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O25826

- RPPH_HELPY

UniProt

O25826 - RPPH_HELPY

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Protein

RNA pyrophosphohydrolase

Gene
rppH, nudH, HP_1228
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage By similarity.UniRule annotation

Cofactori

Divalent ions By similarity.UniRule annotation

GO - Molecular functioni

  1. hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciHPY:HP1228-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA pyrophosphohydrolase (EC:3.6.1.-)
Alternative name(s):
(Di)nucleoside polyphosphate hydrolase
Gene namesi
Name:rppH
Synonyms:nudH
Ordered Locus Names:HP_1228
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 155155RNA pyrophosphohydrolaseUniRule annotationPRO_0000057010Add
BLAST

Proteomic databases

PRIDEiO25826.

Interactioni

Protein-protein interaction databases

IntActiO25826. 2 interactions.
STRINGi85962.HP1228.

Structurei

3D structure databases

ProteinModelPortaliO25826.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 147143Nudix hydrolaseAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 6322Nudix boxUniRule annotationAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0494.
KOiK08311.
OMAiLPGLEWQ.
OrthoDBiEOG6Q2SKR.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
HAMAPiMF_00298. Nudix_RppH.
InterProiIPR020476. Nudix_hydrolase.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR022927. RppH.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
PRINTSiPR00502. NUDIXFAMILY.
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O25826-1 [UniParc]FASTAAdd to Basket

« Hide

MLHKKYRPNV AAIIMSPDYP NACEVFIAER IDIEGAWQFP QGGIDEGETP    50
LEALHRELLE EIGTNEIEIL AQYPRWIAYD FPSNMEHKFY SFDGQKQRYF 100
LVRLKHTNNI DLNKHTPEFR AYQFIHLKDL LKRIVPFKRQ VYRQVIAYFK 150
REGYL 155
Length:155
Mass (Da):18,550
Last modified:January 1, 1998 - v1
Checksum:iB1C4E814116D8F0E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08273.1.
PIRiD64673.
RefSeqiNP_208020.1. NC_000915.1.
YP_006935146.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08273; AAD08273; HP_1228.
GeneIDi13870433.
898789.
KEGGiheo:C694_06340.
hpy:HP1228.
PATRICi20593827. VBIHelPyl33062_1284.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08273.1 .
PIRi D64673.
RefSeqi NP_208020.1. NC_000915.1.
YP_006935146.1. NC_018939.1.

3D structure databases

ProteinModelPortali O25826.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O25826. 2 interactions.
STRINGi 85962.HP1228.

Proteomic databases

PRIDEi O25826.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD08273 ; AAD08273 ; HP_1228 .
GeneIDi 13870433.
898789.
KEGGi heo:C694_06340.
hpy:HP1228.
PATRICi 20593827. VBIHelPyl33062_1284.

Phylogenomic databases

eggNOGi COG0494.
KOi K08311.
OMAi LPGLEWQ.
OrthoDBi EOG6Q2SKR.

Enzyme and pathway databases

BioCyci HPY:HP1228-MONOMER.

Family and domain databases

Gene3Di 3.90.79.10. 1 hit.
HAMAPi MF_00298. Nudix_RppH.
InterProi IPR020476. Nudix_hydrolase.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR022927. RppH.
[Graphical view ]
Pfami PF00293. NUDIX. 1 hit.
[Graphical view ]
PRINTSi PR00502. NUDIXFAMILY.
SUPFAMi SSF55811. SSF55811. 1 hit.
PROSITEi PS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiRPPH_HELPY
AccessioniPrimary (citable) accession number: O25826
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi