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Protein

Sec-independent protein translocase protein TatC

Gene

tatC

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciHPY:HP1061-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sec-independent protein translocase protein TatCUniRule annotation
Gene namesi
Name:tatCUniRule annotation
Ordered Locus Names:HP_1061
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei18 – 3821HelicalUniRule annotationAdd
BLAST
Transmembranei69 – 8921HelicalUniRule annotationAdd
BLAST
Transmembranei96 – 11621HelicalUniRule annotationAdd
BLAST
Transmembranei151 – 17121HelicalUniRule annotationAdd
BLAST
Transmembranei187 – 20721HelicalUniRule annotationAdd
BLAST
Transmembranei208 – 22821HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 253253Sec-independent protein translocase protein TatCPRO_0000098087Add
BLAST

Proteomic databases

PRIDEiO25701.

Interactioni

Subunit structurei

The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.UniRule annotation

Protein-protein interaction databases

STRINGi85962.HP1061.

Structurei

3D structure databases

ProteinModelPortaliO25701.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TatC family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0805.
KOiK03118.
OMAiATQIYKF.
OrthoDBiEOG60SCQS.

Family and domain databases

HAMAPiMF_00902. TatC.
InterProiIPR019820. Sec-indep_translocase_CS.
IPR002033. TatC.
[Graphical view]
PANTHERiPTHR30371:SF0. PTHR30371:SF0. 1 hit.
PfamiPF00902. TatC. 1 hit.
[Graphical view]
PRINTSiPR01840. TATCFAMILY.
TIGRFAMsiTIGR00945. tatC. 1 hit.
PROSITEiPS01218. TATC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O25701-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFEDLKPHLQ ELRKRLMVSV GTILVAFLGC FHFWKSIFEF VKNSYKGTLI
60 70 80 90 100
QLSPIEGVMV AVKISFSAAI VISMPIIFWQ LWLFIAPGLY KNEKKVILPF
110 120 130 140 150
VFFGSGMFLI GAAFSYYVVF PFIIEYLATF GSDVFAANIS ASSYVSFFTR
160 170 180 190 200
LILGFGVAFE LPVLAYFLAK VGLITDASLK AYFKYAIVVI FIVAAIITPP
210 220 230 240 250
DVVSQIFMAL PLVGLYGLSI LIAKMVNPAP KDNENNNENN NENNTKENTK

SES
Length:253
Mass (Da):28,226
Last modified:January 1, 1998 - v1
Checksum:i65F0D8D3251DA8CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08101.1.
PIRiE64652.
RefSeqiNP_207852.1. NC_000915.1.
WP_000461250.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08101; AAD08101; HP_1061.
GeneIDi899596.
KEGGiheo:C694_05485.
hpy:HP1061.
PATRICi20593459. VBIHelPyl33062_1110.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08101.1.
PIRiE64652.
RefSeqiNP_207852.1. NC_000915.1.
WP_000461250.1. NC_018939.1.

3D structure databases

ProteinModelPortaliO25701.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi85962.HP1061.

Proteomic databases

PRIDEiO25701.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08101; AAD08101; HP_1061.
GeneIDi899596.
KEGGiheo:C694_05485.
hpy:HP1061.
PATRICi20593459. VBIHelPyl33062_1110.

Phylogenomic databases

eggNOGiCOG0805.
KOiK03118.
OMAiATQIYKF.
OrthoDBiEOG60SCQS.

Enzyme and pathway databases

BioCyciHPY:HP1061-MONOMER.

Family and domain databases

HAMAPiMF_00902. TatC.
InterProiIPR019820. Sec-indep_translocase_CS.
IPR002033. TatC.
[Graphical view]
PANTHERiPTHR30371:SF0. PTHR30371:SF0. 1 hit.
PfamiPF00902. TatC. 1 hit.
[Graphical view]
PRINTSiPR01840. TATCFAMILY.
TIGRFAMsiTIGR00945. tatC. 1 hit.
PROSITEiPS01218. TATC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiTATC_HELPY
AccessioniPrimary (citable) accession number: O25701
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: July 22, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.