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Protein
Submitted name:

Gamma-glutamyltranspeptidase (Ggt)

Gene

HP_1118

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • glutathione metabolic process Source: InterPro
  • negative regulation of cell cycle G1/S phase transition Source: CACAO
  • negative regulation of T cell proliferation Source: CACAO
  • positive regulation of interleukin-8 production Source: CACAO
Complete GO annotation...

Enzyme and pathway databases

BioCyciHPY:HP1118-MONOMER.
BRENDAi3.4.19.13. 2604.

Names & Taxonomyi

Protein namesi
Submitted name:
Gamma-glutamyltranspeptidase (Ggt)Imported
Gene namesi
Ordered Locus Names:HP_1118Imported
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)Imported
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

PTM / Processingi

Proteomic databases

PaxDbiO25743.
PRIDEiO25743.

Interactioni

Protein-protein interaction databases

DIPiDIP-3652N.
IntActiO25743. 11 interactors.
MINTiMINT-160568.
STRINGi85962.HP1118.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NQOX-ray1.90A/C27-379[»]
B/D380-567[»]
2QM6X-ray1.60A/C25-379[»]
B/D380-567[»]
2QMCX-ray1.55A/C25-379[»]
B/D380-567[»]
3FNMX-ray1.70A/C25-379[»]
B/D380-567[»]
5BPKX-ray1.49A/B1-379[»]
C/D380-567[»]
ProteinModelPortaliO25743.
SMRiO25743.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4105CFB. Bacteria.
COG0405. LUCA.
KOiK00681.
OMAiSFEYTYD.

Family and domain databases

InterProiIPR000101. GGT_peptidase.
IPR029055. Ntn_hydrolases_N.
[Graphical view]
PANTHERiPTHR11686. PTHR11686. 1 hit.
PfamiPF01019. G_glu_transpept. 1 hit.
[Graphical view]
PRINTSiPR01210. GGTRANSPTASE.
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR00066. g_glut_trans. 1 hit.
PROSITEiPS00462. G_GLU_TRANSPEPTIDASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O25743-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRSFLKTIG LGVIALFLGL LNPLSAASYP PIKNTKVGLA LSSHPLASEI
60 70 80 90 100
GQKVLEEGGN AIDAAVAIGF ALAVVHPAAG NIGGGGFAVI HLANGENVAL
110 120 130 140 150
DFREKAPLKA TKNMFLDKQG NVVPKLSEDG YLAAGVPGTV AGMEAMLKKY
160 170 180 190 200
GTKKLSQLID PAIKLAENGY AISQRQAETL KEARERFLKY SSSKKYFFKK
210 220 230 240 250
GHLDYQEGDL FVQKDLAKTL NQIKTLGAKG FYQGQVAELI EKDMKKNGGI
260 270 280 290 300
ITKEDLASYN VKWRKPVVGS YRGYKIISMS PPSSGGTHLI QILNVMENAD
310 320 330 340 350
LSALGYGASK NIHIAAEAMR QAYADRSVYM GDADFVSVPV DKLINKAYAK
360 370 380 390 400
KIFDTIQPDT VTPSSQIKPG MGQLHEGSNT THYSVADRWG NAVSVTYTIN
410 420 430 440 450
ASYGSAASID GAGFLLNNEM DDFSIKPGNP NLYGLVGGDA NAIEANKRPL
460 470 480 490 500
SSMSPTIVLK NNKVFLVVGS PGGSRIITTV LQVISNVIDY NMNISEAVSA
510 520 530 540 550
PRFHMQWLPD ELRIEKFGMP ADVKDNLTKM GYQIVTKPVM GDVNAIQVLP
560
KTKGSVFYGS TDPRKEF
Length:567
Mass (Da):61,151
Last modified:January 1, 1998 - v1
Checksum:i9A5B4E06B6B8967F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08162.1.
PIRiF64659.
RefSeqiNP_207909.1. NC_000915.1.
WP_001254471.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08162; AAD08162; HP_1118.
GeneIDi899655.
KEGGiheo:C694_05770.
hpy:HP1118.
PATRICi20593579. VBIHelPyl33062_1169.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08162.1.
PIRiF64659.
RefSeqiNP_207909.1. NC_000915.1.
WP_001254471.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NQOX-ray1.90A/C27-379[»]
B/D380-567[»]
2QM6X-ray1.60A/C25-379[»]
B/D380-567[»]
2QMCX-ray1.55A/C25-379[»]
B/D380-567[»]
3FNMX-ray1.70A/C25-379[»]
B/D380-567[»]
5BPKX-ray1.49A/B1-379[»]
C/D380-567[»]
ProteinModelPortaliO25743.
SMRiO25743.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3652N.
IntActiO25743. 11 interactors.
MINTiMINT-160568.
STRINGi85962.HP1118.

Proteomic databases

PaxDbiO25743.
PRIDEiO25743.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08162; AAD08162; HP_1118.
GeneIDi899655.
KEGGiheo:C694_05770.
hpy:HP1118.
PATRICi20593579. VBIHelPyl33062_1169.

Phylogenomic databases

eggNOGiENOG4105CFB. Bacteria.
COG0405. LUCA.
KOiK00681.
OMAiSFEYTYD.

Enzyme and pathway databases

BioCyciHPY:HP1118-MONOMER.
BRENDAi3.4.19.13. 2604.

Family and domain databases

InterProiIPR000101. GGT_peptidase.
IPR029055. Ntn_hydrolases_N.
[Graphical view]
PANTHERiPTHR11686. PTHR11686. 1 hit.
PfamiPF01019. G_glu_transpept. 1 hit.
[Graphical view]
PRINTSiPR01210. GGTRANSPTASE.
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR00066. g_glut_trans. 1 hit.
PROSITEiPS00462. G_GLU_TRANSPEPTIDASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO25743_HELPY
AccessioniPrimary (citable) accession number: O25743
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.