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O25534 (PGBB_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Plasminogen-binding protein PgbB
Gene names
Name:pgbB
Ordered Locus Names:HP_0863
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length542 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds plasminogen, specifically, and in a concentration and lysine-dependent manner. Plasminogen is the precursor of plasmin, a serine protease that cleaves fibrin, fibronectin, laminin and vitronectin. Acquisition of plasminogen/plasmin could enable H.pylori to degrade host components.

Subcellular location

Cell surface Probable. Note: The plasminogen-binding region is localized on the surface the bacterium Probable.

Miscellaneous

Plasminogen bound to PgbB is capable of being converted to functionally active plasmin.

Ontologies

Keywords
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcell surface

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 542542Plasminogen-binding protein PgbB
PRO_0000058353

Regions

Compositional bias303 – 542240Lys-rich

Sequences

Sequence LengthMass (Da)Tools
O25534 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: E77A4EF68A04ECED

FASTA54261,900
        10         20         30         40         50         60 
MNKPFLILLI ALIVFSGCNM RKYFKPAKHQ IKGEAYFPNH LQESIVSSNR YGAILKNGAV 

        70         80         90        100        110        120 
IGDKGLTQLR IGKNFNYESS FLNESQGFFI LAQDCLNKID KKTNKSKVAK TEETELKLKG 

       130        140        150        160        170        180 
VEAEVQDKVC HQVELISNNP NASQQSIVIP LETFALSASV KGNLLAVVLA DNSANLYDIT 

       190        200        210        220        230        240 
SQKLLFSEKG SPSTTINSLM AMPIFMDTVV VFPMLDGRLL VVDYVHGNPT PIRNIVISSD 

       250        260        270        280        290        300 
KFFNNITYLI VDGNNMIAST GKRILSVVSG QEFNYDGDIV DLLYDKGTLY VLTLDGQILQ 

       310        320        330        340        350        360 
MDKSLRELNS VKLPSSLNTI VLNHNKLYSL EKRGYVIEVD LNDFDSYNVY KTPTIGSFKF 

       370        380        390        400        410        420 
FSSNRLDKGV FYDKNRVYYD RYYLDYNDFK PKLYPVVEKS ASKKSQKGEK GNAPIYLQER 

       430        440        450        460        470        480 
HKAKENKQPL EENKVKPRNS GFEEEEVKTR RPEPIRDQNN ATQQGETKNN ESKNAPVLKE 

       490        500        510        520        530        540 
NAAKKEVPKP NSKEEKRRLK EEKKKAKAEQ RAREFEQRAR EHQERDEKEL EERRKALEMN 


KK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD07917.1.
PIRG64627.
RefSeqNP_207657.1. NC_000915.1.
YP_006934777.1. NC_018939.1.

3D structure databases

ProteinModelPortalO25534.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING85962.HP0863.

Proteomic databases

PRIDEO25534.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD07917; AAD07917; HP_0863.
GeneID13870047.
899392.
KEGGheo:C694_04420.
hpy:HP0863.
PATRIC20593015. VBIHelPyl33062_0895.

Phylogenomic databases

eggNOGNOG14491.
OMAFPMLDGR.
OrthoDBEOG6J48HH.
ProtClustDBCLSK872461.

Enzyme and pathway databases

BioCycHPY:HP0863-MONOMER.

Family and domain databases

Gene3D2.130.10.10. 1 hit.
InterProIPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
SUPFAMSSF50978. SSF50978. 1 hit.
PROSITEPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGBB_HELPY
AccessionPrimary (citable) accession number: O25534
Entry history
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 1, 1998
Last modified: February 19, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names