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Protein

Probable sugar efflux transporter

Gene

sotB

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciHPY:HP1185-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable sugar efflux transporterUniRule annotation
Gene namesi
Name:sotBUniRule annotation
Ordered Locus Names:HP_1185
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 36HelicalUniRule annotationAdd BLAST21
Transmembranei51 – 71HelicalUniRule annotationAdd BLAST21
Transmembranei82 – 102HelicalUniRule annotationAdd BLAST21
Transmembranei110 – 130HelicalUniRule annotationAdd BLAST21
Transmembranei138 – 158HelicalUniRule annotationAdd BLAST21
Transmembranei170 – 190HelicalUniRule annotationAdd BLAST21
Transmembranei210 – 230HelicalUniRule annotationAdd BLAST21
Transmembranei247 – 267HelicalUniRule annotationAdd BLAST21
Transmembranei277 – 297HelicalUniRule annotationAdd BLAST21
Transmembranei300 – 320HelicalUniRule annotationAdd BLAST21
Transmembranei338 – 358HelicalUniRule annotationAdd BLAST21
Transmembranei361 – 381HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002093281 – 391Probable sugar efflux transporterAdd BLAST391

Proteomic databases

PaxDbiO25797.

Interactioni

Protein-protein interaction databases

DIPiDIP-3477N.
IntActiO25797. 1 interactor.
MINTiMINT-185868.
STRINGi85962.HP1185.

Structurei

3D structure databases

ProteinModelPortaliO25797.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily. SotB (TC 2.A.1.2) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105F27. Bacteria.
COG2814. LUCA.
KOiK03445.
K08159.
OMAiITLYAWL.

Family and domain databases

CDDicd06174. MFS. 1 hit.
HAMAPiMF_00517. MFS_SotB. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR023495. Sugar_effux_transptr_put.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O25797-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMITKQSYQK FALMRVFVFS LSAFIFNTTE FVPVALLSDI AKSFEMESAT
60 70 80 90 100
VGLMITAYAW VVSLGSLPLM LLSAKIERKR LLLFLFALFI LSHILSALAW
110 120 130 140 150
NFWVLLLSRM GIAFAHSIFW SITASLVIRV APRNKKQQAL GLLALGSSLA
160 170 180 190 200
MILGLPLGRI IGQILDWRST FGVIGGVATL IALLMWKLLP HLPSRNAGTL
210 220 230 240 250
ASVPVLMKRP LLMGIYLLVI MVISGHFTTY SYIEPFIIQI SQFSPDITTL
260 270 280 290 300
MLFVFGLAGV VGSFLFGRLY AKNSRKFIAF AMVLVICPQL LLFVFKNLEW
310 320 330 340 350
VVFLQIFLWG IGITSLGISL QMRVLQLAPD ATDVASAIYS GSYNVGIGSG
360 370 380 390
ALFGSIVIHQ LGLGYIGFVG GALGLLALFW LRFITIKFKK T
Length:391
Mass (Da):43,110
Last modified:January 1, 1998 - v1
Checksum:i5F6E163019FBD6B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08231.1.
PIRiA64668.
RefSeqiNP_207976.1. NC_000915.1.
WP_000973595.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08231; AAD08231; HP_1185.
GeneIDi899947.
KEGGiheo:C694_06130.
hpy:HP1185.
PATRICi20593725. VBIHelPyl33062_1240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08231.1.
PIRiA64668.
RefSeqiNP_207976.1. NC_000915.1.
WP_000973595.1. NC_018939.1.

3D structure databases

ProteinModelPortaliO25797.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3477N.
IntActiO25797. 1 interactor.
MINTiMINT-185868.
STRINGi85962.HP1185.

Proteomic databases

PaxDbiO25797.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08231; AAD08231; HP_1185.
GeneIDi899947.
KEGGiheo:C694_06130.
hpy:HP1185.
PATRICi20593725. VBIHelPyl33062_1240.

Phylogenomic databases

eggNOGiENOG4105F27. Bacteria.
COG2814. LUCA.
KOiK03445.
K08159.
OMAiITLYAWL.

Enzyme and pathway databases

BioCyciHPY:HP1185-MONOMER.

Family and domain databases

CDDicd06174. MFS. 1 hit.
HAMAPiMF_00517. MFS_SotB. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR023495. Sugar_effux_transptr_put.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSOTB_HELPY
AccessioniPrimary (citable) accession number: O25797
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 1, 1998
Last modified: October 5, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.