O25730 (6PGL_HELPY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
6-phosphogluconolactonase
Short name=6PGL
EC=3.1.1.31

Gene names

Name:	pgl
Synonyms:	devB
Ordered Locus Names:	HP_1102

Organism

Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)

Taxonomic identifier

85962 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
Catalytic activity	6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.
Sequence similarities	Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	pentose-phosphate shunt Inferred from electronic annotation. Source: InterPro
Molecular function	6-phosphogluconolactonase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 227	227	6-phosphogluconolactonase		PRO_0000090095

Sequences

	Sequence		Length	Mass (Da)
	O25730 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: B2592B35B63971A6	FASTA	227	25,728
	10 20 30 40 50 60 MGYQLFEFEN LKDCHKALTE RFKEFFNTAL KKHHQISIAF SGGRSPISLL QKLSVLNLKW 70 80 90 100 110 120 HECLISLVDE RIIDTSHDDS NTKLLHDYLL QNNALKASFI PLLPEKISSD TNALFNFANQ 130 140 150 160 170 180 HFKQPHLAIL GMGTDGHTAS LFPETSAFLN EEKENIVLTK PINAPYERLS MSVNALENCE 190 200 210 220 KLFLSISGVE KRGVLEKALK ENAPYSLPIA RILHSQKVTT EVFYAKN

References

[1]

"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed: 9252185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000511 Genomic DNA. Translation: AAD08145.1.
PIR	F64657.
RefSeq	NP_207893.1. NC_000915.1.
3D structure databases
ProteinModelPortal	O25730.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-3651N.
MINT	MINT-159493.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	899638.
GenomeReviews	Gene locus HP_1102 in contig AE000511_GR.
KEGG	hpy:HP1102.
NMPDR	fig|85962.1.peg.1089.
PATRIC	20593543. VBIHelPyl33062_1151.
TIGR	HP_1102.
Phylogenomic databases
HOGENOM	HBG725991.
OMA	NAPYERL.
ProtClustDB	CLSK872499.
Family and domain databases
InterPro	IPR005900. 6-phosphogluconolactonase_DevB. IPR006148. Glc/Gal-6P_isomerase. [Graphical view]
KO	K01057.
Pfam	PF01182. Glucosamine_iso. 1 hit. [Graphical view]
TIGRFAMs	TIGR01198. Pgl. 1 hit.
ProtoNet	Search...

Entry information

Entry name

6PGL_HELPY

Accession

Primary (citable) accession number: O25730

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 1, 1998
Last modified:	January 25, 2012
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program