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O25610

- Y956_HELPY

UniProt

O25610 - Y956_HELPY

Protein

Uncharacterized RNA pseudouridine synthase HP_0956

Gene

HP_0956

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    RNA uridine = RNA pseudouridine.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei93 – 931By similarity

    GO - Molecular functioni

    1. pseudouridine synthase activity Source: InterPro
    2. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. pseudouridine synthesis Source: InterPro

    Keywords - Molecular functioni

    Isomerase

    Keywords - Ligandi

    RNA-binding

    Enzyme and pathway databases

    BioCyciHPY:HP0956-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uncharacterized RNA pseudouridine synthase HP_0956 (EC:5.4.99.-)
    Alternative name(s):
    RNA pseudouridylate synthase
    RNA-uridine isomerase
    Gene namesi
    Ordered Locus Names:HP_0956
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 242242Uncharacterized RNA pseudouridine synthase HP_0956PRO_0000162737Add
    BLAST

    Proteomic databases

    PRIDEiO25610.

    PTM databases

    PhosSiteiP11071051.

    Interactioni

    Protein-protein interaction databases

    IntActiO25610. 2 interactions.
    STRINGi85962.HP0956.

    Structurei

    3D structure databases

    ProteinModelPortaliO25610.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 6261S4 RNA-bindingPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the pseudouridine synthase RluA family.Curated
    Contains 1 S4 RNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0564.
    KOiK06179.
    OMAiYGDSQHS.
    OrthoDBiEOG6P070X.

    Family and domain databases

    InterProiIPR020103. PsdUridine_synth_cat_dom.
    IPR006224. PsdUridine_synth_RluC/D_CS.
    IPR006145. PsdUridine_synth_RsuA/RluD.
    IPR002942. S4_RNA-bd.
    [Graphical view]
    PfamiPF00849. PseudoU_synth_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF55120. SSF55120. 1 hit.
    PROSITEiPS01129. PSI_RLU. 1 hit.
    PS50889. S4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O25610-1 [UniParc]FASTAAdd to Basket

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    MEKAYKILSV QENISHKKAK ALIDSGLVSI GGKKLMVARK ELPKNTHFSV    50
    QKVEKPSVIF EDENILALFK PPFIESYDLA SFFKGWALLH RLDKETSGVV 100
    LLVKENSEFH LKAKKAFKDR AVKKEYLALT QGIIEEEREI NAPILTFKTT 150
    KAFSKISKKG QEAVTIITPL KIINKKTLLK VGIKTGRTHQ IRVHLKHINH 200
    PIIGDTLYNN EPSLAKRLML HAHKIALLGY EFEAIAPKEF EI 242
    Length:242
    Mass (Da):27,457
    Last modified:January 1, 1998 - v1
    Checksum:iBB94C062C7BE8165
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07999.1.
    PIRiD64639.
    RefSeqiNP_207748.1. NC_000915.1.
    YP_006934873.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07999; AAD07999; HP_0956.
    GeneIDi13870149.
    899489.
    KEGGiheo:C694_04925.
    hpy:HP0956.
    PATRICi20593225. VBIHelPyl33062_0994.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07999.1 .
    PIRi D64639.
    RefSeqi NP_207748.1. NC_000915.1.
    YP_006934873.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali O25610.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O25610. 2 interactions.
    STRINGi 85962.HP0956.

    PTM databases

    PhosSitei P11071051.

    Proteomic databases

    PRIDEi O25610.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07999 ; AAD07999 ; HP_0956 .
    GeneIDi 13870149.
    899489.
    KEGGi heo:C694_04925.
    hpy:HP0956.
    PATRICi 20593225. VBIHelPyl33062_0994.

    Phylogenomic databases

    eggNOGi COG0564.
    KOi K06179.
    OMAi YGDSQHS.
    OrthoDBi EOG6P070X.

    Enzyme and pathway databases

    BioCyci HPY:HP0956-MONOMER.

    Family and domain databases

    InterProi IPR020103. PsdUridine_synth_cat_dom.
    IPR006224. PsdUridine_synth_RluC/D_CS.
    IPR006145. PsdUridine_synth_RsuA/RluD.
    IPR002942. S4_RNA-bd.
    [Graphical view ]
    Pfami PF00849. PseudoU_synth_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55120. SSF55120. 1 hit.
    PROSITEi PS01129. PSI_RLU. 1 hit.
    PS50889. S4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiY956_HELPY
    AccessioniPrimary (citable) accession number: O25610
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3