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Protein

Plasminogen-binding protein PgbB

Gene

pgbB

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds plasminogen, specifically, and in a concentration and lysine-dependent manner. Plasminogen is the precursor of plasmin, a serine protease that cleaves fibrin, fibronectin, laminin and vitronectin. Acquisition of plasminogen/plasmin could enable H.pylori to degrade host components.

Miscellaneous

Plasminogen bound to PgbB is capable of being converted to functionally active plasmin.

Enzyme and pathway databases

BioCyciHPY:HP0863-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Plasminogen-binding protein PgbB
Gene namesi
Name:pgbB
Ordered Locus Names:HP_0863
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

  • Cell surface Curated
  • Note: The plasminogen-binding region is localized on the surface the bacterium.Curated

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000583531 – 542Plasminogen-binding protein PgbBAdd BLAST542

Proteomic databases

PaxDbiO25534
PRIDEiO25534

Interactioni

Protein-protein interaction databases

STRINGi85962.HP0863

Structurei

3D structure databases

ProteinModelPortaliO25534
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi303 – 542Lys-richAdd BLAST240

Phylogenomic databases

eggNOGiENOG4108TX7 Bacteria
ENOG4111FJR LUCA
OMAiNYESSFL

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR032737 PGBA_C
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF15437 PGBA_C, 1 hit
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS51257 PROKAR_LIPOPROTEIN, 1 hit

Sequencei

Sequence statusi: Complete.

O25534-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKPFLILLI ALIVFSGCNM RKYFKPAKHQ IKGEAYFPNH LQESIVSSNR
60 70 80 90 100
YGAILKNGAV IGDKGLTQLR IGKNFNYESS FLNESQGFFI LAQDCLNKID
110 120 130 140 150
KKTNKSKVAK TEETELKLKG VEAEVQDKVC HQVELISNNP NASQQSIVIP
160 170 180 190 200
LETFALSASV KGNLLAVVLA DNSANLYDIT SQKLLFSEKG SPSTTINSLM
210 220 230 240 250
AMPIFMDTVV VFPMLDGRLL VVDYVHGNPT PIRNIVISSD KFFNNITYLI
260 270 280 290 300
VDGNNMIAST GKRILSVVSG QEFNYDGDIV DLLYDKGTLY VLTLDGQILQ
310 320 330 340 350
MDKSLRELNS VKLPSSLNTI VLNHNKLYSL EKRGYVIEVD LNDFDSYNVY
360 370 380 390 400
KTPTIGSFKF FSSNRLDKGV FYDKNRVYYD RYYLDYNDFK PKLYPVVEKS
410 420 430 440 450
ASKKSQKGEK GNAPIYLQER HKAKENKQPL EENKVKPRNS GFEEEEVKTR
460 470 480 490 500
RPEPIRDQNN ATQQGETKNN ESKNAPVLKE NAAKKEVPKP NSKEEKRRLK
510 520 530 540
EEKKKAKAEQ RAREFEQRAR EHQERDEKEL EERRKALEMN KK
Length:542
Mass (Da):61,900
Last modified:January 1, 1998 - v1
Checksum:iE77A4EF68A04ECED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD07917.1
PIRiG64627
RefSeqiNP_207657.1, NC_000915.1
WP_001039566.1, NC_018939.1

Genome annotation databases

EnsemblBacteriaiAAD07917; AAD07917; HP_0863
GeneIDi899392
KEGGiheo:C694_04420
hpy:HP0863
PATRICifig|85962.47.peg.917

Similar proteinsi

Entry informationi

Entry nameiPGBB_HELPY
AccessioniPrimary (citable) accession number: O25534
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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