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O25781

- G6PI_HELPY

UniProt

O25781 - G6PI_HELPY

Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei351 – 3511Proton donorBy similarity
    Active sitei382 – 3821By similarity
    Active sitei510 – 5101By similarity

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP
    2. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis

    Enzyme and pathway databases

    BioCyciHPY:HP1166-MONOMER.
    UniPathwayiUPA00109; UER00181.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate isomerase (EC:5.3.1.9)
    Short name:
    GPI
    Alternative name(s):
    Phosphoglucose isomerase
    Short name:
    PGI
    Phosphohexose isomerase
    Short name:
    PHI
    Gene namesi
    Name:pgi
    Ordered Locus Names:HP_1166
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 545545Glucose-6-phosphate isomerasePRO_0000180652Add
    BLAST

    Proteomic databases

    PRIDEiO25781.

    Interactioni

    Protein-protein interaction databases

    STRINGi85962.HP1166.

    Structurei

    3D structure databases

    ProteinModelPortaliO25781.
    SMRiO25781. Positions 2-542.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GPI family.Curated

    Phylogenomic databases

    eggNOGiCOG0166.
    KOiK01810.
    OMAiRAHYVSN.
    OrthoDBiEOG64R61J.

    Family and domain databases

    Gene3Di1.10.1390.10. 1 hit.
    HAMAPiMF_00473. G6P_isomerase.
    InterProiIPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view]
    PANTHERiPTHR11469. PTHR11469. 1 hit.
    PfamiPF00342. PGI. 1 hit.
    [Graphical view]
    PRINTSiPR00662. G6PISOMERASE.
    PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O25781-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLTQLKTYPK LLKHYEEIKE VHMRDWFFKD KERASRYFLQ FESLSLDYSK    50
    NRLNDTTLKL LFELANDCSL KEKIEAMFKG EKINTTEKRA VLHTALRSLN 100
    DTEILLDNME VLKSIRSVLK RMRAFSDSVR SGKRLGYTNQ VITDIVNIGI 150
    GGSDLGALMV CTALKRYAHP RLKMHFVSNV DGTQILDVLE KLNPASTLFI 200
    VASKTFSTQE TLTNALTARK WFVERSGDEK HIAKHFVAVS TNKEAVQQFG 250
    IDEHNMFEFW DFVGGRYSLW SAIGLSIMIY LGKKNFNALL KGAYLMDEHF 300
    RNAPFESNLP VLMGLIGVWY INFFQSKSHL IAPYDQYLRH FPKFIQQLDM 350
    ESNGKRISKK GEIIPYDTCP VVWGDMGINA QHAFFQLLHQ GTHLIPIDFI 400
    ASLDKKPNAK GHHEILFSNV LAQAQAFMKG KSYEEALGEL LFKGLDKDEA 450
    KDLAHHRVFF GNRPSNILLL EKISPSNIGA LVALYEHKVF VQGVIWDINS 500
    FDQWGVELGK ELAVPILQEL EGHKSNAYFD SSTKHLIELY KNYNQ 545
    Length:545
    Mass (Da):62,487
    Last modified:January 1, 1998 - v1
    Checksum:iBDC68D1625190236
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08211.1.
    PIRiF64665.
    RefSeqiNP_207957.1. NC_000915.1.
    YP_006935082.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD08211; AAD08211; HP_1166.
    GeneIDi13870361.
    899926.
    KEGGiheo:C694_06020.
    hpy:HP1166.
    PATRICi20593683. VBIHelPyl33062_1220.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08211.1 .
    PIRi F64665.
    RefSeqi NP_207957.1. NC_000915.1.
    YP_006935082.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali O25781.
    SMRi O25781. Positions 2-542.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 85962.HP1166.

    Proteomic databases

    PRIDEi O25781.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD08211 ; AAD08211 ; HP_1166 .
    GeneIDi 13870361.
    899926.
    KEGGi heo:C694_06020.
    hpy:HP1166.
    PATRICi 20593683. VBIHelPyl33062_1220.

    Phylogenomic databases

    eggNOGi COG0166.
    KOi K01810.
    OMAi RAHYVSN.
    OrthoDBi EOG64R61J.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00181 .
    BioCyci HPY:HP1166-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1390.10. 1 hit.
    HAMAPi MF_00473. G6P_isomerase.
    InterProi IPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view ]
    PANTHERi PTHR11469. PTHR11469. 1 hit.
    Pfami PF00342. PGI. 1 hit.
    [Graphical view ]
    PRINTSi PR00662. G6PISOMERASE.
    PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiG6PI_HELPY
    AccessioniPrimary (citable) accession number: O25781
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3