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O25537

- LPXB_HELPY

UniProt

O25537 - LPXB_HELPY

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.By similarity

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciHPY:HP0867-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:HP_0867
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 360360Lipid-A-disaccharide synthasePRO_0000190169Add
BLAST

Proteomic databases

PRIDEiO25537.

Interactioni

Protein-protein interaction databases

STRINGi85962.HP0867.

Structurei

3D structure databases

ProteinModelPortaliO25537.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.Curated

Phylogenomic databases

eggNOGiCOG0763.
KOiK00748.
OMAiIARMLVN.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

O25537-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPTILVSALE ASSNAHLEEL RQNLPEDYRF IGVFEGKEVL YSPREFSIMG
60 70 80 90 100
FRDVIGRLGF LLKAHKEMVQ LAKQADMVLL MDSSSFNIPL AKKIKKQDPH
110 120 130 140 150
KKIMYYILPQ VWAWKKWRAK SLEKYCDFLG AILPFEVGYY QKKAQYVGHP
160 170 180 190 200
LLDEIKHYKK DIKGETLVFM PGSRKSEIAK MFPLFVKAAQ MLEQNEGFKR
210 220 230 240 250
RVLVVPSFFK GLDLKALYGE DIQLFEISYD AHKSLFEAEF AFICSGTATL
260 270 280 290 300
EAALIGTPFV LAYRAKTMDF LIARMLVNLH YIGLANIFYN ALNNETPGLG
310 320 330 340 350
ESQLHPELIQ HFLSVEGLLK AYKEMDRERY FKESLRLREY LKHGSARKIA
360
NEMAFLLNLT
Length:360
Mass (Da):41,518
Last modified:January 1, 1998 - v1
Checksum:i420421646FCE067D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07909.1.
PIRiC64628.
RefSeqiNP_207661.1. NC_000915.1.
YP_006934781.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07909; AAD07909; HP_0867.
GeneIDi13870051.
899396.
KEGGiheo:C694_04440.
hpy:HP0867.
PATRICi20593023. VBIHelPyl33062_0899.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07909.1 .
PIRi C64628.
RefSeqi NP_207661.1. NC_000915.1.
YP_006934781.1. NC_018939.1.

3D structure databases

ProteinModelPortali O25537.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 85962.HP0867.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Proteomic databases

PRIDEi O25537.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07909 ; AAD07909 ; HP_0867 .
GeneIDi 13870051.
899396.
KEGGi heo:C694_04440.
hpy:HP0867.
PATRICi 20593023. VBIHelPyl33062_0899.

Phylogenomic databases

eggNOGi COG0763.
KOi K00748.
OMAi IARMLVN.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci HPY:HP0867-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiLPXB_HELPY
AccessioniPrimary (citable) accession number: O25537
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: October 1, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3