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O25614 (GPDA_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycerol-3-phosphate dehydrogenase [NAD(P)+]

EC=1.1.1.94
Alternative name(s):
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase
Gene names
Name:gpsA
Ordered Locus Names:HP_0961
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H. HAMAP-Rule MF_00394

Pathway

Membrane lipid metabolism; glycerophospholipid metabolism. HAMAP-Rule MF_00394

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00394.

Sequence similarities

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 312312Glycerol-3-phosphate dehydrogenase [NAD(P)+] HAMAP-Rule MF_00394
PRO_0000137971

Regions

Nucleotide binding7 – 126NAD By similarity
Region241 – 2422Substrate binding By similarity

Sites

Active site1771Proton acceptor By similarity
Binding site951NAD; via amide nitrogen By similarity
Binding site951Substrate By similarity
Binding site1271NAD; via amide nitrogen By similarity
Binding site2411NAD By similarity
Binding site2671NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
O25614 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 5786864D43E8D266

FASTA31233,392
        10         20         30         40         50         60 
MEIAVFGGGA WGRALAFAFG EKNEVKIISR RDLNEPLKKL NDALISKGSA PIEQVDLQRG 

        70         80         90        100        110        120 
LKATLYVIAI SVQHLREWFQ NASLPKNAKV LIASKGIEVL NKAFVSEIAK DFIDPNSLCF 

       130        140        150        160        170        180 
LAGPSFAAEI IQGLPCALVI HSNNQALALE FANKTPSFIR AYAQQDIIGG EIAGAYKNVI 

       190        200        210        220        230        240 
AIAGGVCDGL KLGNSAKASL LSRGLVEMQR FGAFFGGKTE TFLGLSGAGD LFLTANSILS 

       250        260        270        280        290        300 
RNYRVGLGLA QNKPLEVVLE ELGEVAEGVK TTNAIVEIAR KYGIYTPIAS ELALLLKGKS 

       310 
VLESMNDLIR RA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD08003.1.
PIRA64640.
RefSeqNP_207753.1. NC_000915.1.
YP_006934878.1. NC_018939.1.

3D structure databases

ProteinModelPortalO25614.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-3377N.
IntActO25614. 1 interaction.
MINTMINT-175509.
STRING85962.HP0961.

Proteomic databases

PRIDEO25614.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD08003; AAD08003; HP_0961.
GeneID13870154.
899494.
KEGGheo:C694_04950.
hpy:HP0961.
PATRIC20593235. VBIHelPyl33062_0999.

Phylogenomic databases

eggNOGCOG0240.
KOK00057.
OMALMEIAVF.
OrthoDBEOG6JDWF4.
ProtClustDBPRK00094.

Enzyme and pathway databases

BioCycHPY:HP0961-MONOMER.
UniPathwayUPA00940.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPMF_00394. NAD_Glyc3P_dehydrog.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11728. PTHR11728. 1 hit.
PfamPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSPR00077. GPDHDRGNASE.
SUPFAMSSF48179. SSF48179. 1 hit.
PROSITEPS00957. NAD_G3PDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGPDA_HELPY
AccessionPrimary (citable) accession number: O25614
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: January 1, 1998
Last modified: February 19, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names