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O25801

- DHAS_HELPY

UniProt

O25801 - DHAS_HELPY

Protein

Aspartate-semialdehyde dehydrogenase

Gene

asd

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.UniRule annotation

    Catalytic activityi

    L-aspartate 4-semialdehyde + phosphate + NADP+ = L-4-aspartyl phosphate + NADPH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei101 – 1011PhosphateUniRule annotation
    Active sitei131 – 1311Acyl-thioester intermediateUniRule annotation
    Binding sitei158 – 1581SubstrateUniRule annotation
    Binding sitei225 – 2251PhosphateUniRule annotation
    Binding sitei246 – 2461SubstrateUniRule annotation
    Active sitei253 – 2531Proton acceptorUniRule annotation
    Binding sitei326 – 3261NADPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 154NADPUniRule annotation
    Nucleotide bindingi40 – 412NADPUniRule annotation
    Nucleotide bindingi161 – 1622NADPUniRule annotation

    GO - Molecular functioni

    1. aspartate-semialdehyde dehydrogenase activity Source: UniProtKB-HAMAP
    2. N-acetyl-gamma-glutamyl-phosphate reductase activity Source: InterPro
    3. NAD binding Source: InterPro
    4. NADP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' L-methionine biosynthetic process Source: UniProtKB-HAMAP
    2. diaminopimelate biosynthetic process Source: UniProtKB-HAMAP
    3. isoleucine biosynthetic process Source: InterPro
    4. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
    5. threonine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Diaminopimelate biosynthesis, Lysine biosynthesis, Methionine biosynthesis, Threonine biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciHPY:HP1189-MONOMER.
    UniPathwayiUPA00034; UER00016.
    UPA00050; UER00463.
    UPA00051; UER00464.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aspartate-semialdehyde dehydrogenaseUniRule annotation (EC:1.2.1.11UniRule annotation)
    Short name:
    ASA dehydrogenaseUniRule annotation
    Short name:
    ASADHUniRule annotation
    Alternative name(s):
    Aspartate-beta-semialdehyde dehydrogenaseUniRule annotation
    Gene namesi
    Name:asdUniRule annotation
    Ordered Locus Names:HP_1189
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 346346Aspartate-semialdehyde dehydrogenasePRO_0000141376Add
    BLAST

    Proteomic databases

    PRIDEiO25801.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    DIPiDIP-3753N.
    IntActiO25801. 1 interaction.
    MINTiMINT-169344.
    STRINGi85962.HP1189.

    Structurei

    3D structure databases

    ProteinModelPortaliO25801.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aspartate-semialdehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0136.
    KOiK00133.
    OMAiNKIMHSN.
    OrthoDBiEOG6JB158.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_02121. ASADH.
    InterProiIPR000319. Asp-semialdehyde_DH_CS.
    IPR012080. Asp_semialdehyde_DH.
    IPR005986. Asp_semialdehyde_DH_beta.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    IPR012280. Semialdhyde_DH_dimer_dom.
    [Graphical view]
    PfamiPF01118. Semialdhyde_dh. 1 hit.
    PF02774. Semialdhyde_dhC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000148. ASA_dh. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01296. asd_B. 1 hit.
    PROSITEiPS01103. ASD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O25801-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTYNVAIVG ASGAVGQELI KGLENSFFPI KKFVPLASTR SAGKKIKAFN    50
    KDYEILETTH EVFEREKIDI AFFSAGGSVS EEFATSASKT ALVVDNTSFF 100
    RLNKDVPLVV PEINAKEIFN APLNIIANPN CSTIQMTQIL NPLHLHFKIK 150
    SVIVSTYQAV SGAGNKGIES LKNELKTALE CLEKDPTIDL NQVLQAGAFA 200
    YPIAFNAIAH IDTFKENGYT KEELKMLHET HKIMGVDFPI SATCVRVPVL 250
    RSHSESLSIA FEKEFDLKEV YEVLKNAPSV AVCDDPSHNL YPTPLKASHT 300
    DSVFIGRLRK DLFDKKTLHG FCVADQLRVG AATNALKIAL HYIKNA 346
    Length:346
    Mass (Da):38,116
    Last modified:January 1, 1998 - v1
    Checksum:iEAF10B9108A72330
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08235.1.
    PIRiE64668.
    RefSeqiNP_207980.1. NC_000915.1.
    YP_006935109.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD08235; AAD08235; HP_1189.
    GeneIDi13870389.
    899951.
    KEGGiheo:C694_06155.
    hpy:HP1189.
    PATRICi20593737. VBIHelPyl33062_1246.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08235.1 .
    PIRi E64668.
    RefSeqi NP_207980.1. NC_000915.1.
    YP_006935109.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali O25801.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-3753N.
    IntActi O25801. 1 interaction.
    MINTi MINT-169344.
    STRINGi 85962.HP1189.

    Chemistry

    BindingDBi O25801.
    ChEMBLi CHEMBL5687.

    Proteomic databases

    PRIDEi O25801.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD08235 ; AAD08235 ; HP_1189 .
    GeneIDi 13870389.
    899951.
    KEGGi heo:C694_06155.
    hpy:HP1189.
    PATRICi 20593737. VBIHelPyl33062_1246.

    Phylogenomic databases

    eggNOGi COG0136.
    KOi K00133.
    OMAi NKIMHSN.
    OrthoDBi EOG6JB158.

    Enzyme and pathway databases

    UniPathwayi UPA00034 ; UER00016 .
    UPA00050 ; UER00463 .
    UPA00051 ; UER00464 .
    BioCyci HPY:HP1189-MONOMER.

    Miscellaneous databases

    PROi O25801.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_02121. ASADH.
    InterProi IPR000319. Asp-semialdehyde_DH_CS.
    IPR012080. Asp_semialdehyde_DH.
    IPR005986. Asp_semialdehyde_DH_beta.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    IPR012280. Semialdhyde_DH_dimer_dom.
    [Graphical view ]
    Pfami PF01118. Semialdhyde_dh. 1 hit.
    PF02774. Semialdhyde_dhC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000148. ASA_dh. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01296. asd_B. 1 hit.
    PROSITEi PS01103. ASD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiDHAS_HELPY
    AccessioniPrimary (citable) accession number: O25801
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3