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O25748

- SLYD_HELPY

UniProt

O25748 - SLYD_HELPY

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Protein

FKBP-type peptidyl-prolyl cis-trans isomerase SlyD

Gene

slyD

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Folding helper with both chaperone and peptidyl-prolyl cis-trans isomerase (PPIase) activities. Chaperone activity prevents aggregation of unfolded or partially folded proteins and promotes their correct folding. PPIases catalyze the cis-trans isomerization of Xaa-Pro bonds of peptides, which accelerates slow steps of protein folding and thus shortens the lifetime of intermediates. Both strategies lower the concentration of intermediates and increase the productivity and yield of the folding reaction (By similarity).By similarity
Also involved in hydrogenase metallocenter assembly, probably by participating in the nickel insertion step. This function in hydrogenase biosynthesis requires chaperone activity and the presence of the metal-binding domain, but not PPIase activity (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW

GO - Biological processi

  1. protein folding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone, Isomerase, Rotamase

Keywords - Ligandi

Metal-binding, Nickel

Enzyme and pathway databases

BioCyciHPY:HP1123-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
FKBP-type peptidyl-prolyl cis-trans isomerase SlyD (EC:5.2.1.8)
Short name:
PPIase
Alternative name(s):
Metallochaperone SlyD
Gene namesi
Name:slyD
Ordered Locus Names:HP_1123
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185FKBP-type peptidyl-prolyl cis-trans isomerase SlyDPRO_0000075359Add
BLAST

Proteomic databases

PRIDEiO25748.

Interactioni

Protein-protein interaction databases

STRINGi85962.HP1123.

Structurei

Secondary structure

1
185
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi12 – 2312Combined sources
Beta strandi27 – 315Combined sources
Turni32 – 343Combined sources
Beta strandi37 – 404Combined sources
Helixi48 – 547Combined sources
Beta strandi62 – 676Combined sources
Turni69 – 735Combined sources
Beta strandi80 – 856Combined sources
Helixi86 – 894Combined sources
Beta strandi99 – 1046Combined sources
Turni105 – 1073Combined sources
Beta strandi108 – 11710Combined sources
Beta strandi119 – 1268Combined sources
Beta strandi135 – 14511Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KR7NMR-A1-151[»]
ProteinModelPortaliO25748.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO25748.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 9999PPIase FKBP-typePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 7474PPIase first partBy similarityAdd
BLAST
Regioni81 – 12545IF-chaperoneBy similarityAdd
BLAST
Regioni134 – 15623PPIase second partBy similarityAdd
BLAST
Regioni157 – 18529Metal-bindingBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi158 – 18528Gly-richAdd
BLAST

Domaini

The N-terminal region consists of two globular folded domains that contain prolyl isomerase and chaperone activities.By similarity
The C-terminal region binds nickel ions.By similarity

Sequence similaritiesi

Belongs to the FKBP-type PPIase family.Curated
Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1047.
KOiK03775.
OMAiTEDHQTI.
OrthoDBiEOG6Q8J79.

Family and domain databases

InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O25748-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQNHDLESIK QAALIEYEVR EQGSSIVLDS NISKEPLEFI IGTNQIIAGL
60 70 80 90 100
EKAVLKAQIG EWEEVVIAPE EAYGVYESSY LQEVPRDQFE GIELEKGMSV
110 120 130 140 150
FGQTEDNQTI QAIIKDFSAT HVMVDYNHPL AGKTLAFRFK VLGFREVSEE
160 170 180
EILASHHGGG TGCCGGHGGH GGKKGGGCGC SCSHG
Length:185
Mass (Da):19,997
Last modified:January 1, 1998 - v1
Checksum:i26D0D84D771997FF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08168.1.
PIRiC64660.
RefSeqiNP_207914.1. NC_000915.1.
WP_001179304.1. NC_018939.1.
YP_006935040.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08168; AAD08168; HP_1123.
GeneIDi13870318.
899660.
KEGGiheo:C694_05800.
hpy:HP1123.
PATRICi20593591. VBIHelPyl33062_1175.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08168.1 .
PIRi C64660.
RefSeqi NP_207914.1. NC_000915.1.
WP_001179304.1. NC_018939.1.
YP_006935040.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2KR7 NMR - A 1-151 [» ]
ProteinModelPortali O25748.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 85962.HP1123.

Proteomic databases

PRIDEi O25748.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD08168 ; AAD08168 ; HP_1123 .
GeneIDi 13870318.
899660.
KEGGi heo:C694_05800.
hpy:HP1123.
PATRICi 20593591. VBIHelPyl33062_1175.

Phylogenomic databases

eggNOGi COG1047.
KOi K03775.
OMAi TEDHQTI.
OrthoDBi EOG6Q8J79.

Enzyme and pathway databases

BioCyci HPY:HP1123-MONOMER.

Miscellaneous databases

EvolutionaryTracei O25748.

Family and domain databases

InterProi IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view ]
PANTHERi PTHR10516. PTHR10516. 1 hit.
Pfami PF00254. FKBP_C. 1 hit.
[Graphical view ]
PROSITEi PS50059. FKBP_PPIASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiSLYD_HELPY
AccessioniPrimary (citable) accession number: O25748
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3