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Protein

Probable sugar efflux transporter

Gene

sotB

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites.UniRule annotation

GO - Molecular functioni

  1. carbohydrate transmembrane transporter activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciHPY:HP1185-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable sugar efflux transporterUniRule annotation
Gene namesi
Name:sotBUniRule annotation
Ordered Locus Names:HP_1185
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429 Componenti: Chromosome

Subcellular locationi

  1. Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621HelicalUniRule annotationAdd
BLAST
Transmembranei51 – 7121HelicalUniRule annotationAdd
BLAST
Transmembranei82 – 10221HelicalUniRule annotationAdd
BLAST
Transmembranei110 – 13021HelicalUniRule annotationAdd
BLAST
Transmembranei138 – 15821HelicalUniRule annotationAdd
BLAST
Transmembranei170 – 19021HelicalUniRule annotationAdd
BLAST
Transmembranei210 – 23021HelicalUniRule annotationAdd
BLAST
Transmembranei247 – 26721HelicalUniRule annotationAdd
BLAST
Transmembranei277 – 29721HelicalUniRule annotationAdd
BLAST
Transmembranei300 – 32021HelicalUniRule annotationAdd
BLAST
Transmembranei338 – 35821HelicalUniRule annotationAdd
BLAST
Transmembranei361 – 38121HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 391391Probable sugar efflux transporterPRO_0000209328Add
BLAST

Proteomic databases

PRIDEiO25797.

Interactioni

Protein-protein interaction databases

DIPiDIP-3477N.
IntActiO25797. 1 interaction.
MINTiMINT-185868.
STRINGi85962.HP1185.

Structurei

3D structure databases

ProteinModelPortaliO25797.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily. SotB (TC 2.A.1.2) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2814.
KOiK03445.
K08159.
OMAiYIEPFII.
OrthoDBiEOG6TJ7VJ.

Family and domain databases

HAMAPiMF_00517. MFS_SotB.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR023495. Sugar_effux_transptr_put.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O25797-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMITKQSYQK FALMRVFVFS LSAFIFNTTE FVPVALLSDI AKSFEMESAT
60 70 80 90 100
VGLMITAYAW VVSLGSLPLM LLSAKIERKR LLLFLFALFI LSHILSALAW
110 120 130 140 150
NFWVLLLSRM GIAFAHSIFW SITASLVIRV APRNKKQQAL GLLALGSSLA
160 170 180 190 200
MILGLPLGRI IGQILDWRST FGVIGGVATL IALLMWKLLP HLPSRNAGTL
210 220 230 240 250
ASVPVLMKRP LLMGIYLLVI MVISGHFTTY SYIEPFIIQI SQFSPDITTL
260 270 280 290 300
MLFVFGLAGV VGSFLFGRLY AKNSRKFIAF AMVLVICPQL LLFVFKNLEW
310 320 330 340 350
VVFLQIFLWG IGITSLGISL QMRVLQLAPD ATDVASAIYS GSYNVGIGSG
360 370 380 390
ALFGSIVIHQ LGLGYIGFVG GALGLLALFW LRFITIKFKK T
Length:391
Mass (Da):43,110
Last modified:January 1, 1998 - v1
Checksum:i5F6E163019FBD6B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08231.1.
PIRiA64668.
RefSeqiNP_207976.1. NC_000915.1.
YP_006935104.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08231; AAD08231; HP_1185.
GeneIDi899947.
KEGGiheo:C694_06130.
hpy:HP1185.
PATRICi20593725. VBIHelPyl33062_1240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08231.1.
PIRiA64668.
RefSeqiNP_207976.1. NC_000915.1.
YP_006935104.1. NC_018939.1.

3D structure databases

ProteinModelPortaliO25797.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3477N.
IntActiO25797. 1 interaction.
MINTiMINT-185868.
STRINGi85962.HP1185.

Proteomic databases

PRIDEiO25797.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08231; AAD08231; HP_1185.
GeneIDi899947.
KEGGiheo:C694_06130.
hpy:HP1185.
PATRICi20593725. VBIHelPyl33062_1240.

Phylogenomic databases

eggNOGiCOG2814.
KOiK03445.
K08159.
OMAiYIEPFII.
OrthoDBiEOG6TJ7VJ.

Enzyme and pathway databases

BioCyciHPY:HP1185-MONOMER.

Family and domain databases

HAMAPiMF_00517. MFS_SotB.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR023495. Sugar_effux_transptr_put.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiSOTB_HELPY
AccessioniPrimary (citable) accession number: O25797
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 1, 1998
Last modified: April 29, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.