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Protein

Glycerol-3-phosphate dehydrogenase [NAD(P)+]

Gene

gpsA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei95 – 951NAD; via amide nitrogenUniRule annotation
Binding sitei95 – 951SubstrateUniRule annotation
Binding sitei127 – 1271NAD; via amide nitrogenUniRule annotation
Active sitei177 – 1771Proton acceptorUniRule annotation
Binding sitei241 – 2411NADUniRule annotation
Binding sitei267 – 2671NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 126NADUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciHPY:HP0961-MONOMER.
UniPathwayiUPA00940.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(P)+]UniRule annotation (EC:1.1.1.94UniRule annotation)
Alternative name(s):
NAD(P)H-dependent glycerol-3-phosphate dehydrogenaseUniRule annotation
Gene namesi
Name:gpsAUniRule annotation
Ordered Locus Names:HP_0961
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Glycerol-3-phosphate dehydrogenase [NAD(P)+]PRO_0000137971Add
BLAST

Proteomic databases

PRIDEiO25614.

Interactioni

Protein-protein interaction databases

DIPiDIP-3377N.
IntActiO25614. 4 interactions.
MINTiMINT-175509.
STRINGi85962.HP0961.

Structurei

3D structure databases

ProteinModelPortaliO25614.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni241 – 2422Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0240.
KOiK00057.
OMAiACCKGVD.
OrthoDBiEOG6JDWF4.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPiMF_00394. NAD_Glyc3P_dehydrog.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O25614-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIAVFGGGA WGRALAFAFG EKNEVKIISR RDLNEPLKKL NDALISKGSA
60 70 80 90 100
PIEQVDLQRG LKATLYVIAI SVQHLREWFQ NASLPKNAKV LIASKGIEVL
110 120 130 140 150
NKAFVSEIAK DFIDPNSLCF LAGPSFAAEI IQGLPCALVI HSNNQALALE
160 170 180 190 200
FANKTPSFIR AYAQQDIIGG EIAGAYKNVI AIAGGVCDGL KLGNSAKASL
210 220 230 240 250
LSRGLVEMQR FGAFFGGKTE TFLGLSGAGD LFLTANSILS RNYRVGLGLA
260 270 280 290 300
QNKPLEVVLE ELGEVAEGVK TTNAIVEIAR KYGIYTPIAS ELALLLKGKS
310
VLESMNDLIR RA
Length:312
Mass (Da):33,392
Last modified:January 1, 1998 - v1
Checksum:i5786864D43E8D266
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08003.1.
PIRiA64640.
RefSeqiNP_207753.1. NC_000915.1.
WP_000401714.1. NC_018939.1.
YP_006934878.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08003; AAD08003; HP_0961.
GeneIDi899494.
KEGGiheo:C694_04950.
hpy:HP0961.
PATRICi20593235. VBIHelPyl33062_0999.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08003.1.
PIRiA64640.
RefSeqiNP_207753.1. NC_000915.1.
WP_000401714.1. NC_018939.1.
YP_006934878.1. NC_018939.1.

3D structure databases

ProteinModelPortaliO25614.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3377N.
IntActiO25614. 4 interactions.
MINTiMINT-175509.
STRINGi85962.HP0961.

Proteomic databases

PRIDEiO25614.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08003; AAD08003; HP_0961.
GeneIDi899494.
KEGGiheo:C694_04950.
hpy:HP0961.
PATRICi20593235. VBIHelPyl33062_0999.

Phylogenomic databases

eggNOGiCOG0240.
KOiK00057.
OMAiACCKGVD.
OrthoDBiEOG6JDWF4.

Enzyme and pathway databases

UniPathwayiUPA00940.
BioCyciHPY:HP0961-MONOMER.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPiMF_00394. NAD_Glyc3P_dehydrog.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiGPDA_HELPY
AccessioniPrimary (citable) accession number: O25614
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: January 1, 1998
Last modified: May 27, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.