Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O25826 (RPPH_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RNA pyrophosphohydrolase

EC=3.6.1.-
Alternative name(s):
(Di)nucleoside polyphosphate hydrolase
Gene names
Name:rppH
Synonyms:nudH
Ordered Locus Names:HP_1228
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length155 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage By similarity. HAMAP-Rule MF_00298

Cofactor

Divalent ions By similarity. HAMAP-Rule MF_00298

Sequence similarities

Belongs to the Nudix hydrolase family. RppH subfamily.

Contains 1 nudix hydrolase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 155155RNA pyrophosphohydrolase HAMAP-Rule MF_00298
PRO_0000057010

Regions

Domain5 – 147143Nudix hydrolase
Motif42 – 6322Nudix box HAMAP-Rule MF_00298

Sequences

Sequence LengthMass (Da)Tools
O25826 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: B1C4E814116D8F0E

FASTA15518,550
        10         20         30         40         50         60 
MLHKKYRPNV AAIIMSPDYP NACEVFIAER IDIEGAWQFP QGGIDEGETP LEALHRELLE 

        70         80         90        100        110        120 
EIGTNEIEIL AQYPRWIAYD FPSNMEHKFY SFDGQKQRYF LVRLKHTNNI DLNKHTPEFR 

       130        140        150 
AYQFIHLKDL LKRIVPFKRQ VYRQVIAYFK REGYL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD08273.1.
PIRD64673.
RefSeqNP_208020.1. NC_000915.1.
YP_006935146.1. NC_018939.1.

3D structure databases

ProteinModelPortalO25826.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING85962.HP1228.

Proteomic databases

PRIDEO25826.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD08273; AAD08273; HP_1228.
GeneID13870433.
898789.
KEGGheo:C694_06340.
hpy:HP1228.
PATRIC20593827. VBIHelPyl33062_1284.

Phylogenomic databases

eggNOGCOG0494.
KOK08311.
OMANSEYDGS.
OrthoDBEOG6Q2SKR.
ProtClustDBPRK00714.

Enzyme and pathway databases

BioCycHPY:HP1228-MONOMER.

Family and domain databases

Gene3D3.90.79.10. 1 hit.
HAMAPMF_00298. Nudix_RppH.
InterProIPR020476. Nudix_hydrolase.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR022927. RppH.
[Graphical view]
PfamPF00293. NUDIX. 1 hit.
[Graphical view]
PRINTSPR00502. NUDIXFAMILY.
SUPFAMSSF55811. SSF55811. 1 hit.
PROSITEPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRPPH_HELPY
AccessionPrimary (citable) accession number: O25826
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 1, 1998
Last modified: April 16, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names