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O25534

- PGBB_HELPY

UniProt

O25534 - PGBB_HELPY

Protein

Plasminogen-binding protein PgbB

Gene

pgbB

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Binds plasminogen, specifically, and in a concentration and lysine-dependent manner. Plasminogen is the precursor of plasmin, a serine protease that cleaves fibrin, fibronectin, laminin and vitronectin. Acquisition of plasminogen/plasmin could enable H.pylori to degrade host components.

    Enzyme and pathway databases

    BioCyciHPY:HP0863-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Plasminogen-binding protein PgbB
    Gene namesi
    Name:pgbB
    Ordered Locus Names:HP_0863
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    Subcellular locationi

    Cell surface Curated
    Note: The plasminogen-binding region is localized on the surface the bacterium.Curated

    GO - Cellular componenti

    1. cell surface Source: UniProtKB-SubCell

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 542542Plasminogen-binding protein PgbBPRO_0000058353Add
    BLAST

    Proteomic databases

    PRIDEiO25534.

    Interactioni

    Protein-protein interaction databases

    STRINGi85962.HP0863.

    Structurei

    3D structure databases

    ProteinModelPortaliO25534.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi303 – 542240Lys-richAdd
    BLAST

    Phylogenomic databases

    eggNOGiNOG14491.
    OMAiFPMLDGR.
    OrthoDBiEOG6J48HH.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR015943. WD40/YVTN_repeat-like_dom.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O25534-1 [UniParc]FASTAAdd to Basket

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    MNKPFLILLI ALIVFSGCNM RKYFKPAKHQ IKGEAYFPNH LQESIVSSNR    50
    YGAILKNGAV IGDKGLTQLR IGKNFNYESS FLNESQGFFI LAQDCLNKID 100
    KKTNKSKVAK TEETELKLKG VEAEVQDKVC HQVELISNNP NASQQSIVIP 150
    LETFALSASV KGNLLAVVLA DNSANLYDIT SQKLLFSEKG SPSTTINSLM 200
    AMPIFMDTVV VFPMLDGRLL VVDYVHGNPT PIRNIVISSD KFFNNITYLI 250
    VDGNNMIAST GKRILSVVSG QEFNYDGDIV DLLYDKGTLY VLTLDGQILQ 300
    MDKSLRELNS VKLPSSLNTI VLNHNKLYSL EKRGYVIEVD LNDFDSYNVY 350
    KTPTIGSFKF FSSNRLDKGV FYDKNRVYYD RYYLDYNDFK PKLYPVVEKS 400
    ASKKSQKGEK GNAPIYLQER HKAKENKQPL EENKVKPRNS GFEEEEVKTR 450
    RPEPIRDQNN ATQQGETKNN ESKNAPVLKE NAAKKEVPKP NSKEEKRRLK 500
    EEKKKAKAEQ RAREFEQRAR EHQERDEKEL EERRKALEMN KK 542
    Length:542
    Mass (Da):61,900
    Last modified:January 1, 1998 - v1
    Checksum:iE77A4EF68A04ECED
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07917.1.
    PIRiG64627.
    RefSeqiNP_207657.1. NC_000915.1.
    YP_006934777.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07917; AAD07917; HP_0863.
    GeneIDi13870047.
    899392.
    KEGGiheo:C694_04420.
    hpy:HP0863.
    PATRICi20593015. VBIHelPyl33062_0895.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07917.1 .
    PIRi G64627.
    RefSeqi NP_207657.1. NC_000915.1.
    YP_006934777.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali O25534.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 85962.HP0863.

    Proteomic databases

    PRIDEi O25534.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07917 ; AAD07917 ; HP_0863 .
    GeneIDi 13870047.
    899392.
    KEGGi heo:C694_04420.
    hpy:HP0863.
    PATRICi 20593015. VBIHelPyl33062_0895.

    Phylogenomic databases

    eggNOGi NOG14491.
    OMAi FPMLDGR.
    OrthoDBi EOG6J48HH.

    Enzyme and pathway databases

    BioCyci HPY:HP0863-MONOMER.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR015943. WD40/YVTN_repeat-like_dom.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS51257. PROKAR_LIPOPROTEIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.
    2. "Molecular cloning and characterization of two Helicobacter pylori genes coding for plasminogen-binding proteins."
      Joensson K., Guo B.P., Monstein H.J., Mekalanos J.J., Kronvall G.
      Proc. Natl. Acad. Sci. U.S.A. 101:1852-1857(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PLASMINOGEN-BINDING ACTIVITY.
      Strain: ATCC 700392 / 26695 and DSM 4867 / CCUG 17874 / NCTC 11638.

    Entry informationi

    Entry nameiPGBB_HELPY
    AccessioniPrimary (citable) accession number: O25534
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Plasminogen bound to PgbB is capable of being converted to functionally active plasmin.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names

    External Data

    Dasty 3