O25610 (Y956_HELPY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized RNA pseudouridine synthase HP_0956
EC=5.4.99.-

Alternative name(s):
RNA pseudouridylate synthase
RNA-uridine isomerase

Gene names

Ordered Locus Names:

HP_0956

Organism

Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]

Taxonomic identifier

85962 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › Helicobacter pylori

Protein attributes

Sequence length	242 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	RNA uridine = RNA pseudouridine.
Sequence similarities	Belongs to the pseudouridine synthase RluA family. Contains 1 S4 RNA-binding domain.

Ontologies

Keywords
Ligand	RNA-binding
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	pseudouridine synthesis Inferred from electronic annotation. Source: InterPro
Molecular_function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW pseudouridine synthase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 242	242	Uncharacterized RNA pseudouridine synthase HP_0956		PRO_0000162737
Regions
	Domain	2 – 62	61	S4 RNA-binding
Sites
	Active site	93	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	O25610 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: BB94C062C7BE8165	FASTA	242	27,457
	10 20 30 40 50 60 MEKAYKILSV QENISHKKAK ALIDSGLVSI GGKKLMVARK ELPKNTHFSV QKVEKPSVIF 70 80 90 100 110 120 EDENILALFK PPFIESYDLA SFFKGWALLH RLDKETSGVV LLVKENSEFH LKAKKAFKDR 130 140 150 160 170 180 AVKKEYLALT QGIIEEEREI NAPILTFKTT KAFSKISKKG QEAVTIITPL KIINKKTLLK 190 200 210 220 230 240 VGIKTGRTHQ IRVHLKHINH PIIGDTLYNN EPSLAKRLML HAHKIALLGY EFEAIAPKEF EI

References

[1]

"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000511 Genomic DNA. Translation: AAD07999.1.
PIR	D64639.
RefSeq	NP_207748.1. NC_000915.1. YP_006934873.1. NC_018939.1.
3D structure databases
ProteinModelPortal	O25610.
ModBase	Search...
Protein-protein interaction databases
STRING	85962.HP0956.
PTM databases
PhosSite	P11071051.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAD07999; AAD07999; HP_0956.
GeneID	13870149. 899489.
KEGG	heo:C694_04925. hpy:HP0956.
PATRIC	20593225. VBIHelPyl33062_0994.
Phylogenomic databases
eggNOG	COG0564.
KO	K06179.
OMA	WALLHRL.
ProtClustDB	CLSK872473.
Family and domain databases
InterPro	IPR020103. PsdUridine_synth_cat_dom. IPR006224. PsdUridine_synth_RluC/D_CS. IPR006145. PsdUridine_synth_RsuA/RluD. IPR002942. S4_RNA-bd. [Graphical view]
Pfam	PF00849. PseudoU_synth_2. 1 hit. [Graphical view]
SUPFAM	SSF55120. PsdUridine_synth_cat_dom. 1 hit.
PROSITE	PS01129. PSI_RLU. 1 hit. PS50889. S4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Y956_HELPY

Accession

Primary (citable) accession number: O25610

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program