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O25722

- FTSK_HELPY

UniProt

O25722 - FTSK_HELPY

Protein

DNA translocase FtsK

Gene

ftsK

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi552 – 5576ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. chromosome segregation Source: UniProtKB-KW

    Keywords - Biological processi

    Cell cycle, Cell division, Chromosome partition

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHPY:HP1090-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA translocase FtsK
    Gene namesi
    Name:ftsK
    Ordered Locus Names:HP_1090
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    Subcellular locationi

    Cell inner membrane By similarity; Multi-pass membrane protein By similarity
    Note: Located at the septum.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 858858DNA translocase FtsKPRO_0000098262Add
    BLAST

    Proteomic databases

    PRIDEiO25722.

    Interactioni

    Subunit structurei

    Homohexamer. Forms a ring that surrounds DNA By similarity.By similarity

    Protein-protein interaction databases

    STRINGi85962.HP1090.

    Structurei

    3D structure databases

    ProteinModelPortaliO25722.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini137 – 858722CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 2921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei48 – 6821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei74 – 9421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei116 – 13621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini532 – 722191FtsKPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains multimerise to produce a hexameric ring, contain the nucleotide binding motif and form the DNA pump. The gamma subdomain is a regulatory subdomain that controls translocation of DNA by recognition of KOPS motifs and interacts with XerD recombinase By similarity.By similarity

    Sequence similaritiesi

    Belongs to the FtsK/SpoIIIE/SftA family.Curated
    Contains 1 FtsK domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1674.
    KOiK03466.
    OMAiCAESIRI.
    OrthoDBiEOG6S52GD.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR002543. FtsK_dom.
    IPR018541. Ftsk_gamma.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF09397. Ftsk_gamma. 1 hit.
    PF01580. FtsK_SpoIIIE. 1 hit.
    [Graphical view]
    SMARTiSM00843. Ftsk_gamma. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS50901. FTSK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O25722-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQPMKSKKLY LALIIGVLLA FLTLSSWLGN SGLVGRFGVW FAALNKKYFG    50
    HLSFINLPYL AWVLFLLYKT KNPFTEIVLE KTLGHLLGIL SLLFLQSSLL 100
    NQGEIGNSAR LFLRPFIGDF GLYALITLMV VISYLILFKL PPKSVFYPYM 150
    NKTQNLLKEI YKQCLQAFSP NFSPKKEGFE NTPSDIQKKE TKNDKEKENR 200
    KENPINENHK TPNEEPFLAI PTPYNTTLND SEPQEGLVQI SSHPPTHYTI 250
    YPKRNRFDDL TNPTNPPLKE IKQETKEREP TPTKETLTPT TPKPIMPTLA 300
    PIIENDNKTE NQKTPNHPKK EENPQENTQE EMIEGRIEEM IKENLKKEEK 350
    EVQNAPNFSP VTPTSAKKPV MVKELSENKE ILDGLDYGEV QKPKDYELPT 400
    TQLLNAVCLK DTSLDENEID QKIQDLLSKL RTFKIDGDII RTYSGPIVTT 450
    FEFRPAPNVK VSRILGLSDD LAMTLCAESI RIQAPIKGKD VVGIEIPNSQ 500
    SQIIYLREIL ESELFQKSSS PLTLALGKDI VGNPFITDLK KLPHLLIAGT 550
    TGSGKSVGVN AMILSLLYKN PPDQLKLVMI DPKMVEFSIY ADIPHLLTPI 600
    ITDPKKAIGA LQSVAKEMER RYSLMSEYKV KTIDSYNEQA PSNGVEAFPY 650
    LIVVIDELAD LMMTGGKEAE FPIARIAQMG RASGLHLIVA TQRPSVDVVT 700
    GLIKTNLPSR VSFRVGTKID SKVILDTDGA QSLLGRGDML FTPPGANGLV 750
    RLHAPFATED EIKKIVDFIK AQKEVQYDKD FLLEESRMPL DTPNYQGDDI 800
    LERAKAVILE KKITSTSFLQ RQLKIGYNQA ATITDELEAQ GFLSPRNAKG 850
    NREILQNF 858
    Length:858
    Mass (Da):96,445
    Last modified:January 1, 1998 - v1
    Checksum:i273C6384DB36B377
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08132.1.
    PIRiB64656.
    RefSeqiNP_207881.1. NC_000915.1.

    Genome annotation databases

    EnsemblBacteriaiAAD08132; AAD08132; HP_1090.
    GeneIDi899626.
    KEGGihpy:HP1090.
    PATRICi20593519. VBIHelPyl33062_1139.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08132.1 .
    PIRi B64656.
    RefSeqi NP_207881.1. NC_000915.1.

    3D structure databases

    ProteinModelPortali O25722.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 85962.HP1090.

    Proteomic databases

    PRIDEi O25722.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD08132 ; AAD08132 ; HP_1090 .
    GeneIDi 899626.
    KEGGi hpy:HP1090.
    PATRICi 20593519. VBIHelPyl33062_1139.

    Phylogenomic databases

    eggNOGi COG1674.
    KOi K03466.
    OMAi CAESIRI.
    OrthoDBi EOG6S52GD.

    Enzyme and pathway databases

    BioCyci HPY:HP1090-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR002543. FtsK_dom.
    IPR018541. Ftsk_gamma.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF09397. Ftsk_gamma. 1 hit.
    PF01580. FtsK_SpoIIIE. 1 hit.
    [Graphical view ]
    SMARTi SM00843. Ftsk_gamma. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS50901. FTSK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiFTSK_HELPY
    AccessioniPrimary (citable) accession number: O25722
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2003
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3