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O25728

- HCPC_HELPY

UniProt

O25728 - HCPC_HELPY

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Protein

Putative beta-lactamase HcpC

Gene

hcpC

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May hydrolyze 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives.By similarity

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Enzyme and pathway databases

BioCyciHPY:HP1098-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative beta-lactamase HcpC (EC:3.5.2.6)
Alternative name(s):
Cysteine-rich protein C
Gene namesi
Name:hcpC
Ordered Locus Names:HP_1098
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 290265Putative beta-lactamase HcpCPRO_0000013196Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi56 ↔ 641 Publication
Disulfide bondi92 ↔ 1001 Publication
Disulfide bondi128 ↔ 1361 Publication
Disulfide bondi164 ↔ 1721 Publication
Disulfide bondi200 ↔ 2081 Publication
Disulfide bondi236 ↔ 2441 Publication
Disulfide bondi272 ↔ 2801 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiO25728.

Interactioni

Protein-protein interaction databases

DIPiDIP-3502N.
IntActiO25728. 1 interaction.
MINTiMINT-164700.
STRINGi85962.HP1098.

Structurei

Secondary structure

1
290
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi29 – 4113Combined sources
Helixi45 – 5713Combined sources
Helixi61 – 7313Combined sources
Beta strandi75 – 773Combined sources
Helixi81 – 9313Combined sources
Helixi97 – 10913Combined sources
Beta strandi111 – 1133Combined sources
Helixi117 – 12913Combined sources
Helixi133 – 14513Combined sources
Beta strandi147 – 1493Combined sources
Helixi153 – 16513Combined sources
Helixi169 – 18113Combined sources
Beta strandi183 – 1853Combined sources
Helixi189 – 20113Combined sources
Helixi205 – 21713Combined sources
Helixi225 – 23713Combined sources
Helixi241 – 25212Combined sources
Beta strandi255 – 2584Combined sources
Helixi264 – 27411Combined sources
Helixi277 – 2848Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OUVX-ray2.00A24-290[»]
ProteinModelPortaliO25728.
SMRiO25728. Positions 28-290.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO25728.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati29 – 6234TPR 1Add
BLAST
Repeati64 – 9835TPR 2Add
BLAST
Repeati100 – 13334TPR 3Add
BLAST
Repeati134 – 17037TPR 4Add
BLAST
Repeati172 – 20534TPR 5Add
BLAST
Repeati206 – 24237TPR 6Add
BLAST
Repeati244 – 27835TPR 7Add
BLAST

Sequence similaritiesi

Belongs to the hcp beta-lactamase family.Curated
Contains 7 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, TPR repeat

Phylogenomic databases

eggNOGiCOG0790.
KOiK07126.
OMAiKDFTQAK.
OrthoDBiEOG6TJ7WZ.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR006597. Sel1-like.
IPR011990. TPR-like_helical_dom.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF08238. Sel1. 6 hits.
PF07719. TPR_2. 1 hit.
[Graphical view]
SMARTiSM00671. SEL1. 7 hits.
[Graphical view]
PROSITEiPS50005. TPR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O25728-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLENVKKSFF RVLCLGALCL GGLMAEQDPK ELVGLGAKSY KEKDFTQAKK
60 70 80 90 100
YFEKACDLKE NSGCFNLGVL YYQGQGVEKN LKKAASFYAK ACDLNYSNGC
110 120 130 140 150
HLLGNLYYSG QGVSQNTNKA LQYYSKACDL KYAEGCASLG GIYHDGKVVT
160 170 180 190 200
RDFKKAVEYF TKACDLNDGD GCTILGSLYD AGRGTPKDLK KALASYDKAC
210 220 230 240 250
DLKDSPGCFN AGNMYHHGEG ATKNFKEALA RYSKACELEN GGGCFNLGAM
260 270 280 290
QYNGEGVTRN EKQAIENFKK GCKLGAKGAC DILKQLKIKV
Length:290
Mass (Da):31,594
Last modified:January 1, 1998 - v1
Checksum:i0F0CFD779A6F108E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08141.1.
PIRiB64657.
RefSeqiNP_207889.1. NC_000915.1.
YP_006935013.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08141; AAD08141; HP_1098.
GeneIDi13870291.
899634.
KEGGiheo:C694_05665.
hpy:HP1098.
PATRICi20593535. VBIHelPyl33062_1147.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08141.1 .
PIRi B64657.
RefSeqi NP_207889.1. NC_000915.1.
YP_006935013.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1OUV X-ray 2.00 A 24-290 [» ]
ProteinModelPortali O25728.
SMRi O25728. Positions 28-290.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-3502N.
IntActi O25728. 1 interaction.
MINTi MINT-164700.
STRINGi 85962.HP1098.

Proteomic databases

PRIDEi O25728.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD08141 ; AAD08141 ; HP_1098 .
GeneIDi 13870291.
899634.
KEGGi heo:C694_05665.
hpy:HP1098.
PATRICi 20593535. VBIHelPyl33062_1147.

Phylogenomic databases

eggNOGi COG0790.
KOi K07126.
OMAi KDFTQAK.
OrthoDBi EOG6TJ7WZ.

Enzyme and pathway databases

BioCyci HPY:HP1098-MONOMER.

Miscellaneous databases

EvolutionaryTracei O25728.

Family and domain databases

Gene3Di 1.25.40.10. 1 hit.
InterProi IPR006597. Sel1-like.
IPR011990. TPR-like_helical_dom.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
[Graphical view ]
Pfami PF08238. Sel1. 6 hits.
PF07719. TPR_2. 1 hit.
[Graphical view ]
SMARTi SM00671. SEL1. 7 hits.
[Graphical view ]
PROSITEi PS50005. TPR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.
  2. Cited for: ANTIGENICITY.
  3. "Detection of high titers of antibody against Helicobacter cysteine-rich proteins A, B, C, and E in Helicobacter pylori-infected individuals."
    Mittl P.R.E., Luethy L., Reinhardt C., Joller H.
    Clin. Diagn. Lab. Immunol. 10:542-545(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: ANTIGENICITY.
  4. "The crystal structure of Helicobacter cysteine-rich protein C at 2.0 A resolution: similar peptide-binding sites in TPR and SEL1-like repeat proteins."
    Luethy L., Grutter M.G., Mittl P.R.E.
    J. Mol. Biol. 340:829-841(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 24-290, DISULFIDE BONDS.

Entry informationi

Entry nameiHCPC_HELPY
AccessioniPrimary (citable) accession number: O25728
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Antibodies against HcpC are present in sera from human patients infected by Helicobacter pylori.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3