ID   TATC_HELPY              Reviewed;         253 AA.
AC   O25701;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   27-MAR-2024, entry version 126.
DE   RecName: Full=Sec-independent protein translocase protein TatC {ECO:0000255|HAMAP-Rule:MF_00902};
GN   Name=tatC {ECO:0000255|HAMAP-Rule:MF_00902};
GN   OrderedLocusNames=HP_1061;
OS   Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC   Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695;
RX   PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA   Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA   Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA   McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA   Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA   Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA   Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
CC   -!- FUNCTION: Part of the twin-arginine translocation (Tat) system that
CC       transports large folded proteins containing a characteristic twin-
CC       arginine motif in their signal peptide across membranes. Together with
CC       TatB, TatC is part of a receptor directly interacting with Tat signal
CC       peptides. {ECO:0000255|HAMAP-Rule:MF_00902}.
CC   -!- SUBUNIT: The Tat system comprises two distinct complexes: a TatABC
CC       complex, containing multiple copies of TatA, TatB and TatC subunits,
CC       and a separate TatA complex, containing only TatA subunits. Substrates
CC       initially bind to the TatABC complex, which probably triggers
CC       association of the separate TatA complex to form the active translocon.
CC       {ECO:0000255|HAMAP-Rule:MF_00902}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00902}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00902}.
CC   -!- SIMILARITY: Belongs to the TatC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00902}.
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DR   EMBL; AE000511; AAD08101.1; -; Genomic_DNA.
DR   PIR; E64652; E64652.
DR   RefSeq; NP_207852.1; NC_000915.1.
DR   RefSeq; WP_000461250.1; NC_018939.1.
DR   AlphaFoldDB; O25701; -.
DR   SMR; O25701; -.
DR   STRING; 85962.HP_1061; -.
DR   PaxDb; 85962-C694_05485; -.
DR   EnsemblBacteria; AAD08101; AAD08101; HP_1061.
DR   KEGG; hpy:HP_1061; -.
DR   PATRIC; fig|85962.47.peg.1140; -.
DR   eggNOG; COG0805; Bacteria.
DR   InParanoid; O25701; -.
DR   OrthoDB; 9777044at2; -.
DR   PhylomeDB; O25701; -.
DR   Proteomes; UP000000429; Chromosome.
DR   GO; GO:0033281; C:TAT protein transport complex; IBA:GO_Central.
DR   GO; GO:0009977; F:proton motive force dependent protein transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0065002; P:intracellular protein transmembrane transport; IBA:GO_Central.
DR   GO; GO:0043953; P:protein transport by the Tat complex; IBA:GO_Central.
DR   HAMAP; MF_00902; TatC; 1.
DR   InterPro; IPR019820; Sec-indep_translocase_CS.
DR   InterPro; IPR002033; TatC.
DR   NCBIfam; TIGR00945; tatC; 1.
DR   PANTHER; PTHR30371; SEC-INDEPENDENT PROTEIN TRANSLOCASE PROTEIN TATC; 1.
DR   PANTHER; PTHR30371:SF0; SEC-INDEPENDENT PROTEIN TRANSLOCASE PROTEIN TATC, CHLOROPLASTIC-RELATED; 1.
DR   Pfam; PF00902; TatC; 1.
DR   PRINTS; PR01840; TATCFAMILY.
DR   PROSITE; PS01218; TATC; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Protein transport;
KW   Reference proteome; Translocation; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..253
FT                   /note="Sec-independent protein translocase protein TatC"
FT                   /id="PRO_0000098087"
FT   TRANSMEM        18..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00902"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00902"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00902"
FT   TRANSMEM        151..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00902"
FT   TRANSMEM        187..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00902"
FT   TRANSMEM        208..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00902"
FT   REGION          231..253
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   253 AA;  28226 MW;  65F0D8D3251DA8CC CRC64;
     MFEDLKPHLQ ELRKRLMVSV GTILVAFLGC FHFWKSIFEF VKNSYKGTLI QLSPIEGVMV
     AVKISFSAAI VISMPIIFWQ LWLFIAPGLY KNEKKVILPF VFFGSGMFLI GAAFSYYVVF
     PFIIEYLATF GSDVFAANIS ASSYVSFFTR LILGFGVAFE LPVLAYFLAK VGLITDASLK
     AYFKYAIVVI FIVAAIITPP DVVSQIFMAL PLVGLYGLSI LIAKMVNPAP KDNENNNENN
     NENNTKENTK SES
//