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O25655

- PYRD_HELPY

UniProt

O25655 - PYRD_HELPY

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Protein
Dihydroorotate dehydrogenase (quinone)
Gene
pyrD, HP_1011
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor By similarity.UniRule annotation

Catalytic activityi

(S)-dihydroorotate + a quinone = orotate + a quinol.UniRule annotation

Cofactori

Binds 1 FMN per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei71 – 711Substrate By similarity
Binding sitei91 – 911FMN; via amide nitrogen By similarity
Binding sitei145 – 1451FMN By similarity
Binding sitei178 – 1781FMN By similarity
Binding sitei178 – 1781Substrate By similarity
Active sitei181 – 1811Nucleophile By similarity
Binding sitei183 – 1831Substrate By similarity
Binding sitei214 – 2141FMN By similarity
Binding sitei242 – 2421FMN; via carbonyl oxygen By similarity
Binding sitei262 – 2621FMN; via amide nitrogen By similarity
Binding sitei291 – 2911FMN; via amide nitrogen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi67 – 715FMN By similarity
Nucleotide bindingi312 – 3132FMN By similarity

GO - Molecular functioni

  1. dihydroorotate oxidase activity Source: InterPro

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyrimidine biosynthesis

Keywords - Ligandi

Flavoprotein, FMN

Enzyme and pathway databases

BioCyciHPY:HP1011-MONOMER.
UniPathwayiUPA00070; UER00946.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroorotate dehydrogenase (quinone) (EC:1.3.5.2)
Alternative name(s):
DHOdehase
Short name:
DHOD
Short name:
DHODase
Dihydroorotate oxidase
Gene namesi
Name:pyrD
Ordered Locus Names:HP_1011
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351Dihydroorotate dehydrogenase (quinone)UniRule annotation
PRO_0000148445Add
BLAST

Proteomic databases

PRIDEiO25655.

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi85962.HP1011.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 116
Helixi13 – 208
Helixi23 – 3614
Helixi48 – 503
Beta strandi52 – 543
Beta strandi57 – 659
Beta strandi73 – 753
Helixi76 – 827
Beta strandi85 – 928
Beta strandi105 – 1084
Turni109 – 1124
Beta strandi113 – 1164
Helixi125 – 1317
Turni136 – 1394
Beta strandi142 – 1465
Helixi157 – 16913
Beta strandi173 – 1797
Helixi193 – 20311
Beta strandi211 – 2155
Helixi221 – 23414
Beta strandi238 – 2414
Beta strandi245 – 2473
Beta strandi256 – 2627
Helixi263 – 2653
Helixi266 – 28015
Beta strandi284 – 2918
Helixi295 – 30410
Beta strandi307 – 3126
Helixi313 – 3186
Helixi321 – 33717
Helixi342 – 3454
Helixi348 – 3503

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LX3model-A1-351[»]
ProteinModelPortaliO25655.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni116 – 1205Substrate binding By similarity
Regioni243 – 2442Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0167.
KOiK00254.
OMAiNEGHAAA.
OrthoDBiEOG65BDN8.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00225. DHO_dh_type2.
InterProiIPR013785. Aldolase_TIM.
IPR012135. Dihydroorotate_DH_1_2.
IPR005719. Dihydroorotate_DH_2.
IPR001295. Dihydroorotate_DH_CS.
[Graphical view]
PfamiPF01180. DHO_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000164. DHO_oxidase. 1 hit.
TIGRFAMsiTIGR01036. pyrD_sub2. 1 hit.
PROSITEiPS00911. DHODEHASE_1. 1 hit.
PS00912. DHODEHASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O25655-1 [UniParc]FASTAAdd to Basket

« Hide

MLYSLVKKYL FSLDAEDAHE KVCKILRMLS SSPFLCNLID SQWGYQNPKL    50
ENEILGLHFP NPLGLAAGFD KNASMLRALM AFGFGYLEAG TLTNEAQVGN 100
ERPRLFRHIE EESLQNAMGF NNYGAILGVR SFKRFAPYKT PIGINLGKNK 150
HIEQAHALED YKAVLSKCLN IGDYYTFNLS SPNTPNLRDL QNKAFVHELF 200
CMAKEMTHKP LFLKIAPDLE TDDMLEIVNS AIGAGAHGII ATNTTIDKSL 250
VFAPKEMGGL SGKCLTKKSR EIFKELAKAF FNKSVLVSVG GISDAKEAYE 300
RIKMGASLLQ IYSAFIYNGP NLCQNILKDL VKLLQKDGFL SVKEAIGADL 350
R 351
Length:351
Mass (Da):39,002
Last modified:January 1, 1998 - v1
Checksum:i784D32A23A36F20C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08055.1.
PIRiC64646.
RefSeqiNP_207801.1. NC_000915.1.
YP_006934927.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08055; AAD08055; HP_1011.
GeneIDi13870204.
899546.
KEGGiheo:C694_05235.
hpy:HP1011.
PATRICi20593357. VBIHelPyl33062_1059.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08055.1 .
PIRi C64646.
RefSeqi NP_207801.1. NC_000915.1.
YP_006934927.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1LX3 model - A 1-351 [» ]
ProteinModelPortali O25655.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 85962.HP1011.

Proteomic databases

PRIDEi O25655.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD08055 ; AAD08055 ; HP_1011 .
GeneIDi 13870204.
899546.
KEGGi heo:C694_05235.
hpy:HP1011.
PATRICi 20593357. VBIHelPyl33062_1059.

Phylogenomic databases

eggNOGi COG0167.
KOi K00254.
OMAi NEGHAAA.
OrthoDBi EOG65BDN8.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00946 .
BioCyci HPY:HP1011-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00225. DHO_dh_type2.
InterProi IPR013785. Aldolase_TIM.
IPR012135. Dihydroorotate_DH_1_2.
IPR005719. Dihydroorotate_DH_2.
IPR001295. Dihydroorotate_DH_CS.
[Graphical view ]
Pfami PF01180. DHO_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000164. DHO_oxidase. 1 hit.
TIGRFAMsi TIGR01036. pyrD_sub2. 1 hit.
PROSITEi PS00911. DHODEHASE_1. 1 hit.
PS00912. DHODEHASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiPYRD_HELPY
AccessioniPrimary (citable) accession number: O25655
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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