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O25826

- RPPH_HELPY

UniProt

O25826 - RPPH_HELPY

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Protein
RNA pyrophosphohydrolase
Gene
rppH, nudH, HP_1228
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage By similarity.UniRule annotation

Cofactori

Divalent ions By similarity.UniRule annotation

GO - Molecular functioni

  1. hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciHPY:HP1228-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA pyrophosphohydrolase (EC:3.6.1.-)
    Alternative name(s):
    (Di)nucleoside polyphosphate hydrolase
    Gene namesi
    Name:rppH
    Synonyms:nudH
    Ordered Locus Names:HP_1228
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 155155RNA pyrophosphohydrolaseUniRule annotation
    PRO_0000057010Add
    BLAST

    Proteomic databases

    PRIDEiO25826.

    Interactioni

    Protein-protein interaction databases

    IntActiO25826. 2 interactions.
    STRINGi85962.HP1228.

    Structurei

    3D structure databases

    ProteinModelPortaliO25826.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini5 – 147143Nudix hydrolase
    Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 6322Nudix boxUniRule annotation
    Add
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0494.
    KOiK08311.
    OMAiLPGLEWQ.
    OrthoDBiEOG6Q2SKR.

    Family and domain databases

    Gene3Di3.90.79.10. 1 hit.
    HAMAPiMF_00298. Nudix_RppH.
    InterProiIPR020476. Nudix_hydrolase.
    IPR020084. NUDIX_hydrolase_CS.
    IPR000086. NUDIX_hydrolase_dom.
    IPR015797. NUDIX_hydrolase_dom-like.
    IPR022927. RppH.
    [Graphical view]
    PfamiPF00293. NUDIX. 1 hit.
    [Graphical view]
    PRINTSiPR00502. NUDIXFAMILY.
    SUPFAMiSSF55811. SSF55811. 1 hit.
    PROSITEiPS51462. NUDIX. 1 hit.
    PS00893. NUDIX_BOX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O25826-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLHKKYRPNV AAIIMSPDYP NACEVFIAER IDIEGAWQFP QGGIDEGETP    50
    LEALHRELLE EIGTNEIEIL AQYPRWIAYD FPSNMEHKFY SFDGQKQRYF 100
    LVRLKHTNNI DLNKHTPEFR AYQFIHLKDL LKRIVPFKRQ VYRQVIAYFK 150
    REGYL 155
    Length:155
    Mass (Da):18,550
    Last modified:January 1, 1998 - v1
    Checksum:iB1C4E814116D8F0E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08273.1.
    PIRiD64673.
    RefSeqiNP_208020.1. NC_000915.1.
    YP_006935146.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD08273; AAD08273; HP_1228.
    GeneIDi13870433.
    898789.
    KEGGiheo:C694_06340.
    hpy:HP1228.
    PATRICi20593827. VBIHelPyl33062_1284.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08273.1 .
    PIRi D64673.
    RefSeqi NP_208020.1. NC_000915.1.
    YP_006935146.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali O25826.
    ModBasei Search...

    Protein-protein interaction databases

    IntActi O25826. 2 interactions.
    STRINGi 85962.HP1228.

    Proteomic databases

    PRIDEi O25826.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD08273 ; AAD08273 ; HP_1228 .
    GeneIDi 13870433.
    898789.
    KEGGi heo:C694_06340.
    hpy:HP1228.
    PATRICi 20593827. VBIHelPyl33062_1284.

    Phylogenomic databases

    eggNOGi COG0494.
    KOi K08311.
    OMAi LPGLEWQ.
    OrthoDBi EOG6Q2SKR.

    Enzyme and pathway databases

    BioCyci HPY:HP1228-MONOMER.

    Family and domain databases

    Gene3Di 3.90.79.10. 1 hit.
    HAMAPi MF_00298. Nudix_RppH.
    InterProi IPR020476. Nudix_hydrolase.
    IPR020084. NUDIX_hydrolase_CS.
    IPR000086. NUDIX_hydrolase_dom.
    IPR015797. NUDIX_hydrolase_dom-like.
    IPR022927. RppH.
    [Graphical view ]
    Pfami PF00293. NUDIX. 1 hit.
    [Graphical view ]
    PRINTSi PR00502. NUDIXFAMILY.
    SUPFAMi SSF55811. SSF55811. 1 hit.
    PROSITEi PS51462. NUDIX. 1 hit.
    PS00893. NUDIX_BOX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiRPPH_HELPY
    AccessioniPrimary (citable) accession number: O25826
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: January 1, 1998
    Last modified: September 3, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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