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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.By similarity

Catalytic activityi

UDP-2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosamine + 2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate = UDP + 2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-beta-D-glucosaminyl-(1->6)-2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate.

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciHPY:HP0867-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:HP_0867
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 360360Lipid-A-disaccharide synthasePRO_0000190169Add
BLAST

Proteomic databases

PRIDEiO25537.

Interactioni

Protein-protein interaction databases

STRINGi85962.HP0867.

Structurei

3D structure databases

ProteinModelPortaliO25537.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.Curated

Phylogenomic databases

eggNOGiCOG0763.
KOiK00748.
OMAiIARMLVN.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

O25537-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTILVSALE ASSNAHLEEL RQNLPEDYRF IGVFEGKEVL YSPREFSIMG
60 70 80 90 100
FRDVIGRLGF LLKAHKEMVQ LAKQADMVLL MDSSSFNIPL AKKIKKQDPH
110 120 130 140 150
KKIMYYILPQ VWAWKKWRAK SLEKYCDFLG AILPFEVGYY QKKAQYVGHP
160 170 180 190 200
LLDEIKHYKK DIKGETLVFM PGSRKSEIAK MFPLFVKAAQ MLEQNEGFKR
210 220 230 240 250
RVLVVPSFFK GLDLKALYGE DIQLFEISYD AHKSLFEAEF AFICSGTATL
260 270 280 290 300
EAALIGTPFV LAYRAKTMDF LIARMLVNLH YIGLANIFYN ALNNETPGLG
310 320 330 340 350
ESQLHPELIQ HFLSVEGLLK AYKEMDRERY FKESLRLREY LKHGSARKIA
360
NEMAFLLNLT
Length:360
Mass (Da):41,518
Last modified:January 1, 1998 - v1
Checksum:i420421646FCE067D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07909.1.
PIRiC64628.
RefSeqiNP_207661.1. NC_000915.1.
YP_006934781.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07909; AAD07909; HP_0867.
GeneIDi899396.
KEGGiheo:C694_04440.
hpy:HP0867.
PATRICi20593023. VBIHelPyl33062_0899.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07909.1.
PIRiC64628.
RefSeqiNP_207661.1. NC_000915.1.
YP_006934781.1. NC_018939.1.

3D structure databases

ProteinModelPortaliO25537.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi85962.HP0867.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Proteomic databases

PRIDEiO25537.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07909; AAD07909; HP_0867.
GeneIDi899396.
KEGGiheo:C694_04440.
hpy:HP0867.
PATRICi20593023. VBIHelPyl33062_0899.

Phylogenomic databases

eggNOGiCOG0763.
KOiK00748.
OMAiIARMLVN.
OrthoDBiEOG6FBWZR.

Enzyme and pathway databases

UniPathwayiUPA00359; UER00481.
BioCyciHPY:HP0867-MONOMER.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiLPXB_HELPY
AccessioniPrimary (citable) accession number: O25537
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: April 29, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.