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Protein

Putative beta-lactamase HcpC

Gene

hcpC

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May hydrolyze 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives.By similarity

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Enzyme and pathway databases

BioCyciHPY:HP1098-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative beta-lactamase HcpC (EC:3.5.2.6)
Alternative name(s):
Cysteine-rich protein C
Gene namesi
Name:hcpC
Ordered Locus Names:HP_1098
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000001319626 – 290Putative beta-lactamase HcpCAdd BLAST265

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi56 ↔ 641 Publication
Disulfide bondi92 ↔ 1001 Publication
Disulfide bondi128 ↔ 1361 Publication
Disulfide bondi164 ↔ 1721 Publication
Disulfide bondi200 ↔ 2081 Publication
Disulfide bondi236 ↔ 2441 Publication
Disulfide bondi272 ↔ 2801 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO25728.

Interactioni

Protein-protein interaction databases

DIPiDIP-3502N.
IntActiO25728. 1 interactor.
MINTiMINT-164700.
STRINGi85962.HP1098.

Structurei

Secondary structure

1290
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi29 – 41Combined sources13
Helixi45 – 57Combined sources13
Helixi61 – 73Combined sources13
Beta strandi75 – 77Combined sources3
Helixi81 – 93Combined sources13
Helixi97 – 109Combined sources13
Beta strandi111 – 113Combined sources3
Helixi117 – 129Combined sources13
Helixi133 – 145Combined sources13
Beta strandi147 – 149Combined sources3
Helixi153 – 165Combined sources13
Helixi169 – 181Combined sources13
Beta strandi183 – 185Combined sources3
Helixi189 – 201Combined sources13
Helixi205 – 217Combined sources13
Helixi225 – 237Combined sources13
Helixi241 – 252Combined sources12
Beta strandi255 – 258Combined sources4
Helixi264 – 274Combined sources11
Helixi277 – 284Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OUVX-ray2.00A24-290[»]
ProteinModelPortaliO25728.
SMRiO25728.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO25728.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati29 – 62TPR 1Add BLAST34
Repeati64 – 98TPR 2Add BLAST35
Repeati100 – 133TPR 3Add BLAST34
Repeati134 – 170TPR 4Add BLAST37
Repeati172 – 205TPR 5Add BLAST34
Repeati206 – 242TPR 6Add BLAST37
Repeati244 – 278TPR 7Add BLAST35

Sequence similaritiesi

Belongs to the hcp beta-lactamase family.Curated
Contains 7 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, TPR repeat

Phylogenomic databases

eggNOGiENOG4105EUU. Bacteria.
COG0790. LUCA.
KOiK07126.
OMAiKKQAFYW.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR006597. Sel1-like.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF08238. Sel1. 7 hits.
[Graphical view]
SMARTiSM00671. SEL1. 7 hits.
SM00028. TPR. 3 hits.
[Graphical view]
PROSITEiPS50005. TPR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O25728-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLENVKKSFF RVLCLGALCL GGLMAEQDPK ELVGLGAKSY KEKDFTQAKK
60 70 80 90 100
YFEKACDLKE NSGCFNLGVL YYQGQGVEKN LKKAASFYAK ACDLNYSNGC
110 120 130 140 150
HLLGNLYYSG QGVSQNTNKA LQYYSKACDL KYAEGCASLG GIYHDGKVVT
160 170 180 190 200
RDFKKAVEYF TKACDLNDGD GCTILGSLYD AGRGTPKDLK KALASYDKAC
210 220 230 240 250
DLKDSPGCFN AGNMYHHGEG ATKNFKEALA RYSKACELEN GGGCFNLGAM
260 270 280 290
QYNGEGVTRN EKQAIENFKK GCKLGAKGAC DILKQLKIKV
Length:290
Mass (Da):31,594
Last modified:January 1, 1998 - v1
Checksum:i0F0CFD779A6F108E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08141.1.
PIRiB64657.
RefSeqiNP_207889.1. NC_000915.1.
WP_000892717.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08141; AAD08141; HP_1098.
GeneIDi899634.
KEGGiheo:C694_05665.
hpy:HP1098.
PATRICi20593535. VBIHelPyl33062_1147.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08141.1.
PIRiB64657.
RefSeqiNP_207889.1. NC_000915.1.
WP_000892717.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OUVX-ray2.00A24-290[»]
ProteinModelPortaliO25728.
SMRiO25728.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3502N.
IntActiO25728. 1 interactor.
MINTiMINT-164700.
STRINGi85962.HP1098.

Proteomic databases

PaxDbiO25728.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08141; AAD08141; HP_1098.
GeneIDi899634.
KEGGiheo:C694_05665.
hpy:HP1098.
PATRICi20593535. VBIHelPyl33062_1147.

Phylogenomic databases

eggNOGiENOG4105EUU. Bacteria.
COG0790. LUCA.
KOiK07126.
OMAiKKQAFYW.

Enzyme and pathway databases

BioCyciHPY:HP1098-MONOMER.

Miscellaneous databases

EvolutionaryTraceiO25728.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR006597. Sel1-like.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF08238. Sel1. 7 hits.
[Graphical view]
SMARTiSM00671. SEL1. 7 hits.
SM00028. TPR. 3 hits.
[Graphical view]
PROSITEiPS50005. TPR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHCPC_HELPY
AccessioniPrimary (citable) accession number: O25728
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Antibodies against HcpC are present in sera from human patients infected by Helicobacter pylori.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.