Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei351 – 3511Proton donorBy similarity
Active sitei382 – 3821By similarity
Active sitei510 – 5101By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciHPY:HP1166-MONOMER.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgi
Ordered Locus Names:HP_1166
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 545545Glucose-6-phosphate isomerasePRO_0000180652Add
BLAST

Proteomic databases

PRIDEiO25781.

Interactioni

Protein-protein interaction databases

STRINGi85962.HP1166.

Structurei

3D structure databases

ProteinModelPortaliO25781.
SMRiO25781. Positions 2-542.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

eggNOGiCOG0166.
KOiK01810.
OMAiFELANDC.
OrthoDBiEOG64R61J.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O25781-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTQLKTYPK LLKHYEEIKE VHMRDWFFKD KERASRYFLQ FESLSLDYSK
60 70 80 90 100
NRLNDTTLKL LFELANDCSL KEKIEAMFKG EKINTTEKRA VLHTALRSLN
110 120 130 140 150
DTEILLDNME VLKSIRSVLK RMRAFSDSVR SGKRLGYTNQ VITDIVNIGI
160 170 180 190 200
GGSDLGALMV CTALKRYAHP RLKMHFVSNV DGTQILDVLE KLNPASTLFI
210 220 230 240 250
VASKTFSTQE TLTNALTARK WFVERSGDEK HIAKHFVAVS TNKEAVQQFG
260 270 280 290 300
IDEHNMFEFW DFVGGRYSLW SAIGLSIMIY LGKKNFNALL KGAYLMDEHF
310 320 330 340 350
RNAPFESNLP VLMGLIGVWY INFFQSKSHL IAPYDQYLRH FPKFIQQLDM
360 370 380 390 400
ESNGKRISKK GEIIPYDTCP VVWGDMGINA QHAFFQLLHQ GTHLIPIDFI
410 420 430 440 450
ASLDKKPNAK GHHEILFSNV LAQAQAFMKG KSYEEALGEL LFKGLDKDEA
460 470 480 490 500
KDLAHHRVFF GNRPSNILLL EKISPSNIGA LVALYEHKVF VQGVIWDINS
510 520 530 540
FDQWGVELGK ELAVPILQEL EGHKSNAYFD SSTKHLIELY KNYNQ
Length:545
Mass (Da):62,487
Last modified:January 1, 1998 - v1
Checksum:iBDC68D1625190236
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08211.1.
PIRiF64665.
RefSeqiNP_207957.1. NC_000915.1.
YP_006935082.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08211; AAD08211; HP_1166.
GeneIDi899926.
KEGGiheo:C694_06020.
hpy:HP1166.
PATRICi20593683. VBIHelPyl33062_1220.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08211.1.
PIRiF64665.
RefSeqiNP_207957.1. NC_000915.1.
YP_006935082.1. NC_018939.1.

3D structure databases

ProteinModelPortaliO25781.
SMRiO25781. Positions 2-542.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi85962.HP1166.

Proteomic databases

PRIDEiO25781.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08211; AAD08211; HP_1166.
GeneIDi899926.
KEGGiheo:C694_06020.
hpy:HP1166.
PATRICi20593683. VBIHelPyl33062_1220.

Phylogenomic databases

eggNOGiCOG0166.
KOiK01810.
OMAiFELANDC.
OrthoDBiEOG64R61J.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
BioCyciHPY:HP1166-MONOMER.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiG6PI_HELPY
AccessioniPrimary (citable) accession number: O25781
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: April 29, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.