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Protein

6-phosphogluconolactonase

Gene

pgl

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Pathwayi

GO - Molecular functioni

  1. 6-phosphogluconolactonase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciHPY:HP1102-MONOMER.
UniPathwayiUPA00115; UER00409.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonase (EC:3.1.1.31)
Short name:
6PGL
Gene namesi
Name:pgl
Synonyms:devB
Ordered Locus Names:HP_1102
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2272276-phosphogluconolactonasePRO_0000090095Add
BLAST

Proteomic databases

PRIDEiO25730.

Interactioni

Protein-protein interaction databases

DIPiDIP-3651N.
IntActiO25730. 3 interactions.
MINTiMINT-159493.
STRINGi85962.HP1102.

Structurei

3D structure databases

ProteinModelPortaliO25730.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0363.
KOiK01057.
OMAiQGQSKLA.
OrthoDBiEOG63FW46.

Family and domain databases

InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.

Sequencei

Sequence statusi: Complete.

O25730-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGYQLFEFEN LKDCHKALTE RFKEFFNTAL KKHHQISIAF SGGRSPISLL
60 70 80 90 100
QKLSVLNLKW HECLISLVDE RIIDTSHDDS NTKLLHDYLL QNNALKASFI
110 120 130 140 150
PLLPEKISSD TNALFNFANQ HFKQPHLAIL GMGTDGHTAS LFPETSAFLN
160 170 180 190 200
EEKENIVLTK PINAPYERLS MSVNALENCE KLFLSISGVE KRGVLEKALK
210 220
ENAPYSLPIA RILHSQKVTT EVFYAKN
Length:227
Mass (Da):25,728
Last modified:January 1, 1998 - v1
Checksum:iB2592B35B63971A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08145.1.
PIRiF64657.
RefSeqiNP_207893.1. NC_000915.1.
YP_006935017.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08145; AAD08145; HP_1102.
GeneIDi13870295.
899638.
KEGGiheo:C694_05685.
hpy:HP1102.
PATRICi20593543. VBIHelPyl33062_1151.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08145.1.
PIRiF64657.
RefSeqiNP_207893.1. NC_000915.1.
YP_006935017.1. NC_018939.1.

3D structure databases

ProteinModelPortaliO25730.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3651N.
IntActiO25730. 3 interactions.
MINTiMINT-159493.
STRINGi85962.HP1102.

Proteomic databases

PRIDEiO25730.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08145; AAD08145; HP_1102.
GeneIDi13870295.
899638.
KEGGiheo:C694_05685.
hpy:HP1102.
PATRICi20593543. VBIHelPyl33062_1151.

Phylogenomic databases

eggNOGiCOG0363.
KOiK01057.
OMAiQGQSKLA.
OrthoDBiEOG63FW46.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409.
BioCyciHPY:HP1102-MONOMER.

Family and domain databases

InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry namei6PGL_HELPY
AccessioniPrimary (citable) accession number: O25730
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: March 4, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.