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O25610 (Y956_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uncharacterized RNA pseudouridine synthase HP_0956

EC=5.4.99.-
Alternative name(s):
RNA pseudouridylate synthase
RNA-uridine isomerase
Gene names
Ordered Locus Names:HP_0956
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length242 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

RNA uridine = RNA pseudouridine.

Sequence similarities

Belongs to the pseudouridine synthase RluA family.

Contains 1 S4 RNA-binding domain.

Ontologies

Keywords
   LigandRNA-binding
   Molecular functionIsomerase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpseudouridine synthesis

Inferred from electronic annotation. Source: InterPro

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

pseudouridine synthase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 242242Uncharacterized RNA pseudouridine synthase HP_0956
PRO_0000162737

Regions

Domain2 – 6261S4 RNA-binding

Sites

Active site931 By similarity

Sequences

Sequence LengthMass (Da)Tools
O25610 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: BB94C062C7BE8165

FASTA24227,457
        10         20         30         40         50         60 
MEKAYKILSV QENISHKKAK ALIDSGLVSI GGKKLMVARK ELPKNTHFSV QKVEKPSVIF 

        70         80         90        100        110        120 
EDENILALFK PPFIESYDLA SFFKGWALLH RLDKETSGVV LLVKENSEFH LKAKKAFKDR 

       130        140        150        160        170        180 
AVKKEYLALT QGIIEEEREI NAPILTFKTT KAFSKISKKG QEAVTIITPL KIINKKTLLK 

       190        200        210        220        230        240 
VGIKTGRTHQ IRVHLKHINH PIIGDTLYNN EPSLAKRLML HAHKIALLGY EFEAIAPKEF 


EI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD07999.1.
PIRD64639.
RefSeqNP_207748.1. NC_000915.1.
YP_006934873.1. NC_018939.1.

3D structure databases

ProteinModelPortalO25610.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO25610. 2 interactions.
STRING85962.HP0956.

PTM databases

PhosSiteP11071051.

Proteomic databases

PRIDEO25610.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD07999; AAD07999; HP_0956.
GeneID899489.
KEGGheo:C694_04925.
hpy:HP0956.
PATRIC20593225. VBIHelPyl33062_0994.

Phylogenomic databases

eggNOGCOG0564.
KOK06179.
OMAYGDSQHS.
OrthoDBEOG6P070X.

Enzyme and pathway databases

BioCycHPY:HP0956-MONOMER.

Family and domain databases

InterProIPR020103. PsdUridine_synth_cat_dom.
IPR006224. PsdUridine_synth_RluC/D_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
IPR002942. S4_RNA-bd.
[Graphical view]
PfamPF00849. PseudoU_synth_2. 1 hit.
[Graphical view]
SUPFAMSSF55120. SSF55120. 1 hit.
PROSITEPS01129. PSI_RLU. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameY956_HELPY
AccessionPrimary (citable) accession number: O25610
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names