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O25728 (HCPC_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative beta-lactamase HcpC

EC=3.5.2.6
Alternative name(s):
Cysteine-rich protein C
Gene names
Name:hcpC
Ordered Locus Names:HP_1098
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length290 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May hydrolyze 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives By similarity.

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Subcellular location

Secreted Potential.

Miscellaneous

Antibodies against HcpC are present in sera from human patients infected by Helicobacter pylori.

Sequence similarities

Belongs to the hcp beta-lactamase family.

Contains 7 TPR repeats.

Ontologies

Keywords
   Biological processAntibiotic resistance
   Cellular componentSecreted
   DomainRepeat
Signal
TPR repeat
   Molecular functionHydrolase
   PTMDisulfide bond
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processresponse to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 290265Putative beta-lactamase HcpC
PRO_0000013196

Regions

Repeat29 – 6234TPR 1
Repeat64 – 9835TPR 2
Repeat100 – 13334TPR 3
Repeat134 – 17037TPR 4
Repeat172 – 20534TPR 5
Repeat206 – 24237TPR 6
Repeat244 – 27835TPR 7

Amino acid modifications

Disulfide bond56 ↔ 64 Ref.4
Disulfide bond92 ↔ 100 Ref.4
Disulfide bond128 ↔ 136 Ref.4
Disulfide bond164 ↔ 172 Ref.4
Disulfide bond200 ↔ 208 Ref.4
Disulfide bond236 ↔ 244 Ref.4
Disulfide bond272 ↔ 280 Ref.4

Secondary structure

......................................... 290
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O25728 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 0F0CFD779A6F108E

FASTA29031,594
        10         20         30         40         50         60 
MLENVKKSFF RVLCLGALCL GGLMAEQDPK ELVGLGAKSY KEKDFTQAKK YFEKACDLKE 

        70         80         90        100        110        120 
NSGCFNLGVL YYQGQGVEKN LKKAASFYAK ACDLNYSNGC HLLGNLYYSG QGVSQNTNKA 

       130        140        150        160        170        180 
LQYYSKACDL KYAEGCASLG GIYHDGKVVT RDFKKAVEYF TKACDLNDGD GCTILGSLYD 

       190        200        210        220        230        240 
AGRGTPKDLK KALASYDKAC DLKDSPGCFN AGNMYHHGEG ATKNFKEALA RYSKACELEN 

       250        260        270        280        290 
GGGCFNLGAM QYNGEGVTRN EKQAIENFKK GCKLGAKGAC DILKQLKIKV 

« Hide

References

« Hide 'large scale' references
[1]"The complete genome sequence of the gastric pathogen Helicobacter pylori."
Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. expand/collapse author list , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.
Nature 388:539-547(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700392 / 26695.
[2]"Immunoproteomics of Helicobacter pylori infection and relation to gastric disease."
Haas G., Karaali G., Ebermayer K., Metzger W.G., Lamer S., Zimny-Arndt U., Diescher S., Goebel U.B., Vogt K., Roznowski A.B., Wiedenmann B.J., Meyer T.F., Aebischer T., Jungblut P.R.
Proteomics 2:313-324(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: ANTIGENICITY.
[3]"Detection of high titers of antibody against Helicobacter cysteine-rich proteins A, B, C, and E in Helicobacter pylori-infected individuals."
Mittl P.R.E., Luethy L., Reinhardt C., Joller H.
Clin. Diagn. Lab. Immunol. 10:542-545(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: ANTIGENICITY.
[4]"The crystal structure of Helicobacter cysteine-rich protein C at 2.0 A resolution: similar peptide-binding sites in TPR and SEL1-like repeat proteins."
Luethy L., Grutter M.G., Mittl P.R.E.
J. Mol. Biol. 340:829-841(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 24-290, DISULFIDE BONDS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD08141.1.
PIRB64657.
RefSeqNP_207889.1. NC_000915.1.
YP_006935013.1. NC_018939.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1OUVX-ray2.00A24-290[»]
ProteinModelPortalO25728.
SMRO25728. Positions 28-290.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-3502N.
IntActO25728. 1 interaction.
MINTMINT-164700.
STRING85962.HP1098.

Proteomic databases

PRIDEO25728.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD08141; AAD08141; HP_1098.
GeneID899634.
KEGGheo:C694_05665.
hpy:HP1098.
PATRIC20593535. VBIHelPyl33062_1147.

Phylogenomic databases

eggNOGCOG0790.
KOK07126.
OMAKDFTQAK.
OrthoDBEOG6TJ7WZ.

Enzyme and pathway databases

BioCycHPY:HP1098-MONOMER.

Family and domain databases

Gene3D1.25.40.10. 1 hit.
InterProIPR006597. Sel1-like.
IPR011990. TPR-like_helical.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
[Graphical view]
PfamPF08238. Sel1. 6 hits.
PF07719. TPR_2. 1 hit.
[Graphical view]
SMARTSM00671. SEL1. 7 hits.
[Graphical view]
PROSITEPS50005. TPR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceO25728.

Entry information

Entry nameHCPC_HELPY
AccessionPrimary (citable) accession number: O25728
Entry history
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names