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O25801 (DHAS_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Aspartate-semialdehyde dehydrogenase
Short name=ASA dehydrogenase
Short name=ASADH
EC=1.2.1.11
Alternative name(s):
Aspartate-beta-semialdehyde dehydrogenase
Gene names
Name:asd
Ordered Locus Names:HP_1189
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter ›

Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate By similarity. HAMAP-Rule MF_02121

Catalytic activity

L-aspartate 4-semialdehyde + phosphate + NADP+ = L-4-aspartyl phosphate + NADPH. HAMAP-Rule MF_02121

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4. HAMAP-Rule MF_02121

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3. HAMAP-Rule MF_02121

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5. HAMAP-Rule MF_02121

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the aspartate-semialdehyde dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 346346Aspartate-semialdehyde dehydrogenase HAMAP-Rule MF_02121
PRO_0000141376

Regions

Nucleotide binding12 – 154NADP By similarity
Nucleotide binding40 – 412NADP By similarity
Nucleotide binding161 – 1622NADP By similarity

Sites

Active site1311Acyl-thioester intermediate By similarity
Active site2531Proton acceptor By similarity
Binding site1011Phosphate By similarity
Binding site1581Substrate By similarity
Binding site2251Phosphate By similarity
Binding site2461Substrate By similarity
Binding site3261NADP By similarity

Sequences

Sequence LengthMass (Da)Tools
O25801 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: EAF10B9108A72330

FASTA34638,116
        10         20         30         40         50         60 
MKTYNVAIVG ASGAVGQELI KGLENSFFPI KKFVPLASTR SAGKKIKAFN KDYEILETTH 

        70         80         90        100        110        120 
EVFEREKIDI AFFSAGGSVS EEFATSASKT ALVVDNTSFF RLNKDVPLVV PEINAKEIFN 

       130        140        150        160        170        180 
APLNIIANPN CSTIQMTQIL NPLHLHFKIK SVIVSTYQAV SGAGNKGIES LKNELKTALE 

       190        200        210        220        230        240 
CLEKDPTIDL NQVLQAGAFA YPIAFNAIAH IDTFKENGYT KEELKMLHET HKIMGVDFPI 

       250        260        270        280        290        300 
SATCVRVPVL RSHSESLSIA FEKEFDLKEV YEVLKNAPSV AVCDDPSHNL YPTPLKASHT 

       310        320        330        340 
DSVFIGRLRK DLFDKKTLHG FCVADQLRVG AATNALKIAL HYIKNA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000511 Genomic DNA. Translation: AAD08235.1.
PIRE64668.
RefSeqNP_207980.1. NC_000915.1.
YP_006935109.1. NC_018939.1.

3D structure databases

ProteinModelPortalO25801.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-3753N.
MINTMINT-169344.
STRING85962.HP1189.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD08235; AAD08235; HP_1189.
GeneID13870389.
899951.
KEGGheo:C694_06155.
hpy:HP1189.
PATRIC20593737. VBIHelPyl33062_1246.

Phylogenomic databases

eggNOGCOG0136.
KOK00133.
OMAFPIKKFV.
ProtClustDBCLSK496405.

Enzyme and pathway databases

UniPathwayUPA00034; UER00016.
UPA00050; UER00463.
UPA00051; UER00464.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_02121. ASADH.
InterProIPR000319. Asp-semialdehyde_DH_CS.
IPR012080. Asp_semialdehyde_DH.
IPR005986. Asp_semialdehyde_DH_beta.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
IPR012280. Semialdhyde_DH_dimer_dom.
[Graphical view]
PfamPF01118. Semialdhyde_dh. 1 hit.
PF02774. Semialdhyde_dhC. 1 hit.
[Graphical view]
PIRSFPIRSF000148. ASA_dh. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR01296. asd_B. 1 hit.
PROSITEPS01103. ASD. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

BindingDBO25801.
ChEMBLCHEMBL5687.

Entry information

Entry nameDHAS_HELPY
AccessionPrimary (citable) accession number: O25801
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: May 1, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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