O25826 (RPPH_HELPY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
RNA pyrophosphohydrolase
EC=3.6.1.-

Alternative name(s):
(Di)nucleoside polyphosphate hydrolase

Gene names

Name:	rppH
Synonyms:	nudH
Ordered Locus Names:	HP_1228

Organism

Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]

Taxonomic identifier

85962 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › Helicobacter pylori

Protein attributes

Sequence length	155 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage By similarity. HAMAP-Rule MF_00298
Cofactor	Divalent ions By similarity.
Sequence similarities	Belongs to the Nudix hydrolase family. RppH subfamily. Contains 1 nudix hydrolase domain.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 155	155	RNA pyrophosphohydrolase HAMAP-Rule MF_00298		PRO_0000057010
Regions
	Domain	5 – 147	143	Nudix hydrolase
	Motif	42 – 63	22	Nudix box HAMAP-Rule MF_00298

Sequences

	Sequence		Length	Mass (Da)
	O25826 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: B1C4E814116D8F0E	FASTA	155	18,550
	10 20 30 40 50 60 MLHKKYRPNV AAIIMSPDYP NACEVFIAER IDIEGAWQFP QGGIDEGETP LEALHRELLE 70 80 90 100 110 120 EIGTNEIEIL AQYPRWIAYD FPSNMEHKFY SFDGQKQRYF LVRLKHTNNI DLNKHTPEFR 130 140 150 AYQFIHLKDL LKRIVPFKRQ VYRQVIAYFK REGYL

References

[1]

"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000511 Genomic DNA. Translation: AAD08273.1.
PIR	D64673.
RefSeq	NP_208020.1. NC_000915.1. YP_006935146.1. NC_018939.1.
3D structure databases
ProteinModelPortal	O25826.
ModBase	Search...
Protein-protein interaction databases
STRING	85962.HP1228.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAD08273; AAD08273; HP_1228.
GeneID	13870433. 898789.
KEGG	heo:C694_06340. hpy:HP1228.
PATRIC	20593827. VBIHelPyl33062_1284.
Phylogenomic databases
eggNOG	COG0494.
KO	K08311.
OMA	PEHVQIL.
ProtClustDB	PRK00714.
Family and domain databases
Gene3D	3.90.79.10. 1 hit.
HAMAP	MF_00298. Nudix_RppH.
InterPro	IPR020476. Nudix_hydrolase. IPR020084. NUDIX_hydrolase_CS. IPR000086. NUDIX_hydrolase_dom. IPR015797. NUDIX_hydrolase_dom-like. IPR022927. RppH. [Graphical view]
Pfam	PF00293. NUDIX. 1 hit. [Graphical view]
PRINTS	PR00502. NUDIXFAMILY.
SUPFAM	SSF55811. NUDIX_hydrolase. 1 hit.
PROSITE	PS51462. NUDIX. 1 hit. PS00893. NUDIX_BOX. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RPPH_HELPY

Accession

Primary (citable) accession number: O25826

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program