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O25817

- PUR2_HELPY

UniProt

O25817 - PUR2_HELPY

Protein

Phosphoribosylamine--glycine ligase

Gene

purD

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide.

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi137 – 18953ATPPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: InterPro
    3. phosphoribosylamine-glycine ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
    2. purine nucleobase biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHPY:HP1218-MONOMER.
    UniPathwayiUPA00074; UER00125.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylamine--glycine ligase (EC:6.3.4.13)
    Alternative name(s):
    GARS
    Glycinamide ribonucleotide synthetase
    Phosphoribosylglycinamide synthetase
    Gene namesi
    Name:purD
    Ordered Locus Names:HP_1218
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 424424Phosphoribosylamine--glycine ligasePRO_0000151453Add
    BLAST

    Proteomic databases

    PRIDEiO25817.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-3667N.
    IntActiO25817. 3 interactions.
    MINTiMINT-179697.
    STRINGi85962.HP1218.

    Structurei

    3D structure databases

    ProteinModelPortaliO25817.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini111 – 312202ATP-graspPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the GARS family.Curated
    Contains 1 ATP-grasp domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0151.
    KOiK01945.
    OMAiFKQSNES.
    OrthoDBiEOG69SKD1.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    3.90.600.10. 1 hit.
    InterProiIPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR016185. PreATP-grasp_dom.
    IPR020561. PRibGlycinamid_synth_ATP-grasp.
    IPR000115. PRibGlycinamide_synth.
    IPR020560. PRibGlycinamide_synth_C-dom.
    IPR020562. PRibGlycinamide_synth_N.
    IPR011054. Rudment_hybrid_motif.
    [Graphical view]
    PfamiPF01071. GARS_A. 1 hit.
    PF02843. GARS_C. 1 hit.
    PF02844. GARS_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF51246. SSF51246. 1 hit.
    SSF52440. SSF52440. 1 hit.
    TIGRFAMsiTIGR00877. purD. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O25817-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKDNNNYNVL IVGNKGREYA LAQRLQQDER VNALYFCLGN GGTQDLGENL    50
    ECEHYEHIVE LALKKQIHLA IISEEEFLVL GLTEMLEKAG ILVFGASKEA 100
    AKLEASKSYM KAFVKECGIK SASYFETNDL KEALSYIQNA SFPLVIKALN 150
    KNTSIVYQEE EAIKILEDAF KQSNEPVIIE PFLEGFELSV TALIANDDFI 200
    LLPFCQNYKR LLEGDNGVNT GGMGAIAPAN FFSNELEEKI KNHIFKPTLE 250
    KLQADNTPFK GVLLAEIVII EEKGVLEPYL LDFSVRFKDI ECQTILPLLE 300
    SSLLDLCLAT AKGELHSLEL VFSKEFVMSV ALVSRNYPTS SSPKQTLYID 350
    PVDEKKGHLI LGEVEQDNGV FESSGGRVIF AIGRGKSLLE ARNHAYEIAQ 400
    KVHFEGMFYR KDIGFKVLDL KEYS 424
    Length:424
    Mass (Da):47,504
    Last modified:January 1, 1998 - v1
    Checksum:iF093B63E7DCCCCC2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08261.1.
    PIRiB64672.
    RefSeqiNP_208010.1. NC_000915.1.
    YP_006935137.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD08261; AAD08261; HP_1218.
    GeneIDi13870424.
    898842.
    KEGGiheo:C694_06295.
    hpy:HP1218.
    PATRICi20593809. VBIHelPyl33062_1275.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08261.1 .
    PIRi B64672.
    RefSeqi NP_208010.1. NC_000915.1.
    YP_006935137.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali O25817.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-3667N.
    IntActi O25817. 3 interactions.
    MINTi MINT-179697.
    STRINGi 85962.HP1218.

    Proteomic databases

    PRIDEi O25817.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD08261 ; AAD08261 ; HP_1218 .
    GeneIDi 13870424.
    898842.
    KEGGi heo:C694_06295.
    hpy:HP1218.
    PATRICi 20593809. VBIHelPyl33062_1275.

    Phylogenomic databases

    eggNOGi COG0151.
    KOi K01945.
    OMAi FKQSNES.
    OrthoDBi EOG69SKD1.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00125 .
    BioCyci HPY:HP1218-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    3.90.600.10. 1 hit.
    InterProi IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR016185. PreATP-grasp_dom.
    IPR020561. PRibGlycinamid_synth_ATP-grasp.
    IPR000115. PRibGlycinamide_synth.
    IPR020560. PRibGlycinamide_synth_C-dom.
    IPR020562. PRibGlycinamide_synth_N.
    IPR011054. Rudment_hybrid_motif.
    [Graphical view ]
    Pfami PF01071. GARS_A. 1 hit.
    PF02843. GARS_C. 1 hit.
    PF02844. GARS_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51246. SSF51246. 1 hit.
    SSF52440. SSF52440. 1 hit.
    TIGRFAMsi TIGR00877. purD. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiPUR2_HELPY
    AccessioniPrimary (citable) accession number: O25817
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3