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O25766

- TRMD_HELPY

UniProt

O25766 - TRMD_HELPY

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Protein

tRNA (guanine-N(1)-)-methyltransferase

Gene

trmD

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Specifically methylates guanosine-37 in various tRNAs.By similarity

Catalytic activityi

S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei109 – 1091S-adenosyl-L-methionine; via amide nitrogenBy similarity

GO - Molecular functioni

  1. tRNA (guanine(37)-N(1))-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciHPY:HP1148-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(1)-)-methyltransferase (EC:2.1.1.228)
Alternative name(s):
M1G-methyltransferase
tRNA [GM37] methyltransferase
Gene namesi
Name:trmD
Ordered Locus Names:HP_1148
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229tRNA (guanine-N(1)-)-methyltransferasePRO_0000060388Add
BLAST

Proteomic databases

PRIDEiO25766.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

DIPiDIP-3681N.
IntActiO25766. 4 interactions.
MINTiMINT-179982.
STRINGi85962.HP1148.

Structurei

3D structure databases

ProteinModelPortaliO25766.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni129 – 1346S-adenosyl-L-methionine bindingBy similarity

Sequence similaritiesi

Belongs to the RNA methyltransferase TrmD family.Curated

Phylogenomic databases

eggNOGiCOG0336.
KOiK00554.
OMAiEQSRMIT.
OrthoDBiEOG6J48RZ.

Family and domain databases

Gene3Di1.10.1270.20. 1 hit.
3.40.1280.10. 1 hit.
HAMAPiMF_00605. TrmD.
InterProiIPR029028. Alpha/beta_knot_MTases.
IPR002649. tRNA_m1G_MeTrfase_bac.
IPR023148. tRNA_m1G_MeTrfase_C.
IPR029026. tRNA_m1G_MTases_N.
IPR016009. tRNA_MeTrfase_TRMD/TRM10.
[Graphical view]
PfamiPF01746. tRNA_m1G_MT. 1 hit.
[Graphical view]
PIRSFiPIRSF000386. tRNA_mtase. 1 hit.
SUPFAMiSSF75217. SSF75217. 1 hit.
TIGRFAMsiTIGR00088. trmD. 1 hit.

Sequencei

Sequence statusi: Complete.

O25766-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKFSVLTLFP QLVWPYFEDS ILKRALEKNL FELEVLNLRD FSANKYQKAD
60 70 80 90 100
HTLIGGGAGQ ILDPEMVENA LHSVKNPKHT IFLSAVGKPF KQTDAMRLAQ
110 120 130 140 150
KKHVVLVCGR YEGFDERSIE LGADEVFCIG DFILTGGELG ALCLIDSIAR
160 170 180 190 200
HIQGVLGNAQ SLENESFENH YLEAPNFANA VFKSKEINKI PAPLEYSKGN
210 220
HAKIKQLKLD LSKLRTKFYR LDLFKQHKS
Length:229
Mass (Da):25,879
Last modified:January 1, 1998 - v1
Checksum:i2D7135818A13D822
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08192.1.
PIRiD64663.
RefSeqiNP_207939.1. NC_000915.1.
YP_006935064.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08192; AAD08192; HP_1148.
GeneIDi13870343.
899686.
KEGGiheo:C694_05930.
hpy:HP1148.
PATRICi20593647. VBIHelPyl33062_1202.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08192.1 .
PIRi D64663.
RefSeqi NP_207939.1. NC_000915.1.
YP_006935064.1. NC_018939.1.

3D structure databases

ProteinModelPortali O25766.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-3681N.
IntActi O25766. 4 interactions.
MINTi MINT-179982.
STRINGi 85962.HP1148.

Proteomic databases

PRIDEi O25766.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD08192 ; AAD08192 ; HP_1148 .
GeneIDi 13870343.
899686.
KEGGi heo:C694_05930.
hpy:HP1148.
PATRICi 20593647. VBIHelPyl33062_1202.

Phylogenomic databases

eggNOGi COG0336.
KOi K00554.
OMAi EQSRMIT.
OrthoDBi EOG6J48RZ.

Enzyme and pathway databases

BioCyci HPY:HP1148-MONOMER.

Family and domain databases

Gene3Di 1.10.1270.20. 1 hit.
3.40.1280.10. 1 hit.
HAMAPi MF_00605. TrmD.
InterProi IPR029028. Alpha/beta_knot_MTases.
IPR002649. tRNA_m1G_MeTrfase_bac.
IPR023148. tRNA_m1G_MeTrfase_C.
IPR029026. tRNA_m1G_MTases_N.
IPR016009. tRNA_MeTrfase_TRMD/TRM10.
[Graphical view ]
Pfami PF01746. tRNA_m1G_MT. 1 hit.
[Graphical view ]
PIRSFi PIRSF000386. tRNA_mtase. 1 hit.
SUPFAMi SSF75217. SSF75217. 1 hit.
TIGRFAMsi TIGR00088. trmD. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiTRMD_HELPY
AccessioniPrimary (citable) accession number: O25766
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3