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Protein

Aspartate carbamoyltransferase

Gene

pyrB

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes (S)-dihydroorotate from bicarbonate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Carbamoyl-phosphate synthase small chain (carA), Carbamoyl-phosphate synthase large chain (carB)
  2. Aspartate carbamoyltransferase (pyrB)
  3. Dihydroorotase (pyrC)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-dihydroorotate from bicarbonate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

BioCyciHPY:HP1084-MONOMER
UniPathwayiUPA00070; UER00116

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate carbamoyltransferase (EC:2.1.3.2)
Alternative name(s):
Aspartate transcarbamylase
Short name:
ATCase
Gene namesi
Name:pyrB
Ordered Locus Names:HP_1084
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001131411 – 307Aspartate carbamoyltransferaseAdd BLAST307

Proteomic databases

PaxDbiO25716
PRIDEiO25716

Interactioni

Protein-protein interaction databases

DIPiDIP-3378N
IntActiO25716, 3 interactors
MINTiO25716
STRINGi85962.HP1084

Structurei

3D structure databases

ProteinModelPortaliO25716
SMRiO25716
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATCase/OTCase family.Curated

Phylogenomic databases

eggNOGiENOG4105CXT Bacteria
COG0540 LUCA
KOiK00609
OMAiWCDVANM

Family and domain databases

Gene3Di3.40.50.1370, 3 hits
HAMAPiMF_00001 Asp_carb_tr, 1 hit
InterProiView protein in InterPro
IPR006132 Asp/Orn_carbamoyltranf_P-bd
IPR006130 Asp/Orn_carbamoylTrfase
IPR036901 Asp/Orn_carbamoylTrfase_sf
IPR002082 Asp_carbamoyltransf
IPR006131 Asp_carbamoyltransf_Asp/Orn-bd
PANTHERiPTHR11405:SF16 PTHR11405:SF16, 1 hit
PfamiView protein in Pfam
PF00185 OTCace, 1 hit
PF02729 OTCace_N, 1 hit
PRINTSiPR00100 AOTCASE
PR00101 ATCASE
SUPFAMiSSF53671 SSF53671, 1 hit
TIGRFAMsiTIGR00670 asp_carb_tr, 1 hit
PROSITEiView protein in PROSITE
PS00097 CARBAMOYLTRANSFERASE, 1 hit

Sequencei

Sequence statusi: Complete.

O25716-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKKCRHLLQ TSDLSLDEIK LLLEKASVYA NDFNAVSLET KEKMHNKIIV
60 70 80 90 100
ALFFENSTRT VSSFEIASLR LGAKIVKLNM QTSSASKGET LTDTFKNIHA
110 120 130 140 150
MQPDAIITRH AFSSAPFKLA EFSQCPLINA GSGVSAHPTQ ALLDLLTLYQ
160 170 180 190 200
HFGSLENLKG KKIAFIGDVK NSRVANSNIK LLQRLGLEIM LCAPSSMLPS
210 220 230 240 250
VSLKTTHNVE EAIAFADILM SLRTQTERHN TPIFASLKDY GNAYCITQQR
260 270 280 290 300
LKAHAKNKEV IILHPGPVHR DIDIESAVLE DERSKVLEQV KNGVAMRMAV

LEFLLLD
Length:307
Mass (Da):34,068
Last modified:January 1, 1998 - v1
Checksum:iB77C515883A45074
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD08128.1
PIRiD64655
RefSeqiNP_207875.1, NC_000915.1
WP_001124546.1, NC_018939.1

Genome annotation databases

EnsemblBacteriaiAAD08128; AAD08128; HP_1084
GeneIDi899620
KEGGiheo:C694_05600
hpy:HP1084
PATRICifig|85962.47.peg.1163

Similar proteinsi

Entry informationi

Entry nameiPYRB_HELPY
AccessioniPrimary (citable) accession number: O25716
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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