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O25797 (SOTB_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable sugar efflux transporter
Gene names
Name:sotB
Ordered Locus Names:HP_1185
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length391 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites By similarity. HAMAP-Rule MF_00517

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_00517.

Sequence similarities

Belongs to the major facilitator superfamily. SotB (TC 2.A.1.2) family. [View classification]

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 391391Probable sugar efflux transporter HAMAP-Rule MF_00517
PRO_0000209328

Regions

Transmembrane16 – 3621Helical; Potential
Transmembrane51 – 7121Helical; Potential
Transmembrane82 – 10221Helical; Potential
Transmembrane110 – 13021Helical; Potential
Transmembrane138 – 15821Helical; Potential
Transmembrane170 – 19021Helical; Potential
Transmembrane210 – 23021Helical; Potential
Transmembrane247 – 26721Helical; Potential
Transmembrane277 – 29721Helical; Potential
Transmembrane300 – 32021Helical; Potential
Transmembrane338 – 35821Helical; Potential
Transmembrane361 – 38121Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
O25797 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 5F6E163019FBD6B5

FASTA39143,110
        10         20         30         40         50         60 
MMITKQSYQK FALMRVFVFS LSAFIFNTTE FVPVALLSDI AKSFEMESAT VGLMITAYAW 

        70         80         90        100        110        120 
VVSLGSLPLM LLSAKIERKR LLLFLFALFI LSHILSALAW NFWVLLLSRM GIAFAHSIFW 

       130        140        150        160        170        180 
SITASLVIRV APRNKKQQAL GLLALGSSLA MILGLPLGRI IGQILDWRST FGVIGGVATL 

       190        200        210        220        230        240 
IALLMWKLLP HLPSRNAGTL ASVPVLMKRP LLMGIYLLVI MVISGHFTTY SYIEPFIIQI 

       250        260        270        280        290        300 
SQFSPDITTL MLFVFGLAGV VGSFLFGRLY AKNSRKFIAF AMVLVICPQL LLFVFKNLEW 

       310        320        330        340        350        360 
VVFLQIFLWG IGITSLGISL QMRVLQLAPD ATDVASAIYS GSYNVGIGSG ALFGSIVIHQ 

       370        380        390 
LGLGYIGFVG GALGLLALFW LRFITIKFKK T 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD08231.1.
PIRA64668.
RefSeqNP_207976.1. NC_000915.1.
YP_006935104.1. NC_018939.1.

3D structure databases

ProteinModelPortalO25797.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-3477N.
IntActO25797. 1 interaction.
MINTMINT-185868.
STRING85962.HP1185.

Proteomic databases

PRIDEO25797.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD08231; AAD08231; HP_1185.
GeneID899947.
KEGGheo:C694_06130.
hpy:HP1185.
PATRIC20593725. VBIHelPyl33062_1240.

Phylogenomic databases

eggNOGCOG2814.
KOK03445.
K08159.
OMAALFILSH.
OrthoDBEOG6TJ7VJ.

Enzyme and pathway databases

BioCycHPY:HP1185-MONOMER.

Family and domain databases

HAMAPMF_00517. MFS_SotB.
InterProIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR023495. Sugar_effux_transptr_put.
[Graphical view]
PfamPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 1 hit.
PROSITEPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSOTB_HELPY
AccessionPrimary (citable) accession number: O25797
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names