O25534 (PGBB_HELPY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Plasminogen-binding protein PgbB

Gene names

Name:	pgbB
Ordered Locus Names:	HP_0863

Organism

Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]

Taxonomic identifier

85962 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › Helicobacter pylori

Protein attributes

Sequence length	542 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds plasminogen, specifically, and in a concentration and lysine-dependent manner. Plasminogen is the precursor of plasmin, a serine protease that cleaves fibrin, fibronectin, laminin and vitronectin. Acquisition of plasminogen/plasmin could enable H.pylori to degrade host components.
Subcellular location	Cell surface Probable. Note: The plasminogen-binding region is localized on the surface the bacterium Probable.
Miscellaneous	Plasminogen bound to PgbB is capable of being converted to functionally active plasmin.

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cell surface Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 542	542	Plasminogen-binding protein PgbB		PRO_0000058353
Regions
	Compositional bias	303 – 542	240	Lys-rich

Sequences

	Sequence		Length	Mass (Da)
	O25534 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: E77A4EF68A04ECED	FASTA	542	61,900
	10 20 30 40 50 60 MNKPFLILLI ALIVFSGCNM RKYFKPAKHQ IKGEAYFPNH LQESIVSSNR YGAILKNGAV 70 80 90 100 110 120 IGDKGLTQLR IGKNFNYESS FLNESQGFFI LAQDCLNKID KKTNKSKVAK TEETELKLKG 130 140 150 160 170 180 VEAEVQDKVC HQVELISNNP NASQQSIVIP LETFALSASV KGNLLAVVLA DNSANLYDIT 190 200 210 220 230 240 SQKLLFSEKG SPSTTINSLM AMPIFMDTVV VFPMLDGRLL VVDYVHGNPT PIRNIVISSD 250 260 270 280 290 300 KFFNNITYLI VDGNNMIAST GKRILSVVSG QEFNYDGDIV DLLYDKGTLY VLTLDGQILQ 310 320 330 340 350 360 MDKSLRELNS VKLPSSLNTI VLNHNKLYSL EKRGYVIEVD LNDFDSYNVY KTPTIGSFKF 370 380 390 400 410 420 FSSNRLDKGV FYDKNRVYYD RYYLDYNDFK PKLYPVVEKS ASKKSQKGEK GNAPIYLQER 430 440 450 460 470 480 HKAKENKQPL EENKVKPRNS GFEEEEVKTR RPEPIRDQNN ATQQGETKNN ESKNAPVLKE 490 500 510 520 530 540 NAAKKEVPKP NSKEEKRRLK EEKKKAKAEQ RAREFEQRAR EHQERDEKEL EERRKALEMN KK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.
[2]	"Molecular cloning and characterization of two Helicobacter pylori genes coding for plasminogen-binding proteins." Joensson K., Guo B.P., Monstein H.J., Mekalanos J.J., Kronvall G. Proc. Natl. Acad. Sci. U.S.A. 101:1852-1857(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PLASMINOGEN-BINDING ACTIVITY. Strain: ATCC 700392 / 26695 and DSM 4867 / CCUG 17874 / NCTC 11638.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000511 Genomic DNA. Translation: AAD07917.1.
PIR	G64627.
RefSeq	NP_207657.1. NC_000915.1. YP_006934777.1. NC_018939.1.
3D structure databases
ProteinModelPortal	O25534.
ModBase	Search...
Protein-protein interaction databases
STRING	85962.HP0863.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAD07917; AAD07917; HP_0863.
GeneID	13870047. 899392.
KEGG	heo:C694_04420. hpy:HP0863.
PATRIC	20593015. VBIHelPyl33062_0895.
Phylogenomic databases
eggNOG	NOG14491.
OMA	NNMIAST.
ProtClustDB	CLSK872461.
Family and domain databases
Gene3D	2.130.10.10. 1 hit.
InterPro	IPR015943. WD40/YVTN_repeat-like_dom. IPR017986. WD40_repeat_dom. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS51257. PROKAR_LIPOPROTEIN. 1 hit. Uncertain. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGBB_HELPY

Accession

Primary (citable) accession number: O25534

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program