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O25766

- TRMD_HELPY

UniProt

O25766 - TRMD_HELPY

Protein

tRNA (guanine-N(1)-)-methyltransferase

Gene

trmD

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Specifically methylates guanosine-37 in various tRNAs.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei109 – 1091S-adenosyl-L-methionine; via amide nitrogenBy similarity

    GO - Molecular functioni

    1. tRNA (guanine(37)-N(1))-methyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciHPY:HP1148-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(1)-)-methyltransferase (EC:2.1.1.228)
    Alternative name(s):
    M1G-methyltransferase
    tRNA [GM37] methyltransferase
    Gene namesi
    Name:trmD
    Ordered Locus Names:HP_1148
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 229229tRNA (guanine-N(1)-)-methyltransferasePRO_0000060388Add
    BLAST

    Proteomic databases

    PRIDEiO25766.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    DIPiDIP-3681N.
    IntActiO25766. 4 interactions.
    MINTiMINT-179982.
    STRINGi85962.HP1148.

    Structurei

    3D structure databases

    ProteinModelPortaliO25766.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni129 – 1346S-adenosyl-L-methionine bindingBy similarity

    Sequence similaritiesi

    Belongs to the RNA methyltransferase TrmD family.Curated

    Phylogenomic databases

    eggNOGiCOG0336.
    KOiK00554.
    OMAiEQSRMIT.
    OrthoDBiEOG6J48RZ.

    Family and domain databases

    Gene3Di1.10.1270.20. 1 hit.
    3.40.1280.10. 1 hit.
    HAMAPiMF_00605. TrmD.
    InterProiIPR029028. Alpha/beta_knot_MTases.
    IPR002649. tRNA_m1G_MeTrfase_bac.
    IPR023148. tRNA_m1G_MeTrfase_C.
    IPR029026. tRNA_m1G_MTases_N.
    IPR016009. tRNA_MeTrfase_TRMD/TRM10.
    [Graphical view]
    PfamiPF01746. tRNA_m1G_MT. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000386. tRNA_mtase. 1 hit.
    SUPFAMiSSF75217. SSF75217. 1 hit.
    TIGRFAMsiTIGR00088. trmD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O25766-1 [UniParc]FASTAAdd to Basket

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    MKFSVLTLFP QLVWPYFEDS ILKRALEKNL FELEVLNLRD FSANKYQKAD    50
    HTLIGGGAGQ ILDPEMVENA LHSVKNPKHT IFLSAVGKPF KQTDAMRLAQ 100
    KKHVVLVCGR YEGFDERSIE LGADEVFCIG DFILTGGELG ALCLIDSIAR 150
    HIQGVLGNAQ SLENESFENH YLEAPNFANA VFKSKEINKI PAPLEYSKGN 200
    HAKIKQLKLD LSKLRTKFYR LDLFKQHKS 229
    Length:229
    Mass (Da):25,879
    Last modified:January 1, 1998 - v1
    Checksum:i2D7135818A13D822
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08192.1.
    PIRiD64663.
    RefSeqiNP_207939.1. NC_000915.1.
    YP_006935064.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD08192; AAD08192; HP_1148.
    GeneIDi13870343.
    899686.
    KEGGiheo:C694_05930.
    hpy:HP1148.
    PATRICi20593647. VBIHelPyl33062_1202.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08192.1 .
    PIRi D64663.
    RefSeqi NP_207939.1. NC_000915.1.
    YP_006935064.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali O25766.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-3681N.
    IntActi O25766. 4 interactions.
    MINTi MINT-179982.
    STRINGi 85962.HP1148.

    Proteomic databases

    PRIDEi O25766.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD08192 ; AAD08192 ; HP_1148 .
    GeneIDi 13870343.
    899686.
    KEGGi heo:C694_05930.
    hpy:HP1148.
    PATRICi 20593647. VBIHelPyl33062_1202.

    Phylogenomic databases

    eggNOGi COG0336.
    KOi K00554.
    OMAi EQSRMIT.
    OrthoDBi EOG6J48RZ.

    Enzyme and pathway databases

    BioCyci HPY:HP1148-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1270.20. 1 hit.
    3.40.1280.10. 1 hit.
    HAMAPi MF_00605. TrmD.
    InterProi IPR029028. Alpha/beta_knot_MTases.
    IPR002649. tRNA_m1G_MeTrfase_bac.
    IPR023148. tRNA_m1G_MeTrfase_C.
    IPR029026. tRNA_m1G_MTases_N.
    IPR016009. tRNA_MeTrfase_TRMD/TRM10.
    [Graphical view ]
    Pfami PF01746. tRNA_m1G_MT. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000386. tRNA_mtase. 1 hit.
    SUPFAMi SSF75217. SSF75217. 1 hit.
    TIGRFAMsi TIGR00088. trmD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiTRMD_HELPY
    AccessioniPrimary (citable) accession number: O25766
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3