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Reviewed, UniProtKB/Swiss-Prot O25686 (ACSA_HELPY)

Last modified February 9, 2010. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Acetyl-coenzyme A synthetase
    EC=6.2.1.1
Alternative name(s):
    Acetate--CoA ligase
    Acyl-activating enzyme
Gene names
Name: acsA
Synonyms: acs
Ordered Locus Names: HP_1045
OrganismHelicobacter pylori (Campylobacter pylori) [Complete proteome] [HAMAP]
Taxonomic identifier210 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length662 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123

Post-translational modification

Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123

Miscellaneous

There is no ortholog for acsA in strain J99. HAMAP MF_01123

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   PTMAcetylation
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processmetabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionAMP binding

Inferred from electronic annotation. Source: InterPro

ATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

acetate-CoA ligase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 662662Acetyl-coenzyme A synthetase HAMAP MF_01123
PRO_0000208365

Sites

Active site5271 By similarity

Amino acid modifications

Modified residue6231N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
O25686-1 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: A83E0F9A34F021F3

FASTA66274,948
        10         20         30         40         50         60 
MQLDEDLEFA KKIFNPNRAF AKQARIKNMC EYKDLVHEAN EDYEHFWGDL AKQKLTWFKP 

        70         80         90        100        110        120 
FDKVLNSDNA PFFKWFENGK INVSYNCIDR HLKDKKNKVA IIFEGEMGDY NVITYRKLHS 

       130        140        150        160        170        180 
EVNKTANLLK NEFNVKKGDR VIIYMPMIVE SVYMMLACTR IGAIHSIVFA GFSPEALRDR 

       190        200        210        220        230        240 
INDAQAKLVI TADGTFRKGK PYMLKPALDK ALENNACPSV EKALIVIRNA KEIDYVRGRD 

       250        260        270        280        290        300 
FVYNEMVNYQ SDKCEPEMMD SEDPLFLLYT SGSTGKPKGV QHSSAGYLLW AQMTMEWVFD 

       310        320        330        340        350        360 
IRDNDNFWCT ADIGWITGHT YVVYGPLACG ATTLILEGTM SYPDYGRWWR MIEEYRVDKF 

       370        380        390        400        410        420 
YTSPTAIRML HAKGENEPSK YNLESLKVLG TVGEPINPTA WKWFYEKIGN SKCSIVDTWW 

       430        440        450        460        470        480 
QTETGGHIIS PLPGATPIRA SCATLPLPGI HAEVLNEDGT KTKPGEQGFL CITKPWPSMI 

       490        500        510        520        530        540 
RNIWGDEKRY IDSYFSQIKL NGEYVYLSGD GAIVDENGYI TIIGRTDDIV NVSGHRIGTA 

       550        560        570        580        590        600 
EVESAISKHE MVAECAVVGI PDAIKGEGLF AFVVLCDGAK CNLGESLELL KEMNHILSIE 

       610        620        630        640        650        660 
IGKIAKLDNV MYVPGLPKTR SGKIMRRLLK SIAKKEPITQ DLSTLEDVNV VKEIMSIAQM 


EE 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD08090.1.
PIRE64650.
RefSeqNP_207835.1.

3D structure databases

SMRO25686. Positions 17-654.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-3168N.

Genome annotation databases

GeneID899580.
GenomeReviewsGene locus HP_1045 in contig AE000511_GR.
KEGGhpy:HP1045.
NMPDRfig|85962.1.peg.1032.
TIGRHP_1045.

Phylogenomic databases

HOGENOMHBG547964.
OMAHQRMVDT.

Enzyme and pathway databases

BRENDA6.2.1.1. 1131.

Family and domain databases

HAMAPMF_01123. Ac_CoA_synth.
[Tree]
InterProIPR011904. Ac_CoA_lig_AcsA.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamPF00501. AMP-binding. 1 hit.
[Graphical view]
TIGRFAMsTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACSA_HELPY
AccessionPrimary (citable) accession number: O25686
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: February 9, 2010
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents