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O25797

- SOTB_HELPY

UniProt

O25797 - SOTB_HELPY

Protein

Probable sugar efflux transporter

Gene

sotB

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites.UniRule annotation

    GO - Molecular functioni

    1. carbohydrate transmembrane transporter activity Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Sugar transport, Transport

    Enzyme and pathway databases

    BioCyciHPY:HP1185-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable sugar efflux transporterUniRule annotation
    Gene namesi
    Name:sotBUniRule annotation
    Ordered Locus Names:HP_1185
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 391391Probable sugar efflux transporterPRO_0000209328Add
    BLAST

    Proteomic databases

    PRIDEiO25797.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-3477N.
    IntActiO25797. 1 interaction.
    MINTiMINT-185868.
    STRINGi85962.HP1185.

    Structurei

    3D structure databases

    ProteinModelPortaliO25797.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei16 – 3621HelicalUniRule annotationAdd
    BLAST
    Transmembranei51 – 7121HelicalUniRule annotationAdd
    BLAST
    Transmembranei82 – 10221HelicalUniRule annotationAdd
    BLAST
    Transmembranei110 – 13021HelicalUniRule annotationAdd
    BLAST
    Transmembranei138 – 15821HelicalUniRule annotationAdd
    BLAST
    Transmembranei170 – 19021HelicalUniRule annotationAdd
    BLAST
    Transmembranei210 – 23021HelicalUniRule annotationAdd
    BLAST
    Transmembranei247 – 26721HelicalUniRule annotationAdd
    BLAST
    Transmembranei277 – 29721HelicalUniRule annotationAdd
    BLAST
    Transmembranei300 – 32021HelicalUniRule annotationAdd
    BLAST
    Transmembranei338 – 35821HelicalUniRule annotationAdd
    BLAST
    Transmembranei361 – 38121HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the major facilitator superfamily. SotB (TC 2.A.1.2) family. [View classification]UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2814.
    KOiK03445.
    K08159.
    OMAiALFILSH.
    OrthoDBiEOG6TJ7VJ.

    Family and domain databases

    HAMAPiMF_00517. MFS_SotB.
    InterProiIPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR023495. Sugar_effux_transptr_put.
    [Graphical view]
    PfamiPF07690. MFS_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O25797-1 [UniParc]FASTAAdd to Basket

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    MMITKQSYQK FALMRVFVFS LSAFIFNTTE FVPVALLSDI AKSFEMESAT    50
    VGLMITAYAW VVSLGSLPLM LLSAKIERKR LLLFLFALFI LSHILSALAW 100
    NFWVLLLSRM GIAFAHSIFW SITASLVIRV APRNKKQQAL GLLALGSSLA 150
    MILGLPLGRI IGQILDWRST FGVIGGVATL IALLMWKLLP HLPSRNAGTL 200
    ASVPVLMKRP LLMGIYLLVI MVISGHFTTY SYIEPFIIQI SQFSPDITTL 250
    MLFVFGLAGV VGSFLFGRLY AKNSRKFIAF AMVLVICPQL LLFVFKNLEW 300
    VVFLQIFLWG IGITSLGISL QMRVLQLAPD ATDVASAIYS GSYNVGIGSG 350
    ALFGSIVIHQ LGLGYIGFVG GALGLLALFW LRFITIKFKK T 391
    Length:391
    Mass (Da):43,110
    Last modified:January 1, 1998 - v1
    Checksum:i5F6E163019FBD6B5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08231.1.
    PIRiA64668.
    RefSeqiNP_207976.1. NC_000915.1.
    YP_006935104.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD08231; AAD08231; HP_1185.
    GeneIDi13870384.
    899947.
    KEGGiheo:C694_06130.
    hpy:HP1185.
    PATRICi20593725. VBIHelPyl33062_1240.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08231.1 .
    PIRi A64668.
    RefSeqi NP_207976.1. NC_000915.1.
    YP_006935104.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali O25797.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-3477N.
    IntActi O25797. 1 interaction.
    MINTi MINT-185868.
    STRINGi 85962.HP1185.

    Proteomic databases

    PRIDEi O25797.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD08231 ; AAD08231 ; HP_1185 .
    GeneIDi 13870384.
    899947.
    KEGGi heo:C694_06130.
    hpy:HP1185.
    PATRICi 20593725. VBIHelPyl33062_1240.

    Phylogenomic databases

    eggNOGi COG2814.
    KOi K03445.
    K08159.
    OMAi ALFILSH.
    OrthoDBi EOG6TJ7VJ.

    Enzyme and pathway databases

    BioCyci HPY:HP1185-MONOMER.

    Family and domain databases

    HAMAPi MF_00517. MFS_SotB.
    InterProi IPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR023495. Sugar_effux_transptr_put.
    [Graphical view ]
    Pfami PF07690. MFS_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiSOTB_HELPY
    AccessioniPrimary (citable) accession number: O25797
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3