Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O25812

- PNP_HELPY

UniProt

O25812 - PNP_HELPY

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi484 – 4841MagnesiumUniRule annotation
    Metal bindingi490 – 4901MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
    4. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA catabolic process Source: UniProtKB-HAMAP
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciHPY:HP1213-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:HP_1213
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 688688Polyribonucleotide nucleotidyltransferasePRO_0000329678Add
    BLAST

    Proteomic databases

    PRIDEiO25812.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-3551N.
    IntActiO25812. 3 interactions.
    MINTiMINT-181907.
    STRINGi85962.HP1213.

    Structurei

    3D structure databases

    ProteinModelPortaliO25812.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini550 – 60960KHUniRule annotationAdd
    BLAST
    Domaini626 – 68863S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    KOiK00962.
    OMAiEYIINPD.
    OrthoDBiEOG6WT8CC.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF00013. KH_1. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005499. PNPase. 1 hit.
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O25812-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDFITINSSN KTEEFALKQV AKQATSSLLY RLGKTIILAS VCVEREPVSE    50
    DFLPLVVQFL EKSYAAGKIP GGFVKREGRA QDFEILTSRL IDRTLRPLFP 100
    KDYRYPTQIT LMVLSHDIEN DLQVSALNAA SAALFLAHIA PIKSVSACRI 150
    ARMDNEFIIN PSASLLNQSS LDLFVSGTKE SLNMIEMRSL GQKLNALEEP 200
    LMLEALELAQ KSLEETCTLY EEIFTPHQNE LFFKESQGIV FNERLLDLLK 250
    NQYFDEIIKG IESSALSERE NVFNEIARKI SEAHSEFSLE EIELSLEKVK 300
    KTEIRRMIIK DKIRPDKRAL EEVRPILIES DLLPMAHSSI LFTRGQTQSL 350
    VVGVLGTDND AQTHESLEHK APIKERFMFH YNFPPFCVGE ASSIGAASRR 400
    ELGHGNLAKR ALETSIKNKE QVIRLVSEIL ESNGSSSMAS VCAGSLALYA 450
    SGVEIYDLVA GVAMGMVSEG QDHAILSDIS GLEDAEGDMD FKIAGNLEGI 500
    TAMQMDTKMS GIKLEILYQA LLQAKEARKH ILKIMHEAKE KIVINFSHLP 550
    TTEIFNVAPD KIVEIIGQGG RVIKEIVEKF EVKIDLNKPS GEVKIMGNKE 600
    RVLKTKEFIL NYLHSLDQEL EQYAIDEVLE AQVKRIVDFG AFLSLPKGGE 650
    GLLRKQNMDK CQVVLKEGDS IRCRVISFNK GKIALDLA 688
    Length:688
    Mass (Da):76,895
    Last modified:January 1, 1998 - v1
    Checksum:iBECF5C91ECC1E489
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08258.1.
    PIRiE64671.
    RefSeqiNP_208005.1. NC_000915.1.
    YP_006935133.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD08258; AAD08258; HP_1213.
    GeneIDi13870420.
    899970.
    KEGGiheo:C694_06275.
    hpy:HP1213.
    PATRICi20593799. VBIHelPyl33062_1270.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08258.1 .
    PIRi E64671.
    RefSeqi NP_208005.1. NC_000915.1.
    YP_006935133.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali O25812.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-3551N.
    IntActi O25812. 3 interactions.
    MINTi MINT-181907.
    STRINGi 85962.HP1213.

    Proteomic databases

    PRIDEi O25812.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD08258 ; AAD08258 ; HP_1213 .
    GeneIDi 13870420.
    899970.
    KEGGi heo:C694_06275.
    hpy:HP1213.
    PATRICi 20593799. VBIHelPyl33062_1270.

    Phylogenomic databases

    eggNOGi COG1185.
    KOi K00962.
    OMAi EYIINPD.
    OrthoDBi EOG6WT8CC.

    Enzyme and pathway databases

    BioCyci HPY:HP1213-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF00013. KH_1. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005499. PNPase. 1 hit.
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiPNP_HELPY
    AccessioniPrimary (citable) accession number: O25812
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3