified:January 1, 1998 - v1
    Checksum:iA03FD6E279345659
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08325.1.
    PIRiA64680.
    RefSeqiNP_208073.1. NC_000915.1.
    YP_006935202.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD08325; AAD08325; HP_1281.
    GeneIDi13870489.
    898814.
    KEGGiheo:C694_06620.
    hpy:HP1281.
    PATRICi20593939. VBIHelPyl33062_1340.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08325.1 .
    PIRi A64680.
    RefSeqi NP_208073.1. NC_000915.1.
    YP_006935202.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali O25868.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O25868. 1 interaction.
    STRINGi 85962.HP1281.

    Proteomic databases

    PRIDEi O25868.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD08325 ; AAD08325 ; HP_1281 .
    GeneIDi 13870489.
    898814.
    KEGGi heo:C694_06620.
    hpy:HP1281.
    PATRICi 20593939. VBIHelPyl33062_1340.

    Phylogenomic databases

    eggNOGi COG0512.
    KOi K01658.
    OMAi HGKLGAM.
    OrthoDBi EOG6M9F11.

    Enzyme and pathway databases

    UniPathwayi UPA00035 ; UER00040 .
    BioCyci HPY:HP1281-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.880. 1 hit.
    InterProi IPR029062. Class_I_gatase-like.
    IPR017926. GATASE.
    IPR006221. TrpG/PapA_dom.
    [Graphical view ]
    Pfami PF00117. GATase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52317. SSF52317. 1 hit.
    TIGRFAMsi TIGR00566. trpG_papA. 1 hit.
    PROSITEi PS51273. GATASE_TYPE_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiTRPG_HELPY
    AccessioniPrimary (citable) accession number: O25868
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3