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Protein

RNA pyrophosphohydrolase

Gene

rppH

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciHPY:HP1228-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA pyrophosphohydrolaseUniRule annotation (EC:3.6.1.-UniRule annotation)
Alternative name(s):
(Di)nucleoside polyphosphate hydrolaseUniRule annotation
Gene namesi
Name:rppHUniRule annotation
Synonyms:nudHUniRule annotation
Ordered Locus Names:HP_1228
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000570101 – 155RNA pyrophosphohydrolaseAdd BLAST155

Proteomic databases

PaxDbiO25826.

Interactioni

Protein-protein interaction databases

IntActiO25826. 2 interactors.
STRINGi85962.HP1228.

Structurei

3D structure databases

ProteinModelPortaliO25826.
SMRiO25826.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 147Nudix hydrolaseUniRule annotationAdd BLAST143

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 63Nudix boxAdd BLAST22

Sequence similaritiesi

Belongs to the Nudix hydrolase family. RppH subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EJF. Bacteria.
COG0494. LUCA.
KOiK08311.
OMAiRPCVGIM.

Family and domain databases

CDDicd03671. Ap4A_hydrolase_plant_like. 1 hit.
HAMAPiMF_00298. Nudix_RppH. 1 hit.
InterProiView protein in InterPro
IPR020476. Nudix_hydrolase.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR022927. RppH.
PfamiView protein in Pfam
PF00293. NUDIX. 1 hit.
PRINTSiPR00502. NUDIXFAMILY.
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiView protein in PROSITE
PS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.

Sequencei

Sequence statusi: Complete.

O25826-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHKKYRPNV AAIIMSPDYP NACEVFIAER IDIEGAWQFP QGGIDEGETP
60 70 80 90 100
LEALHRELLE EIGTNEIEIL AQYPRWIAYD FPSNMEHKFY SFDGQKQRYF
110 120 130 140 150
LVRLKHTNNI DLNKHTPEFR AYQFIHLKDL LKRIVPFKRQ VYRQVIAYFK

REGYL
Length:155
Mass (Da):18,550
Last modified:January 1, 1998 - v1
Checksum:iB1C4E814116D8F0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08273.1.
PIRiD64673.
RefSeqiNP_208020.1. NC_000915.1.
WP_000902563.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08273; AAD08273; HP_1228.
GeneIDi898789.
KEGGiheo:C694_06340.
hpy:HP1228.
PATRICifig|85962.47.peg.1316.

Similar proteinsi

Entry informationi

Entry nameiRPPH_HELPY
AccessioniPrimary (citable) accession number: O25826
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 1, 1998
Last modified: August 30, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families