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Protein
Submitted name:

Cation efflux system protein (CzcA)

Gene

HP_0969

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

BioCyciHPY:HP0969-MONOMER.

Protein family/group databases

TCDBi2.A.6.1.14. the resistance-nodulation-cell division (rnd) superfamily.

Names & Taxonomyi

Protein namesi
Submitted name:
Cation efflux system protein (CzcA)Imported
Gene namesi
Ordered Locus Names:HP_0969Imported
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)Imported
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei330 – 353HelicalSequence analysisAdd BLAST24
Transmembranei360 – 377HelicalSequence analysisAdd BLAST18
Transmembranei389 – 411HelicalSequence analysisAdd BLAST23
Transmembranei432 – 457HelicalSequence analysisAdd BLAST26
Transmembranei469 – 492HelicalSequence analysisAdd BLAST24
Transmembranei524 – 542HelicalSequence analysisAdd BLAST19
Transmembranei858 – 877HelicalSequence analysisAdd BLAST20
Transmembranei884 – 904HelicalSequence analysisAdd BLAST21
Transmembranei910 – 934HelicalSequence analysisAdd BLAST25
Transmembranei955 – 975HelicalSequence analysisAdd BLAST21
Transmembranei987 – 1014HelicalSequence analysisAdd BLAST28

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiO25622.

Interactioni

Protein-protein interaction databases

DIPiDIP-3083N.
IntActiO25622. 5 interactors.
MINTiMINT-170458.
STRINGi85962.HP0969.

Structurei

3D structure databases

ProteinModelPortaliO25622.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. [View classification]SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG4108IJF. Bacteria.
COG3696. LUCA.
KOiK15726.
OMAiYDRSEFT.

Family and domain databases

Gene3Di3.30.2090.10. 2 hits.
InterProiIPR027463. AcrB_DN_DC_subdom.
IPR001036. Acrflvin-R.
IPR004763. CzcA/CusA/SilA/NccA/HelA/CnrA.
[Graphical view]
PfamiPF00873. ACR_tran. 1 hit.
[Graphical view]
PRINTSiPR00702. ACRIFLAVINRP.
SUPFAMiSSF82714. SSF82714. 2 hits.
TIGRFAMsiTIGR00914. 2A0601. 1 hit.

Sequencei

Sequence statusi: Complete.

O25622-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLASIIEFS LRQRVIVIVG AILILFFGTY SFINTPVDAF PDISPTQVKI
60 70 80 90 100
ILKLPGSSPE EMENNIVRPL ELELLGLKGQ KSLRSVSKYS ISDITIDFDD
110 120 130 140 150
SVDIYLARNI VNERLSSVMK DLPVGVEGGM APIVTPLSDI FMFTIDGNIT
160 170 180 190 200
EIEKRQLLDF VIRPQLRMIS GVADVNSIGG FSRAFVIVPD FNDMARLGVS
210 220 230 240 250
ISDLESAVRV NLRNSGAGRV DRDGETFLVK IQTASLSLED IGKITVSTNL
260 270 280 290 300
GHLHIKDFAK VISQSRTRLG FVTKDGVGET TEGLVLSLKD ANTKEIITQV
310 320 330 340 350
YQKLEELKPF LPNGVSINVF YDRSEFTQKA IATVSKTLIE AVVLIIITLF
360 370 380 390 400
LFLGNLRASV AVGVILPLSL SVAFIFIKFS DLTLNLMSLG GLVIAIGMLI
410 420 430 440 450
DSAVVVVENA FEKLSANTKT TKLHAIYRSC KEIAVSVVSG VVIIIVFFVP
460 470 480 490 500
ILTLQGLEGK MFRPLAQSIV YALLGTLVLS ITIIPVVSSL VLKATPHSET
510 520 530 540 550
FLTRFLNRIY APLLEFFVHN PKKVILGAFV FLIASLSLFP FVGKNFMPVL
560 570 580 590 600
DEGDVVLSVE TTPSISLDQS RDLMLNIESA IKKHVKEVKS IVARTGSDEL
610 620 630 640 650
GLDLGGLNQT DTFISFIPKK EWSVKTKDEL LEKIMDSLKD FKGINFSFTQ
660 670 680 690 700
PIEMRISEML TGVRGDLAVK IFGDGISELN ELSFQIAQAL KGIKGSSEVL
710 720 730 740 750
TTLNEGVNYL YVTPNKESMA DVGITSDEFS KFLKSALEGL VVDVIPTGIS
760 770 780 790 800
RTPVMIRQES DFASSITKIK SLALTSKYGV LVPITSIAKI EEVDGPVSVV
810 820 830 840 850
RENSMRMSVV RSNVVGRDLK SFVEEAKKVI AQNIKLPPSY YITYGGQFEN
860 870 880 890 900
QQRANKRLST VIPLSILAIF FILFFTFKSI PLALLILLNI PFAVTGGLIA
910 920 930 940 950
LFAVGEYISV PASVGFIALF GIAVLNGVVM IGYFKELLLQ GKSVEECVLL
960 970 980 990 1000
GAKRRLRPVL MTACIAGLGL LPLLFSHSVG SEVQKPLAIV VLGGLVTSSA
1010 1020
LTLLLLPPMF MLIAKKIKIV
Length:1,020
Mass (Da):111,323
Last modified:January 1, 1998 - v1
Checksum:i4C0D3B12ADCF4731
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08012.1.
PIRiA64641.
RefSeqiNP_207760.1. NC_000915.1.
WP_000978968.1. NC_000915.1.

Genome annotation databases

EnsemblBacteriaiAAD08012; AAD08012; HP_0969.
GeneIDi899501.
KEGGihpy:HP0969.
PATRICi20593251. VBIHelPyl33062_1007.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08012.1.
PIRiA64641.
RefSeqiNP_207760.1. NC_000915.1.
WP_000978968.1. NC_000915.1.

3D structure databases

ProteinModelPortaliO25622.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3083N.
IntActiO25622. 5 interactors.
MINTiMINT-170458.
STRINGi85962.HP0969.

Protein family/group databases

TCDBi2.A.6.1.14. the resistance-nodulation-cell division (rnd) superfamily.

Proteomic databases

PaxDbiO25622.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08012; AAD08012; HP_0969.
GeneIDi899501.
KEGGihpy:HP0969.
PATRICi20593251. VBIHelPyl33062_1007.

Phylogenomic databases

eggNOGiENOG4108IJF. Bacteria.
COG3696. LUCA.
KOiK15726.
OMAiYDRSEFT.

Enzyme and pathway databases

BioCyciHPY:HP0969-MONOMER.

Family and domain databases

Gene3Di3.30.2090.10. 2 hits.
InterProiIPR027463. AcrB_DN_DC_subdom.
IPR001036. Acrflvin-R.
IPR004763. CzcA/CusA/SilA/NccA/HelA/CnrA.
[Graphical view]
PfamiPF00873. ACR_tran. 1 hit.
[Graphical view]
PRINTSiPR00702. ACRIFLAVINRP.
SUPFAMiSSF82714. SSF82714. 2 hits.
TIGRFAMsiTIGR00914. 2A0601. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiO25622_HELPY
AccessioniPrimary (citable) accession number: O25622
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.