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O25867

- TRPC_HELPY

UniProt

O25867 - TRPC_HELPY

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Protein

Tryptophan biosynthesis protein TrpCF

Gene

trpC

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain (By similarity).By similarity

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.

Pathwayi

GO - Molecular functioni

  1. indole-3-glycerol-phosphate synthase activity Source: UniProtKB-EC
  2. phosphoribosylanthranilate isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. tryptophan biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Isomerase, Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciHPY:HP1279-MONOMER.
UniPathwayiUPA00035; UER00042.
UPA00035; UER00043.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan biosynthesis protein TrpCF
Including the following 2 domains:
Indole-3-glycerol phosphate synthase (EC:4.1.1.48)
Short name:
IGPS
N-(5'-phospho-ribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:trpC
Ordered Locus Names:HP_1279
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452Tryptophan biosynthesis protein TrpCFPRO_0000154280Add
BLAST

Proteomic databases

PRIDEiO25867.

Interactioni

Protein-protein interaction databases

IntActiO25867. 2 interactions.
MINTiMINT-181675.
STRINGi85962.HP1279.

Structurei

3D structure databases

ProteinModelPortaliO25867.
SMRiO25867. Positions 1-256.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 253253Indole-3-glycerol phosphate synthaseAdd
BLAST
Regioni254 – 448195N-(5'-phosphoribosyl)anthranilate isomeraseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the TrpC family.Curated
In the C-terminal section; belongs to the TrpF family.Curated

Phylogenomic databases

eggNOGiCOG0134.
KOiK13498.
OMAiNKQEIKR.
OrthoDBiEOG6WT8JX.

Family and domain databases

Gene3Di3.20.20.70. 2 hits.
HAMAPiMF_00134_B. IGPS_B.
MF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00218. IGPS. 1 hit.
PF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 2 hits.
PROSITEiPS00614. IGPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O25867-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPSVLENILK DKLLEVSDLK KNHALPININ PSDRDFKKAL LEKKTSFILE
60 70 80 90 100
CKKASPSKGL IRKDFDLLKI TKTYEKFASC ISVLADSKYF LGSYENIKIV
110 120 130 140 150
SQHSTKPILC KDFIIDAFQI KLARMMGANA VLLMLSVLDD KNYLELFNLA
160 170 180 190 200
KSLNMSVLTE VSNQQEIEHL LKLQYDIIGI NNRDLHTLKT DINHTLKLRP
210 220 230 240 250
LLPKDALIIS ESGIYSHAQI KALAPYVNGF LVGSSLMKEK DLKKACIKLI
260 270 280 290 300
LGENKVCGLT RIKDAKAVYK NHFIYGGLIF EKSSPRYIKP KEALKITKAV
310 320 330 340 350
KKLDFVGVFV KDSIKKIQKI VKKLDLKAVQ LYGYSQKEIA QLKKALPKTC
360 370 380 390 400
AIWQVISVMS AKDLVPKTKE ASLILYDTKG DKMGGNGVSF DWEILENVKT
410 420 430 440 450
PFMLAGGLNL DNIQKALKVE ALGLDFNSGL EISPGIKNKD KIKRLARILR

EY
Length:452
Mass (Da):50,858
Last modified:January 1, 1998 - v1
Checksum:iE5451CE56B75145E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08324.1.
PIRiG64679.
RefSeqiNP_208071.1. NC_000915.1.
YP_006935200.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08324; AAD08324; HP_1279.
GeneIDi13870487.
898793.
KEGGiheo:C694_06610.
hpy:HP1279.
PATRICi20593935. VBIHelPyl33062_1338.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08324.1 .
PIRi G64679.
RefSeqi NP_208071.1. NC_000915.1.
YP_006935200.1. NC_018939.1.

3D structure databases

ProteinModelPortali O25867.
SMRi O25867. Positions 1-256.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O25867. 2 interactions.
MINTi MINT-181675.
STRINGi 85962.HP1279.

Proteomic databases

PRIDEi O25867.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD08324 ; AAD08324 ; HP_1279 .
GeneIDi 13870487.
898793.
KEGGi heo:C694_06610.
hpy:HP1279.
PATRICi 20593935. VBIHelPyl33062_1338.

Phylogenomic databases

eggNOGi COG0134.
KOi K13498.
OMAi NKQEIKR.
OrthoDBi EOG6WT8JX.

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00042 .
UPA00035 ; UER00043 .
BioCyci HPY:HP1279-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 2 hits.
HAMAPi MF_00134_B. IGPS_B.
MF_00135. PRAI.
InterProi IPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00218. IGPS. 1 hit.
PF00697. PRAI. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 2 hits.
PROSITEi PS00614. IGPS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiTRPC_HELPY
AccessioniPrimary (citable) accession number: O25867
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: October 1, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3