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O25801

- DHAS_HELPY

UniProt

O25801 - DHAS_HELPY

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Protein

Aspartate-semialdehyde dehydrogenase

Gene

asd

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.UniRule annotation

Catalytic activityi

L-aspartate 4-semialdehyde + phosphate + NADP+ = L-4-aspartyl phosphate + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei101 – 1011PhosphateUniRule annotation
Active sitei131 – 1311Acyl-thioester intermediateUniRule annotation
Binding sitei158 – 1581SubstrateUniRule annotation
Binding sitei225 – 2251PhosphateUniRule annotation
Binding sitei246 – 2461SubstrateUniRule annotation
Active sitei253 – 2531Proton acceptorUniRule annotation
Binding sitei326 – 3261NADPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 154NADPUniRule annotation
Nucleotide bindingi40 – 412NADPUniRule annotation
Nucleotide bindingi161 – 1622NADPUniRule annotation

GO - Molecular functioni

  1. aspartate-semialdehyde dehydrogenase activity Source: UniProtKB-HAMAP
  2. N-acetyl-gamma-glutamyl-phosphate reductase activity Source: InterPro
  3. NAD binding Source: InterPro
  4. NADP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' L-methionine biosynthetic process Source: UniProtKB-HAMAP
  2. diaminopimelate biosynthetic process Source: UniProtKB-HAMAP
  3. isoleucine biosynthetic process Source: InterPro
  4. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
  5. threonine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Diaminopimelate biosynthesis, Lysine biosynthesis, Methionine biosynthesis, Threonine biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciHPY:HP1189-MONOMER.
UniPathwayiUPA00034; UER00016.
UPA00050; UER00463.
UPA00051; UER00464.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate-semialdehyde dehydrogenaseUniRule annotation (EC:1.2.1.11UniRule annotation)
Short name:
ASA dehydrogenaseUniRule annotation
Short name:
ASADHUniRule annotation
Alternative name(s):
Aspartate-beta-semialdehyde dehydrogenaseUniRule annotation
Gene namesi
Name:asdUniRule annotation
Ordered Locus Names:HP_1189
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Aspartate-semialdehyde dehydrogenasePRO_0000141376Add
BLAST

Proteomic databases

PRIDEiO25801.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

DIPiDIP-3753N.
IntActiO25801. 1 interaction.
MINTiMINT-169344.
STRINGi85962.HP1189.

Structurei

3D structure databases

ProteinModelPortaliO25801.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aspartate-semialdehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0136.
KOiK00133.
OMAiNKIMHSN.
OrthoDBiEOG6JB158.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_02121. ASADH.
InterProiIPR000319. Asp-semialdehyde_DH_CS.
IPR012080. Asp_semialdehyde_DH.
IPR005986. Asp_semialdehyde_DH_beta.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
IPR012280. Semialdhyde_DH_dimer_dom.
[Graphical view]
PfamiPF01118. Semialdhyde_dh. 1 hit.
PF02774. Semialdhyde_dhC. 1 hit.
[Graphical view]
PIRSFiPIRSF000148. ASA_dh. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01296. asd_B. 1 hit.
PROSITEiPS01103. ASD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O25801-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTYNVAIVG ASGAVGQELI KGLENSFFPI KKFVPLASTR SAGKKIKAFN
60 70 80 90 100
KDYEILETTH EVFEREKIDI AFFSAGGSVS EEFATSASKT ALVVDNTSFF
110 120 130 140 150
RLNKDVPLVV PEINAKEIFN APLNIIANPN CSTIQMTQIL NPLHLHFKIK
160 170 180 190 200
SVIVSTYQAV SGAGNKGIES LKNELKTALE CLEKDPTIDL NQVLQAGAFA
210 220 230 240 250
YPIAFNAIAH IDTFKENGYT KEELKMLHET HKIMGVDFPI SATCVRVPVL
260 270 280 290 300
RSHSESLSIA FEKEFDLKEV YEVLKNAPSV AVCDDPSHNL YPTPLKASHT
310 320 330 340
DSVFIGRLRK DLFDKKTLHG FCVADQLRVG AATNALKIAL HYIKNA
Length:346
Mass (Da):38,116
Last modified:January 1, 1998 - v1
Checksum:iEAF10B9108A72330
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08235.1.
PIRiE64668.
RefSeqiNP_207980.1. NC_000915.1.
YP_006935109.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08235; AAD08235; HP_1189.
GeneIDi13870389.
899951.
KEGGiheo:C694_06155.
hpy:HP1189.
PATRICi20593737. VBIHelPyl33062_1246.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08235.1 .
PIRi E64668.
RefSeqi NP_207980.1. NC_000915.1.
YP_006935109.1. NC_018939.1.

3D structure databases

ProteinModelPortali O25801.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-3753N.
IntActi O25801. 1 interaction.
MINTi MINT-169344.
STRINGi 85962.HP1189.

Chemistry

BindingDBi O25801.
ChEMBLi CHEMBL5687.

Proteomic databases

PRIDEi O25801.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD08235 ; AAD08235 ; HP_1189 .
GeneIDi 13870389.
899951.
KEGGi heo:C694_06155.
hpy:HP1189.
PATRICi 20593737. VBIHelPyl33062_1246.

Phylogenomic databases

eggNOGi COG0136.
KOi K00133.
OMAi NKIMHSN.
OrthoDBi EOG6JB158.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00016 .
UPA00050 ; UER00463 .
UPA00051 ; UER00464 .
BioCyci HPY:HP1189-MONOMER.

Miscellaneous databases

PROi O25801.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_02121. ASADH.
InterProi IPR000319. Asp-semialdehyde_DH_CS.
IPR012080. Asp_semialdehyde_DH.
IPR005986. Asp_semialdehyde_DH_beta.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
IPR012280. Semialdhyde_DH_dimer_dom.
[Graphical view ]
Pfami PF01118. Semialdhyde_dh. 1 hit.
PF02774. Semialdhyde_dhC. 1 hit.
[Graphical view ]
PIRSFi PIRSF000148. ASA_dh. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01296. asd_B. 1 hit.
PROSITEi PS01103. ASD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiDHAS_HELPY
AccessioniPrimary (citable) accession number: O25801
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: October 1, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3