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Protein

Uncharacterized RNA pseudouridine synthase HP_0956

Gene

HP_0956

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

RNA uridine = RNA pseudouridine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei93 – 931By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciHPY:HP0956-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized RNA pseudouridine synthase HP_0956 (EC:5.4.99.-)
Alternative name(s):
RNA pseudouridylate synthase
RNA-uridine isomerase
Gene namesi
Ordered Locus Names:HP_0956
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 242242Uncharacterized RNA pseudouridine synthase HP_0956PRO_0000162737Add
BLAST

Proteomic databases

PRIDEiO25610.

Interactioni

Protein-protein interaction databases

IntActiO25610. 2 interactions.
STRINGi85962.HP0956.

Structurei

3D structure databases

ProteinModelPortaliO25610.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 6261S4 RNA-bindingPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the pseudouridine synthase RluA family.Curated
Contains 1 S4 RNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0564.
KOiK06179.
OMAiNERMANI.
OrthoDBiEOG6P070X.

Family and domain databases

InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR006224. PsdUridine_synth_RluC/D_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
IPR002942. S4_RNA-bd.
[Graphical view]
PfamiPF00849. PseudoU_synth_2. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
PROSITEiPS01129. PSI_RLU. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O25610-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKAYKILSV QENISHKKAK ALIDSGLVSI GGKKLMVARK ELPKNTHFSV
60 70 80 90 100
QKVEKPSVIF EDENILALFK PPFIESYDLA SFFKGWALLH RLDKETSGVV
110 120 130 140 150
LLVKENSEFH LKAKKAFKDR AVKKEYLALT QGIIEEEREI NAPILTFKTT
160 170 180 190 200
KAFSKISKKG QEAVTIITPL KIINKKTLLK VGIKTGRTHQ IRVHLKHINH
210 220 230 240
PIIGDTLYNN EPSLAKRLML HAHKIALLGY EFEAIAPKEF EI
Length:242
Mass (Da):27,457
Last modified:January 1, 1998 - v1
Checksum:iBB94C062C7BE8165
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07999.1.
PIRiD64639.
RefSeqiNP_207748.1. NC_000915.1.
WP_000409617.1. NC_018939.1.
YP_006934873.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07999; AAD07999; HP_0956.
GeneIDi899489.
KEGGiheo:C694_04925.
hpy:HP0956.
PATRICi20593225. VBIHelPyl33062_0994.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07999.1.
PIRiD64639.
RefSeqiNP_207748.1. NC_000915.1.
WP_000409617.1. NC_018939.1.
YP_006934873.1. NC_018939.1.

3D structure databases

ProteinModelPortaliO25610.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO25610. 2 interactions.
STRINGi85962.HP0956.

Proteomic databases

PRIDEiO25610.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07999; AAD07999; HP_0956.
GeneIDi899489.
KEGGiheo:C694_04925.
hpy:HP0956.
PATRICi20593225. VBIHelPyl33062_0994.

Phylogenomic databases

eggNOGiCOG0564.
KOiK06179.
OMAiNERMANI.
OrthoDBiEOG6P070X.

Enzyme and pathway databases

BioCyciHPY:HP0956-MONOMER.

Family and domain databases

InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR006224. PsdUridine_synth_RluC/D_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
IPR002942. S4_RNA-bd.
[Graphical view]
PfamiPF00849. PseudoU_synth_2. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
PROSITEiPS01129. PSI_RLU. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiY956_HELPY
AccessioniPrimary (citable) accession number: O25610
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: May 27, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.