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O25817

- PUR2_HELPY

UniProt

O25817 - PUR2_HELPY

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Protein

Phosphoribosylamine--glycine ligase

Gene

purD

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi137 – 18953ATPPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: InterPro
  3. phosphoribosylamine-glycine ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
  2. purine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPY:HP1218-MONOMER.
UniPathwayiUPA00074; UER00125.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylamine--glycine ligase (EC:6.3.4.13)
Alternative name(s):
GARS
Glycinamide ribonucleotide synthetase
Phosphoribosylglycinamide synthetase
Gene namesi
Name:purD
Ordered Locus Names:HP_1218
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 424424Phosphoribosylamine--glycine ligasePRO_0000151453Add
BLAST

Proteomic databases

PRIDEiO25817.

Interactioni

Protein-protein interaction databases

DIPiDIP-3667N.
IntActiO25817. 3 interactions.
MINTiMINT-179697.
STRINGi85962.HP1218.

Structurei

3D structure databases

ProteinModelPortaliO25817.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini111 – 312202ATP-graspPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the GARS family.Curated
Contains 1 ATP-grasp domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0151.
KOiK01945.
OMAiFKQSNES.
OrthoDBiEOG69SKD1.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.600.10. 1 hit.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR020562. PRibGlycinamide_synth_N.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamiPF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
[Graphical view]
SUPFAMiSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR00877. purD. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O25817-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MKDNNNYNVL IVGNKGREYA LAQRLQQDER VNALYFCLGN GGTQDLGENL
60 70 80 90 100
ECEHYEHIVE LALKKQIHLA IISEEEFLVL GLTEMLEKAG ILVFGASKEA
110 120 130 140 150
AKLEASKSYM KAFVKECGIK SASYFETNDL KEALSYIQNA SFPLVIKALN
160 170 180 190 200
KNTSIVYQEE EAIKILEDAF KQSNEPVIIE PFLEGFELSV TALIANDDFI
210 220 230 240 250
LLPFCQNYKR LLEGDNGVNT GGMGAIAPAN FFSNELEEKI KNHIFKPTLE
260 270 280 290 300
KLQADNTPFK GVLLAEIVII EEKGVLEPYL LDFSVRFKDI ECQTILPLLE
310 320 330 340 350
SSLLDLCLAT AKGELHSLEL VFSKEFVMSV ALVSRNYPTS SSPKQTLYID
360 370 380 390 400
PVDEKKGHLI LGEVEQDNGV FESSGGRVIF AIGRGKSLLE ARNHAYEIAQ
410 420
KVHFEGMFYR KDIGFKVLDL KEYS
Length:424
Mass (Da):47,504
Last modified:January 1, 1998 - v1
Checksum:iF093B63E7DCCCCC2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08261.1.
PIRiB64672.
RefSeqiNP_208010.1. NC_000915.1.
YP_006935137.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08261; AAD08261; HP_1218.
GeneIDi13870424.
898842.
KEGGiheo:C694_06295.
hpy:HP1218.
PATRICi20593809. VBIHelPyl33062_1275.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08261.1 .
PIRi B64672.
RefSeqi NP_208010.1. NC_000915.1.
YP_006935137.1. NC_018939.1.

3D structure databases

ProteinModelPortali O25817.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-3667N.
IntActi O25817. 3 interactions.
MINTi MINT-179697.
STRINGi 85962.HP1218.

Proteomic databases

PRIDEi O25817.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD08261 ; AAD08261 ; HP_1218 .
GeneIDi 13870424.
898842.
KEGGi heo:C694_06295.
hpy:HP1218.
PATRICi 20593809. VBIHelPyl33062_1275.

Phylogenomic databases

eggNOGi COG0151.
KOi K01945.
OMAi FKQSNES.
OrthoDBi EOG69SKD1.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00125 .
BioCyci HPY:HP1218-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.600.10. 1 hit.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR020562. PRibGlycinamide_synth_N.
IPR011054. Rudment_hybrid_motif.
[Graphical view ]
Pfami PF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
[Graphical view ]
SUPFAMi SSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR00877. purD. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiPUR2_HELPY
AccessioniPrimary (citable) accession number: O25817
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: October 1, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3