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Protein

RNA pyrophosphohydrolase

Gene

rppH

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

GO - Molecular functioni

  1. hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciHPY:HP1228-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA pyrophosphohydrolaseUniRule annotation (EC:3.6.1.-UniRule annotation)
Alternative name(s):
(Di)nucleoside polyphosphate hydrolaseUniRule annotation
Gene namesi
Name:rppHUniRule annotation
Synonyms:nudHUniRule annotation
Ordered Locus Names:HP_1228
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 155155RNA pyrophosphohydrolasePRO_0000057010Add
BLAST

Proteomic databases

PRIDEiO25826.

Interactioni

Protein-protein interaction databases

IntActiO25826. 2 interactions.
STRINGi85962.HP1228.

Structurei

3D structure databases

ProteinModelPortaliO25826.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 147143Nudix hydrolaseUniRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 6322Nudix boxAdd
BLAST

Sequence similaritiesi

Belongs to the Nudix hydrolase family. RppH subfamily.UniRule annotation
Contains 1 nudix hydrolase domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0494.
KOiK08311.
OMAiRPCVGIM.
OrthoDBiEOG6Q2SKR.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
HAMAPiMF_00298. Nudix_RppH.
InterProiIPR020476. Nudix_hydrolase.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR022927. RppH.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
PRINTSiPR00502. NUDIXFAMILY.
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O25826-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHKKYRPNV AAIIMSPDYP NACEVFIAER IDIEGAWQFP QGGIDEGETP
60 70 80 90 100
LEALHRELLE EIGTNEIEIL AQYPRWIAYD FPSNMEHKFY SFDGQKQRYF
110 120 130 140 150
LVRLKHTNNI DLNKHTPEFR AYQFIHLKDL LKRIVPFKRQ VYRQVIAYFK

REGYL
Length:155
Mass (Da):18,550
Last modified:January 1, 1998 - v1
Checksum:iB1C4E814116D8F0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08273.1.
PIRiD64673.
RefSeqiNP_208020.1. NC_000915.1.
YP_006935146.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08273; AAD08273; HP_1228.
GeneIDi13870433.
898789.
KEGGiheo:C694_06340.
hpy:HP1228.
PATRICi20593827. VBIHelPyl33062_1284.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08273.1.
PIRiD64673.
RefSeqiNP_208020.1. NC_000915.1.
YP_006935146.1. NC_018939.1.

3D structure databases

ProteinModelPortaliO25826.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO25826. 2 interactions.
STRINGi85962.HP1228.

Proteomic databases

PRIDEiO25826.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08273; AAD08273; HP_1228.
GeneIDi13870433.
898789.
KEGGiheo:C694_06340.
hpy:HP1228.
PATRICi20593827. VBIHelPyl33062_1284.

Phylogenomic databases

eggNOGiCOG0494.
KOiK08311.
OMAiRPCVGIM.
OrthoDBiEOG6Q2SKR.

Enzyme and pathway databases

BioCyciHPY:HP1228-MONOMER.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
HAMAPiMF_00298. Nudix_RppH.
InterProiIPR020476. Nudix_hydrolase.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR022927. RppH.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
PRINTSiPR00502. NUDIXFAMILY.
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiRPPH_HELPY
AccessioniPrimary (citable) accession number: O25826
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 1, 1998
Last modified: January 7, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.