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O25728

- HCPC_HELPY

UniProt

O25728 - HCPC_HELPY

Protein

Putative beta-lactamase HcpC

Gene

hcpC

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    May hydrolyze 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives.By similarity

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.

    GO - Molecular functioni

    1. beta-lactamase activity Source: UniProtKB-EC

    GO - Biological processi

    1. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance

    Enzyme and pathway databases

    BioCyciHPY:HP1098-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative beta-lactamase HcpC (EC:3.5.2.6)
    Alternative name(s):
    Cysteine-rich protein C
    Gene namesi
    Name:hcpC
    Ordered Locus Names:HP_1098
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 290265Putative beta-lactamase HcpCPRO_0000013196Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi56 ↔ 641 Publication
    Disulfide bondi92 ↔ 1001 Publication
    Disulfide bondi128 ↔ 1361 Publication
    Disulfide bondi164 ↔ 1721 Publication
    Disulfide bondi200 ↔ 2081 Publication
    Disulfide bondi236 ↔ 2441 Publication
    Disulfide bondi272 ↔ 2801 Publication

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiO25728.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-3502N.
    IntActiO25728. 1 interaction.
    MINTiMINT-164700.
    STRINGi85962.HP1098.

    Structurei

    Secondary structure

    1
    290
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi29 – 4113
    Helixi45 – 5713
    Helixi61 – 7313
    Beta strandi75 – 773
    Helixi81 – 9313
    Helixi97 – 10913
    Beta strandi111 – 1133
    Helixi117 – 12913
    Helixi133 – 14513
    Beta strandi147 – 1493
    Helixi153 – 16513
    Helixi169 – 18113
    Beta strandi183 – 1853
    Helixi189 – 20113
    Helixi205 – 21713
    Helixi225 – 23713
    Helixi241 – 25212
    Beta strandi255 – 2584
    Helixi264 – 27411
    Helixi277 – 2848

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1OUVX-ray2.00A24-290[»]
    ProteinModelPortaliO25728.
    SMRiO25728. Positions 28-290.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO25728.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati29 – 6234TPR 1Add
    BLAST
    Repeati64 – 9835TPR 2Add
    BLAST
    Repeati100 – 13334TPR 3Add
    BLAST
    Repeati134 – 17037TPR 4Add
    BLAST
    Repeati172 – 20534TPR 5Add
    BLAST
    Repeati206 – 24237TPR 6Add
    BLAST
    Repeati244 – 27835TPR 7Add
    BLAST

    Sequence similaritiesi

    Belongs to the hcp beta-lactamase family.Curated
    Contains 7 TPR repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, TPR repeat

    Phylogenomic databases

    eggNOGiCOG0790.
    KOiK07126.
    OMAiKDFTQAK.
    OrthoDBiEOG6TJ7WZ.

    Family and domain databases

    Gene3Di1.25.40.10. 1 hit.
    InterProiIPR006597. Sel1-like.
    IPR011990. TPR-like_helical.
    IPR013105. TPR_2.
    IPR019734. TPR_repeat.
    [Graphical view]
    PfamiPF08238. Sel1. 6 hits.
    PF07719. TPR_2. 1 hit.
    [Graphical view]
    SMARTiSM00671. SEL1. 7 hits.
    [Graphical view]
    PROSITEiPS50005. TPR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O25728-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLENVKKSFF RVLCLGALCL GGLMAEQDPK ELVGLGAKSY KEKDFTQAKK    50
    YFEKACDLKE NSGCFNLGVL YYQGQGVEKN LKKAASFYAK ACDLNYSNGC 100
    HLLGNLYYSG QGVSQNTNKA LQYYSKACDL KYAEGCASLG GIYHDGKVVT 150
    RDFKKAVEYF TKACDLNDGD GCTILGSLYD AGRGTPKDLK KALASYDKAC 200
    DLKDSPGCFN AGNMYHHGEG ATKNFKEALA RYSKACELEN GGGCFNLGAM 250
    QYNGEGVTRN EKQAIENFKK GCKLGAKGAC DILKQLKIKV 290
    Length:290
    Mass (Da):31,594
    Last modified:January 1, 1998 - v1
    Checksum:i0F0CFD779A6F108E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08141.1.
    PIRiB64657.
    RefSeqiNP_207889.1. NC_000915.1.
    YP_006935013.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD08141; AAD08141; HP_1098.
    GeneIDi13870291.
    899634.
    KEGGiheo:C694_05665.
    hpy:HP1098.
    PATRICi20593535. VBIHelPyl33062_1147.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08141.1 .
    PIRi B64657.
    RefSeqi NP_207889.1. NC_000915.1.
    YP_006935013.1. NC_018939.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1OUV X-ray 2.00 A 24-290 [» ]
    ProteinModelPortali O25728.
    SMRi O25728. Positions 28-290.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-3502N.
    IntActi O25728. 1 interaction.
    MINTi MINT-164700.
    STRINGi 85962.HP1098.

    Proteomic databases

    PRIDEi O25728.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD08141 ; AAD08141 ; HP_1098 .
    GeneIDi 13870291.
    899634.
    KEGGi heo:C694_05665.
    hpy:HP1098.
    PATRICi 20593535. VBIHelPyl33062_1147.

    Phylogenomic databases

    eggNOGi COG0790.
    KOi K07126.
    OMAi KDFTQAK.
    OrthoDBi EOG6TJ7WZ.

    Enzyme and pathway databases

    BioCyci HPY:HP1098-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei O25728.

    Family and domain databases

    Gene3Di 1.25.40.10. 1 hit.
    InterProi IPR006597. Sel1-like.
    IPR011990. TPR-like_helical.
    IPR013105. TPR_2.
    IPR019734. TPR_repeat.
    [Graphical view ]
    Pfami PF08238. Sel1. 6 hits.
    PF07719. TPR_2. 1 hit.
    [Graphical view ]
    SMARTi SM00671. SEL1. 7 hits.
    [Graphical view ]
    PROSITEi PS50005. TPR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.
    2. Cited for: ANTIGENICITY.
    3. "Detection of high titers of antibody against Helicobacter cysteine-rich proteins A, B, C, and E in Helicobacter pylori-infected individuals."
      Mittl P.R.E., Luethy L., Reinhardt C., Joller H.
      Clin. Diagn. Lab. Immunol. 10:542-545(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: ANTIGENICITY.
    4. "The crystal structure of Helicobacter cysteine-rich protein C at 2.0 A resolution: similar peptide-binding sites in TPR and SEL1-like repeat proteins."
      Luethy L., Grutter M.G., Mittl P.R.E.
      J. Mol. Biol. 340:829-841(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 24-290, DISULFIDE BONDS.

    Entry informationi

    Entry nameiHCPC_HELPY
    AccessioniPrimary (citable) accession number: O25728
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 15, 2003
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Antibodies against HcpC are present in sera from human patients infected by Helicobacter pylori.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3