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Protein

DNA translocase FtsK

Gene

ftsK

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi552 – 5576ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Chromosome partition

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPY:HP1090-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA translocase FtsK
Gene namesi
Name:ftsK
Ordered Locus Names:HP_1090
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2921HelicalSequence AnalysisAdd
BLAST
Transmembranei48 – 6821HelicalSequence AnalysisAdd
BLAST
Transmembranei74 – 9421HelicalSequence AnalysisAdd
BLAST
Transmembranei116 – 13621HelicalSequence AnalysisAdd
BLAST
Topological domaini137 – 858722CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 858858DNA translocase FtsKPRO_0000098262Add
BLAST

Proteomic databases

PRIDEiO25722.

Interactioni

Subunit structurei

Homohexamer. Forms a ring that surrounds DNA (By similarity).By similarity

Protein-protein interaction databases

STRINGi85962.HP1090.

Structurei

3D structure databases

ProteinModelPortaliO25722.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini532 – 722191FtsKPROSITE-ProRule annotationAdd
BLAST

Domaini

Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains multimerise to produce a hexameric ring, contain the nucleotide binding motif and form the DNA pump. The gamma subdomain is a regulatory subdomain that controls translocation of DNA by recognition of KOPS motifs and interacts with XerD recombinase (By similarity).By similarity

Sequence similaritiesi

Belongs to the FtsK/SpoIIIE/SftA family.Curated
Contains 1 FtsK domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1674.
KOiK03466.
OMAiCAESIRI.
OrthoDBiEOG6S52GD.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR002543. FtsK_dom.
IPR018541. Ftsk_gamma.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF09397. Ftsk_gamma. 1 hit.
PF01580. FtsK_SpoIIIE. 1 hit.
[Graphical view]
SMARTiSM00843. Ftsk_gamma. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50901. FTSK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O25722-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPMKSKKLY LALIIGVLLA FLTLSSWLGN SGLVGRFGVW FAALNKKYFG
60 70 80 90 100
HLSFINLPYL AWVLFLLYKT KNPFTEIVLE KTLGHLLGIL SLLFLQSSLL
110 120 130 140 150
NQGEIGNSAR LFLRPFIGDF GLYALITLMV VISYLILFKL PPKSVFYPYM
160 170 180 190 200
NKTQNLLKEI YKQCLQAFSP NFSPKKEGFE NTPSDIQKKE TKNDKEKENR
210 220 230 240 250
KENPINENHK TPNEEPFLAI PTPYNTTLND SEPQEGLVQI SSHPPTHYTI
260 270 280 290 300
YPKRNRFDDL TNPTNPPLKE IKQETKEREP TPTKETLTPT TPKPIMPTLA
310 320 330 340 350
PIIENDNKTE NQKTPNHPKK EENPQENTQE EMIEGRIEEM IKENLKKEEK
360 370 380 390 400
EVQNAPNFSP VTPTSAKKPV MVKELSENKE ILDGLDYGEV QKPKDYELPT
410 420 430 440 450
TQLLNAVCLK DTSLDENEID QKIQDLLSKL RTFKIDGDII RTYSGPIVTT
460 470 480 490 500
FEFRPAPNVK VSRILGLSDD LAMTLCAESI RIQAPIKGKD VVGIEIPNSQ
510 520 530 540 550
SQIIYLREIL ESELFQKSSS PLTLALGKDI VGNPFITDLK KLPHLLIAGT
560 570 580 590 600
TGSGKSVGVN AMILSLLYKN PPDQLKLVMI DPKMVEFSIY ADIPHLLTPI
610 620 630 640 650
ITDPKKAIGA LQSVAKEMER RYSLMSEYKV KTIDSYNEQA PSNGVEAFPY
660 670 680 690 700
LIVVIDELAD LMMTGGKEAE FPIARIAQMG RASGLHLIVA TQRPSVDVVT
710 720 730 740 750
GLIKTNLPSR VSFRVGTKID SKVILDTDGA QSLLGRGDML FTPPGANGLV
760 770 780 790 800
RLHAPFATED EIKKIVDFIK AQKEVQYDKD FLLEESRMPL DTPNYQGDDI
810 820 830 840 850
LERAKAVILE KKITSTSFLQ RQLKIGYNQA ATITDELEAQ GFLSPRNAKG

NREILQNF
Length:858
Mass (Da):96,445
Last modified:January 1, 1998 - v1
Checksum:i273C6384DB36B377
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08132.1.
PIRiB64656.
RefSeqiNP_207881.1. NC_000915.1.
WP_010875590.1. NC_000915.1.

Genome annotation databases

EnsemblBacteriaiAAD08132; AAD08132; HP_1090.
GeneIDi899626.
KEGGihpy:HP1090.
PATRICi20593519. VBIHelPyl33062_1139.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08132.1.
PIRiB64656.
RefSeqiNP_207881.1. NC_000915.1.
WP_010875590.1. NC_000915.1.

3D structure databases

ProteinModelPortaliO25722.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi85962.HP1090.

Proteomic databases

PRIDEiO25722.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08132; AAD08132; HP_1090.
GeneIDi899626.
KEGGihpy:HP1090.
PATRICi20593519. VBIHelPyl33062_1139.

Phylogenomic databases

eggNOGiCOG1674.
KOiK03466.
OMAiCAESIRI.
OrthoDBiEOG6S52GD.

Enzyme and pathway databases

BioCyciHPY:HP1090-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR002543. FtsK_dom.
IPR018541. Ftsk_gamma.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF09397. Ftsk_gamma. 1 hit.
PF01580. FtsK_SpoIIIE. 1 hit.
[Graphical view]
SMARTiSM00843. Ftsk_gamma. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50901. FTSK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiFTSK_HELPY
AccessioniPrimary (citable) accession number: O25722
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: January 1, 1998
Last modified: May 27, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.