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Protein

Glycerol-3-phosphate dehydrogenase [NAD(P)+]

Gene

gpsA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H.UniRule annotation

Pathwayi: glycerophospholipid metabolism

This protein is involved in the pathway glycerophospholipid metabolism, which is part of Membrane lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway glycerophospholipid metabolism and in Membrane lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei95NAD; via amide nitrogenUniRule annotation1
Binding sitei95SubstrateUniRule annotation1
Binding sitei127NAD; via amide nitrogenUniRule annotation1
Active sitei177Proton acceptorUniRule annotation1
Binding sitei241NADUniRule annotation1
Binding sitei267NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 12NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
LigandNAD

Enzyme and pathway databases

BioCyciHPY:HP0961-MONOMER
UniPathwayiUPA00940

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(P)+]UniRule annotation (EC:1.1.1.94UniRule annotation)
Alternative name(s):
NAD(P)H-dependent glycerol-3-phosphate dehydrogenaseUniRule annotation
Gene namesi
Name:gpsAUniRule annotation
Ordered Locus Names:HP_0961
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001379711 – 312Glycerol-3-phosphate dehydrogenase [NAD(P)+]Add BLAST312

Proteomic databases

PaxDbiO25614

Interactioni

Protein-protein interaction databases

DIPiDIP-3377N
IntActiO25614, 4 interactors
MINTiO25614
STRINGi85962.HP0961

Structurei

3D structure databases

ProteinModelPortaliO25614
SMRiO25614
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni241 – 242Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CSF Bacteria
COG0240 LUCA
KOiK00057
OMAiQPWFRCY

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
HAMAPiMF_00394 NAD_Glyc3P_dehydrog, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR006168 G3P_DH_NAD-dep
IPR006109 G3P_DH_NAD-dep_C
IPR011128 G3P_DH_NAD-dep_N
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF07479 NAD_Gly3P_dh_C, 1 hit
PF01210 NAD_Gly3P_dh_N, 1 hit
PIRSFiPIRSF000114 Glycerol-3-P_dh, 1 hit
PRINTSiPR00077 GPDHDRGNASE
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00957 NAD_G3PDH, 1 hit

Sequencei

Sequence statusi: Complete.

O25614-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIAVFGGGA WGRALAFAFG EKNEVKIISR RDLNEPLKKL NDALISKGSA
60 70 80 90 100
PIEQVDLQRG LKATLYVIAI SVQHLREWFQ NASLPKNAKV LIASKGIEVL
110 120 130 140 150
NKAFVSEIAK DFIDPNSLCF LAGPSFAAEI IQGLPCALVI HSNNQALALE
160 170 180 190 200
FANKTPSFIR AYAQQDIIGG EIAGAYKNVI AIAGGVCDGL KLGNSAKASL
210 220 230 240 250
LSRGLVEMQR FGAFFGGKTE TFLGLSGAGD LFLTANSILS RNYRVGLGLA
260 270 280 290 300
QNKPLEVVLE ELGEVAEGVK TTNAIVEIAR KYGIYTPIAS ELALLLKGKS
310
VLESMNDLIR RA
Length:312
Mass (Da):33,392
Last modified:January 1, 1998 - v1
Checksum:i5786864D43E8D266
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD08003.1
PIRiA64640
RefSeqiNP_207753.1, NC_000915.1
WP_000401714.1, NC_018939.1

Genome annotation databases

EnsemblBacteriaiAAD08003; AAD08003; HP_0961
GeneIDi899494
KEGGiheo:C694_04950
hpy:HP0961
PATRICifig|85962.47.peg.1029

Similar proteinsi

Entry informationi

Entry nameiGPDA_HELPY
AccessioniPrimary (citable) accession number: O25614
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: January 1, 1998
Last modified: April 25, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health