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O25766

- TRMD_HELPY

UniProt

O25766 - TRMD_HELPY

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Protein
tRNA (guanine-N(1)-)-methyltransferase
Gene
trmD, HP_1148
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Specifically methylates guanosine-37 in various tRNAs By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei109 – 1091S-adenosyl-L-methionine; via amide nitrogen By similarity

GO - Molecular functioni

  1. tRNA (guanine(37)-N(1))-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciHPY:HP1148-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(1)-)-methyltransferase (EC:2.1.1.228)
Alternative name(s):
M1G-methyltransferase
tRNA [GM37] methyltransferase
Gene namesi
Name:trmD
Ordered Locus Names:HP_1148
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229tRNA (guanine-N(1)-)-methyltransferaseUniRule annotation
PRO_0000060388Add
BLAST

Proteomic databases

PRIDEiO25766.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

DIPiDIP-3681N.
IntActiO25766. 4 interactions.
MINTiMINT-179982.
STRINGi85962.HP1148.

Structurei

3D structure databases

ProteinModelPortaliO25766.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni129 – 1346S-adenosyl-L-methionine binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0336.
KOiK00554.
OMAiEQSRMIT.
OrthoDBiEOG6J48RZ.

Family and domain databases

Gene3Di1.10.1270.20. 1 hit.
3.40.1280.10. 1 hit.
HAMAPiMF_00605. TrmD.
InterProiIPR029028. Alpha/beta_knot_MTases.
IPR002649. tRNA_m1G_MeTrfase_bac.
IPR023148. tRNA_m1G_MeTrfase_C.
IPR029026. tRNA_m1G_MTases_N.
IPR016009. tRNA_MeTrfase_TRMD/TRM10.
[Graphical view]
PfamiPF01746. tRNA_m1G_MT. 1 hit.
[Graphical view]
PIRSFiPIRSF000386. tRNA_mtase. 1 hit.
SUPFAMiSSF75217. SSF75217. 1 hit.
TIGRFAMsiTIGR00088. trmD. 1 hit.

Sequencei

Sequence statusi: Complete.

O25766-1 [UniParc]FASTAAdd to Basket

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MKFSVLTLFP QLVWPYFEDS ILKRALEKNL FELEVLNLRD FSANKYQKAD    50
HTLIGGGAGQ ILDPEMVENA LHSVKNPKHT IFLSAVGKPF KQTDAMRLAQ 100
KKHVVLVCGR YEGFDERSIE LGADEVFCIG DFILTGGELG ALCLIDSIAR 150
HIQGVLGNAQ SLENESFENH YLEAPNFANA VFKSKEINKI PAPLEYSKGN 200
HAKIKQLKLD LSKLRTKFYR LDLFKQHKS 229
Length:229
Mass (Da):25,879
Last modified:January 1, 1998 - v1
Checksum:i2D7135818A13D822
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08192.1.
PIRiD64663.
RefSeqiNP_207939.1. NC_000915.1.
YP_006935064.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08192; AAD08192; HP_1148.
GeneIDi13870343.
899686.
KEGGiheo:C694_05930.
hpy:HP1148.
PATRICi20593647. VBIHelPyl33062_1202.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08192.1 .
PIRi D64663.
RefSeqi NP_207939.1. NC_000915.1.
YP_006935064.1. NC_018939.1.

3D structure databases

ProteinModelPortali O25766.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-3681N.
IntActi O25766. 4 interactions.
MINTi MINT-179982.
STRINGi 85962.HP1148.

Proteomic databases

PRIDEi O25766.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD08192 ; AAD08192 ; HP_1148 .
GeneIDi 13870343.
899686.
KEGGi heo:C694_05930.
hpy:HP1148.
PATRICi 20593647. VBIHelPyl33062_1202.

Phylogenomic databases

eggNOGi COG0336.
KOi K00554.
OMAi EQSRMIT.
OrthoDBi EOG6J48RZ.

Enzyme and pathway databases

BioCyci HPY:HP1148-MONOMER.

Family and domain databases

Gene3Di 1.10.1270.20. 1 hit.
3.40.1280.10. 1 hit.
HAMAPi MF_00605. TrmD.
InterProi IPR029028. Alpha/beta_knot_MTases.
IPR002649. tRNA_m1G_MeTrfase_bac.
IPR023148. tRNA_m1G_MeTrfase_C.
IPR029026. tRNA_m1G_MTases_N.
IPR016009. tRNA_MeTrfase_TRMD/TRM10.
[Graphical view ]
Pfami PF01746. tRNA_m1G_MT. 1 hit.
[Graphical view ]
PIRSFi PIRSF000386. tRNA_mtase. 1 hit.
SUPFAMi SSF75217. SSF75217. 1 hit.
TIGRFAMsi TIGR00088. trmD. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiTRMD_HELPY
AccessioniPrimary (citable) accession number: O25766
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi