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O25722 (FTSK_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA translocase FtsK
Gene names
Name:ftsK
Ordered Locus Names:HP_1090
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length858 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif By similarity.

Subunit structure

Homohexamer. Forms a ring that surrounds DNA By similarity.

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity. Note: Located at the septum By similarity.

Domain

Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains multimerise to produce a hexameric ring, contain the nucleotide binding motif and form the DNA pump. The gamma subdomain is a regulatory subdomain that controls translocation of DNA by recognition of KOPS motifs and interacts with XerD recombinase By similarity.

Sequence similarities

Belongs to the FtsK/SpoIIIE/SftA family.

Contains 1 FtsK domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 858858DNA translocase FtsK
PRO_0000098262

Regions

Transmembrane9 – 2921Helical; Potential
Transmembrane48 – 6821Helical; Potential
Transmembrane74 – 9421Helical; Potential
Transmembrane116 – 13621Helical; Potential
Topological domain137 – 858722Cytoplasmic Potential
Domain532 – 722191FtsK
Nucleotide binding552 – 5576ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
O25722 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 273C6384DB36B377

FASTA85896,445
        10         20         30         40         50         60 
MQPMKSKKLY LALIIGVLLA FLTLSSWLGN SGLVGRFGVW FAALNKKYFG HLSFINLPYL 

        70         80         90        100        110        120 
AWVLFLLYKT KNPFTEIVLE KTLGHLLGIL SLLFLQSSLL NQGEIGNSAR LFLRPFIGDF 

       130        140        150        160        170        180 
GLYALITLMV VISYLILFKL PPKSVFYPYM NKTQNLLKEI YKQCLQAFSP NFSPKKEGFE 

       190        200        210        220        230        240 
NTPSDIQKKE TKNDKEKENR KENPINENHK TPNEEPFLAI PTPYNTTLND SEPQEGLVQI 

       250        260        270        280        290        300 
SSHPPTHYTI YPKRNRFDDL TNPTNPPLKE IKQETKEREP TPTKETLTPT TPKPIMPTLA 

       310        320        330        340        350        360 
PIIENDNKTE NQKTPNHPKK EENPQENTQE EMIEGRIEEM IKENLKKEEK EVQNAPNFSP 

       370        380        390        400        410        420 
VTPTSAKKPV MVKELSENKE ILDGLDYGEV QKPKDYELPT TQLLNAVCLK DTSLDENEID 

       430        440        450        460        470        480 
QKIQDLLSKL RTFKIDGDII RTYSGPIVTT FEFRPAPNVK VSRILGLSDD LAMTLCAESI 

       490        500        510        520        530        540 
RIQAPIKGKD VVGIEIPNSQ SQIIYLREIL ESELFQKSSS PLTLALGKDI VGNPFITDLK 

       550        560        570        580        590        600 
KLPHLLIAGT TGSGKSVGVN AMILSLLYKN PPDQLKLVMI DPKMVEFSIY ADIPHLLTPI 

       610        620        630        640        650        660 
ITDPKKAIGA LQSVAKEMER RYSLMSEYKV KTIDSYNEQA PSNGVEAFPY LIVVIDELAD 

       670        680        690        700        710        720 
LMMTGGKEAE FPIARIAQMG RASGLHLIVA TQRPSVDVVT GLIKTNLPSR VSFRVGTKID 

       730        740        750        760        770        780 
SKVILDTDGA QSLLGRGDML FTPPGANGLV RLHAPFATED EIKKIVDFIK AQKEVQYDKD 

       790        800        810        820        830        840 
FLLEESRMPL DTPNYQGDDI LERAKAVILE KKITSTSFLQ RQLKIGYNQA ATITDELEAQ 

       850 
GFLSPRNAKG NREILQNF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD08132.1.
PIRB64656.
RefSeqNP_207881.1. NC_000915.1.

3D structure databases

ProteinModelPortalO25722.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING85962.HP1090.

Proteomic databases

PRIDEO25722.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD08132; AAD08132; HP_1090.
GeneID899626.
KEGGhpy:HP1090.
PATRIC20593519. VBIHelPyl33062_1139.

Phylogenomic databases

eggNOGCOG1674.
KOK03466.
OMACAESIRI.
OrthoDBEOG6S52GD.

Enzyme and pathway databases

BioCycHPY:HP1090-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR002543. Cell_div_FtsK/SpoIIIE.
IPR018541. DNA_translocase_Ftsk_gamma.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF09397. Ftsk_gamma. 1 hit.
PF01580. FtsK_SpoIIIE. 1 hit.
[Graphical view]
SMARTSM00843. Ftsk_gamma. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS50901. FTSK. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTSK_HELPY
AccessionPrimary (citable) accession number: O25722
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: January 1, 1998
Last modified: May 14, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names