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O25537 (LPXB_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lipid-A-disaccharide synthase

EC=2.4.1.182
Gene names
Name:lpxB
Ordered Locus Names:HP_0867
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length360 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392

Catalytic activity

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392

Sequence similarities

Belongs to the LpxB family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 360360Lipid-A-disaccharide synthase HAMAP-Rule MF_00392
PRO_0000190169

Sequences

Sequence LengthMass (Da)Tools
O25537 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 420421646FCE067D

FASTA36041,518
        10         20         30         40         50         60 
MPTILVSALE ASSNAHLEEL RQNLPEDYRF IGVFEGKEVL YSPREFSIMG FRDVIGRLGF 

        70         80         90        100        110        120 
LLKAHKEMVQ LAKQADMVLL MDSSSFNIPL AKKIKKQDPH KKIMYYILPQ VWAWKKWRAK 

       130        140        150        160        170        180 
SLEKYCDFLG AILPFEVGYY QKKAQYVGHP LLDEIKHYKK DIKGETLVFM PGSRKSEIAK 

       190        200        210        220        230        240 
MFPLFVKAAQ MLEQNEGFKR RVLVVPSFFK GLDLKALYGE DIQLFEISYD AHKSLFEAEF 

       250        260        270        280        290        300 
AFICSGTATL EAALIGTPFV LAYRAKTMDF LIARMLVNLH YIGLANIFYN ALNNETPGLG 

       310        320        330        340        350        360 
ESQLHPELIQ HFLSVEGLLK AYKEMDRERY FKESLRLREY LKHGSARKIA NEMAFLLNLT 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD07909.1.
PIRC64628.
RefSeqNP_207661.1. NC_000915.1.
YP_006934781.1. NC_018939.1.

3D structure databases

ProteinModelPortalO25537.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING85962.HP0867.

Protein family/group databases

CAZyGT19. Glycosyltransferase Family 19.

Proteomic databases

PRIDEO25537.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD07909; AAD07909; HP_0867.
GeneID13870051.
899396.
KEGGheo:C694_04440.
hpy:HP0867.
PATRIC20593023. VBIHelPyl33062_0899.

Phylogenomic databases

eggNOGCOG0763.
KOK00748.
OMAIARMLVN.
OrthoDBEOG6FBWZR.
ProtClustDBPRK14089.

Enzyme and pathway databases

BioCycHPY:HP0867-MONOMER.
UniPathwayUPA00359; UER00481.

Family and domain databases

HAMAPMF_00392. LpxB.
InterProIPR003835. Glyco_trans_19.
[Graphical view]
PfamPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00215. lpxB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLPXB_HELPY
AccessionPrimary (citable) accession number: O25537
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: February 19, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names