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O25536

- DUT_HELPY

UniProt

O25536 - DUT_HELPY

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Protein
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Gene
dut, HP_0865
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity.UniRule annotation

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei75 – 751Substrate By similarity
Binding sitei89 – 891Substrate; via amide nitrogen and carbonyl oxygen By similarity

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. dUMP biosynthetic process Source: UniProtKB-UniPathway
  2. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciHPY:HP0865-MONOMER.
UniPathwayiUPA00610; UER00666.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
Name:dut
Ordered Locus Names:HP_0865
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 145145Deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation
PRO_0000182869Add
BLAST

Proteomic databases

PRIDEiO25536.

Interactioni

Protein-protein interaction databases

IntActiO25536. 1 interaction.
STRINGi85962.HP0865.

Structurei

3D structure databases

ProteinModelPortaliO25536.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni62 – 643Substrate binding By similarity
Regioni79 – 813Substrate binding By similarity

Sequence similaritiesi

Belongs to the dUTPase family.

Phylogenomic databases

eggNOGiCOG0756.
KOiK01520.
OMAiMLANTIG.
OrthoDBiEOG689HXK.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_00116. dUTPase_bact.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR00576. dut. 1 hit.

Sequencei

Sequence statusi: Complete.

O25536-1 [UniParc]FASTAAdd to Basket

« Hide

MKIKIQKIHP NALIPKYQTD GSSGFDLHAV EEVMIKPHSV GLVKIGICLS    50
LEVGYELQVR TRSGLALNHQ VMVLNSPGTV DNDYRGEIKV ILANLSDKDF 100
KVQVGDRIAQ GVVQKTYKAE FIECEQLDET SRGSGGFGST GVSKA 145
Length:145
Mass (Da):15,801
Last modified:January 1, 1998 - v1
Checksum:i98504D2FC8605013
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07907.1.
PIRiA64628.
RefSeqiNP_207659.1. NC_000915.1.
YP_006934779.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07907; AAD07907; HP_0865.
GeneIDi13870049.
899394.
KEGGiheo:C694_04430.
hpy:HP0865.
PATRICi20593019. VBIHelPyl33062_0897.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07907.1 .
PIRi A64628.
RefSeqi NP_207659.1. NC_000915.1.
YP_006934779.1. NC_018939.1.

3D structure databases

ProteinModelPortali O25536.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O25536. 1 interaction.
STRINGi 85962.HP0865.

Chemistry

BindingDBi O25536.

Proteomic databases

PRIDEi O25536.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07907 ; AAD07907 ; HP_0865 .
GeneIDi 13870049.
899394.
KEGGi heo:C694_04430.
hpy:HP0865.
PATRICi 20593019. VBIHelPyl33062_0897.

Phylogenomic databases

eggNOGi COG0756.
KOi K01520.
OMAi MLANTIG.
OrthoDBi EOG689HXK.

Enzyme and pathway databases

UniPathwayi UPA00610 ; UER00666 .
BioCyci HPY:HP0865-MONOMER.

Family and domain databases

Gene3Di 2.70.40.10. 1 hit.
HAMAPi MF_00116. dUTPase_bact.
InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 1 hit.
TIGRFAMsi TIGR00576. dut. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiDUT_HELPY
AccessioniPrimary (citable) accession number: O25536
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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