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O25868 (TRPG_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Anthranilate synthase component II

EC=4.1.3.27
Alternative name(s):
Glutamine amido-transferase
Gene names
Name:trpG
Ordered Locus Names:HP_1281
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length194 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Catalytic activity

Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.

Subunit structure

Tetramer of two components I and two components II.

Miscellaneous

Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.

Sequence similarities

Contains 1 glutamine amidotransferase type-1 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 194194Anthranilate synthase component II
PRO_0000056884

Regions

Domain2 – 194193Glutamine amidotransferase type-1

Sites

Active site841 By similarity
Active site1701 By similarity
Active site1721 By similarity

Sequences

Sequence LengthMass (Da)Tools
O25868 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: A03FD6E279345659

FASTA19421,438
        10         20         30         40         50         60 
MKIFFIDNFD SFSYNLVYEL ECLGYEVAVY QNDIDPSYLM DLMNEESKTP LLFISPGPGN 

        70         80         90        100        110        120 
PNSSGNLLKI IAMAKKKFPI LGICLGLQAL AQSYGAKIIR SKEIVHGKAT AIALKKHAVF 

       130        140        150        160        170        180 
KGLGESMVVG RYHSLMASGL PKNLEVIAEH DNIPMAIVNE EDKILAYQFH PESIMTLQGR 

       190 
ALLEQSVGFL EGLL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD08325.1.
PIRA64680.
RefSeqNP_208073.1. NC_000915.1.
YP_006935202.1. NC_018939.1.

3D structure databases

ProteinModelPortalO25868.
ModBaseSearch...

Protein-protein interaction databases

STRING85962.HP1281.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD08325; AAD08325; HP_1281.
GeneID13870489.
898814.
KEGGheo:C694_06620.
hpy:HP1281.
PATRIC20593939. VBIHelPyl33062_1340.

Phylogenomic databases

eggNOGCOG0512.
KOK01658.
OMADNEAMFK.
ProtClustDBPRK05670.

Enzyme and pathway databases

UniPathwayUPA00035; UER00040.

Family and domain databases

InterProIPR017926. GATASE_1.
IPR006221. TrpG/PapA.
[Graphical view]
PfamPF00117. GATase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00566. trpG_papA. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRPG_HELPY
AccessionPrimary (citable) accession number: O25868
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: May 1, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families