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O25797

- SOTB_HELPY

UniProt

O25797 - SOTB_HELPY

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Protein

Probable sugar efflux transporter

Gene

sotB

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites.UniRule annotation

GO - Molecular functioni

  1. carbohydrate transmembrane transporter activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciHPY:HP1185-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable sugar efflux transporterUniRule annotation
Gene namesi
Name:sotBUniRule annotation
Ordered Locus Names:HP_1185
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 391391Probable sugar efflux transporterPRO_0000209328Add
BLAST

Proteomic databases

PRIDEiO25797.

Interactioni

Protein-protein interaction databases

DIPiDIP-3477N.
IntActiO25797. 1 interaction.
MINTiMINT-185868.
STRINGi85962.HP1185.

Structurei

3D structure databases

ProteinModelPortaliO25797.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621HelicalUniRule annotationAdd
BLAST
Transmembranei51 – 7121HelicalUniRule annotationAdd
BLAST
Transmembranei82 – 10221HelicalUniRule annotationAdd
BLAST
Transmembranei110 – 13021HelicalUniRule annotationAdd
BLAST
Transmembranei138 – 15821HelicalUniRule annotationAdd
BLAST
Transmembranei170 – 19021HelicalUniRule annotationAdd
BLAST
Transmembranei210 – 23021HelicalUniRule annotationAdd
BLAST
Transmembranei247 – 26721HelicalUniRule annotationAdd
BLAST
Transmembranei277 – 29721HelicalUniRule annotationAdd
BLAST
Transmembranei300 – 32021HelicalUniRule annotationAdd
BLAST
Transmembranei338 – 35821HelicalUniRule annotationAdd
BLAST
Transmembranei361 – 38121HelicalUniRule annotationAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily. SotB (TC 2.A.1.2) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2814.
KOiK03445.
K08159.
OMAiALFILSH.
OrthoDBiEOG6TJ7VJ.

Family and domain databases

HAMAPiMF_00517. MFS_SotB.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR023495. Sugar_effux_transptr_put.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O25797-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMITKQSYQK FALMRVFVFS LSAFIFNTTE FVPVALLSDI AKSFEMESAT
60 70 80 90 100
VGLMITAYAW VVSLGSLPLM LLSAKIERKR LLLFLFALFI LSHILSALAW
110 120 130 140 150
NFWVLLLSRM GIAFAHSIFW SITASLVIRV APRNKKQQAL GLLALGSSLA
160 170 180 190 200
MILGLPLGRI IGQILDWRST FGVIGGVATL IALLMWKLLP HLPSRNAGTL
210 220 230 240 250
ASVPVLMKRP LLMGIYLLVI MVISGHFTTY SYIEPFIIQI SQFSPDITTL
260 270 280 290 300
MLFVFGLAGV VGSFLFGRLY AKNSRKFIAF AMVLVICPQL LLFVFKNLEW
310 320 330 340 350
VVFLQIFLWG IGITSLGISL QMRVLQLAPD ATDVASAIYS GSYNVGIGSG
360 370 380 390
ALFGSIVIHQ LGLGYIGFVG GALGLLALFW LRFITIKFKK T
Length:391
Mass (Da):43,110
Last modified:January 1, 1998 - v1
Checksum:i5F6E163019FBD6B5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08231.1.
PIRiA64668.
RefSeqiNP_207976.1. NC_000915.1.
YP_006935104.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08231; AAD08231; HP_1185.
GeneIDi13870384.
899947.
KEGGiheo:C694_06130.
hpy:HP1185.
PATRICi20593725. VBIHelPyl33062_1240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08231.1 .
PIRi A64668.
RefSeqi NP_207976.1. NC_000915.1.
YP_006935104.1. NC_018939.1.

3D structure databases

ProteinModelPortali O25797.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-3477N.
IntActi O25797. 1 interaction.
MINTi MINT-185868.
STRINGi 85962.HP1185.

Proteomic databases

PRIDEi O25797.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD08231 ; AAD08231 ; HP_1185 .
GeneIDi 13870384.
899947.
KEGGi heo:C694_06130.
hpy:HP1185.
PATRICi 20593725. VBIHelPyl33062_1240.

Phylogenomic databases

eggNOGi COG2814.
KOi K03445.
K08159.
OMAi ALFILSH.
OrthoDBi EOG6TJ7VJ.

Enzyme and pathway databases

BioCyci HPY:HP1185-MONOMER.

Family and domain databases

HAMAPi MF_00517. MFS_SotB.
InterProi IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR023495. Sugar_effux_transptr_put.
[Graphical view ]
Pfami PF07690. MFS_1. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiSOTB_HELPY
AccessioniPrimary (citable) accession number: O25797
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3