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Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta

Gene

accD

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.UniRule annotation

Catalytic activityi

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD), Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi31 – 311ZincUniRule annotation
Metal bindingi34 – 341ZincUniRule annotation
Metal bindingi50 – 501ZincUniRule annotation
Metal bindingi53 – 531ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri31 – 5323C4-typeUniRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Fatty acid biosynthesisUniRule annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciHPY:HP0950-MONOMER.
UniPathwayiUPA00655; UER00711.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit betaUniRule annotation (EC:6.4.1.2UniRule annotation)
Short name:
ACCase subunit betaUniRule annotation
Short name:
Acetyl-CoA carboxylase carboxyltransferase subunit betaUniRule annotation
Gene namesi
Name:accDUniRule annotation
Ordered Locus Names:HP_0950Imported
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)Imported
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiO25604.

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).UniRule annotationSAAS annotation

Protein-protein interaction databases

DIPiDIP-3163N.
IntActiO25604. 12 interactions.
MINTiMINT-163318.
STRINGi85962.HP0950.

Structurei

3D structure databases

ProteinModelPortaliO25604.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 262215CarboxyltransferaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the AccD/PCCB family.UniRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri31 – 5323C4-typeUniRule annotationAdd
BLAST

Keywords - Domaini

Zinc-fingerUniRule annotation

Phylogenomic databases

eggNOGiENOG4107QTG. Bacteria.
COG0777. LUCA.
KOiK01963.
OMAiPEGLWIK.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
HAMAPiMF_01395. AcetylCoA_CT_beta. 1 hit.
InterProiIPR000438. Acetyl_CoA_COase_Trfase_b_su.
IPR000022. Carboxyl_trans.
IPR029045. ClpP/crotonase-like_dom.
IPR011762. COA_CT_N.
[Graphical view]
PfamiPF01039. Carboxyl_trans. 1 hit.
[Graphical view]
PRINTSiPR01070. ACCCTRFRASEB.
SUPFAMiSSF52096. SSF52096. 1 hit.
TIGRFAMsiTIGR00515. accD. 1 hit.
PROSITEiPS50980. COA_CT_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O25604-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFADFFKNF KINKLRTAPS KEEQPSHWVK CPKCYALMYH KEVFSKYSVC
60 70 80 90 100
LKCHYHFRMK AAERIEFLCD VGSFEEFDKH LRPNDPLNFV DKESYKQRIK
110 120 130 140 150
KYEKRTNRPS SVISGEAKIN RMPLQIVVFD FSFMGGSLGS VEGEKIVRAI
160 170 180 190 200
NRAVAKREAL LIVSASGGAR MQESTYSLMQ MAKTSAALNR LSEAKLPFIS
210 220 230 240 250
LLSDPTYGGV SASFAFLGDL IIAEPGAMIG FAGPRVIKQT IGADLPEGFQ
260 270 280
TAEFLLEHGL IDMIVHRKDL KKTLSDLIAM MTHKTSKIF
Length:289
Mass (Da):32,553
Last modified:January 1, 1998 - v1
Checksum:iA57ADDAF34B0AF1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07995.1.
PIRiF64638.
RefSeqiNP_207742.1. NC_000915.1.
WP_000505053.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07995; AAD07995; HP_0950.
GeneIDi899483.
KEGGiheo:C694_04895.
hpy:HP0950.
PATRICi20593213. VBIHelPyl33062_0988.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07995.1.
PIRiF64638.
RefSeqiNP_207742.1. NC_000915.1.
WP_000505053.1. NC_018939.1.

3D structure databases

ProteinModelPortaliO25604.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3163N.
IntActiO25604. 12 interactions.
MINTiMINT-163318.
STRINGi85962.HP0950.

Proteomic databases

PaxDbiO25604.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07995; AAD07995; HP_0950.
GeneIDi899483.
KEGGiheo:C694_04895.
hpy:HP0950.
PATRICi20593213. VBIHelPyl33062_0988.

Phylogenomic databases

eggNOGiENOG4107QTG. Bacteria.
COG0777. LUCA.
KOiK01963.
OMAiPEGLWIK.

Enzyme and pathway databases

UniPathwayiUPA00655; UER00711.
BioCyciHPY:HP0950-MONOMER.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
HAMAPiMF_01395. AcetylCoA_CT_beta. 1 hit.
InterProiIPR000438. Acetyl_CoA_COase_Trfase_b_su.
IPR000022. Carboxyl_trans.
IPR029045. ClpP/crotonase-like_dom.
IPR011762. COA_CT_N.
[Graphical view]
PfamiPF01039. Carboxyl_trans. 1 hit.
[Graphical view]
PRINTSiPR01070. ACCCTRFRASEB.
SUPFAMiSSF52096. SSF52096. 1 hit.
TIGRFAMsiTIGR00515. accD. 1 hit.
PROSITEiPS50980. COA_CT_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO25604_HELPY
AccessioniPrimary (citable) accession number: O25604
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.